Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Epi­demi­ol­ogy & Bio­sta­tis­tics, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.



Recent Publications

  1. Beecham, GW, Bis, JC, Martin, ER, Choi, SH, DeStefano, AL, van Duijn, CM, Fornage, M, Gabriel, SB, Koboldt, DC, Larson, DE et al.. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurol Genet 2017; 3 (5): e194. PubMed PMID:29184913 PubMed Central PMC5646177.
  2. Cukier, HN, Kunkle, BK, Hamilton, KL, Rolati, S, Kohli, MA, Whitehead, PL, Jaworski, J, Vance, JM, Cuccaro, ML, Carney, RM et al.. Exome Sequencing of Extended Families with Alzheimer's Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function. J Alzheimers Dis Parkinsonism 2017; 7 (4): . PubMed PMID:29177109 PubMed Central PMC5698805.
  3. Chintalapudi, SR, Maria, D, Di Wang, X, Bailey, JNC, NEIGHBORHOOD consortium, International Glaucoma Genetics consortium, Hysi, PG, Wiggs, JL, Williams, RW, Jablonski, MM et al.. Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility. Nat Commun 2017; 8 (1): 1755. PubMed PMID:29176626 PubMed Central PMC5701146.
  4. Griswold, AJ, Van Booven, D, Cuccaro, ML, Haines, JL, Gilbert, JR, Pericak-Vance, MA. Identification of rare noncoding sequence variants in gamma-aminobutyric acid A receptor, alpha 4 subunit in autism spectrum disorder. Neurogenetics 2017; : . PubMed PMID:29151244 .
  5. Rehker, J, Rodhe, J, Nesbitt, RR, Boyle, EA, Martin, BK, Lord, J, Karaca, I, Naj, A, Jessen, F, Helisalmi, S et al.. Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. PLoS ONE 2017; 12 (10): e0185777. PubMed PMID:28985224 PubMed Central PMC5630132.
  6. Haines, JL, Sheffield, VC. The molecular genetics of eye diseases. Hum. Mol. Genet. 2017; 26 (R1): R1. PubMed PMID:28854578 .
  7. Persad, PJ, Heid, IM, Weeks, DE, Baird, PN, de Jong, EK, Haines, JL, Pericak-Vance, MA, Scott, WK, for the International Age-Related Macular Degeneration Genomics Consortium (IAMDGC). Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1. Invest. Ophthalmol. Vis. Sci. 2017; 58 (10): 4027-4038. PubMed PMID:28813576 PubMed Central PMC5559178.
  8. Kunkle, BW, Vardarajan, BN, Naj, AC, Whitehead, PL, Rolati, S, Slifer, S, Carney, RM, Cuccaro, ML, Vance, JM, Gilbert, JR et al.. Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport. JAMA Neurol 2017; 74 (9): 1113-1122. PubMed PMID:28738127 PubMed Central PMC5691589.
  9. Hou, L, Kember, RL, Roach, JC, O'Connell, JR, Craig, DW, Bucan, M, Scott, WK, Pericak-Vance, M, Haines, JL, Crawford, MH et al.. A population-specific reference panel empowers genetic studies of Anabaptist populations. Sci Rep 2017; 7 (1): 6079. PubMed PMID:28729679 PubMed Central PMC5519631.
  10. Sims, R, van der Lee, SJ, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC et al.. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat. Genet. 2017; 49 (9): 1373-1384. PubMed PMID:28714976 PubMed Central PMC5669039.
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