Associate Director for Bioinformatics Research

William S. Bush, Ph.D. is an Assistant Professor in the Department of Epidemiology and Biostatistics and the Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his Ph.D. at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.



Featured Publications

Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study.

Bartlett J, Predazzi IM, Williams SM, Bush WS, Kim Y, Havas S, Toth PP, Fazio S, Miller M,. Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) […]

The phenotypic legacy of admixture between modern humans and Neandertals.

Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA,. Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such […]

Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, ,. Late-onset Alzheimer disease (AD) has a complex genetic etiology, involving locus heterogeneity, polygenic inheritance, and gene-gene interactions; however, the investigation […]

Recent Publications

  1. Hart, NJ, Aramandla, R, Poffenberger, G, Fayolle, C, Thames, AH, Bautista, A, Spigelman, AF, Babon, JAB, DeNicola, ME, Dadi, PK et al.. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight 2018; 3 (8): . PubMed PMID:29669939 .
  2. Butkiewicz, M, Blue, E, Leung, F, Jian, X, Marcora, E, Renton, A, Kuzma, A, Wang, LS, Koboldt, D, Haines, JL et al.. Functional Annotation of genomic variants in studies of Late-Onset Alzheimer's Disease. Bioinformatics 2018; : . PubMed PMID:29590295 .
  3. Blue, EE, Bis, JC, Dorschner, MO, Tsuang, DW, Barral, SM, Beecham, G, Below, JE, Bush, WS, Butkiewicz, M, Cruchaga, C et al.. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord 2018; 45 (1-2): 1-17. PubMed PMID:29486463 .
  4. Sivley, RM, Dou, X, Meiler, J, Bush, WS, Capra, JA. Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures. Am. J. Hum. Genet. 2018; 102 (3): 415-426. PubMed PMID:29455857 .
  5. Gong, J, Nishimura, KK, Fernandez-Rhodes, L, Haessler, J, Bien, S, Graff, M, Lim, U, Lu, Y, Gross, M, Fornage, M et al.. Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 2018; 42 (3): 384-390. PubMed PMID:29381148 PubMed Central PMC5876082.
  6. Sivley, RM, Sheehan, JH, Kropski, JA, Cogan, J, Blackwell, TS, Phillips, JA, Bush, WS, Meiler, J, Capra, JA. Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia. BMC Bioinformatics 2018; 19 (1): 18. PubMed PMID:29361909 PubMed Central PMC5781290.
  7. Bush, WS, Crawford, DC, Briggs, F, Freedman, D, Sloan, C. INTEGRATING COMMUNITY-LEVEL DATA RESOURCES FOR PRECISION MEDICINE RESEARCH. Pac Symp Biocomput 2018; 23 : 618-622. PubMed PMID:29218920 .
  8. Fish, AE, Crawford, DC, Capra, JA, Bush, WS. Local ancestry transitions modify snp-trait associations. Pac Symp Biocomput 2018; 23 : 424-435. PubMed PMID:29218902 PubMed Central PMC5728664.
  9. Beecham, GW, Bis, JC, Martin, ER, Choi, SH, DeStefano, AL, van Duijn, CM, Fornage, M, Gabriel, SB, Koboldt, DC, Larson, DE et al.. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurol Genet 2017; 3 (5): e194. PubMed PMID:29184913 PubMed Central PMC5646177.
  10. Conti, DV, Wang, K, Sheng, X, Bensen, JT, Hazelett, DJ, Cook, MB, Ingles, SA, Kittles, RA, Strom, SS, Rybicki, BA et al.. Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. J. Natl. Cancer Inst. 2017; 109 (8): . PubMed PMID:29117387 PubMed Central PMC5448553.
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