DANA C. CRAWFORD, PHD

Associate Director for Population and Diversity Research

Dana Craw­ford, PhD, is Pro­fes­sor in the Department of Population and Quantitative Health Sciences and Associate Director for Population and Diversity Research in the Cleveland Insti­tute for Com­pu­ta­tional Biol­ogy. She also has a secondary appointment in the Department of Genetics and Genome Sciences. Dr. Craw­ford received her Ph.D. at Emory Uni­ver­sity in genet­ics and mol­e­c­u­lar biol­ogy in 2000 and then trained as a post-doctoral fel­low as an Epi­demic Intel­li­gence Ser­vice Offi­cer at the Cen­ters for Dis­ease Con­trol and Pre­ven­tion (2000–2002) and as a senior fel­low at the Uni­ver­sity of Washington’s Depart­ment of Genome Sci­ences (2002–2006). Prior to her most cur­rent posi­tion, Dr. Craw­ford spent eight years as tenure-track fac­ulty in the Depart­ment of Mol­e­c­u­lar Phys­i­ol­ogy and Bio­physics and Inves­ti­ga­tor in the Cen­ter for Human Genet­ics Research at Van­der­bilt Uni­ver­sity. As a genetic epi­demi­ol­o­gist at CWRU, Dr. Crawford’s broad research inter­ests include apply­ing genetic vari­a­tion data to large-scale epi­demi­o­logic and clin­i­cal cohorts to bet­ter under­stand human genotype-phenotype asso­ci­a­tions with an empha­sis on diverse populations.

Recent Publications

  1. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
  2. Ong, E, Wang, LL, Schaub, J, O'Toole, JF, Steck, B, Rosenberg, AZ, Dowd, F, Hansen, J, Barisoni, L, Jain, S et al.. Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project. Nat Rev Nephrol 2020; 16 (11): 686-696. PubMed PMID:32939051 .
  3. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, UKGPCS Collaborators, Lophatananon, A, Tangen, CM et al.. African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Int J Cancer 2020; : . PubMed PMID:32930425 .
  4. McDonough, CW, Babcock, K, Chucri, K, Crawford, DC, Bian, J, Modave, F, Cooper-DeHoff, RM, Hogan, WR. Optimizing identification of resistant hypertension: Computable phenotype development and validation. Pharmacoepidemiol Drug Saf 2020; 29 (11): 1393-1401. PubMed PMID:32844549 .
  5. Darst, BF, Wan, P, Sheng, X, Bensen, JT, Ingles, SA, Rybicki, BA, Nemesure, B, John, EM, Fowke, JH, Stevens, VL et al.. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur Urol 2020; 78 (3): 316-320. PubMed PMID:32409115 .
  6. Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS One 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
  7. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
  8. Bush, WS, Cooke Bailey, JN, Beno, MF, Crawford, DC. Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. Public Health Genomics 2019; 22 (1-2): 16-24. PubMed PMID:31454805 PubMed Central PMC6752968.
  9. Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC et al.. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
  10. Crawford, DC, Cooke Bailey, JN, Briggs, FBS. Mind the gap: resources required to receive, process and interpret research-returned whole genome data. Hum Genet 2019; 138 (7): 691-701. PubMed PMID:31161416 PubMed Central PMC6767905.
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Featured Publications

Using Electronic Health Records to Generate Phenotypes for Research

Sarah A. Pendergrass and Dana C. Crawford Electronic health records contain patient-level data collected during and for clinical care. Data within the electronic health record include diagnostic billing codes, procedure codes, vital signs, laboratory test results, clinical imaging, and physician notes. With repeated clinic visits, these data are longitudinal, providing important information on disease development, […]

Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records.

