JONATHAN HAINES, PH.D.

Director

Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al.. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol. Psychiatry 2018; : . PubMed PMID:30108311 .
  2. Vardarajan, BN, Beecham, GW, Haines, JL. Pedigree Selection and Information Content. Curr Protoc Hum Genet 2018; 97 (1): e56. PubMed PMID:30040223 .
  3. Deming, Y, Dumitrescu, L, Barnes, LL, Thambisetty, M, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL et al.. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018; : . PubMed PMID:29967939 .
  4. Fan, BJ, Chen, X, Sondhi, N, Sharmila, PF, Soumittra, N, Sripriya, S, Sacikala, S, Asokan, R, Friedman, DS, Pasquale, LR et al.. Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus. Invest. Ophthalmol. Vis. Sci. 2018; 59 (6): 2495-2502. PubMed PMID:29847655 PubMed Central PMC5961220.
  5. Hohman, TJ, Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S et al.. Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol 2018; 75 (8): 989-998. PubMed PMID:29801024 .
  6. Khawaja, AP, Cooke Bailey, JN, Wareham, NJ, Scott, RA, Simcoe, M, Igo, RP Jr, Song, YE, Wojciechowski, R, Cheng, CY, Khaw, PT et al.. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat. Genet. 2018; 50 (6): 778-782. PubMed PMID:29785010 PubMed Central PMC5985943.
  7. Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Höhn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE et al.. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nat Commun 2018; 9 (1): 1864. PubMed PMID:29760442 PubMed Central PMC5951816.
  8. Hou, L, Kember, RL, Roach, JC, O'Connell, JR, Craig, DW, Bucan, M, Scott, WK, Pericak-Vance, M, Haines, JL, Crawford, MH et al.. Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations. Sci Rep 2018; 8 (1): 6771. PubMed PMID:29691419 PubMed Central PMC5915589.
  9. Vardarajan, BN, Barral, S, Jaworski, J, Beecham, GW, Blue, E, Tosto, G, Reyes-Dumeyer, D, Medrano, M, Lantigua, R, Naj, A et al.. Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Ann Clin Transl Neurol 2018; 5 (4): 406-417. PubMed PMID:29688227 PubMed Central PMC5899906.
  10. Lancour, D, Naj, A, Mayeux, R, Haines, JL, Pericak-Vance, MA, Schellenberg, GD, Crovella, M, Farrer, LA, Kasif, S. One for all and all for One: Improving replication of genetic studies through network diffusion. PLoS Genet. 2018; 14 (4): e1007306. PubMed PMID:29684019 PubMed Central PMC5933817.
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