DANA C. CRAWFORD, PHD

Associate Director for Population and Diversity Research

Dana Crawford, PhD, is Professor in the Department of Population and Quantitative Health Sciences and Associate Director for Population and Diversity Research in the Cleveland Institute for Computational Biology. She also has a secondary appointment in the Department of Genetics and Genome Sciences. Dr. Crawford received her Ph.D. at Emory University in genetics and molecular biology in 2000 and then trained as a post-doctoral fellow as an Epidemic Intelligence Service Officer at the Centers for Disease Control and Prevention (2000–2002) and as a senior fellow at the University of Washington’s Department of Genome Sciences (2002–2006). Prior to her most current position, Dr. Crawford spent eight years as tenure-track faculty in the Department of Molecular Physiology and Biophysics and Investigator in the Center for Human Genetics Research at Vanderbilt University. As a genetic epidemiologist at CWRU, Dr. Crawford’s broad research interests include applying genetic variation data to large-scale epidemiologic and clinical cohorts to better understand human genotype-phenotype associations with an emphasis on diverse populations.

Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, UKGPCS collaborators, Lophatananon, A, Tangen, CM et al.. African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Int. J. Cancer 2020; : . PubMed PMID:32930425 .
McDonough, CW, Babcock, K, Chucri, K, Crawford, DC, Bian, J, Modave, F, Cooper-DeHoff, RM, Hogan, WR. Optimizing identification of resistant hypertension: Computable phenotype development and validation. Pharmacoepidemiol Drug Saf 2020; : . PubMed PMID:32844549 .
Darst, BF, Wan, P, Sheng, X, Bensen, JT, Ingles, SA, Rybicki, BA, Nemesure, B, John, EM, Fowke, JH, Stevens, VL et al.. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur. Urol. 2020; 78 (3): 316-320. PubMed PMID:32409115 .
Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS ONE 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
Bush, WS, Cooke Bailey, JN, Beno, MF, Crawford, DC. Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. Public Health Genomics 2019; 22 (1-2): 16-24. PubMed PMID:31454805 PubMed Central PMC6752968.
Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC et al.. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
Crawford, DC, Cooke Bailey, JN, Briggs, FBS. Mind the gap: resources required to receive, process and interpret research-returned whole genome data. Hum. Genet. 2019; 138 (7): 691-701. PubMed PMID:31161416 PubMed Central PMC6767905.
Hollister, BM, Farber-Eger, E, Aldrich, MC, Crawford, DC. A Social Determinant of Health May Modify Genetic Associations for Blood Pressure: Evidence From a SNP by Education Interaction in an African American Population. Front Genet 2019; 10 : 428. PubMed PMID:31134134 PubMed Central PMC6523518.
Pendergrass, SA, Crawford, DC. Using Electronic Health Records To Generate Phenotypes For Research. Curr Protoc Hum Genet 2019; 100 (1): e80. PubMed PMID:30516347 PubMed Central PMC6318047.

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Using Electronic Health Records to Generate Phenotypes for Research

Sarah A. Pendergrass and Dana C. Crawford Electronic health records contain patient-level data collected during and for clinical care. Data within the electronic health record include diagnostic billing codes, procedure codes, vital signs, laboratory test results, clinical imaging, and physician notes. With repeated clinic visits, these data are longitudinal, providing important information on disease development, […]

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

Restrepo NA, Laper S, Farber-Eger E, Crawford DC. Glaucoma is a leading cause of blindness in developed countries. Primary open-angle glaucoma (POAG), the most prevalent clinical subtype of glaucoma in the United States, affects African Americans at a higher rate compared with European Americans. Risk factors identified for POAG include increased age and family history, […]

Reducing Clinical Noise for Body Mass Index Measures Due to Unit and Transcription Errors in the Electronic Health Record.

Goodloe R, Farber-Eger E, Boston J, Crawford DC, Bush WS,. Body mass index (BMI) is an important outcome and covariate adjustment for many clinical association studies. Accurate assessment of BMI, therefore, is a critical part of many study designs. Electronic health records (EHRs) are a growing source of clinical data for research purposes, and have […]

Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.

