Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.



Recent Publications

  1. Li, D, Farrell, JJ, Mez, J, Martin, ER, Bush, WS, Ruiz, A, Boada, M, de Rojas, I, Mayeux, R, Haines, JL et al.. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. Alzheimers Dement 2023; : . PubMed PMID:37260021 .
  2. Byfield, G, Starks, TD, Luther, R, Edwards, CL, Lloyd, SL, Caban-Holt, A, Adams, LD, Vance, JM, Cuccaro, M, Haines, JL et al.. Leveraging African American family connectors for Alzheimer's disease genomic studies. Alzheimers Dement 2023; : . PubMed PMID:37212603 .
  3. Oncel, D, Corradetti, G, He, Y, Ashrafkhorasani, M, Nittala, MG, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Assessment of intraretinal hyperreflective foci using multimodal imaging in eyes with age-related macular degeneration. Acta Ophthalmol 2023; : . PubMed PMID:37199278 .
  4. Oncel, D, Corradetti, G, Wakatsuki, Y, Nittala, MG, Velaga, SB, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Drusen morphometrics on optical coherence tomography in eyes with age-related macular degeneration and normal aging. Graefes Arch Clin Exp Ophthalmol 2023; : . PubMed PMID:37133500 .
  5. Bai, H, Naj, AC, Benchek, P, Dumitrescu, L, Hohman, T, Hamilton-Nelson, K, Kallianpur, AR, Griswold, AJ, Vardarajan, B, Martin, ER et al.. A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease. Alzheimers Dement 2023; : . PubMed PMID:37051669 .
  6. Qiao, M, Lee, AJ, Reyes-Dumeyer, D, Tosto, G, Faber, K, Goate, A, Renton, A, Chao, M, Boeve, B, Cruchaga, C et al.. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. Ann Clin Transl Neurol 2023; 10 (5): 744-756. PubMed PMID:36946865 PubMed Central PMC10187719.
  7. Zaman, A, Caywood, L, Prough, M, Clouse, J, Harrington, S, Adams, L, Fuzzell, D, Fuzzell, S, Laux, R, Hochstetler, SD et al.. Psychometric approaches to defining cognitive phenotypes in the Old Order Amish. Int J Geriatr Psychiatry 2023; 38 (4): e5903. PubMed PMID:36929524 .
  8. Aboobakar, IF, Kinzy, TG, Zhao, Y, Fan, B, Pasquale, LR, Qassim, A, Kolovos, A, Schmidt, JM, Craig, JE, Cooke Bailey, JN et al.. Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes. Ophthalmology 2023; : . PubMed PMID:36813040 .
  9. de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Jansen, IE, Pedersen, NL, Stringa, N, Zettergren, A, Hernández, I et al.. Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun 2023; 14 (1): 716. PubMed PMID:36759603 PubMed Central PMC9911386.
  10. Rajabli, F, Tosto, G, Hamilton-Nelson, KL, Kunkle, BW, Vardarajan, BN, Naj, A, Whitehead, PG, Gardner, OK, Bush, WS, Sariya, S et al.. Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans. Alzheimers Dement 2022; : . PubMed PMID:36539198 .
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