Professor and Associate Director for Translational Informatics

Dr. Barnholtz-Sloan is multi-disciplinary researcher trained in biostatistics, population genetics, and human genetics. Her role in team science has been essential for multiple, successful multi-disciplinary research projects. She is the PI of the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA). She is also the scientific PI of the Central Brain Tumor Registry for the United States (CBTRUS). She has extensive experience with multi-site, brain tumor, patient recruitment and bio specimen collection, storage, and clinical annotation. She has multiple roles in the Case Western (CWRU) School of Medicine and the University Hospitals Health System (UHHS), which all focus on optimizing the use of data and analytics to advance health care.

At CWRU she is the Associate Director for Data Sciences at the Case Comprehensive Cancer Center and the Associate Director for Translational Informatics for the Cleveland Institute of Computational Biology. In these roles, she advances research endeavors by advocating for and assisting researchers in obtaining access to and using large health datasets (publicly available or controlled access) to answer research questions. Dr. Barnholtz-Sloan also aids investigators in the use of secure database infrastructure needed for human subjects’ research, the implementation of robust study designs, as well as the interpretation of results. These efforts aim to reduce the burden and barriers researchers may encounter in gaining access to and analyzing “big data”, enabling them to think about and perform research that has previously not been pursued.

As the Director for Research Health Analytics and Informatics at UHHS, she facilitates access to and analysis of UHHS data. Dr. Barnholtz-Sloan’s efforts focus on aiding clinicians in utilizing “big data” to impact clinical outcomes modeling that can drive both health operations and clinical decision making.

Dr. Barnholtz-Sloan is also Director of the Cleveland Center for Health Outcomes Research (CCHOR), which was established in the summer of 2018. The goal of the CCHOR is to integrate, innovate, and optimize the use of “big data”.  CCHOR facilitates access to datasets and helps support analysis to test hypotheses and drive discoveries, facilitating understanding and impact on health.

Together, all of these roles draw upon her extensive experience in hypothesis development, study design and statistical analysis for studies of various phenotypes in humans and animals, and analysis of all types of high throughput “omics” and clinical outcomes data.

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Featured Publications

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, Morozova O, Robertson AG, Noushmehr H, Laird PW, Cherniack AD, Akbani R, Huse JT, Ciriello G, Poisson LM, Barnholtz-Sloan JS, Berger MS, Brennan C, Colen RR, Colman H, Flanders AE, Giannini C, Grifford M, Iavarone A, […]

Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011.

Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS,. The CBTRUS Statistical Report: Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011 comprehensively describes the current population-based incidence of […]

The somatic genomic landscape of glioblastoma.

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, […]

Recent Publications

  1. Zhao, Y, Feng, X, Chen, Y, Selfridge, JE, Gorityala, S, Du, Z, Wang, JM, Hao, Y, Cioffi, G, Conlon, RA et al.. 5-fluorouracil enhances the anti-tumor activity of the glutaminase inhibitor CB-839 against PIK3CA-mutant colorectal cancers. Cancer Res. 2020; : . PubMed PMID:32907836 .
  2. Barnholtz-Sloan, JS, Salata, R, Zaidi, M, Petersen, LA, Kisielewski, M, Waite, K, Todd, RF 3rd. Participation in Health Services/Population Health Research in US Departments of Medicine. Am. J. Med. 2020; : . PubMed PMID:32858022 .
  3. Soler, DC, Kerstetter-Fogle, A, Elder, T, Raghavan, A, Barnholtz-Sloan, JS, Cooper, KD, McCormick, TS, Sloan, AE. A Liquid Biopsy to Assess Brain Tumor Recurrence: Presence of Circulating Mo-MDSC and CD14+ VNN2+ Myeloid Cells as Biomarkers That Distinguish Brain Metastasis From Radiation Necrosis Following Stereotactic Radiosurgery. Neurosurgery 2020; : . PubMed PMID:32823285 .
  4. Malay, S, Somasundaram, E, Patil, N, Buerki, R, Sloan, A, Barnholtz-Sloan, JS. Treatment and surgical factors associated with longer-term glioblastoma survival: a National Cancer Database study. Neurooncol Adv 2020; 2 (Suppl 1): 1-10. PubMed PMID:32642726 PubMed Central PMC7332237.
  5. Vadmal, V, Junno, G, Badve, C, Huang, W, Waite, KA, Barnholtz-Sloan, JS. MRI image analysis methods and applications: an algorithmic perspective using brain tumors as an exemplar. Neurooncol Adv ; 2 (1): vdaa049. PubMed PMID:32642702 PubMed Central PMC7236385.
  6. Stetson, LC, Ostrom, QT, Schlatzer, D, Liao, P, Devine, K, Waite, K, Couce, ME, Harris, PLR, Kerstetter-Fogle, A, Berens, ME et al.. Proteins inform survival-based differences in patients with glioblastoma. Neurooncol Adv ; 2 (1): vdaa039. PubMed PMID:32642694 PubMed Central PMC7212893.
  7. Johansen, ML, Stetson, LC, Vadmal, V, Waite, K, Berens, ME, Connor, JR, Lathia, J, Rubin, JB, Barnholtz-Sloan, JS. Gliomas display distinct sex-based differential methylation patterns based on molecular subtype. Neurooncol Adv ; 2 (1): vdaa002. PubMed PMID:32642674 PubMed Central PMC7212920.
  8. Nesterova, DS, Midya, V, Zacharia, BE, Proctor, EA, Lee, SY, Stetson, LC, Lathia, JD, Rubin, JB, Waite, KA, Berens, ME et al.. Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma. Neurooncol Adv ; 2 (1): vdaa001. PubMed PMID:32642673 PubMed Central PMC7212901.
  9. Sheikh, S, Radivoyevitch, T, Barnholtz-Sloan, JS, Vogelbaum, M. Long-term trends in glioblastoma survival: implications for historical control groups in clinical trials. Neurooncol Pract 2020; 7 (2): 158-163. PubMed PMID:32626584 PubMed Central PMC7318862.
  10. Zhang, YD, Hurson, AN, Zhang, H, Choudhury, PP, Easton, DF, Milne, RL, Simard, J, Hall, P, Michailidou, K, Dennis, J et al.. Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers. Nat Commun 2020; 11 (1): 3353. PubMed PMID:32620889 PubMed Central PMC7335068.
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