Symposium Speaker: Fred Schumacher, PhD

Dr. Fred Schumacher is Associate Professor in the Department of Population and Quantitative Health Sciences and Faculty in the Cleveland Institute for Computational Biology, both at Case Western Reserve University.  Dr. Schumacher is also Co-Leader of the Cancer Prevention Control & Population Research Program as part of the Case Comprehensive Cancer Center. His primary research focus is on cancer, particularly prostate cancer. As an investigator and leader in several major international consortium, Dr. Schumacher has

  • Identified multiple novel genomic regions associated with prostate, testicular and breast cancer, representing discoveries based on incorporating genome-wide association studies (GWAS) with cancer epidemiology
  • Expanded the use of GWAS through combined studies of varying design, providing the power to evaluate candidate gene pathways, incorporate related biomarkers, and assess cancer sub-types
  • Explored the potential biological overlap of complex traits and conditions (such as diabetes) with cancer, providing a better understanding of the cancer initiation process and highlighting several areas for potential disease risk reduction.
  • Developed and implemented polygenic risk scores to improve screening modalities and treatment paradigms

 

Recent Publications

  1. Huang, CT, Taguchi, K, Schumacher, FR, Bodner, D, Pauchard, FI, Salvado, JA, Wood, K, Stoller, M, Wu, CW. Age-dependent convergence of kidney stone incidence rates between male and female populations. Sci Rep 2026; 16 : 36963. PubMed PMID:43019203 PubMed Central PMC13736193.
  2. Parsaeian, M, Chan, WC, Atkins, JR, Papier, K, Breeur, M, Desai, TA, Huang, Z, Ogamba, CF, Conti, DV, Bogumil, D et al.. Prospective and genetic analyses implicate lower immunosurveillance in the aetiology of prostate cancer. Nat Commun 2026; 17 (1): . PubMed PMID:43009480 PubMed Central PMC13752312.
  3. Destin, DD, Schumacher, FR, Walter, V, Liu, DJ, Thompson, CL. Associations of Obesity and Inherited Genetic Variation with Aromatase Inhibitor Induced Musculoskeletal Syndrome in the All of Us Cohort. Cancer Epidemiol Biomarkers Prev 2026; : . PubMed PMID:42954861 .
  4. Huang, CT, Assimos, D, Schumacher, FR, Bodner, D, Stoller, M, Wu, CW. Redefining Kidney Stone Incidence: Emerging Age-Related Patterns. J Endourol 2026; : 8927790261495498. PubMed PMID:42870750 .
  5. Yang, M, Lovrenert, K, Thirumavalavan, N, Eisenberg, ML, Schumacher, FR, Wu, CW. Gene set enrichment analysis of curated monogenic loci highlights key pathways and multisystem involvement in male infertility. Basic Clin Androl 2026; 36 (1): . PubMed PMID:42271209 PubMed Central PMC13251197.
  6. Wu, CW, Chang, J, Lovrenert, K, Bodner, D, Hildebrandt, F, Schumacher, FR. How variant discovery redefines genetic prevalence: the case of cystine stone disease. Eur J Hum Genet 2026; 34 (7): 956-963. PubMed PMID:41957517 PubMed Central PMC13341753.
  7. Iyer, HS, Perlstein, M, Joseph, SA, Roscoe, C, Zeinomar, N, Cole, AP, Schumacher, FR, Beebe-Dimmer, J, Ruterbusch, JJ, Wiggins, CL et al.. Associations of fine particulate matter pollution components with overall, prostate cancer, and cardiovascular disease mortality in men with prostate cancer: A cohort study. Environ Res 2026; 294 : 123909. PubMed PMID:41617107 PubMed Central PMC13005271.
  8. Vassy, JL, Dornisch, AM, Karunamuni, R, Gatzen, M, Kachulis, CJ, Lennon, NJ, Brunette, CA, Danowski, ME, Hauger, RL, Garraway, IP et al.. Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study. Nat Cancer 2026; 7 (2): 352-367. PubMed PMID:41588240 PubMed Central PMC13181739.
  9. McCall, MK, Destin, D, Miller, ME, Schumacher, FR, Thompson, CL. Prevalence and predictive testing preferences for breast cancer treatment side effects. Support Care Cancer 2025; 33 (12): 1095. PubMed PMID:41261260 PubMed Central PMC12630186.
  10. Ziadeh, H, Calaway, A, Gupta, S, Bodner, D, Brown, JR, Schumacher, FR, Wu, CW. Increased risk of upper tract urothelial carcinoma in patients with kidney stones: a large-scale analysis of the UK biobank. Urolithiasis 2025; 53 (1): 87. PubMed PMID:40335677 PubMed Central PMC12912260.
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