Zubair N, Graff M, Luis Ambite J, Bush WS, Kichaev G, Lu Y, Manichaikul A, Sheu WH, Absher D, Assimes TL, Bielinski SJ, Bottinger EP, Buzkova P, Chuang LM, Chung RH, Cochran B, Dumitrescu L, Gottesman O, Haessler JW, Haiman C, Heiss G, Hsiung CA, Hung YJ, Hwu CM, Juang JJ, Le Marchand L, Lee […]

Patton Oswalt 4 days ago

Mandy has “The” Sword! #PrincessBrideReunion Retweeted by Dana Crawford

test Twitter Media - RT @pattonoswalt: Mandy has “The” Sword! #PrincessBrideReunion https://t.co/FphXnXdskV

Dana Crawford 4 days ago

Josh Gad—you’re on mute!

Dana Crawford 4 days ago

#PrincessBrideReunion !!!

Julia Austin 1 week ago

"I've known a great many clever men. I've outlived them all. You know why? I ignored them. The lords of Westeros are sheep. Are you a sheep? No. You're a dragon. Be a dragon." Best line from GoT. RIP Dame Diana Rigg 💙 twitter.com/i/events/13040… Retweeted by Dana Crawford

Dana Crawford 1 week ago

Congrats to @CWRUSOM's @a_k_miller, @scottwilliams9, and @BuchnerLab for being selected for a platform presentation at the upcoming #ASHG2020! Looking forward to the epistasis talk at 10:45am ET on 10/28 (abstract 1124).

Dana Crawford 2 weeks ago

Missed the @Cleveland_ICB North Coast Conference on Precision Medicine? Don't worry-- recorded talks by @K_Actkins, @a_k_miller, @li_ruowang, Carla Márquez Luna, Fred Schumacher, Jessica Cooke Bailey, and Athena Starlard-Davenport are all available at tinyurl.com/y4u35rbw

Dana Crawford 3 weeks ago

Thanks for the shoutout @wakibbe! For those interested in this topic, please consider contributing your work to a new call for papers co-organized by @genome_gov NHGRI's Dr. Lucia Hindorff: tinyurl.com/y69qwcz9 twitter.com/wakibbe/status…

Great and timely editorial in .@FrontiersIn on "The Importance of Diversity in Precision Medicine Research" by Jessica Cooke Bailey, William S. Bush, and @CaturDNA @CWRUSOM https://t.co/VZHIS7zstU
— Warren Kibbe (@wakibbe) August 26, 2020

Dana Crawford 3 weeks ago

Second day of school: two more positive cases, one identified after a visit to the student gym. Me thinks the campus dashboard should be updated more frequently than weekly...

Dana Crawford 3 weeks ago

First day of school: 8 positive cases, 60 contacts in quarantine, and a national Zoom outage. This can't be a good sign.

Melissa Haendel 3 weeks ago

Yeah, you know it. You enjoy using other people’s data! Celebrate the Bucket Brigade and the best quality data to make science go faster. Nominate yourself or someone you love. @ASAPbio_ #openscience #teamscience #Reproducibility #attributionForAll twitter.com/GreeneScientis… Retweeted by Dana Crawford

Dana Crawford 1 month ago

Here's hoping @scottmwilliams9 is right! twitter.com/scottmwilliams…

Prepare to come out of COVID-19 with the International Congress of Human Genetic in early 2022, Cape Town, South Africa

https://t.co/rwQnFRy6zk
— Scott Williams (@scottmwilliams9) August 14, 2020

Dana Crawford 1 month ago

We can't wait to hear @K_Actkins, @a_k_miller, @li_ruowang, Carla Márquez Luna, Fred Schumacher, Jessica Cooke Bailey, and Athena Starlard-Davenport speak about their genomics research on diverse populations! @Cleveland_ICB tinyurl.com/y4u35rbw