JONATHAN HAINES, PH.D.

Director

Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Ma, Y, Jun, GR, Zhang, X, Chung, J, Naj, AC, Chen, Y, Bellenguez, C, Hamilton-Nelson, K, Martin, ER, Kunkle, BW et al.. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA Neurol 2019; : . PubMed PMID:31180460 PubMed Central PMC6563544.
  2. Gardner, OK, Wang, L, Van Booven, D, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Starks, TD, Hofmann, NK, Vance, JM, Cuccaro, ML et al.. RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways. Hum. Mol. Genet. 2019; : . PubMed PMID:31162550 .
  3. Ma, Y, Jun, GR, Chung, J, Zhang, X, Kunkle, BW, Naj, AC, White, CC, Bennett, DA, De Jager, PL, Alzheimer’s Disease Genetics Consortium et al.. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging Cell 2019; 18 (4): e12964. PubMed PMID:31144443 PubMed Central PMC6612647.
  4. Laville, V, Kang, JH, Cousins, CC, Iglesias, AI, Nagy, R, Cooke Bailey, JN, Igo, RP Jr, Song, YE, Chasman, DI, Christen, WG et al.. Genetic correlations between diabetes and glaucoma: an analysis of continuous and dichotomous phenotypes. Am. J. Ophthalmol. 2019; : . PubMed PMID:31121135 .
  5. Patel, D, Mez, J, Vardarajan, BN, Staley, L, Chung, J, Zhang, X, Farrell, JJ, Rynkiewicz, MJ, Cannon-Albright, LA, Teerlink, CC et al.. Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry. JAMA Netw Open 2019; 2 (3): e191350. PubMed PMID:30924900 PubMed Central PMC6450321.
  6. Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A et al.. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat. Genet. 2019; 51 (3): 414-430. PubMed PMID:30820047 PubMed Central PMC6463297.
  7. Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Höhn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE et al.. Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nat Commun 2019; 10 (1): 155. PubMed PMID:30622277 PubMed Central PMC6325104.
  8. Beecham, GW, Vardarajan, B, Blue, E, Bush, W, Jaworski, J, Barral, S, DeStefano, A, Hamilton-Nelson, K, Kunkle, B, Martin, ER et al.. Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease. Neurol Genet 2018; 4 (6): e286. PubMed PMID:30569016 PubMed Central PMC6278241.
  9. Zhang, X, Zhu, C, Beecham, G, Vardarajan, BN, Ma, Y, Lancour, D, Farrell, JJ, Chung, J, Alzheimer's Disease Sequencing Project, Mayeux, R et al.. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease. Alzheimers Dement 2019; 15 (3): 441-452. PubMed PMID:30503768 PubMed Central PMC6408965.
  10. Rajabli, F, Feliciano, BE, Celis, K, Hamilton-Nelson, KL, Whitehead, PL, Adams, LD, Bussies, PL, Manrique, CP, Rodriguez, A, Rodriguez, V et al.. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS Genet. 2018; 14 (12): e1007791. PubMed PMID:30517106 PubMed Central PMC6281216.
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