JONATHAN HAINES, PHD
Director
Jonathan Haines, PhD, is a genetic epidemiologist, Mary W. Sheldon M.D. Professor of Genomic Sciences, Chair of Department of Population and Quantitative Health Sciences, and Director of the Institute for Computational Biology. Dr. Haines has extensive experience in all aspects of genetic epidemiology with a particular focus on data analytics. He has applied his expertise to numerous neurological and ophthalmological disorders having located and identified over 20 causal and 200 associated loci. His interests are in adapting and applying statistical computational methods to biomedical big data.
Recent Publications
- Cukier, HN, Simon, SA, Tang, E, Golightly, CG, Laverde-Paz, MJ, Adams, LD, Starks, TD, Vance, JM, Cuccaro, ML, Haines, JL et al.. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs). Stem Cell Res 2024; 76 : 103364. PubMed PMID:38422817 .
- Rajabli, F, Seixas, AA, Akgun, B, Adams, LD, Inciute, J, Hamilton, KL, Whithead, PG, Konidari, I, Gu, T, Arvizu, J et al.. African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer's Disease Measured by pTau181. J Alzheimers Dis 2024; 98 (1): 221-229. PubMed PMID:38393909 .
- Cheng, F, Wang, F, Tang, J, Zhou, Y, Fu, Z, Zhang, P, Haines, JL, Leverenz, JB, Gan, L, Hu, J et al.. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease. Cell Rep Med 2024; 5 (2): 101379. PubMed PMID:38382465 PubMed Central PMC10897520.
- Caban-Holt, A, Cuccaro, ML, Lloyd, SL, Starks, TD, Adams, LD, Ford, T, Haines, JL, Beecham, G, Reitz, C, Vance, JM et al.. Attitudes and Perceptions about Brain Donation Among African Americans: Implications for Recruitment into Alzheimer's Disease Research. J Alzheimers Dis 2024; 97 (4): 1621-1627. PubMed PMID:38306029 .
- Wang, P, Lynn, A, Miskimen, K, Song, YE, Wisniewski, T, Cohen, M, Appleby, BS, Safar, JG, Haines, JL. Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease. Alzheimers Dement 2024; 20 (3): 2034-2046. PubMed PMID:38184787 .
- Vance, JM, Farrer, LA, Huang, Y, Cruchaga, C, Hyman, BT, Pericak-Vance, MA, Goate, AM, Greicius, MD, Griswold, AJ, Haines, JL et al.. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Ann Neurol 2024; : . PubMed PMID:38180638 .
- Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2. medRxiv 2023; : . PubMed PMID:38168325 PubMed Central PMC10760262.
- Archer, DB, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement 2024; 20 (2): 1268-1283. PubMed PMID:37985223 PubMed Central PMC10896586.
- Eissman, JM, Archer, DB, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Sex-specific genetic architecture of late-life memory performance. Alzheimers Dement 2024; 20 (2): 1250-1267. PubMed PMID:37984853 PubMed Central PMC10917043.
- Nuytemans, K, Rajabli, F, Jean-Francois, M, Kurup, JT, Adams, LD, Starks, TD, Whitehead, PL, Kunkle, BW, Caban-Holt, A, Haines, JL et al.. Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer's Disease in individuals of African Ancestry. Neurobiol Aging 2024; 133 : 125-133. PubMed PMID:37952397 .