JESSICA N. COOKE BAILEY, PHD, MA

Jessica Cooke Bailey, PhD, MA, is Assistant Professor in the Department of Population and Quantitative Health Sciences with CWRU's School of Medicine. Her research has focused on applying sophisticated statistical methods to understand the genetic basis of glaucoma and age-related macular degeneration in European Americans, including the Amish. Dr. Cooke Bailey is now expanding her work to harness the power of electronic health record (EHR) data coupled with genomics and other “omics” data to understand why African Americans are at increased risk for glaucoma compared with other populations. Understanding glaucoma risk factors will begin to address health disparities with the goal of informing treatment options.

Affiliations

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Recent Publications

  1. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN. Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration. BMC Med Genomics 2020; 13 (1): 95. PubMed PMID:32631374 PubMed Central PMC7336430.
  2. Margeta, MA, Letcher, SM, Igo, RP Jr, Cooke Bailey, JN, Pasquale, LR, Haines, JL, Butovsky, O, Wiggs, JL, NEIGHBORHOOD consortium. Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4. Invest. Ophthalmol. Vis. Sci. 2020; 61 (8): 3. PubMed PMID:32614373 PubMed Central PMC7425753.
  3. Cooke Bailey, JN. Progress, Not Perfection: Intraocular Pressure Genetic Risk Score Stratifies Clinically Relevant Primary Open-Angle Glaucoma Outcomes. Ophthalmology 2020; 127 (7): 908-909. PubMed PMID:32564814 .
  4. Craig, JE, Han, X, Qassim, A, Hassall, M, Cooke Bailey, JN, Kinzy, TG, Khawaja, AP, An, J, Marshall, H, Gharahkhani, P et al.. Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nat. Genet. 2020; 52 (2): 160-166. PubMed PMID:31959993 .
  5. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
  6. Igo, RP Jr, Kinzy, TG, Cooke Bailey, JN. Genetic Risk Scores. Curr Protoc Hum Genet 2019; 104 (1): e95. PubMed PMID:31765077 PubMed Central PMC6941594.
  7. Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser, MA, Allingham, RR, Aung, T, Van Der Heide, CJ, Taylor, KD, Rotter, JI, Wang, SJ, Bonnemaijer, PWM, Williams, SE et al.. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. JAMA 2019; 322 (17): 1682-1691. PubMed PMID:31688885 PubMed Central PMC6865235.
  8. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN, International Age-Related Macular Degeneration Genomics Consortium. Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2019; 60 (12): 4041-4051. PubMed PMID:31560769 PubMed Central PMC6779289.
  9. Bush, WS, Cooke Bailey, JN, Beno, MF, Crawford, DC. Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. Public Health Genomics 2019; 22 (1-2): 16-24. PubMed PMID:31454805 PubMed Central PMC6752968.
  10. Waksmunski, AR, Igo, RP Jr, Song, YE, Cooke Bailey, JN, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M et al.. Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. Hum. Genet. 2019; 138 (10): 1171-1182. PubMed PMID:31367973 PubMed Central PMC6745026.
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