JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. Alzheimers Dement 2026; 22 (4): e71433. PubMed PMID:42043782 PubMed Central PMC13116102.
  2. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-specific genetic drivers of memory, executive functioning and language in older adults. Brain 2026; : . PubMed PMID:41989867 .
  3. Nam, Y, DeRosa, BA, Ramirez, AM, Ayele, BA, Whitehead-Gay, P, Adams, LD, Golightly, CG, Starks, TD, Laverde-Paz, MJ, Cukier, HN et al.. Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7-associated Alzheimer's disease risk. Alzheimers Dement 2026; 22 (4): e71312. PubMed PMID:41912785 .
  4. Dorfsman, D, Prough, MB, Gulyayev, A, Caywood, LJ, Clouse, JE, Herington, SD, Slifer, SH, Adams, LD, Laux, RA, Song, YE et al.. WDR12 and HIVEP3 are contributors to cognitive preservation in Amish SuperAgers. Alzheimers Dement 2026; 22 (3): e71293. PubMed PMID:41894147 PubMed Central PMC13093529.
  5. Liu, S, Bush, WS, Kunkle, BW, Byrd, GS, Reitz, C, Tosto, G, Rajabli, F, Caban-Holt, AM, Cuccaro, M, Starks, T et al.. Dissecting Alzheimer's disease heritability across populations. Alzheimers Dement 2026; 22 (3): e71236. PubMed PMID:41880092 PubMed Central PMC13093350.
  6. Contreras, AG, Walters, S, Eissman, JM, Archer, DB, Regelson, AN, Durant, A, Clifton, M, Mukherjee, S, Lee, ML, Choi, SE et al.. Genetic modifiers of APOE-ε4-associated cognitive decline. Nat Commun 2026; 17 (1): . PubMed PMID:41720779 PubMed Central PMC13036010.
  7. Lorincz-Comi, N, Song, W, Chen, X, Paz, IR, Hou, Y, Zhou, Y, Xu, J, Martin, W, Barnard, J, Pieper, AA et al.. Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery. Nat Commun 2026; 17 (1): . PubMed PMID:41690969 PubMed Central PMC13021989.
  8. Dorfsman, DA, Cai, D, Hamilton-Nelson, KL, Adams, LD, Mena, PR, Rodriguez, VC, Sanchez, JJ, Valladares, GS, Lopez, M, Whitehead, PL et al.. Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181. J Alzheimers Dis 2026; 110 (2): 685-695. PubMed PMID:41660940 PubMed Central PMC12982544.
  9. Cruz, LA, Liu, S, Miskimen, KL, Cooke Bailey, JN, Kinzy, T, Song, YE, Laux, RA, Miron, P, Ogrocki, PK, Lerner, AJ et al.. Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort study. medRxiv 2026; : . PubMed PMID:41646721 PubMed Central PMC12870599.
  10. Chung, YC, Alhelaly, M, Nittala, MG, Velaga, SB, He, Y, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR. OCT Risk Factors for Progression to Late-Stage Age-Related Macular Degeneration in the Amish Eye Study. Ophthalmol Retina 2026; : . PubMed PMID:41577331 .
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