JONATHAN HAINES, PH.D.

Director

Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A et al.. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat. Genet. 2019; 51 (3): 414-430. PubMed PMID:30820047 .
  2. Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Höhn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE et al.. Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nat Commun 2019; 10 (1): 155. PubMed PMID:30622277 PubMed Central PMC6325104.
  3. Beecham, GW, Vardarajan, B, Blue, E, Bush, W, Jaworski, J, Barral, S, DeStefano, A, Hamilton-Nelson, K, Kunkle, B, Martin, ER et al.. Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease. Neurol Genet 2018; 4 (6): e286. PubMed PMID:30569016 PubMed Central PMC6278241.
  4. Zhang, X, Zhu, C, Beecham, G, Vardarajan, BN, Ma, Y, Lancour, D, Farrell, JJ, Chung, J, Alzheimer's Disease Sequencing Project, Mayeux, R et al.. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease. Alzheimers Dement 2019; 15 (3): 441-452. PubMed PMID:30503768 PubMed Central PMC6408965.
  5. Rajabli, F, Feliciano, BE, Celis, K, Hamilton-Nelson, KL, Whitehead, PL, Adams, LD, Bussies, PL, Manrique, CP, Rodriguez, A, Rodriguez, V et al.. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS Genet. 2018; 14 (12): e1007791. PubMed PMID:30517106 PubMed Central PMC6281216.
  6. Haines, JL. Alzheimer Disease: Perspectives from Epidemiology and Genetics. J Law Med Ethics 2018; 46 (3): 694-698. PubMed PMID:30336113 .
  7. Mitchell, SL, Uppal, K, Williamson, SM, Liu, K, Burgess, LG, Tran, V, Umfress, AC, Jarrell, KL, Cooke Bailey, JN, Agarwal, A et al.. The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2018; 59 (12): 4978-4985. PubMed PMID:30326066 PubMed Central PMC6188466.
  8. Gusareva, ES, Twizere, JC, Sleegers, K, Dourlen, P, Abisambra, JF, Meier, S, Cloyd, R, Weiss, B, Dermaut, B, Bessonov, K et al.. Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiol. Aging 2018; 72 : 188.e3-188.e12. PubMed PMID:30201328 .
  9. Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al.. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol. Psychiatry 2018; : . PubMed PMID:30108311 PubMed Central PMC6375806.
  10. Vardarajan, BN, Beecham, GW, Haines, JL. Pedigree Selection and Information Content. Curr Protoc Hum Genet 2018; 97 (1): e56. PubMed PMID:30040223 .
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