JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Zhang, X, Farrell, JJ, Tong, T, Hu, J, Zhu, C, Alzheimer's Disease Sequencing Project, Wang, LS, Mayeux, R, Haines, JL, Pericak-Vance, MA et al.. Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease. Alzheimers Dement 2021; : . PubMed PMID:34152079 .
  2. de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Jansen, IE, Pedersen, NL, Stringa, N, Zettergren, A, Hernández, I et al.. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun 2021; 12 (1): 3417. PubMed PMID:34099642 PubMed Central PMC8184987.
  3. Sariya, S, Felsky, D, Reyes-Dumeyer, D, Lali, R, Lantigua, RA, Vardarajan, B, Jiménez-Velázquez, IZ, Haines, JL, Shellenberg, GD, Pericak-Vance, MA et al.. Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics. Ann Neurol 2021; 90 (3): 366-376. PubMed PMID:34038570 PubMed Central PMC8435026.
  4. Rajabli, F, Feliciano-Astacio, BE, Cukier, HN, Wang, L, Griswold, AJ, Hamilton-Nelson, KL, Adams, LD, Rodriguez, VC, Mena, PR, Tejada, S et al.. Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus. Neurobiol Aging 2021; 104 : 115.e1-115.e7. PubMed PMID:33902942 .
  5. Rakocz, N, Chiang, JN, Nittala, MG, Corradetti, G, Tiosano, L, Velaga, S, Thompson, M, Hill, BL, Sankararaman, S, Haines, JL et al.. Automated identification of clinical features from sparsely annotated 3-dimensional medical imaging. NPJ Digit Med 2021; 4 (1): 44. PubMed PMID:33686212 PubMed Central PMC7940637.
  6. Corvi, F, Corradetti, G, Nittala, MG, Velaga, SB, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR. COMPARISON OF SPECTRALIS AND CIRRUS OPTICAL COHERENCE TOMOGRAPHY FOR THE DETECTION OF INCOMPLETE AND COMPLETE RETINAL PIGMENT EPITHELIUM AND OUTER RETINAL ATROPHY. Retina 2021; 41 (9): 1851-1857. PubMed PMID:33655896 .
  7. Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP, Pendergrass, S, Han, X, Ong, JS, Hewitt, AW, Segrè, AV, Rouhana, JM et al.. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun 2021; 12 (1): 1258. PubMed PMID:33627673 PubMed Central PMC7904932.
  8. Genetics of Exfoliation Syndrome Partnership, Li, Z, Wang, Z, Lee, MC, Zenkel, M, Peh, E, Ozaki, M, Topouzis, F, Nakano, S, Chan, A et al.. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 2021; 325 (8): 753-764. PubMed PMID:33620406 PubMed Central PMC7903258.
  9. Waksmunski, AR, Song, YE, Kinzy, TG, Laux, RA, Sewell, J, Fuzzell, D, Fuzzell, S, Miller, S, Wiggs, JL, Pasquale, LR et al.. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish. Int J Environ Res Public Health 2021; 18 (4): . PubMed PMID:33561996 PubMed Central PMC7915874.
  10. Griswold, AJ, Celis, K, Bussies, PL, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Beecham, GW, Dykxhoorn, DM, Nuytemans, K, Wang, L et al.. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds. Alzheimers Dement 2021; 17 (7): 1179-1188. PubMed PMID:33522086 .
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