David Kaelber, MD, PhD, MPH, MS, FAAP, FACP, FACMI serves on the Executive Committee of the Cleveland Institute for Computational Biology. Dr. Kaelber is a practicing internist, pediatrician, Vice-President of Health Informatics, and Chief Medical Informatics Officer at the MetroHealth System. Dr. Kaelber is also Professor in the CWRU Department of Internal Medicine with a secondary appointment in the Departments of Pediatrics and Epidemiology and Biostatistics. MetroHealth is an integrated health system and a primary teaching site for Case Western Reserve University (CWRU). Since the late 1990s, MetroHealth has been at the forefront in adopting electronic health records to advance high quality clinical care in the Cleveland area. Under Dr. Kaelber's leadership, MetroHealth implemented Care Everywhere, a health information exchange program that enables MetroHealth to share patient information with other healthcare systems in the United States. And, in 2011, Dr. Kaelber was instrumental in the development and launch of MyChart, the personal care health record complement of MetroHealth's EHR (Epic). Dr. Kaelber's research interests are rooted in pediatric populations where he has used EHR data to identify previously under-diagnosed hypertension patients and to monitor obesity trends over time. This work earned Dr. Kaelber recognition by the American Heart Association as one of the top ten breakthroughs in cardiovascular and stroke medicine in 2007. More broadly, Dr. Kaelber's research interests span EHRs, clinical decision support, use of EHRs in chronic disease detection and management, personal health records, and medical informatics.
Recent Publications
- Abdelmaksoud, A, Igoe, A, AbdAlnaeem, MA, Toraih, EA, Roller, BA, Kaelber, KL, Kaelber, DC. Increased Risk of Gout among Patients with Trisomy 21: Insights from a Population-Based Study of over 30,000 Patients with Trisomy 21. Mediterr J Rheumatol 2026; 37 (3): 590-597. PubMed PMID:42756659 PubMed Central PMC13583205.
- Haddad, EN, Amin, RS, Sharma, A, Zhao, A, Kim, SB, Kaelber, DC, Singh, RP, Talcott, KE, Rotroff, DM, Sayegh, RR et al.. Comorbidity Associations with Ocular Pain after Cataract Surgery: Overall and Sex-Stratified Analysis. AJO Int 2026; 3 (3): . PubMed PMID:42746502 PubMed Central PMC13576488.
- Phipatanakul, W, Israel, E, Mauger, DT, Kunselman, SJ, Becker, PM, Gagalis, L, Dabek, RL, Greenwood, J, Kim, H, Zoratti, E et al.. Effect of IL-4RαR576 polymorphism on response to dupilumab in asthma, a genotype-stratified, randomized, placebo- controlled trial (IDEA Trial): Design, Rationale, Methods, Strategies, and Lessons Learned. J Asthma 2026; : 1-24. PubMed PMID:42742633 .
- Guo, CW, Zhao, AH, Kaelber, D, Singh, RP, Talcott, KE. Effect of Hormone Replacement Therapy on Risk of Age-related Macular Degeneration Among an Aggregate Health Record Cohort. Ophthalmic Surg Lasers Imaging Retina 2026; 57 (9): 566-574. PubMed PMID:42683940 .
- Shah, S, Abusafia, M, Sheashaa, H, Jadam, S, Ospina, S, Kaelber, D, Keen, SK, Desai, MY. GLP-1 Receptor Agonist Use and Long-Term Outcomes in Hypertrophic Cardiomyopathy With Obstructive Sleep Apnea: A Real-World Cohort Analysis. JACC Adv 2026; : 102955. PubMed PMID:42663372 .
- Regueiro, ML, Kosuru, SB, Abbass, NJ, Kaelber, DC, Traboulsi, EI, Talcott, KE, Singh, RP. Risk of Systemic Comorbidities in Patients With Inherited Retinal Diseases. Ophthalmic Surg Lasers Imaging Retina 2026; 57 (9): 558-564. PubMed PMID:42658796 .
- Miller, MG, Hailer, A, Wang, PR, Avery, AK, Hileman, CO, Kaelber, DC, Anand, A. Trends in Buprenorphine Prescribing Among Adults with Opioid Use Disorder and Coexisting HIV or Viral Hepatitis, 2015-2025. AIDS Behav 2026; : . PubMed PMID:42642688 .
- Birabaharan, M, Kaelber, DC, Nizet, V, Zarrinpar, A. Thiazolidinedione Use and Risk of Bacterial Enteric Infection Among Adults With Type 2 Diabetes Mellitus. Open Forum Infect Dis 2026; 13 (8): ofag457. PubMed PMID:42626545 PubMed Central PMC13492211.
- Magoline, JA, Wagner, DF, Kaelber, DC, Mistovich, RJ. Quantifying Risk Factors for Osteochondritis Dissecans in Children: A Propensity-Matched Retrospective Cohort Study. Orthop J Sports Med 2026; 14 (8): 23259671261463082. PubMed PMID:42602323 PubMed Central PMC13473787.
- Hamad, CD, Wiener, J, Gutierrez, T, Golzar, A, Kittredge, AP, Su, G, Pearce, L, Kaelber, DC, Bernthal, NM, Sheppard, WL et al.. Dysphagia Risk After Single vs Multi-level Anterior Cervical Discectomy and Fusion in Octogenarians: A Propensity Score Matched Analysis. Spine (Phila Pa 1976) 2026; : . PubMed PMID:42550779 .
