JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Eissman, JM, Dumitrescu, L, Mahoney, ER, Smith, AN, Mukherjee, S, Lee, ML, Scollard, P, Choi, SE, Bush, WS, Engelman, CD et al.. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain 2022; : . PubMed PMID:35552371 .
  2. Yaghy, A, Lee, AY, Keane, PA, Keenan, TDL, Mendonca, LSM, Lee, CS, Cairns, AM, Caroll, J, Chen, H, Clark, J et al.. Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials. Exp Eye Res 2022; : 109092. PubMed PMID:35525297 .
  3. Ramos, J, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD, Slifer, SH, Fuzzell, MD, Fuzzell, SL, Hochstetler, SD, Miskimen, KL et al.. Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets. Alzheimers Dement 2022; : . PubMed PMID:35490390 .
  4. Gardner, OK, Van Booven, D, Wang, L, Gu, T, Hofmann, NK, Whitehead, PL, Nuytemans, K, Hamilton-Nelson, KL, Adams, LD, Starks, TD et al.. Genetic Architecture of RNA Editing Regulation in Alzheimer Disease across Diverse Ancestral Populations. Hum Mol Genet 2022; : . PubMed PMID:35383839 .
  5. Bellenguez, C, Küçükali, F, Jansen, IE, Kleineidam, L, Moreno-Grau, S, Amin, N, Naj, AC, Campos-Martin, R, Grenier-Boley, B, Andrade, V et al.. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet 2022; 54 (4): 412-436. PubMed PMID:35379992 PubMed Central PMC9005347.
  6. Kizil, C, Sariya, S, Kim, YA, Rajabli, F, Martin, E, Reyes-Dumeyer, D, Vardarajan, B, Maldonado, A, Haines, JL, Mayeux, R et al.. Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1. Mol Psychiatry 2022; : . PubMed PMID:35365809 .
  7. Vardarajan, BN, Reyes-Dumeyer, D, Piriz, AL, Lantigua, RA, Medrano, M, Rivera, D, Jiménez-Velázquez, IZ, Martin, E, Pericak-Vance, MA, Bush, W et al.. Progranulin mutations in clinical and neuropathological Alzheimer's disease. Alzheimers Dement 2022; : . PubMed PMID:35258170 .
  8. Jin, B, Capra, JA, Benchek, P, Wheeler, N, Naj, AC, Hamilton-Nelson, KL, Farrell, JJ, Leung, YY, Kunkle, B, Vadarajan, B et al.. An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns. Genome Res 2022; 32 (4): 778-790. PubMed PMID:35210353 PubMed Central PMC8997344.
  9. Shade, LM, Katsumata, Y, Hohman, TJ, Nho, K, Saykin, AJ, Mukherjee, S, Boehme, KL, Kauwe, JS, Farrer, LA, Schellenberg, GD et al.. Genome-wide association study of brain arteriolosclerosis. J Cereb Blood Flow Metab 2022; : 271678X211066299. PubMed PMID:35156446 .
  10. Jun, GR, You, Y, Zhu, C, Meng, G, Chung, J, Panitch, R, Hu, J, Xia, W, Alzheimer's Disease Genetics Consortium, Bennett, DA et al.. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease. Alzheimers Dement 2022; : . PubMed PMID:35142023 .
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