DANA C. CRAWFORD, PHD

Associate Director for Population and Diversity Research

Dana Craw­ford, PhD, is Pro­fes­sor in the Department of Population and Quantitative Health Sciences and Associate Director for Population and Diversity Research in the Cleveland Insti­tute for Com­pu­ta­tional Biol­ogy. She also has a secondary appointment in the Department of Genetics and Genome Sciences. Dr. Craw­ford received her Ph.D. at Emory Uni­ver­sity in genet­ics and mol­e­c­u­lar biol­ogy in 2000 and then trained as a post-doctoral fel­low as an Epi­demic Intel­li­gence Ser­vice Offi­cer at the Cen­ters for Dis­ease Con­trol and Pre­ven­tion (2000–2002) and as a senior fel­low at the Uni­ver­sity of Washington’s Depart­ment of Genome Sci­ences (2002–2006). Prior to her most cur­rent posi­tion, Dr. Craw­ford spent eight years as tenure-track fac­ulty in the Depart­ment of Mol­e­c­u­lar Phys­i­ol­ogy and Bio­physics and Inves­ti­ga­tor in the Cen­ter for Human Genet­ics Research at Van­der­bilt Uni­ver­sity. As a genetic epi­demi­ol­o­gist at CWRU, Dr. Crawford’s broad research inter­ests include apply­ing genetic vari­a­tion data to large-scale epi­demi­o­logic and clin­i­cal cohorts to bet­ter under­stand human genotype-phenotype asso­ci­a­tions with an empha­sis on diverse populations.

Recent Publications

  1. Darst, BF, Hughley, R, Pfennig, A, Hazra, U, Fan, C, Wan, P, Sheng, X, Xia, L, Andrews, C, Chen, F et al.. A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry. Eur Urol 2022; : . PubMed PMID:35031163 .
  2. Liu, S, Crawford, DC. Maturation and application of phenome-wide association studies. Trends Genet 2022; : . PubMed PMID:34991903 .
  3. Nealon, CL, Halladay, CW, Kinzy, TG, Simpson, P, Canania, RL, Anthony, SA, Roncone, DP, Sawicki Rogers, LR, Leber, JN, Dougherty, JM et al.. Development and Evaluation of a Rules-based Algorithm for Primary Open-Angle Glaucoma in the VA Million Veteran Program. Ophthalmic Epidemiol 2021; : 1-9. PubMed PMID:34822319 .
  4. Kaur, H, Crawford, DC, Liang, J, Benchek, P, COGENT BP Consortium, Zhu, X, Kallianpur, AR, Bush, WS. Replication of European hypertension associations in a case-control study of 9,534 African Americans. PLoS One 2021; 16 (11): e0259962. PubMed PMID:34793544 PubMed Central PMC8601554.
  5. Crawford, DC, Williams, SM. Global variation in sequencing impedes SARS-CoV-2 surveillance. PLoS Genet 2021; 17 (7): e1009620. PubMed PMID:34264957 PubMed Central PMC8282079.
  6. Crawford, DC, Sedor, JR. Biobanks Linked to Electronic Health Records Accelerate Genomic Discovery. J Am Soc Nephrol 2021; 32 (8): 1828-1829. PubMed PMID:34244324 PubMed Central PMC8455265.
  7. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Lui, A, Martinez, ME, Rose, BS, Mahal, B, Eeles, RA, Kote-Jarai, Z et al.. Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24. Prostate Cancer Prostatic Dis 2021; : . PubMed PMID:34127801 PubMed Central PMC8669040.
  8. Schmidt, IM, Colona, MR, Kestenbaum, BR, Alexopoulos, LG, Palsson, R, Srivastava, A, Liu, J, Stillman, IE, Rennke, HG, Vaidya, VS et al.. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis. Kidney Int 2021; 100 (3): 672-683. PubMed PMID:34051265 PubMed Central PMC8384690.
  9. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (3): 413. PubMed PMID:33473200 .
  10. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (1): 65-75. PubMed PMID:33398198 PubMed Central PMC8148035.
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Featured Publications

