DANA C. CRAWFORD, PHD

Associate Director for Population and Diversity Research

Dana Craw­ford, PhD, is Pro­fes­sor in the Department of Population and Quantitative Health Sciences and Associate Director for Population and Diversity Research in the Cleveland Insti­tute for Com­pu­ta­tional Biol­ogy. She also has a secondary appointment in the Department of Genetics and Genome Sciences. Dr. Craw­ford received her Ph.D. at Emory Uni­ver­sity in genet­ics and mol­e­c­u­lar biol­ogy in 2000 and then trained as a post-doctoral fel­low as an Epi­demic Intel­li­gence Ser­vice Offi­cer at the Cen­ters for Dis­ease Con­trol and Pre­ven­tion (2000–2002) and as a senior fel­low at the Uni­ver­sity of Washington’s Depart­ment of Genome Sci­ences (2002–2006). Prior to her most cur­rent posi­tion, Dr. Craw­ford spent eight years as tenure-track fac­ulty in the Depart­ment of Mol­e­c­u­lar Phys­i­ol­ogy and Bio­physics and Inves­ti­ga­tor in the Cen­ter for Human Genet­ics Research at Van­der­bilt Uni­ver­sity. As a genetic epi­demi­ol­o­gist at CWRU, Dr. Crawford’s broad research inter­ests include apply­ing genetic vari­a­tion data to large-scale epi­demi­o­logic and clin­i­cal cohorts to bet­ter under­stand human genotype-phenotype asso­ci­a­tions with an empha­sis on diverse populations.

Recent Publications

  1. Nealon, CL, Halladay, CW, Kinzy, TG, Simpson, P, Canania, RL, Anthony, SA, Roncone, DP, Sawicki Rogers, LR, Leber, JN, Dougherty, JM et al.. Development and Evaluation of a Rules-based Algorithm for Primary Open-Angle Glaucoma in the VA Million Veteran Program. Ophthalmic Epidemiol 2021; : 1-9. PubMed PMID:34822319 .
  2. Kaur, H, Crawford, DC, Liang, J, Benchek, P, COGENT BP Consortium, Zhu, X, Kallianpur, AR, Bush, WS. Replication of European hypertension associations in a case-control study of 9,534 African Americans. PLoS One 2021; 16 (11): e0259962. PubMed PMID:34793544 PubMed Central PMC8601554.
  3. Crawford, DC, Williams, SM. Global variation in sequencing impedes SARS-CoV-2 surveillance. PLoS Genet 2021; 17 (7): e1009620. PubMed PMID:34264957 PubMed Central PMC8282079.
  4. Crawford, DC, Sedor, JR. Biobanks Linked to Electronic Health Records Accelerate Genomic Discovery. J Am Soc Nephrol 2021; 32 (8): 1828-1829. PubMed PMID:34244324 PubMed Central PMC8455265.
  5. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Lui, A, Martinez, ME, Rose, BS, Mahal, B, Eeles, RA, Kote-Jarai, Z et al.. Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24. Prostate Cancer Prostatic Dis 2021; : . PubMed PMID:34127801 .
  6. Schmidt, IM, Colona, MR, Kestenbaum, BR, Alexopoulos, LG, Palsson, R, Srivastava, A, Liu, J, Stillman, IE, Rennke, HG, Vaidya, VS et al.. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis. Kidney Int 2021; 100 (3): 672-683. PubMed PMID:34051265 PubMed Central PMC8384690.
  7. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (3): 413. PubMed PMID:33473200 .
  8. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (1): 65-75. PubMed PMID:33398198 PubMed Central PMC8148035.
  9. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
  10. Ong, E, Wang, LL, Schaub, J, O'Toole, JF, Steck, B, Rosenberg, AZ, Dowd, F, Hansen, J, Barisoni, L, Jain, S et al.. Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project. Nat Rev Nephrol 2020; 16 (11): 686-696. PubMed PMID:32939051 PubMed Central PMC8012202.
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Featured Publications

Using Electronic Health Records to Generate Phenotypes for Research

Sarah A. Pendergrass and Dana C. Crawford Electronic health records contain patient-level data collected during and for clinical care. Data within the electronic health record include diagnostic billing codes, procedure codes, vital signs, laboratory test results, clinical imaging, and physician notes. With repeated clinic visits, these data are longitudinal, providing important information on disease development, […]

