JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Rajabli, F, Tosto, G, Hamilton-Nelson, KL, Kunkle, BW, Vardarajan, BN, Naj, A, Whitehead, PG, Gardner, OK, Bush, WS, Sariya, S et al.. Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans. Alzheimers Dement 2022; : . PubMed PMID:36539198 .
  2. Holstege, H, Hulsman, M, Charbonnier, C, Grenier-Boley, B, Quenez, O, Grozeva, D, van Rooij, JGJ, Sims, R, Ahmad, S, Amin, N et al.. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease. Nat Genet 2022; 54 (12): 1786-1794. PubMed PMID:36411364 PubMed Central PMC9729101.
  3. den Hollander, AI, Mullins, RF, Orozco, LD, Voigt, AP, Chen, HH, Strunz, T, Grassmann, F, Haines, JL, Kuiper, JJW, Tumminia, SJ et al.. Systems genomics in age-related macular degeneration. Exp Eye Res 2022; 225 : 109248. PubMed PMID:36108770 .
  4. Waksmunski, AR, Miskimen, K, Song, YE, Grunin, M, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M et al.. Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish. Invest Ophthalmol Vis Sci 2022; 63 (9): 8. PubMed PMID:35930268 PubMed Central PMC9363678.
  5. Osterman, MD, Song, YE, Nittala, M, Sadda, SR, Scott, WK, Stambolian, D, Pericak-Vance, MA, Haines, JL. Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 2022; 63 (8): 17. PubMed PMID:35857289 PubMed Central PMC9315071.
  6. Rajabli, F, Beecham, GW, Hendrie, HC, Baiyewu, O, Ogunniyi, A, Gao, S, Kushch, NA, Lipkin-Vasquez, M, Hamilton-Nelson, KL, Young, JI et al.. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS Genet 2022; 18 (7): e1009977. PubMed PMID:35788729 PubMed Central PMC9286282.
  7. Chung, J, Das, A, Sun, X, Sobreira, DR, Leung, YY, Igartua, C, Mozaffari, S, Chou, YF, Thiagalingam, S, Mez, J et al.. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement 2022; : . PubMed PMID:35770850 PubMed Central PMC9800643.
  8. Oncel, D, Manafi, N, Nittala, MG, Velaga, SB, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Effect of OCT B-Scan Density on Sensitivity for Detection of Intraretinal Hyperreflective Foci in Eyes with Age-Related Macular Degeneration. Curr Eye Res 2022; 47 (9): 1294-1299. PubMed PMID:35603911 .
  9. Osterman, MD, Song, YE, Adams, LD, Laux, RA, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD, Slifer, SH, Lynn, A et al.. The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish. HGG Adv 2022; 3 (3): 100114. PubMed PMID:35599847 PubMed Central PMC9114685.
  10. Eissman, JM, Dumitrescu, L, Mahoney, ER, Smith, AN, Mukherjee, S, Lee, ML, Scollard, P, Choi, SE, Bush, WS, Engelman, CD et al.. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain 2022; 145 (7): 2541-2554. PubMed PMID:35552371 PubMed Central PMC9337804.
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