Restrepo NA, Laper S, Farber-Eger E, Crawford DC. Glaucoma is a leading cause of blindness in developed countries. Primary open-angle glaucoma (POAG), the most prevalent clinical subtype of glaucoma in the United States, affects African Americans at a higher rate compared with European Americans. Risk factors identified for POAG include increased age and family history, […]

Dana on Twitter

Humbled to be named alongside such brilliant human genetics and genomics colleagues in this year's AAAS Fellows list. Thanks to all those who trained and support me @emorygmb @uwgenome @GeneticsSociety @Cleveland_ICB @CWRUSOM twitter.com/aaas/status/13…

Looks like @GeneticsSociety Dr. Pulliam is doing double duty today! #ABRCMS2020 #CWRUSOM twitter.com/bgsocwru/statu…

I missed the talk but was able to join the Q&A. Excellent career advice and nothing but the COVID scientific facts from @KizzyPhD on emerging vaccine efficacy data, SARS-CoV-2 mutation rates, and more at #ABRCMS2020 twitter.com/FutureDrSLove/…

I am both happy and sad. This should have happened in 2016. #BidenHarrisToEndThisNightmare twitter.com/iamsambee/stat…

My new Sammy Bee best @FullFrontalSamB with great memories of the 2010 Rally to Restore Sanity @colbertlateshow Still trying to fix things, 10 years later. #LateShowPreShow #ScreamHere

test Twitter Media - My new Sammy Bee best @FullFrontalSamB with great memories of the 2010 Rally to Restore Sanity @colbertlateshow Still trying to fix things, 10 years later.  #LateShowPreShow #ScreamHere https://t.co/KYUee1v75n

So proud of our grad students doing more than their fair share on #ELECTIONDAY #Election2020 #Vote2020 #VOTE twitter.com/a_k_miller/sta…

Sweet child o' mine, what a #ASHGMemory @illumina! I'm at #ASHG20 partying like it's pre-pandemic ASHG 2018 in San Diego!

Late into the @illumina party, ASHG San Diego 2007. The hip hop dancers have left the scientists to party on. And party on they did. #ASHGMemory #ASHG20

test Twitter Media - Late into the @illumina party, ASHG San Diego 2007.  The hip hop dancers have left the scientists to party on.  And party on they did. #ASHGMemory #ASHG20 https://t.co/ED5HHBui03

@TheRealDrOLab @oconnellphds @OregonCovidSeq @acadey80 @BenBimber @SallyGrindstaff @PDXdengue A great example of residual sample use for genomic surveillance of SARS-CoV-2. If only more in the US would adopt this approach.

Watching the #ASHG20 late-breaking session on COVID-19 genetics. Excited for the science, but sad to be watching it from an Ohio county about to go purple on the alert system because of severe exposure and spread.

@joanneberghout Yes. Srsly, I would characterize the talks so far in this session as focused on approach, not on freq of the variants.

@michaelhoffman Other approaches "leave a lot of signal on the table." Oh, I am gonna use that!

I feel like I am standing in the back of the room at session 21 variant-to-function coupling. Are there any chairs available in the front? No? Only a few random in the middle? #ASHG20

Pretty much every #ASHGMemory: Waiting in the long line at Starbucks hoping to make the first session on time. #ASHG20 Day 2 starts soon! Good luck @a_k_miller! twitter.com/CaturDNA/statu…

test Twitter Media - Pretty much every #ASHGMemory:  Waiting in the long line at Starbucks hoping to make the first session on time.  #ASHG20 Day 2 starts soon!  Good luck @a_k_miller! https://t.co/zn5zaOLLtD https://t.co/uOiVhrDdrX

ASHG 1997 in Baltimore. My second @GeneticsSociety meeting, back when I was still excited about conference hotel gift shops. #ASHG20 #ASHGMemories

test Twitter Media - ASHG 1997 in Baltimore.  My second @GeneticsSociety meeting, back when I was still excited about conference hotel gift shops.  #ASHG20 #ASHGMemories https://t.co/1NpCeCyeLU

How it started (new graduate student at ASHG 1996) v how it’s going (Professor and board member at #ASHG20). Thanks for the mentorship and leadership opportunities @GeneticsSociety

test Twitter Media - How it started (new graduate student at ASHG 1996) v how it’s going (Professor and board member at #ASHG20).  Thanks for the mentorship and leadership opportunities @GeneticsSociety https://t.co/Cv8vvNkPeX
test Twitter Media - How it started (new graduate student at ASHG 1996) v how it’s going (Professor and board member at #ASHG20).  Thanks for the mentorship and leadership opportunities @GeneticsSociety https://t.co/Cv8vvNkPeX

Affiliations

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Curriculum vitae