JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP, Pendergrass, S, Han, X, Ong, JS, Hewitt, AW, Segrè, AV, Rouhana, JM et al.. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun 2021; 12 (1): 1258. PubMed PMID:33627673 .
  2. Genetics of Exfoliation Syndrome Partnership, Li, Z, Wang, Z, Lee, MC, Zenkel, M, Peh, E, Ozaki, M, Topouzis, F, Nakano, S, Chan, A et al.. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 2021; 325 (8): 753-764. PubMed PMID:33620406 .
  3. Waksmunski, AR, Song, YE, Kinzy, TG, Laux, RA, Sewell, J, Fuzzell, D, Fuzzell, S, Miller, S, Wiggs, JL, Pasquale, LR et al.. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish. Int J Environ Res Public Health 2021; 18 (4): . PubMed PMID:33561996 PubMed Central PMC7915874.
  4. Griswold, AJ, Celis, K, Bussies, PL, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Beecham, GW, Dykxhoorn, DM, Nuytemans, K, Wang, L et al.. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds. Alzheimers Dement 2021; : . PubMed PMID:33522086 .
  5. Ramos, J, Chowdhury, AR, Caywood, LJ, Prough, M, Denise Fuzzell, M, Fuzzell, S, Miskimen, K, Whitehead, PL, Adams, LD, Laux, R et al.. Lower Levels of Education Are Associated with Cognitive Impairment in the Old Order Amish. J Alzheimers Dis 2021; 79 (1): 451-458. PubMed PMID:33285633 .
  6. Kunkle, BW, Schmidt, M, Klein, HU, Naj, AC, Hamilton-Nelson, KL, Larson, EB, Evans, DA, De Jager, PL, Crane, PK, Buxbaum, JD et al.. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol 2021; 78 (1): 102-113. PubMed PMID:33074286 PubMed Central PMC7573798.
  7. Lancour, D, Dupuis, J, Mayeux, R, Haines, JL, Pericak-Vance, MA, Schellenberg, GC, Crovella, M, Farrer, LA, Kasif, S. Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease. Alzheimers Res Ther 2020; 12 (1): 103. PubMed PMID:32878640 PubMed Central PMC7469336.
  8. Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al.. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain 2020; 143 (8): 2561-2575. PubMed PMID:32844198 PubMed Central PMC7447518.
  9. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN. Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration. BMC Med Genomics 2020; 13 (1): 95. PubMed PMID:32631374 PubMed Central PMC7336430.
  10. Griswold, AJ, Sivasankaran, SK, Van Booven, D, Gardner, OK, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Scott, AM, Hofmann, NK et al.. Immune and Inflammatory Pathways Implicated by Whole Blood Transcriptomic Analysis in a Diverse Ancestry Alzheimer's Disease Cohort. J Alzheimers Dis 2020; 76 (3): 1047-1060. PubMed PMID:32597797 .
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