JESSICA N. COOKE BAILEY, PHD, MA

Jessica Cooke Bailey, PhD, MA, is Assistant Professor in the Department of Population and Quantitative Health Sciences with CWRU's School of Medicine. Her research has focused on applying sophisticated statistical methods to understand the genetic basis of glaucoma and age-related macular degeneration in European Americans, including the Amish. Dr. Cooke Bailey is now expanding her work to harness the power of electronic health record (EHR) data coupled with genomics and other “omics” data to understand why African Americans are at increased risk for glaucoma compared with other populations. Understanding glaucoma risk factors will begin to address health disparities with the goal of informing treatment options.

Affiliations

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Recent Publications

  1. Zebardast, N, Sekimitsu, S, Wang, J, Elze, T, Gharahkhani, P, Cole, BS, Lin, MM, Segrè, AV, Wiggs, JL, International Glaucoma Genetics Consortium et al.. Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank. Ophthalmology 2021; 128 (9): 1300-1311. PubMed PMID:33713785 .
  2. Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP, Pendergrass, S, Han, X, Ong, JS, Hewitt, AW, Segrè, AV, Rouhana, JM et al.. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun 2021; 12 (1): 1258. PubMed PMID:33627673 PubMed Central PMC7904932.
  3. Genetics of Exfoliation Syndrome Partnership, Li, Z, Wang, Z, Lee, MC, Zenkel, M, Peh, E, Ozaki, M, Topouzis, F, Nakano, S, Chan, A et al.. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 2021; 325 (8): 753-764. PubMed PMID:33620406 PubMed Central PMC7903258.
  4. Waksmunski, AR, Song, YE, Kinzy, TG, Laux, RA, Sewell, J, Fuzzell, D, Fuzzell, S, Miller, S, Wiggs, JL, Pasquale, LR et al.. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish. Int J Environ Res Public Health 2021; 18 (4): . PubMed PMID:33561996 PubMed Central PMC7915874.
  5. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
  6. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN. Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration. BMC Med Genomics 2020; 13 (1): 95. PubMed PMID:32631374 PubMed Central PMC7336430.
  7. Margeta, MA, Letcher, SM, Igo, RP Jr, Cooke Bailey, JN, Pasquale, LR, Haines, JL, Butovsky, O, Wiggs, JL, NEIGHBORHOOD consortium. Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4. Invest Ophthalmol Vis Sci 2020; 61 (8): 3. PubMed PMID:32614373 PubMed Central PMC7425753.
  8. Cooke Bailey, JN. Progress, Not Perfection: Intraocular Pressure Genetic Risk Score Stratifies Clinically Relevant Primary Open-Angle Glaucoma Outcomes. Ophthalmology 2020; 127 (7): 908-909. PubMed PMID:32564814 .
  9. Craig, JE, Han, X, Qassim, A, Hassall, M, Cooke Bailey, JN, Kinzy, TG, Khawaja, AP, An, J, Marshall, H, Gharahkhani, P et al.. Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nat Genet 2020; 52 (2): 160-166. PubMed PMID:31959993 PubMed Central PMC8056672.
  10. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
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