
JONATHAN HAINES, PHD
Director
Jonathan Haines, PhD, is a genetic epidemiologist, Mary W. Sheldon M.D. Professor of Genomic Sciences, Chair of Department of Population and Quantitative Health Sciences, and Director of the Institute for Computational Biology. Dr. Haines has extensive experience in all aspects of genetic epidemiology with a particular focus on data analytics. He has applied his expertise to numerous neurological and ophthalmological disorders having located and identified over 20 causal and 200 associated loci. His interests are in adapting and applying statistical computational methods to biomedical big data.
Recent Publications
- Eissman, JM, Dumitrescu, L, Mahoney, ER, Smith, AN, Mukherjee, S, Lee, ML, Scollard, P, Choi, SE, Bush, WS, Engelman, CD et al.. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain 2022; : . PubMed PMID:35552371 .
- Yaghy, A, Lee, AY, Keane, PA, Keenan, TDL, Mendonca, LSM, Lee, CS, Cairns, AM, Caroll, J, Chen, H, Clark, J et al.. Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials. Exp Eye Res 2022; : 109092. PubMed PMID:35525297 .
- Ramos, J, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD, Slifer, SH, Fuzzell, MD, Fuzzell, SL, Hochstetler, SD, Miskimen, KL et al.. Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets. Alzheimers Dement 2022; : . PubMed PMID:35490390 .
- Gardner, OK, Van Booven, D, Wang, L, Gu, T, Hofmann, NK, Whitehead, PL, Nuytemans, K, Hamilton-Nelson, KL, Adams, LD, Starks, TD et al.. Genetic Architecture of RNA Editing Regulation in Alzheimer Disease across Diverse Ancestral Populations. Hum Mol Genet 2022; : . PubMed PMID:35383839 .
- Bellenguez, C, Küçükali, F, Jansen, IE, Kleineidam, L, Moreno-Grau, S, Amin, N, Naj, AC, Campos-Martin, R, Grenier-Boley, B, Andrade, V et al.. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet 2022; 54 (4): 412-436. PubMed PMID:35379992 PubMed Central PMC9005347.
- Kizil, C, Sariya, S, Kim, YA, Rajabli, F, Martin, E, Reyes-Dumeyer, D, Vardarajan, B, Maldonado, A, Haines, JL, Mayeux, R et al.. Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1. Mol Psychiatry 2022; : . PubMed PMID:35365809 .
- Vardarajan, BN, Reyes-Dumeyer, D, Piriz, AL, Lantigua, RA, Medrano, M, Rivera, D, Jiménez-Velázquez, IZ, Martin, E, Pericak-Vance, MA, Bush, W et al.. Progranulin mutations in clinical and neuropathological Alzheimer's disease. Alzheimers Dement 2022; : . PubMed PMID:35258170 .
- Jin, B, Capra, JA, Benchek, P, Wheeler, N, Naj, AC, Hamilton-Nelson, KL, Farrell, JJ, Leung, YY, Kunkle, B, Vadarajan, B et al.. An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns. Genome Res 2022; 32 (4): 778-790. PubMed PMID:35210353 PubMed Central PMC8997344.
- Shade, LM, Katsumata, Y, Hohman, TJ, Nho, K, Saykin, AJ, Mukherjee, S, Boehme, KL, Kauwe, JS, Farrer, LA, Schellenberg, GD et al.. Genome-wide association study of brain arteriolosclerosis. J Cereb Blood Flow Metab 2022; : 271678X211066299. PubMed PMID:35156446 .
- Jun, GR, You, Y, Zhu, C, Meng, G, Chung, J, Panitch, R, Hu, J, Xia, W, Alzheimer's Disease Genetics Consortium, Bennett, DA et al.. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease. Alzheimers Dement 2022; : . PubMed PMID:35142023 .