Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Epi­demi­ol­ogy & Bio­sta­tis­tics, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.



Recent Publications

  1. Butkiewicz, M, Blue, E, Leung, F, Jian, X, Marcora, E, Renton, A, Kuzma, A, Wang, LS, Koboldt, D, Haines, JL et al.. Functional Annotation of genomic variants in studies of Late-Onset Alzheimer's Disease. Bioinformatics 2018; : . PubMed PMID:29590295 .
  2. Chung, J, Zhang, X, Allen, M, Wang, X, Ma, Y, Beecham, G, Montine, TJ, Younkin, SG, Dickson, DW, Golde, TE et al.. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimers Res Ther 2018; 10 (1): 22. PubMed PMID:29458411 PubMed Central PMC5819208.
  3. Shiga, Y, Akiyama, M, Nishiguchi, KM, Sato, K, Shimozawa, N, Takahashi, A, Momozawa, Y, Hirata, M, Matsuda, K, Yamaji, T et al.. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Hum. Mol. Genet. 2018; 27 (8): 1486-1496. PubMed PMID:29452408 .
  4. Gharahkhani, P, Burdon, KP, Cooke Bailey, JN, Hewitt, AW, Law, MH, Pasquale, LR, Kang, JH, Haines, JL, Souzeau, E, Zhou, T et al.. Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Sci Rep 2018; 8 (1): 3124. PubMed PMID:29449654 PubMed Central PMC5814451.
  5. Bailey, JNC, Gharahkhani, P, Kang, JH, Butkiewicz, M, Sullivan, DA, Weinreb, RN, Aschard, H, Allingham, RR, Ashley-Koch, A, Lee, RK et al.. Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets. Invest. Ophthalmol. Vis. Sci. 2018; 59 (2): 629-636. PubMed PMID:29392307 PubMed Central PMC5795896.
  6. Beecham, GW, Bis, JC, Martin, ER, Choi, SH, DeStefano, AL, van Duijn, CM, Fornage, M, Gabriel, SB, Koboldt, DC, Larson, DE et al.. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurol Genet 2017; 3 (5): e194. PubMed PMID:29184913 PubMed Central PMC5646177.
  7. Cukier, HN, Kunkle, BK, Hamilton, KL, Rolati, S, Kohli, MA, Whitehead, PL, Jaworski, J, Vance, JM, Cuccaro, ML, Carney, RM et al.. Exome Sequencing of Extended Families with Alzheimer's Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function. J Alzheimers Dis Parkinsonism 2017; 7 (4): . PubMed PMID:29177109 PubMed Central PMC5698805.
  8. Chintalapudi, SR, Maria, D, Di Wang, X, Bailey, JNC, NEIGHBORHOOD consortium, International Glaucoma Genetics consortium, Hysi, PG, Wiggs, JL, Williams, RW, Jablonski, MM et al.. Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility. Nat Commun 2017; 8 (1): 1755. PubMed PMID:29176626 PubMed Central PMC5701146.
  9. Griswold, AJ, Van Booven, D, Cuccaro, ML, Haines, JL, Gilbert, JR, Pericak-Vance, MA. Identification of rare noncoding sequence variants in gamma-aminobutyric acid A receptor, alpha 4 subunit in autism spectrum disorder. Neurogenetics 2018; 19 (1): 17-26. PubMed PMID:29151244 PubMed Central PMC5792317.
  10. Rehker, J, Rodhe, J, Nesbitt, RR, Boyle, EA, Martin, BK, Lord, J, Karaca, I, Naj, A, Jessen, F, Helisalmi, S et al.. Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. PLoS ONE 2017; 12 (10): e0185777. PubMed PMID:28985224 PubMed Central PMC5630132.
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