JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Osterman, MD, Song, YE, Lynn, A, Miskimen, K, Adams, LD, Laux, RA, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD et al.. Founder population-specific weights yield improvements in performance of polygenic risk scores for Alzheimer's disease in the Midwestern Amish. HGG Adv 2023; : 100241. PubMed PMID:37742071 .
  2. Liu, WW, Kinzy, TG, Cooke Bailey, JN, Xu, Z, Hysi, P, Wiggs, JL, NEIGHBORHOOD Consortium. Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma. Sci Rep 2023; 13 (1): 15871. PubMed PMID:37741866 PubMed Central PMC10517927.
  3. Celis, K, Zaman, A, Adams, LD, Gardner, O, Farid, R, Starks, TD, Lacroix, FC, Hamilton-Nelson, K, Mena, P, Tejada, S et al.. Neuropsychiatric features in a multi-ethnic population with Alzheimer disease and mild cognitive impairment. Int J Geriatr Psychiatry 2023; 38 (9): e5992. PubMed PMID:37655494 PubMed Central PMC10518518.
  4. Tejeda, M, Farrell, J, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD, Pericak-Vance, MA et al.. DNA from multiple viral species is associated with Alzheimer's disease risk. Alzheimers Dement 2023; : . PubMed PMID:37578203 .
  5. Verma, A, Corradetti, G, He, Y, Nittala, MG, Nassisi, M, Velaga, SB, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR et al.. Relationship between the distribution of intra-retinal hyper-reflective foci and the progression of intermediate age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2023; : . PubMed PMID:37566303 .
  6. Prough, MB, Zaman, A, Caywood, LJ, Clouse, JE, Herington, SD, Slifer, SH, Dorfsman, DA, Adams, LA, Laux, RA, Song, YE et al.. Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias. Alzheimer Dis Assoc Disord ; 37 (3): 195-199. PubMed PMID:37561946 PubMed Central PMC10529392.
  7. Walters, S, Contreras, AG, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS et al.. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol 2023; 80 (9): 929-939. PubMed PMID:37459083 PubMed Central PMC10352930.
  8. Grunin, M, Palmer, E, de Jong, S, Jin, B, Rinker, D, Moth, C, Capra, JA, Haines, JL, Bush, WS, den Hollander, AI et al.. Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease. Adv Exp Med Biol 2023; 1415 : 157-163. PubMed PMID:37440029 .
  9. Kang, M, Ang, TFA, Devine, SA, Sherva, R, Mukherjee, S, Trittschuh, EH, Gibbons, LE, Scollard, P, Lee, M, Choi, SE et al.. A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores. Mol Neurodegener 2023; 18 (1): 40. PubMed PMID:37349795 PubMed Central PMC10286470.
  10. Li, D, Farrell, JJ, Mez, J, Martin, ER, Bush, WS, Ruiz, A, Boada, M, de Rojas, I, Mayeux, R, Haines, JL et al.. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. Alzheimers Dement 2023; : . PubMed PMID:37260021 .
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