Professor and Associate Director for Translational Informatics

Dr. Barnholtz-Sloan is multi-disciplinary researcher trained in biostatistics, population genetics and human genetics. Her role in team science has been essential for multiple, successful multi-disciplinary research projects. She is the PI of the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA), and she is the scientific PI of the Central Brain Tumor Registry for the United States (CBTRUS). She has extensive experience with multi-site, brain tumor, patient recruitment and bio specimen collection, storage, and clinical annotation.

She is the Associate Director for Translational Informatics for the Cleveland Institute of Computational Biology and Associate Director for Bioinformatics at the Case Comprehensive Cancer Center, both administratively housed at Case Western Reserve University (CWRU) School of Medicine, where she is responsible for managing bioinformatics analysis of high throughput "omics" data and implementing and maintaining a translational informatics solution for research.

In addition, she is the Director for Research Health Analytics and Informatics at University Hospitals Health System (UHHS), a teaching affiliate of CWRU School of Medicine. There she helps facilitate access to and analysis of UHHS data for population health. She also serves as Director of the Cleveland Center for Health Outcomes Research (CCHOR) with a primary objective of optimizing "big data" for clinical outcomes modeling, including individualized patient predictions that would drive operational and clinical decision making.

All of this work draws on her extensive experience in hypothesis development, study design and statistical analysis for studies of various phenotypes in humans and animals and analysis of all types of high throughput "omics" data and clinical outcomes.

Read more.




Featured Publications

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, Morozova O, Robertson AG, Noushmehr H, Laird PW, Cherniack AD, Akbani R, Huse JT, Ciriello G, Poisson LM, Barnholtz-Sloan JS, Berger MS, Brennan C, Colen RR, Colman H, Flanders AE, Giannini C, Grifford M, Iavarone A, […]

Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011.

Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS,. The CBTRUS Statistical Report: Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011 comprehensively describes the current population-based incidence of […]

The somatic genomic landscape of glioblastoma.

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, […]

Recent Publications

  1. Tish, S, Habboub, G, Jones, J, Ostrom, QT, Kruchko, C, Barnholtz-Sloan, JS, Recinos, PF, Kshettry, VR. The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014. J. Neurooncol. 2019; : . PubMed PMID:30859483 .
  2. Atkins, I, Kinnersley, B, Ostrom, QT, Labreche, K, Il'yasova, D, Armstrong, GN, Eckel-Passow, JE, Schoemaker, MJ, Nöthen, MM, Barnholtz-Sloan, JS et al.. Transcriptome-wide association study identifies new candidate susceptibility genes for glioma. Cancer Res. 2019; : . PubMed PMID:30709929 .
  3. Barnholtz-Sloan, JS. Brain and central nervous system tumor statistics: access to accurate data for all countries is critical! Neuro-oncology 2019; : . PubMed PMID:30649531 PubMed Central PMC6380403.
  4. Iorgulescu, JB, Torre, M, Harary, M, Smith, TR, Aizer, AA, Reardon, DA, Barnholtz-Sloan, JS, Perry, A. The Misclassification of Diffuse Gliomas: Rates and Outcomes. Clin. Cancer Res. 2019; : . PubMed PMID:30635340 .
  5. Yang, W, Warrington, NM, Taylor, SJ, Whitmire, P, Carrasco, E, Singleton, KW, Wu, N, Lathia, JD, Berens, ME, Kim, AH et al.. Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. Sci Transl Med 2019; 11 (473): . PubMed PMID:30602536 .
  6. Cui, T, Bell, EH, McElroy, J, Becker, AP, Gulati, PM, Geurts, M, Mladkova, N, Gray, A, Liu, K, Yang, L et al.. miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma. Oncogene 2018; : . PubMed PMID:30559405 .
  7. Ostrom, QT, Gittleman, H, Kruchko, C, Barnholtz-Sloan, JS. Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival. J. Neurooncol. 2019; 142 (1): 27-38. PubMed PMID:30543034 .
  8. Hulgan, T, Kallianpur, AR, Guo, Y, Barnholtz-Sloan, JS, Gittleman, H, Brown, TT, Ellis, R, Letendre, S, Heaton, RK, Samuels, DC et al.. Peripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection. J. Acquir. Immune Defic. Syndr. 2019; 80 (4): e95-e102. PubMed PMID:30531306 PubMed Central PMC6391216.
  9. Amirian, ES, Ostrom, QT, Armstrong, GN, Lai, RK, Gu, X, Jacobs, DI, Jalali, A, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D et al.. Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis. Cancer Epidemiol. Biomarkers Prev. 2019; 28 (3): 555-562. PubMed PMID:30482874 PubMed Central PMC6401283.
  10. Moorman, PG, Barrett, NJ, Wang, F, Alberg, JA, Bandera, EV, Barnholtz-Sloan, JB, Bondy, M, Cote, ML, Funkhouser, E, Kelemen, LE et al.. Effect of Cultural, Folk, and Religious Beliefs and Practices on Delays in Diagnosis of Ovarian Cancer in African American Women. J Womens Health (Larchmt) 2018; : . PubMed PMID:30481095 .
Search PubMed