WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study.

Bartlett J, Predazzi IM, Williams SM, Bush WS, Kim Y, Havas S, Toth PP, Fazio S, Miller M,. Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) […]

The phenotypic legacy of admixture between modern humans and Neandertals.

Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA,. Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such […]

Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.

Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, ,. Late-onset Alzheimer disease (AD) has a complex genetic etiology, involving locus heterogeneity, polygenic inheritance, and gene-gene interactions; however, the investigation […]

Recent Publications

  1. Pillai, JA, Bebek, G, Khrestian, M, Bena, J, Bergmann, CC, Bush, WS, Leverenz, JB, Bekris, LM. TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease. Front Aging Neurosci 2021; 13 : 638922. PubMed PMID:33716716 PubMed Central PMC7947258.
  2. Huynh-Le, MP, Fan, CC, Karunamuni, R, Thompson, WK, Martinez, ME, Eeles, RA, Kote-Jarai, Z, Muir, K, Schleutker, J, Pashayan, N et al.. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. Nat Commun 2021; 12 (1): 1236. PubMed PMID:33623038 PubMed Central PMC7902617.
  3. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (3): 413. PubMed PMID:33473200 .
  4. Stein, CM, Benchek, P, Bartlett, J, Igo, RP, Sobota, RS, Chervenak, K, Mayanja-Kizza, H, von Reyn, CF, Lahey, T, Bush, WS et al.. Methylome-wide analysis reveals epigenetic marks associated with resistance to tuberculosis in HIV-infected individuals from East Africa. J Infect Dis 2021; : . PubMed PMID:33400784 .
  5. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (1): 65-75. PubMed PMID:33398198 .
  6. Liu, LY, Bush, WS, Koyutürk, M, Karakurt, G. Interplay between traumatic brain injury and intimate partner violence: data driven analysis utilizing electronic health records. BMC Womens Health 2020; 20 (1): 269. PubMed PMID:33287806 PubMed Central PMC7720451.
  7. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
  8. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, UKGPCS Collaborators, Lophatananon, A, Tangen, CM et al.. African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Int J Cancer 2021; 148 (1): 99-105. PubMed PMID:32930425 .
  9. Tang, ZZ, Sliwoski, GR, Chen, G, Jin, B, Bush, WS, Li, B, Capra, JA. PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection. Genome Biol 2020; 21 (1): 217. PubMed PMID:32847609 PubMed Central PMC7448521.
  10. Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al.. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain 2020; 143 (8): 2561-2575. PubMed PMID:32844198 PubMed Central PMC7447518.
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