JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Griswold, AJ, Rajabli, F, Gu, T, Arvizu, J, Golightly, CG, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Mena, PR et al.. Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries. Alzheimers Dement 2025; 21 (3): e14367. PubMed PMID:40133765 PubMed Central PMC11936763.
  2. Phillips, JM, Dumitrescu, LC, Archer, DB, Regelson, AN, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Kukull, WA et al.. Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease. Brain 2025; : . PubMed PMID:40111762 .
  3. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, BS, Trittschuh, EH, Mez, J, Farrer, LA, Gifford, KA et al.. Evaluating the association of APOE genotype and cognitive resilience in SuperAgers. medRxiv 2025; : . PubMed PMID:39830268 PubMed Central PMC11741496.
  4. Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Examination of MGMT as a risk gene for dementia in the Amish. Alzheimers Dement 2025; 21 (1): e14356. PubMed PMID:39711484 PubMed Central PMC11782184.
  5. Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL et al.. Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset. medRxiv 2024; : . PubMed PMID:39677464 PubMed Central PMC11643159.
  6. Gorman, BR, Voloudakis, G, Igo, RP Jr, Kinzy, T, Halladay, CW, Bigdeli, TB, Zeng, B, Venkatesh, S, Cooke Bailey, JN, Crawford, DC et al.. Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. Nat Genet 2024; 56 (12): 2659-2671. PubMed PMID:39623103 .
  7. Bertholim-Nasciben, L, Nuytemans, K, Van Booven, D, Rajabli, F, Moura, S, Ramirez, AM, Dykxhoorn, DM, Wang, L, Scott, WK, Davis, DA et al.. African origin haplotype protective for Alzheimer's disease in APOEε4 carriers: exploring potential mechanisms. bioRxiv 2024; : . PubMed PMID:39484566 PubMed Central PMC11527192.
  8. Cruz-González, S, Gu, E, Gomez, L, Mews, M, Vance, JM, Cuccaro, ML, Cornejo-Olivas, MR, Feliciano-Astacio, BE, Byrd, GS, Haines, JL et al.. Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals. bioRxiv 2024; : . PubMed PMID:39464059 PubMed Central PMC11507840.
  9. Tong, T, Zhu, C, Farrell, JJ, Khurshid, Z, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Neuroimaging Initiative, Martin, ER, Pericak-Vance, MA, Wang, LS, Bush, WS, Schellenberg, GD et al.. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther 2024; 16 (1): 234. PubMed PMID:39444005 PubMed Central PMC11515778.
  10. Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement 2024; 20 (12): 8470-8483. PubMed PMID:39428839 PubMed Central PMC11667527.
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