
JONATHAN HAINES, PHD
Director
Jonathan Haines, PhD, is a genetic epidemiologist, Mary W. Sheldon M.D. Professor of Genomic Sciences, Chair of Department of Population and Quantitative Health Sciences, and Director of the Institute for Computational Biology. Dr. Haines has extensive experience in all aspects of genetic epidemiology with a particular focus on data analytics. He has applied his expertise to numerous neurological and ophthalmological disorders having located and identified over 20 causal and 200 associated loci. His interests are in adapting and applying statistical computational methods to biomedical big data.
Recent Publications
- Li, D, Farrell, JJ, Mez, J, Martin, ER, Bush, WS, Ruiz, A, Boada, M, de Rojas, I, Mayeux, R, Haines, JL et al.. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. Alzheimers Dement 2023; : . PubMed PMID:37260021 .
- Byfield, G, Starks, TD, Luther, R, Edwards, CL, Lloyd, SL, Caban-Holt, A, Adams, LD, Vance, JM, Cuccaro, M, Haines, JL et al.. Leveraging African American family connectors for Alzheimer's disease genomic studies. Alzheimers Dement 2023; : . PubMed PMID:37212603 .
- Oncel, D, Corradetti, G, He, Y, Ashrafkhorasani, M, Nittala, MG, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Assessment of intraretinal hyperreflective foci using multimodal imaging in eyes with age-related macular degeneration. Acta Ophthalmol 2023; : . PubMed PMID:37199278 .
- Oncel, D, Corradetti, G, Wakatsuki, Y, Nittala, MG, Velaga, SB, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Drusen morphometrics on optical coherence tomography in eyes with age-related macular degeneration and normal aging. Graefes Arch Clin Exp Ophthalmol 2023; : . PubMed PMID:37133500 .
- Bai, H, Naj, AC, Benchek, P, Dumitrescu, L, Hohman, T, Hamilton-Nelson, K, Kallianpur, AR, Griswold, AJ, Vardarajan, B, Martin, ER et al.. A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease. Alzheimers Dement 2023; : . PubMed PMID:37051669 .
- Qiao, M, Lee, AJ, Reyes-Dumeyer, D, Tosto, G, Faber, K, Goate, A, Renton, A, Chao, M, Boeve, B, Cruchaga, C et al.. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. Ann Clin Transl Neurol 2023; 10 (5): 744-756. PubMed PMID:36946865 PubMed Central PMC10187719.
- Zaman, A, Caywood, L, Prough, M, Clouse, J, Harrington, S, Adams, L, Fuzzell, D, Fuzzell, S, Laux, R, Hochstetler, SD et al.. Psychometric approaches to defining cognitive phenotypes in the Old Order Amish. Int J Geriatr Psychiatry 2023; 38 (4): e5903. PubMed PMID:36929524 .
- Aboobakar, IF, Kinzy, TG, Zhao, Y, Fan, B, Pasquale, LR, Qassim, A, Kolovos, A, Schmidt, JM, Craig, JE, Cooke Bailey, JN et al.. Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes. Ophthalmology 2023; : . PubMed PMID:36813040 .
- de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Jansen, IE, Pedersen, NL, Stringa, N, Zettergren, A, Hernández, I et al.. Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun 2023; 14 (1): 716. PubMed PMID:36759603 PubMed Central PMC9911386.
- Rajabli, F, Tosto, G, Hamilton-Nelson, KL, Kunkle, BW, Vardarajan, BN, Naj, A, Whitehead, PG, Gardner, OK, Bush, WS, Sariya, S et al.. Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans. Alzheimers Dement 2022; : . PubMed PMID:36539198 .