Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.



Recent Publications

  1. Verma, A, Nittala, MG, Corradetti, G, Nassisi, M, Velaga, SB, He, Y, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR et al.. Longitudinal Evaluation of the Distribution of Intraretinal Hyper-Reflective Foci in Eyes with Intermediate Age-Related Macular Degeneration. Curr Eye Res 2024; : 1-7. PubMed PMID:38639042 .
  2. Cukier, HN, Simon, SA, Tang, E, Golightly, CG, Laverde-Paz, MJ, Adams, LD, Starks, TD, Vance, JM, Cuccaro, ML, Haines, JL et al.. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs). Stem Cell Res 2024; 76 : 103364. PubMed PMID:38422817 .
  3. Rajabli, F, Seixas, AA, Akgun, B, Adams, LD, Inciute, J, Hamilton, KL, Whithead, PG, Konidari, I, Gu, T, Arvizu, J et al.. African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer's Disease Measured by pTau181. J Alzheimers Dis 2024; 98 (1): 221-229. PubMed PMID:38393909 .
  4. Cheng, F, Wang, F, Tang, J, Zhou, Y, Fu, Z, Zhang, P, Haines, JL, Leverenz, JB, Gan, L, Hu, J et al.. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease. Cell Rep Med 2024; 5 (2): 101379. PubMed PMID:38382465 PubMed Central PMC10897520.
  5. Caban-Holt, A, Cuccaro, ML, Lloyd, SL, Starks, TD, Adams, LD, Ford, T, Haines, JL, Beecham, G, Reitz, C, Vance, JM et al.. Attitudes and Perceptions about Brain Donation Among African Americans: Implications for Recruitment into Alzheimer's Disease Research. J Alzheimers Dis 2024; 97 (4): 1621-1627. PubMed PMID:38306029 .
  6. Wang, P, Lynn, A, Miskimen, K, Song, YE, Wisniewski, T, Cohen, M, Appleby, BS, Safar, JG, Haines, JL. Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease. Alzheimers Dement 2024; 20 (3): 2034-2046. PubMed PMID:38184787 PubMed Central PMC10984493.
  7. Vance, JM, Farrer, LA, Huang, Y, Cruchaga, C, Hyman, BT, Pericak-Vance, MA, Goate, AM, Greicius, MD, Griswold, AJ, Haines, JL et al.. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Ann Neurol 2024; 95 (4): 625-634. PubMed PMID:38180638 .
  8. Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2. medRxiv 2023; : . PubMed PMID:38168325 PubMed Central PMC10760262.
  9. Archer, DB, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement 2024; 20 (2): 1268-1283. PubMed PMID:37985223 PubMed Central PMC10896586.
  10. Eissman, JM, Archer, DB, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Sex-specific genetic architecture of late-life memory performance. Alzheimers Dement 2024; 20 (2): 1250-1267. PubMed PMID:37984853 PubMed Central PMC10917043.
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