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

Restrepo NA, Laper S, Farber-Eger E, Crawford DC. Glaucoma is a leading cause of blindness in developed countries. Primary open-angle glaucoma (POAG), the most prevalent clinical subtype of glaucoma in the United States, affects African Americans at a higher rate compared with European Americans. Risk factors identified for POAG include increased age and family history, […]

Dana on Twitter

Electronic Health Records (EHRs) capture information on a large number of people, and can be used to conduct health studies. We will discuss examples of how quantitative disciplines have gained insights into diseases with EHR data. #2021NDiSTEM bit.ly/3Ec2oeB Retweeted by Dr. Dana Crawford

#2021NDiSTEM twitter.com/CaturDNA/statu…

Great panel, if I do say so myself! #2021INDiSTEM twitter.com/blancahimes/st…

Backstage with @CaturDNA @RhubbBstat for a #SACNAS #NDiSTEM2021 session about using Electronic Health Record data for research sacnas365.junolive.co/live/panels/795 Retweeted by Dr. Dana Crawford

Countdown to our @SACNAS Quantitative Approaches to Understand Diseases with Electronic Health Record Data with @RhubbBstat @blancahimes! #2021INDiSTEM

test Twitter Media - Countdown to our @SACNAS Quantitative Approaches to Understand Diseases with Electronic Health Record Data with @RhubbBstat @blancahimes! #2021INDiSTEM https://t.co/jbNzLktQZy

Welcome to those of you who are first-time #2021NDiSTEM attendees. Here's a throwback of some UCSD McNair Scholars visiting the Birth Home of MLK Jr while attending the @sacnas 2000 meeting in Atlanta. It was the first national conference most of us attended. Retweeted by Dr. Dana Crawford

After 5 days of exciting science at #ASHG21, the final numbers are in! We are excited to report a total of 5,164 total registrants stemming from nearly 81 countries and 48 states as well as 80+ industry partners. Thank you to all that attended! Here are a few highlights ⬇️ Retweeted by Dr. Dana Crawford

@girlscientist Ah, those were the days... To many more #ASHG21!

test Twitter Media - @girlscientist Ah, those were the days...

To many more #ASHG21! https://t.co/Zwwturya5D

#ASHG21 Day 5: It may be the last day, but there's still some great science to be had!

test Twitter Media - #ASHG21 Day 5:  It may be the last day, but there's still some great science to be had! https://t.co/Lx6kqdjkX6

In memoriam on this #ThrowbackThursday at #ASHG21 Steve Warren and me at the 50th meeting of @GeneticsSociety in #Philadelphia October 2000. This was by far Steve’s favorite time of year, favorite Society and most important meeting. Godspeed, Dr. Warren thinking of you this week. Retweeted by Dr. Dana Crawford

What has me so startled? Check out #ASHG21 on demand to find out! twitter.com/GeneticsSociet…

Not gonna lie, some of the questions submitted to this session on diversity, race, inclusion, and equity are... 😬😬😬 Thankfully not very upvoted I'm glad we're holding this session so maybe these scientists can learn why this matters #ASHG21 Retweeted by Dr. Dana Crawford

TBT #ICHG2011: Uh-oh, did someone @Illumina call SEQurity? It's day 4 of #ASHG21!

test Twitter Media - TBT #ICHG2011:  Uh-oh, did someone @Illumina call SEQurity?  It's day 4 of #ASHG21! https://t.co/eN63XUvzEv

Day 3 of #ASHG21: Neurodevelopmental disorders platform session ongoing now. Same stellar research by @GeneticsSociety members, minus the jumbotron.

test Twitter Media - Day 3 of #ASHG21:  Neurodevelopmental disorders platform session ongoing now. Same stellar research by @GeneticsSociety members, minus the jumbotron. https://t.co/2sMYzNyJKi

@CaturDNA @cgonzagaj @GeneticsSociety I miss checking my cubby for notes! (not that I ever got any….)😏 Retweeted by Dr. Dana Crawford

Don't forget to message your @GeneticsSociety friends during #ASHG21 in the chat boxes!

test Twitter Media - Don't forget to message your @GeneticsSociety friends during #ASHG21 in the chat boxes! https://t.co/IuJEyCOV1U

Grab your abstract planner! It's day 2 of #ASHG21!

test Twitter Media - Grab your abstract planner!  It's day 2 of #ASHG21! https://t.co/eaB5nOcLAN

Congrats to my grad student @shiying_l, recipient of one of ten @AFARorg 2021 Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging! #CWRU #CWRUSOM

Affiliations

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Curriculum vitae