JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Ray, NR, Kunkle, BW, Hamilton-Nelson, K, Kurup, JT, Rajabli, F, Qiao, M, Vardarajan, BN, Cosacak, MI, Kizil, C, Jean-Francois, M et al.. Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry. Alzheimers Dement 2024; : . PubMed PMID:38958117 .
  2. Zhu, C, Tong, T, Farrell, JJ, Martin, ER, Bush, WS, Pericak-Vance, MA, Wang, LS, Schellenberg, GD, Haines, JL, Lunetta, KL et al.. MitoH3: Mitochondrial Haplogroup and Homoplasmic/Heteroplasmic Variant Calling Pipeline for Alzheimer's Disease Sequencing Project. J Alzheimers Dis Rep 2024; 8 (1): 575-587. PubMed PMID:38746629 PubMed Central PMC11091720.
  3. Griswold, AJ, Rajabli, F, Gu, T, Arvizu, J, Golightly, CG, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Mena, PR et al.. Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries. medRxiv 2024; : . PubMed PMID:38645114 PubMed Central PMC11030471.
  4. Verma, A, Nittala, MG, Corradetti, G, Nassisi, M, Velaga, SB, He, Y, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR et al.. Longitudinal Evaluation of the Distribution of Intraretinal Hyper-Reflective Foci in Eyes with Intermediate Age-Related Macular Degeneration. Curr Eye Res 2024; : 1-7. PubMed PMID:38639042 .
  5. Cukier, HN, Simon, SA, Tang, E, Golightly, CG, Laverde-Paz, MJ, Adams, LD, Starks, TD, Vance, JM, Cuccaro, ML, Haines, JL et al.. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs). Stem Cell Res 2024; 76 : 103364. PubMed PMID:38422817 .
  6. Rajabli, F, Seixas, AA, Akgun, B, Adams, LD, Inciute, J, Hamilton, KL, Whithead, PG, Konidari, I, Gu, T, Arvizu, J et al.. African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer's Disease Measured by pTau181. J Alzheimers Dis 2024; 98 (1): 221-229. PubMed PMID:38393909 PubMed Central PMC11091636.
  7. Cheng, F, Wang, F, Tang, J, Zhou, Y, Fu, Z, Zhang, P, Haines, JL, Leverenz, JB, Gan, L, Hu, J et al.. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease. Cell Rep Med 2024; 5 (2): 101379. PubMed PMID:38382465 PubMed Central PMC10897520.
  8. Caban-Holt, A, Cuccaro, ML, Lloyd, SL, Starks, TD, Adams, LD, Ford, T, Haines, JL, Beecham, G, Reitz, C, Vance, JM et al.. Attitudes and Perceptions about Brain Donation Among African Americans: Implications for Recruitment into Alzheimer's Disease Research. J Alzheimers Dis 2024; 97 (4): 1621-1627. PubMed PMID:38306029 .
  9. Wang, P, Lynn, A, Miskimen, K, Song, YE, Wisniewski, T, Cohen, M, Appleby, BS, Safar, JG, Haines, JL. Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease. Alzheimers Dement 2024; 20 (3): 2034-2046. PubMed PMID:38184787 PubMed Central PMC10984493.
  10. Vance, JM, Farrer, LA, Huang, Y, Cruchaga, C, Hyman, BT, Pericak-Vance, MA, Goate, AM, Greicius, MD, Griswold, AJ, Haines, JL et al.. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Ann Neurol 2024; 95 (4): 625-634. PubMed PMID:38180638 .
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