Ignacio Mata, PhD, is Assistant Professor at Cleveland Clinic Lerner College of Medicine. He hold a Bachelor of Science and PhD in Human/Medical Genetics from la Universidad de Oviedo in Asturias, Spain, and he received his PhD in Neurogenetics from Mayo Clinic. Dr. Mata's lab is working towards identifying and understanding the genes that play a role in those diseases that affect the brain (neurological disorders). These include the very well-known Parkinson’s disease (PD), but also other less common disorders such as a form of PD that presents with severe cognitive problems/dementia (PDD) and another type of dementia called Dementia with Lewy Bodies (DLB).
Recent Publications
- Sun, W, Schulte, C, Gasser, T, Tan, M, Global Parkinson’s Genetic Program (GP2). TMEM175, SCARB2 and CTSB associations with Parkinson's disease risk across populations. NPJ Parkinsons Dis 2025; 11 (1): 348. PubMed PMID:41331295 PubMed Central PMC12678402.
- Step, K, Ndong Sima, CAA, Grant, S, Kim, JJ, Waldo, E, Bardien, S, Mata, IF. Polygenic risk scores and Parkinson's disease in South Africa: Moving towards ancestry-informed disease prediction. medRxiv 2025; : . PubMed PMID:41256174 PubMed Central PMC12622108.
- Chaparro-Solano, HM, Mata, IF. Is one too many? Rethinking the innocence of heterozygous variants in recessive disorders. Parkinsonism Relat Disord 2025; : 108114. PubMed PMID:41238429 .
- Santos-Lobato, BL, Schuh, AFS, Mata, IF. Household herbicide use is associated with the risk of Parkinson's disease and a younger age at onset in PPMI and Fox Insight cohorts. J Neural Transm (Vienna) 2025; : . PubMed PMID:41171381 .
- Barberena-Jonas, C, Flores-Ocampo, V, Ogonowski, NS, Piña-Escudero, SD, Mata, IF, Yokoyama, JS, García-García, L, Aguilar Salinas, CA, ENSANUT consortium, Tusié-Luna, MT et al.. Genetic analysis of APOE reveals distinct origins and distribution of ancestry-enrichment haplotypes in the Mexican Biobank. Genes Dis 2026; 13 (1): 101542. PubMed PMID:41049132 PubMed Central PMC12495275.
- Hernández, CF, Villaman, C, Tejos, C, Repetto, GM, Leu, C, Lal, D, Mata, IF, Klein, AD, Pérez-Palma, E. Polygenic scores contribution to Parkinson's disease comorbidities. Brain Commun 2025; 7 (5): fcaf325. PubMed PMID:40980402 PubMed Central PMC12448616.
- Sarapura-Castro, E, Milla-Neyra, K, Ríos-Pinto, J, Maguiña, JL, Rivera-Valdivia, A, Inca-Martinez, M, Illanes-Manrique, M, Galecio-Castillo, M, Montano, S, Mata, IF et al.. Prevalence of Parkinson's Disease in a Town of the Central Highlands of Peru: A Population-Based Study. Mov Disord Clin Pract 2025; : . PubMed PMID:40970415 .
- Chaparro-Solano, HM, Teixeira-Dos-Santos, D, Waldo, E, Leal, TP, Inca-Martinez, M, Alcauter, S, Medina-Rivera, A, Ruiz-Contreras, AE, Cornejo-Olivas, M, Mejia-Rojas, K et al.. EPIDEMIOLOGY OF LEVODOPA-INDUCED DYSKINESIA: PREVALENCE AND ASSOCIATED CLINICAL FACTORS IN LATIN AMERICA. medRxiv 2025; : . PubMed PMID:40909824 PubMed Central PMC12407593.
- Blauwendraat, C, Noyce, AJ, Mata, IF, Screven, LA, Solle, J, Dumanis, SB, Riley, EA, Periñan, MT, Okubadejo, N, Klein, C et al.. Tackling a disease on a global scale, the Global Parkinson's Genetics Program, GP2: A new generation of opportunities. Am J Hum Genet 2025; 112 (9): 1988-2000. PubMed PMID:40834859 PubMed Central PMC12461011.
- Step, K, Leal, TP, Kamel, WA, Waldo, E, Bardien, S, Mata, IF. X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome. Front Genet 2025; 16 : 1650259. PubMed PMID:40809846 PubMed Central PMC12343220.
