David C. Kaelber, MD, PhD, MPH

David Kaelber, MD, PhD, MPH, MS, FAAP, FACP, FACMI serves on the Executive Committee of the Cleveland Institute for Computational Biology. Dr. Kaelber is a practicing internist, pediatrician, Vice-President of Health Informatics, and Chief Medical Informatics Officer at the MetroHealth System.  Dr. Kaelber is also Professor in the CWRU Department of Internal Medicine with a secondary appointment in the Departments of Pediatrics and Epidemiology and Biostatistics.  MetroHealth is an integrated health system and a primary teaching site for Case Western Reserve University (CWRU).  Since the late 1990s, MetroHealth has been at the forefront in adopting electronic health records to advance high quality clinical care in the Cleveland area.  Under Dr. Kaelber's leadership, MetroHealth implemented Care Everywhere, a health information exchange program that enables MetroHealth to share patient information with other healthcare systems in the United States.  And, in 2011, Dr. Kaelber was instrumental in the development and launch of MyChart, the personal care health record complement of MetroHealth's EHR (Epic).  Dr. Kaelber's research interests are rooted in pediatric populations where he has used EHR data to identify previously under-diagnosed hypertension patients and to monitor obesity trends over time.  This work earned Dr. Kaelber recognition by the American Heart Association as one of the top ten breakthroughs in cardiovascular and stroke medicine in 2007.  More broadly, Dr. Kaelber's research interests span EHRs, clinical decision support, use of EHRs in chronic disease detection and management, personal health records, and medical informatics.

Recent Publications

  1. Augusto, SN Jr, Kaelber, DC, Chatterjee, S, Tang, WHW. Sodium Glucose Co-transporter-2 Inhibitors in Patients with Systemic Sclerosis with or without Heart Failure. Am J Med 2025; : . PubMed PMID:40812492 .
  2. Wang, L, Volkow, ND, Kaelber, DC, Xu, R. Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes. JAMA Netw Open 2025; 8 (8): e2526327. PubMed PMID:40788646 PubMed Central PMC12340659.
  3. Bruiners, N, Ukey, R, Konvinse, KC, Harris, M, Kalaycioglu, M, Yang, JH, Yang, E, Ganapathi, U, Honnen, W, Andrews, T et al.. Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection. medRxiv 2025; : . PubMed PMID:40778129 PubMed Central PMC12330411.
  4. Ailawadi, S, Kaelber, DC, Elangovan, A. Early-Onset Colorectal Cancer: A Review of Current Insights and a Call for Action. Biomedicines 2025; 13 (7): . PubMed PMID:40722648 PubMed Central PMC12292133.
  5. Abbass, NJ, Yazji, I, Allan, KC, Kaelber, DC, Talcott, KE, Singh, RP. Trends and Disparities in the Incidence and Prevalence of Inherited Retinal Diseases in the United States. Am J Ophthalmol 2025; : . PubMed PMID:40706695 .
  6. Augusto, SN Jr, Issa, R, Kaelber, D, Tang, WHW. Heart failure with microvascular dysfunction: Insights from a propensity-matched analysis of diabetic retinopathy in heart failure with reduced ejection fraction. Curr Probl Cardiol 2025; 50 (10): 103128. PubMed PMID:40684928 .
  7. Jeong, H, Shaia, JK, Kaelber, DC, Talcott, KE, Singh, RP. Associations between obstructive sleep apnoea and the development and severity of retinal vein occlusion. Eye (Lond) 2025; : . PubMed PMID:40670632 .
  8. Lau, J, Kaelber, DC, Otteson, TD. Prevalence of obstructive sleep apnea and related oropharyngeal symptoms in pediatric Ehlers Danlos patients. Int J Pediatr Otorhinolaryngol 2025; 195 : 112460. PubMed PMID:40609249 .
  9. Calcagno, T, Issa, R, Massad, F, Kaelber, D, Martyn, T, Agdamag, A. Finerenone and cardiovascular outcomes in heart failure with mildly reduced and preserved ejection fraction: A propensity-matched analysis. J Cardiol 2025; : . PubMed PMID:40592387 .
  10. Liu, M, Branning, R, Lee, A, Kaelber, D, Gao, K. Racial-Ethnic Disparities in Ketamine and Esketamine Therapy for Major Depressive Disorder. Psychiatr Serv 2025; : appips20240559. PubMed PMID:40556447 .
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Dr. Kaelber on Twitter

Dr. Kaelber on Twitter

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The Kaelber Lab Website

Curriculum vitae