Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry.

Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed populations, such as African Americans, provides a unique opportunity to identify genomic regions and variants associated with the clinical variability observed for diseases and traits across populations.To […]

Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models.

Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10% of individuals over age 80. AMD has a large genetic component, with heritability estimated to be between 45% and 70%. Numerous variants have been identified and implicate various molecular mechanisms and […]

Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models.

Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10% of individuals over age 80. AMD has a large genetic component, with heritability estimated to be between 45% and 70%. Numerous variants have been identified and implicate various molecular mechanisms and […]

Gene expression in cell lines from propionic acidemia patients, carrier parents, and controls.

Propionic acidemia (PA) is an inborn of metabolism which usually presents with metabolic acidosis and accumulation of 3-hydroxypropionate among other toxins. Examining the gene expression in lymphoblastoid cell lines (LCLs) from PA patients, their carrier parents and age/sex-matched controls at normal glucose and low glucose growth conditions demonstrated differences among and between these groups. Using […]

Sex-Specific Parental Effects on Offspring Lipid Levels.

Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.In this study, we analyzed the role of parental levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) in explaining the values of the corresponding traits in adult offspring. […]

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis. Mutations in […]

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Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles.

Human islet research is providing new insights into human islet biology and diabetes, using islets isolated at multiple US centers from donors with varying characteristics. This creates challenges for understanding, interpreting, and integrating research findings from the many laboratories that use these islets. In what is, to our knowledge, the first standardized assessment of human […]

CWRU Cyberinfrastructure Day

Dr. Hadrian Djohari, High Performance Computing Manager at Case Western Reserve University organized the first annual CWRU Cyberinfrastructure Day, held on March 27, 2015.  Dr. Will Bush spoke on the use of large scale computing for biomedical research.  Slides from this presentation are at the left.

Bush Lab Talk at IGES 2014

Jake Hall of the Bush Lab presented “Mixed-model Analysis of Common Variation Reveals Pathways Explaining Variance in AMD Risk” at the International Genetic Epidemiology Society 2014 annual meeting in Vienna, Austria.  Slides from this presentation are available to the left.   

Tutorial on Genome-wide Association Studies

Dr. Indira Ghosh of the Center for Computational Biology and Bioformatics at Jawaharlal Nehru University organized an Indo-US bilateral Conference on Big Data Analysis and Translation in Disease Biology.  At this conference, Dr. Will Bush presented a tutorial on genome-wide association studies on January 21st, 2015.  Slides from this presentation are at the left.