
JONATHAN HAINES, PHD
Director
Jonathan Haines, PhD, is a genetic epidemiologist, Mary W. Sheldon M.D. Professor of Genomic Sciences, Chair of Department of Population and Quantitative Health Sciences, and Director of the Institute for Computational Biology. Dr. Haines has extensive experience in all aspects of genetic epidemiology with a particular focus on data analytics. He has applied his expertise to numerous neurological and ophthalmological disorders having located and identified over 20 causal and 200 associated loci. His interests are in adapting and applying statistical computational methods to biomedical big data.
Recent Publications
- Rajabli, F, Tosto, G, Hamilton-Nelson, KL, Kunkle, BW, Vardarajan, BN, Naj, A, Whitehead, PG, Gardner, OK, Bush, WS, Sariya, S et al.. Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans. Alzheimers Dement 2022; : . PubMed PMID:36539198 .
- Holstege, H, Hulsman, M, Charbonnier, C, Grenier-Boley, B, Quenez, O, Grozeva, D, van Rooij, JGJ, Sims, R, Ahmad, S, Amin, N et al.. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease. Nat Genet 2022; 54 (12): 1786-1794. PubMed PMID:36411364 PubMed Central PMC9729101.
- den Hollander, AI, Mullins, RF, Orozco, LD, Voigt, AP, Chen, HH, Strunz, T, Grassmann, F, Haines, JL, Kuiper, JJW, Tumminia, SJ et al.. Systems genomics in age-related macular degeneration. Exp Eye Res 2022; 225 : 109248. PubMed PMID:36108770 .
- Waksmunski, AR, Miskimen, K, Song, YE, Grunin, M, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M et al.. Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish. Invest Ophthalmol Vis Sci 2022; 63 (9): 8. PubMed PMID:35930268 PubMed Central PMC9363678.
- Osterman, MD, Song, YE, Nittala, M, Sadda, SR, Scott, WK, Stambolian, D, Pericak-Vance, MA, Haines, JL. Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 2022; 63 (8): 17. PubMed PMID:35857289 PubMed Central PMC9315071.
- Rajabli, F, Beecham, GW, Hendrie, HC, Baiyewu, O, Ogunniyi, A, Gao, S, Kushch, NA, Lipkin-Vasquez, M, Hamilton-Nelson, KL, Young, JI et al.. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS Genet 2022; 18 (7): e1009977. PubMed PMID:35788729 PubMed Central PMC9286282.
- Chung, J, Das, A, Sun, X, Sobreira, DR, Leung, YY, Igartua, C, Mozaffari, S, Chou, YF, Thiagalingam, S, Mez, J et al.. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement 2022; : . PubMed PMID:35770850 PubMed Central PMC9800643.
- Oncel, D, Manafi, N, Nittala, MG, Velaga, SB, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Effect of OCT B-Scan Density on Sensitivity for Detection of Intraretinal Hyperreflective Foci in Eyes with Age-Related Macular Degeneration. Curr Eye Res 2022; 47 (9): 1294-1299. PubMed PMID:35603911 .
- Osterman, MD, Song, YE, Adams, LD, Laux, RA, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD, Slifer, SH, Lynn, A et al.. The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish. HGG Adv 2022; 3 (3): 100114. PubMed PMID:35599847 PubMed Central PMC9114685.
- Eissman, JM, Dumitrescu, L, Mahoney, ER, Smith, AN, Mukherjee, S, Lee, ML, Scollard, P, Choi, SE, Bush, WS, Engelman, CD et al.. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain 2022; 145 (7): 2541-2554. PubMed PMID:35552371 PubMed Central PMC9337804.