JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Ramos, J, Chowdhury, AR, Caywood, LJ, Prough, M, Denise Fuzzell, M, Fuzzell, S, Miskimen, K, Whitehead, PL, Adams, LD, Laux, R et al.. Lower Levels of Education Are Associated with Cognitive Impairment in the Old Order Amish. J Alzheimers Dis 2021; 79 (1): 451-458. PubMed PMID:33285633 .
  2. Kunkle, BW, Schmidt, M, Klein, HU, Naj, AC, Hamilton-Nelson, KL, Larson, EB, Evans, DA, De Jager, PL, Crane, PK, Buxbaum, JD et al.. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol 2021; 78 (1): 102-113. PubMed PMID:33074286 PubMed Central PMC7573798.
  3. Lancour, D, Dupuis, J, Mayeux, R, Haines, JL, Pericak-Vance, MA, Schellenberg, GC, Crovella, M, Farrer, LA, Kasif, S. Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease. Alzheimers Res Ther 2020; 12 (1): 103. PubMed PMID:32878640 PubMed Central PMC7469336.
  4. Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al.. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain 2020; 143 (8): 2561-2575. PubMed PMID:32844198 PubMed Central PMC7447518.
  5. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN. Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration. BMC Med Genomics 2020; 13 (1): 95. PubMed PMID:32631374 PubMed Central PMC7336430.
  6. Griswold, AJ, Sivasankaran, SK, Van Booven, D, Gardner, OK, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Scott, AM, Hofmann, NK et al.. Immune and Inflammatory Pathways Implicated by Whole Blood Transcriptomic Analysis in a Diverse Ancestry Alzheimer's Disease Cohort. J Alzheimers Dis 2020; 76 (3): 1047-1060. PubMed PMID:32597797 .
  7. Bussies, PL, Rajabli, F, Griswold, A, Dorfsman, DA, Whitehead, P, Adams, LD, Mena, PR, Cuccaro, M, Haines, JL, Byrd, GS et al.. Use of local genetic ancestry to assess TOMM40-523' and risk for Alzheimer disease. Neurol Genet 2020; 6 (2): e404. PubMed PMID:32337333 PubMed Central PMC7164968.
  8. Reiman, EM, Arboleda-Velasquez, JF, Quiroz, YT, Huentelman, MJ, Beach, TG, Caselli, RJ, Chen, Y, Su, Y, Myers, AJ, Hardy, J et al.. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun 2020; 11 (1): 667. PubMed PMID:32015339 PubMed Central PMC6997393.
  9. Craig, JE, Han, X, Qassim, A, Hassall, M, Cooke Bailey, JN, Kinzy, TG, Khawaja, AP, An, J, Marshall, H, Gharahkhani, P et al.. Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nat Genet 2020; 52 (2): 160-166. PubMed PMID:31959993 .
  10. Wheeler, NR, Benchek, P, Kunkle, BW, Hamilton-Nelson, KL, Warfe, M, Fondran, JR, Haines, JL, Bush, WS. Hadoop and PySpark for reproducibility and scalability of genomic sequencing studies. Pac Symp Biocomput 2020; 25 : 523-534. PubMed PMID:31797624 PubMed Central PMC6956992.
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