JONATHAN HAINES, PH.D.

Director

Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Mitchell, SL, Uppal, K, Williamson, SM, Liu, K, Burgess, LG, Tran, V, Umfress, AC, Jarrell, KL, Cooke Bailey, JN, Agarwal, A et al.. The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2018; 59 (12): 4978-4985. PubMed PMID:30326066 .
  2. Gusareva, ES, Twizere, JC, Sleegers, K, Dourlen, P, Abisambra, JF, Meier, S, Cloyd, R, Weiss, B, Dermaut, B, Bessonov, K et al.. Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiol. Aging 2018; : . PubMed PMID:30201328 .
  3. Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al.. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol. Psychiatry 2018; : . PubMed PMID:30108311 .
  4. Vardarajan, BN, Beecham, GW, Haines, JL. Pedigree Selection and Information Content. Curr Protoc Hum Genet 2018; 97 (1): e56. PubMed PMID:30040223 .
  5. Deming, Y, Dumitrescu, L, Barnes, LL, Thambisetty, M, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL et al.. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018; : . PubMed PMID:29967939 .
  6. Fan, BJ, Chen, X, Sondhi, N, Sharmila, PF, Soumittra, N, Sripriya, S, Sacikala, S, Asokan, R, Friedman, DS, Pasquale, LR et al.. Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus. Invest. Ophthalmol. Vis. Sci. 2018; 59 (6): 2495-2502. PubMed PMID:29847655 PubMed Central PMC5961220.
  7. Hohman, TJ, Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S et al.. Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol 2018; 75 (8): 989-998. PubMed PMID:29801024 PubMed Central PMC6142927.
  8. Khawaja, AP, Cooke Bailey, JN, Wareham, NJ, Scott, RA, Simcoe, M, Igo, RP Jr, Song, YE, Wojciechowski, R, Cheng, CY, Khaw, PT et al.. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat. Genet. 2018; 50 (6): 778-782. PubMed PMID:29785010 PubMed Central PMC5985943.
  9. Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Höhn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE et al.. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nat Commun 2018; 9 (1): 1864. PubMed PMID:29760442 PubMed Central PMC5951816.
  10. Hou, L, Kember, RL, Roach, JC, O'Connell, JR, Craig, DW, Bucan, M, Scott, WK, Pericak-Vance, M, Haines, JL, Crawford, MH et al.. Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations. Sci Rep 2018; 8 (1): 6771. PubMed PMID:29691419 PubMed Central PMC5915589.
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