DANA C. CRAWFORD, PHD

Associate Director for Population and Diversity Research

Dana Craw­ford, PhD, is Pro­fes­sor in the Department of Population and Quantitative Health Sciences and Associate Director for Population and Diversity Research in the Cleveland Insti­tute for Com­pu­ta­tional Biol­ogy. She also has a secondary appointment in the Department of Genetics and Genome Sciences. Dr. Craw­ford received her Ph.D. at Emory Uni­ver­sity in genet­ics and mol­e­c­u­lar biol­ogy in 2000 and then trained as a post-doctoral fel­low as an Epi­demic Intel­li­gence Ser­vice Offi­cer at the Cen­ters for Dis­ease Con­trol and Pre­ven­tion (2000–2002) and as a senior fel­low at the Uni­ver­sity of Washington’s Depart­ment of Genome Sci­ences (2002–2006). Prior to her most cur­rent posi­tion, Dr. Craw­ford spent eight years as tenure-track fac­ulty in the Depart­ment of Mol­e­c­u­lar Phys­i­ol­ogy and Bio­physics and Inves­ti­ga­tor in the Cen­ter for Human Genet­ics Research at Van­der­bilt Uni­ver­sity. As a genetic epi­demi­ol­o­gist at CWRU, Dr. Crawford’s broad research inter­ests include apply­ing genetic vari­a­tion data to large-scale epi­demi­o­logic and clin­i­cal cohorts to bet­ter under­stand human genotype-phenotype asso­ci­a­tions with an empha­sis on diverse populations.

Recent Publications

  1. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, UKGPCS collaborators, Lophatananon, A, Tangen, CM et al.. African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Int. J. Cancer 2020; : . PubMed PMID:32930425 .
  2. McDonough, CW, Babcock, K, Chucri, K, Crawford, DC, Bian, J, Modave, F, Cooper-DeHoff, RM, Hogan, WR. Optimizing identification of resistant hypertension: Computable phenotype development and validation. Pharmacoepidemiol Drug Saf 2020; : . PubMed PMID:32844549 .
  3. Darst, BF, Wan, P, Sheng, X, Bensen, JT, Ingles, SA, Rybicki, BA, Nemesure, B, John, EM, Fowke, JH, Stevens, VL et al.. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur. Urol. 2020; 78 (3): 316-320. PubMed PMID:32409115 .
  4. Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS ONE 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
  5. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
  6. Bush, WS, Cooke Bailey, JN, Beno, MF, Crawford, DC. Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. Public Health Genomics 2019; 22 (1-2): 16-24. PubMed PMID:31454805 PubMed Central PMC6752968.
  7. Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC et al.. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
  8. Crawford, DC, Cooke Bailey, JN, Briggs, FBS. Mind the gap: resources required to receive, process and interpret research-returned whole genome data. Hum. Genet. 2019; 138 (7): 691-701. PubMed PMID:31161416 PubMed Central PMC6767905.
  9. Hollister, BM, Farber-Eger, E, Aldrich, MC, Crawford, DC. A Social Determinant of Health May Modify Genetic Associations for Blood Pressure: Evidence From a SNP by Education Interaction in an African American Population. Front Genet 2019; 10 : 428. PubMed PMID:31134134 PubMed Central PMC6523518.
  10. Pendergrass, SA, Crawford, DC. Using Electronic Health Records To Generate Phenotypes For Research. Curr Protoc Hum Genet 2019; 100 (1): e80. PubMed PMID:30516347 PubMed Central PMC6318047.
Search PubMed

Featured Publications

Using Electronic Health Records to Generate Phenotypes for Research

Sarah A. Pendergrass and Dana C. Crawford Electronic health records contain patient-level data collected during and for clinical care. Data within the electronic health record include diagnostic billing codes, procedure codes, vital signs, laboratory test results, clinical imaging, and physician notes. With repeated clinic visits, these data are longitudinal, providing important information on disease development, […]

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

Restrepo NA, Laper S, Farber-Eger E, Crawford DC. Glaucoma is a leading cause of blindness in developed countries. Primary open-angle glaucoma (POAG), the most prevalent clinical subtype of glaucoma in the United States, affects African Americans at a higher rate compared with European Americans. Risk factors identified for POAG include increased age and family history, […]

Dana on Twitter

Josh Gad—you’re on mute!

