David C. Kaelber, MD, PhD, MPH

David Kaelber, MD, PhD, MPH, MS, FAAP, FACP, FACMI serves on the Executive Committee of the Cleveland Institute for Computational Biology. Dr. Kaelber is a practicing internist, pediatrician, Vice-President of Health Informatics, and Chief Medical Informatics Officer at the MetroHealth System.  Dr. Kaelber is also Professor in the CWRU Department of Internal Medicine with a secondary appointment in the Departments of Pediatrics and Epidemiology and Biostatistics.  MetroHealth is an integrated health system and a primary teaching site for Case Western Reserve University (CWRU).  Since the late 1990s, MetroHealth has been at the forefront in adopting electronic health records to advance high quality clinical care in the Cleveland area.  Under Dr. Kaelber's leadership, MetroHealth implemented Care Everywhere, a health information exchange program that enables MetroHealth to share patient information with other healthcare systems in the United States.  And, in 2011, Dr. Kaelber was instrumental in the development and launch of MyChart, the personal care health record complement of MetroHealth's EHR (Epic).  Dr. Kaelber's research interests are rooted in pediatric populations where he has used EHR data to identify previously under-diagnosed hypertension patients and to monitor obesity trends over time.  This work earned Dr. Kaelber recognition by the American Heart Association as one of the top ten breakthroughs in cardiovascular and stroke medicine in 2007.  More broadly, Dr. Kaelber's research interests span EHRs, clinical decision support, use of EHRs in chronic disease detection and management, personal health records, and medical informatics.

Recent Publications

  1. Kennemer, AA, Gao, Z, Wang, L, Davis, PB, Kaelber, DC, Xu, R. Psychiatric outcomes after mild concussion by treatment timing and age. J Psychiatr Res 2025; 187 : 233-237. PubMed PMID:40382945 .
  2. Shang, T, Kaelber, DC, Chaaban, MR. Impact of Chronic Rhinosinusitis on Granulomatosis with Polyangiitis Exacerbations. J Clin Med 2025; 14 (9): . PubMed PMID:40363994 PubMed Central PMC12073045.
  3. Das, N, Dhamija, R, Kaelber, DC, Kelly, M, Xie, P, Reddy, D. Adverse neurologic events of immune checkpoint inhibitor monotherapy vs. combination therapy for melanoma. Neurooncol Adv 2025; 7 (1): vdaf030. PubMed PMID:40351833 PubMed Central PMC12063080.
  4. Fry, SE, Terebuh, P, Kaelber, DC, Xu, R, Davis, PB. Effectiveness and Safety of Respiratory Syncytial Virus Vaccine for US Adults Aged 60 Years or Older. JAMA Netw Open 2025; 8 (5): e258322. PubMed PMID:40343698 PubMed Central PMC12065041.
  5. Guzmán Rivera, J, Zheng, H, Richlin, B, Suarez, C, Gaur, S, Ricciardi, E, Hasan, UN, Cuddy, W, Singh, AR, Bukulmez, H et al.. Combining Mass Spectrometry with Machine Learning to Identify Novel Protein Signatures: The Example of Multisystem Inflammatory Syndrome in Children. medRxiv 2025; : . PubMed PMID:40313298 PubMed Central PMC12045438.
  6. Augusto, S Jr, Kaelber, DC, Tang, WHW. Testosterone therapy in patients with heart failure and protein-calorie malnutrition: Insights from a propensity-matched cohort study. Curr Probl Cardiol 2025; 50 (7): 103070. PubMed PMID:40311854 .
  7. Bolen, SD, Lever, J, Mundorf, C, Jenkins, A, Waitzman, R, Smith, S, Finley, M, Daprano, J, Johnson, E, Masotya, M et al.. The Impact of a Bidirectional Clinic to Community Social Care Referral Program. Med Care 2025; 63 (6): 449-457. PubMed PMID:40266648 .
  8. Sloan, AR, Gordillo, AJ, Kennemer, A, Khorana, AA, Horbinski, C, Kaelber, DC, Cameron, SJ, Lathia, JD. Venous thromboembolism incidence shortens survival in isocitrate dehydrogenase wild-type glioblastoma. Neurooncol Adv 2025; 7 (1): vdaf018. PubMed PMID:40264942 PubMed Central PMC12012773.
  9. Kim, SB, Shaia, JK, Kaelber, DC, Singh, RP, Talcott, KE. Ocular manifestations in Ehlers-Danlos syndrome. Eye (Lond) 2025; : . PubMed PMID:40211016 .
  10. Khan, R, Ji, W, Guzman Rivera, J, Madhvi, A, Andrews, T, Richlin, B, Suarez, C, Gaur, S, Hasan, UN, Cuddy, W et al.. A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome. J Immunol 2025; 214 (3): 373-83. PubMed PMID:40101747 PubMed Central PMC11952872.
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Dr. Kaelber on Twitter

Dr. Kaelber on Twitter

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The Kaelber Lab Website

Curriculum vitae