Bioinformatics Core

The Bioinformatics Core provides research design and computational and analytical support for a variety of research projects.

Modern high-throughput experiments generate massive amounts of data that must be designed appropriately and then processed and checked extensively for data integrity and quality control.

The Bioinformatics Core supports researchers with standard and customized studies and pipelines for data processing and analysis of next-generation sequencing data.

This core supports:

  • RNA-sequencing and differential expression analysis at the gene and isoform levels
  • DNA sequencing for genomic variant identification
  • Microbiome analysis
  • De novo assembly of genomes
  • Methylation analysis from arrays or sequencing
  • ChIP-seq, ATAC-seq and other functional genomics experiments
  • Pathway or Function-based enrichment analyses
  • Gene and Variant annotation

Data management and security
Our team adheres to all protocols around transmission, management, and storage of data, as determined by relevant data warehouses and each research project’s protocols. We can also help submit your data to public archives such as the SRA, GEO, and Genbank.

Engaging our team
Investigations start with a thorough capabilities assessment and clear experimental design. Our team is available to advise from initiation through implementation. We also can support grant submission and manuscript drafting and editing.
We work closely with the sequencing cores of Case Western Reserve University and the Cleveland Clinic and can help determine your sequencing and analysis needs as well as provide you with a cost estimate. Core charges can be done as either fee-for-service or through collaborative support on grants.

Bioinformatics Core contact
Ricky Chan