"I've known a great many clever men. I've outlived them all. You know why? I ignored them. The lords of Westeros are sheep. Are you a sheep? No. You're a dragon. Be a dragon." Best line from GoT. RIP Dame Diana Rigg 💙 twitter.com/i/events/13040… Retweeted by Dana Crawford

Congrats to @CWRUSOM's @a_k_miller, @scottwilliams9, and @BuchnerLab for being selected for a platform presentation at the upcoming #ASHG2020! Looking forward to the epistasis talk at 10:45am ET on 10/28 (abstract 1124).

Missed the @Cleveland_ICB North Coast Conference on Precision Medicine? Don't worry-- recorded talks by @K_Actkins, @a_k_miller, @li_ruowang, Carla Márquez Luna, Fred Schumacher, Jessica Cooke Bailey, and Athena Starlard-Davenport are all available at tinyurl.com/y4u35rbw

Thanks for the shoutout @wakibbe! For those interested in this topic, please consider contributing your work to a new call for papers co-organized by @genome_gov NHGRI's Dr. Lucia Hindorff: tinyurl.com/y69qwcz9 twitter.com/wakibbe/status…

Second day of school: two more positive cases, one identified after a visit to the student gym. Me thinks the campus dashboard should be updated more frequently than weekly...

First day of school: 8 positive cases, 60 contacts in quarantine, and a national Zoom outage. This can't be a good sign.

Yeah, you know it. You enjoy using other people’s data! Celebrate the Bucket Brigade and the best quality data to make science go faster. Nominate yourself or someone you love. @ASAPbio_ #openscience #teamscience #Reproducibility #attributionForAll twitter.com/GreeneScientis… Retweeted by Dana Crawford

Here's hoping @scottmwilliams9 is right! twitter.com/scottmwilliams…

We can't wait to hear @K_Actkins, @a_k_miller, @li_ruowang, Carla Márquez Luna, Fred Schumacher, Jessica Cooke Bailey, and Athena Starlard-Davenport speak about their genomics research on diverse populations! @Cleveland_ICB tinyurl.com/y4u35rbw

Reaching for the Ben & Jerry's... twitter.com/colbertlatesho…

Go Spartans? twitter.com/debates/status…

We are pleased to announce that the first presidential debate on Sept 29, 2020 will be co-hosted by @cwru and @ClevelandClinic and held at the Health Education Campus (HEC) in Cleveland, OH. Full release here: debates.org/2020/07/27/sta… Retweeted by Dana Crawford

The show must go on...virtually! Registration is now open for the 2020 North Coast Conference on Precision Medicine, an annual symposium organized and sponsored by @Cleveland_ICB at Case Western Reserve University: tinyurl.com/y4u35rbw

The #ASHG20 Program Committee is a tour de force! In awe over the complex and totally cool scientific program they just put together over Zoom. And props to ASHG staff for not going insane during the process! twitter.com/michaelhoffman…

For those who knew Rob, we are collecting photos and stories for his memorial page at case.edu/medicine/pqhs/…. Please consider RTing this message to reach as many gen epi/stats gen colleagues and friends as possible.

This year’s 2020 Advocacy Award winner is Janina Jeff, PhD, MS. Dr. Jeff is the host and executive producer of @inthosegenespod, which focuses on topics in genetics impacting the Black community that have often been overlooked. #ashgawards bit.ly/2Doaw1v Retweeted by Dana Crawford

We are so honored to be awarded the 2020 @GeneticsSociety (ASHG) for our advocacy work through the podcast. ASHG is the largest professional society for human genetics world and to be recognized for being MY AUTHENTIC SELF is surreal! Thanks to the entire @inthosegenespod team! Retweeted by Dana Crawford

Affiliations

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Curriculum vitae