Using Electronic Health Records to Generate Phenotypes for Research

Sarah A. Pendergrass and Dana C. Crawford Electronic health records contain patient-level data collected during and for clinical care. Data within the electronic health record include diagnostic billing codes, procedure codes, vital signs, laboratory test results, clinical imaging, and physician notes. With repeated clinic visits, these data are longitudinal, providing important information on disease development, […]

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

Restrepo NA, Laper S, Farber-Eger E, Crawford DC. Glaucoma is a leading cause of blindness in developed countries. Primary open-angle glaucoma (POAG), the most prevalent clinical subtype of glaucoma in the United States, affects African Americans at a higher rate compared with European Americans. Risk factors identified for POAG include increased age and family history, […]

Dana on Twitter

Featured in this month's issue: a remembrance of Steve Warren, former @AJHGNews Editor & @GeneticsSociety President bit.ly/3pX43jU Retweeted by Dr. Dana Crawford

If only I were there to pick it up. 🌴 twitter.com/PacSymBiocomp/…

Shocked to hear my former post-doc advisor passed away suddenly. As one colleague put it, it's the end of an era. twitter.com/NHGRI_Director…

Want to go to grad school for a #biomedical #PhD? Need a more competitive application? More research experience? If yes, check out CasePREP, an #NIHPREP-funded program at #CWRUSOM for recent college grads from #diverse backgrounds. youtu.be/lJ0RaKVnSOI

Why not, indeed? Meanwhile, in Cleveland right now, #COVID19 #RapidTests 2021 are like #ToiletPaper 2020. twitter.com/rubymaei/statu…

@scottmwilliams9 @hereandnow Many thanks to @scottwilliams9 and @paula_darte @CWRUSOM for talking me through the various interview experiences on the rapidly changing #COVID19 #OmicronVariant situation.

My colleague Dana Crawford speaks on importance of SARS-CV 2 sequencing and prioritization How genomic sequencing makes it possible to track omicron variant spread wbur.fm/3IcnvjD via @hereandnow Retweeted by Dr. Dana Crawford

Completely geeking out over my first @NPR interview with @odowdpeter for @HereandNow about US genomic surveillance for SARS-CoV-2. wbur.org/hereandnow/202…

Agree @razibkhan. @trvrb tweets and YouTube videos of his talks (and nice slides) are making their way into our scientific communication lectures for the graduate students. Great examples. twitter.com/razibkhan/stat…

How many more waves & new variants of concern will we need to understand that as long as there are unvaccinated people anywhere in the world that can get infected, there's a chance for the virus to mutate & acquire new properties to escape immunity. #VaccinateTheWorld🌎 #MaskUp😷 Retweeted by Dr. Dana Crawford

Electronic Health Records (EHRs) capture information on a large number of people, and can be used to conduct health studies. We will discuss examples of how quantitative disciplines have gained insights into diseases with EHR data. #2021NDiSTEM bit.ly/3Ec2oeB Retweeted by Dr. Dana Crawford

#2021NDiSTEM twitter.com/CaturDNA/statu…

Great panel, if I do say so myself! #2021INDiSTEM twitter.com/blancahimes/st…

Backstage with @CaturDNA @RhubbBstat for a #SACNAS #NDiSTEM2021 session about using Electronic Health Record data for research sacnas365.junolive.co/live/panels/795 Retweeted by Dr. Dana Crawford

Countdown to our @SACNAS Quantitative Approaches to Understand Diseases with Electronic Health Record Data with @RhubbBstat @blancahimes! #2021INDiSTEM

test Twitter Media - Countdown to our @SACNAS Quantitative Approaches to Understand Diseases with Electronic Health Record Data with @RhubbBstat @blancahimes! #2021INDiSTEM https://t.co/jbNzLktQZy

Affiliations

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Curriculum vitae