Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.



Recent Publications

  1. Rakocz, N, Chiang, JN, Nittala, MG, Corradetti, G, Tiosano, L, Velaga, S, Thompson, M, Hill, BL, Sankararaman, S, Haines, JL et al.. Automated identification of clinical features from sparsely annotated 3-dimensional medical imaging. NPJ Digit Med 2021; 4 (1): 44. PubMed PMID:33686212 PubMed Central PMC7940637.
  2. Corvi, F, Corradetti, G, Nittala, MG, Velaga, SB, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR. Comparison of Spectralis and Cirrus optical coherence tomography for the detection of incomplete and complete retinal pigment epithelium and outer retinal atrophy. Retina 2021; : . PubMed PMID:33655896 .
  3. Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP, Pendergrass, S, Han, X, Ong, JS, Hewitt, AW, Segrè, AV, Rouhana, JM et al.. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun 2021; 12 (1): 1258. PubMed PMID:33627673 PubMed Central PMC7904932.
  4. Genetics of Exfoliation Syndrome Partnership, Li, Z, Wang, Z, Lee, MC, Zenkel, M, Peh, E, Ozaki, M, Topouzis, F, Nakano, S, Chan, A et al.. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 2021; 325 (8): 753-764. PubMed PMID:33620406 PubMed Central PMC7903258.
  5. Waksmunski, AR, Song, YE, Kinzy, TG, Laux, RA, Sewell, J, Fuzzell, D, Fuzzell, S, Miller, S, Wiggs, JL, Pasquale, LR et al.. The GGLEAM Study: Understanding Glaucoma in the Ohio Amish. Int J Environ Res Public Health 2021; 18 (4): . PubMed PMID:33561996 PubMed Central PMC7915874.
  6. Griswold, AJ, Celis, K, Bussies, PL, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Beecham, GW, Dykxhoorn, DM, Nuytemans, K, Wang, L et al.. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds. Alzheimers Dement 2021; : . PubMed PMID:33522086 .
  7. Ramos, J, Chowdhury, AR, Caywood, LJ, Prough, M, Denise Fuzzell, M, Fuzzell, S, Miskimen, K, Whitehead, PL, Adams, LD, Laux, R et al.. Lower Levels of Education Are Associated with Cognitive Impairment in the Old Order Amish. J Alzheimers Dis 2021; 79 (1): 451-458. PubMed PMID:33285633 .
  8. Kunkle, BW, Schmidt, M, Klein, HU, Naj, AC, Hamilton-Nelson, KL, Larson, EB, Evans, DA, De Jager, PL, Crane, PK, Buxbaum, JD et al.. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol 2021; 78 (1): 102-113. PubMed PMID:33074286 PubMed Central PMC7573798.
  9. Lancour, D, Dupuis, J, Mayeux, R, Haines, JL, Pericak-Vance, MA, Schellenberg, GC, Crovella, M, Farrer, LA, Kasif, S. Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease. Alzheimers Res Ther 2020; 12 (1): 103. PubMed PMID:32878640 PubMed Central PMC7469336.
  10. Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al.. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain 2020; 143 (8): 2561-2575. PubMed PMID:32844198 PubMed Central PMC7447518.
Search PubMed