Professor and Associate Director for Translational Informatics

Dr. Barnholtz-Sloan is multi-disciplinary researcher trained in biostatistics, population genetics, and human genetics. Her role in team science has been essential for multiple, successful multi-disciplinary research projects. She is the PI of the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA). She is also the scientific PI of the Central Brain Tumor Registry for the United States (CBTRUS). She has extensive experience with multi-site, brain tumor, patient recruitment and bio specimen collection, storage, and clinical annotation. She has multiple roles in the Case Western (CWRU) School of Medicine and the University Hospitals Health System (UHHS), which all focus on optimizing the use of data and analytics to advance health care.

At CWRU she is the Associate Director for Data Sciences at the Case Comprehensive Cancer Center and the Associate Director for Translational Informatics for the Cleveland Institute of Computational Biology. In these roles, she advances research endeavors by advocating for and assisting researchers in obtaining access to and using large health datasets (publicly available or controlled access) to answer research questions. Dr. Barnholtz-Sloan also aids investigators in the use of secure database infrastructure needed for human subjects’ research, the implementation of robust study designs, as well as the interpretation of results. These efforts aim to reduce the burden and barriers researchers may encounter in gaining access to and analyzing “big data”, enabling them to think about and perform research that has previously not been pursued.

As the Director for Research Health Analytics and Informatics at UHHS, she facilitates access to and analysis of UHHS data. Dr. Barnholtz-Sloan’s efforts focus on aiding clinicians in utilizing “big data” to impact clinical outcomes modeling that can drive both health operations and clinical decision making.

Dr. Barnholtz-Sloan is also Director of the Cleveland Center for Health Outcomes Research (CCHOR), which was established in the summer of 2018. The goal of the CCHOR is to integrate, innovate, and optimize the use of “big data”.  CCHOR facilitates access to datasets and helps support analysis to test hypotheses and drive discoveries, facilitating understanding and impact on health.

Together, all of these roles draw upon her extensive experience in hypothesis development, study design and statistical analysis for studies of various phenotypes in humans and animals, and analysis of all types of high throughput “omics” and clinical outcomes data.

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Featured Publications

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, Morozova O, Robertson AG, Noushmehr H, Laird PW, Cherniack AD, Akbani R, Huse JT, Ciriello G, Poisson LM, Barnholtz-Sloan JS, Berger MS, Brennan C, Colen RR, Colman H, Flanders AE, Giannini C, Grifford M, Iavarone A, […]

Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011.

Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS,. The CBTRUS Statistical Report: Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011 comprehensively describes the current population-based incidence of […]

The somatic genomic landscape of glioblastoma.

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, […]

Recent Publications

  1. Manichaikul, A, Peres, LC, Wang, XQ, Barnard, ME, Chyn, D, Sheng, X, Du, Z, Tyrer, J, Dennis, J, Schwartz, AG et al.. Identification of novel epithelial ovarian cancer loci in Women of African Ancestry. Int. J. Cancer 2019; : . PubMed PMID:31469419 .
  2. de Blank, P, Badve, C, Gold, DR, Stearns, D, Sunshine, J, Dastmalchian, S, Tomei, K, Sloan, AE, Barnholtz-Sloan, JS, Lane, A et al.. Magnetic Resonance Fingerprinting to Characterize Childhood and Young Adult Brain Tumors. Pediatr Neurosurg 2019; : 1-9. PubMed PMID:31416081 .
  3. Mullins, MA, Peres, LC, Alberg, AJ, Bandera, EV, Barnholtz-Sloan, JS, Bondy, ML, Funkhouser, E, Moorman, PG, Peters, ES, Terry, PD et al.. Perceived discrimination, trust in physicians, and prolonged symptom duration before ovarian cancer diagnosis in the African American Cancer Epidemiology Study. Cancer 2019; : . PubMed PMID:31415710 .
  4. Thiruvengadam, SS, OʼMalley, M, LaGuardia, L, Lopez, R, Wang, Z, Shadrach, BL, Chen, Y, Li, C, Veigl, ML, Barnholtz-Sloan, JS et al.. Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis. Clin Transl Gastroenterol 2019; 10 (6): e00053. PubMed PMID:31211760 PubMed Central PMC6613862.
  5. Truitt, G, Gittleman, H, Leece, R, Ostrom, QT, Kruchko, C, Armstrong, TS, Gilbert, MR, Barnholtz-Sloan, JS. Partnership for defining the impact of 12 selected rare CNS tumors: a report from the CBTRUS and the NCI-CONNECT. J. Neurooncol. 2019; 144 (1): 53-63. PubMed PMID:31209773 .
  6. Cote, DJ, Ostrom, QT, Gittleman, H, Duncan, KR, CreveCoeur, TS, Kruchko, C, Smith, TR, Stampfer, MJ, Barnholtz-Sloan, JS. Glioma incidence and survival variations by county-level socioeconomic measures. Cancer 2019; 125 (19): 3390-3400. PubMed PMID:31206646 PubMed Central PMC6744292.
  7. Wright, JM, Wright, CH, Cioffi, G, Raghavan, A, Hdeib, A, Kasliwal, MK, Kruchko, C, Barnholtz-Sloan, JS, Sloan, AE. Survival in Patients with High-Grade Spinal Meningioma: An Analysis of the National Cancer Database. World Neurosurg 2019; 129 : e749-e753. PubMed PMID:31203074 .
  8. Peres, LC, Hebert, JR, Qin, B, Guertin, KA, Bandera, EV, Shivappa, N, Camacho, TF, Chyn, D, Alberg, AJ, Barnholtz-Sloan, JS et al.. Prediagnostic Proinflammatory Dietary Potential Is Associated with All-Cause Mortality among African-American Women with High-Grade Serous Ovarian Carcinoma. J. Nutr. 2019; 149 (9): 1606-1616. PubMed PMID:31152675 PubMed Central PMC6735701.
  9. Takahashi, H, Cornish, AJ, Sud, A, Law, PJ, Kinnersley, B, Ostrom, QT, Labreche, K, Eckel-Passow, JE, Armstrong, GN, Claus, EB et al.. Publisher Correction: Mendelian randomisation study of the relationship between vitamin D and risk of glioma. Sci Rep 2019; 9 (1): 7924. PubMed PMID:31118477 PubMed Central PMC6531429.
  10. Johansen, ML, Vincent, J, Gittleman, H, Craig, SEL, Couce, M, Sloan, AE, Barnholtz-Sloan, JS, Brady-Kalnay, SM. A PTPmu Biomarker is Associated with Increased Survival in Gliomas. Int J Mol Sci 2019; 20 (10): . PubMed PMID:31091655 PubMed Central PMC6566278.
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