Dr. Giuseppe Tosto is a neurologist and Assistant Professor in Neurology at Columbia University, New York. He completed his residency training in Neurology at University “La Sapienza” in Rome (Italy) where he also completed the Neuroscience PhD program. He then joined Columbia University in 2011, first as a post-doc and then as an Assistant Professor of Neurology. His lab conducts genetic epidemiology research focusing on Alzheimer’s Disease and Related Dementia in admixed populations. He is the PI of multiple projects currently recruiting participants in U.S, Mexico, Peru, and Bolivia.
Recent Publications
- Cieza, B, Pandey, N, Ruhela, V, Ali, S, Tosto, G. SAGA (Simplified Association Genomewide Analyses): a user-friendly Pipeline to Democratize Genome-Wide Association Studies. bioRxiv 2025; : . PubMed PMID:40909723 PubMed Central PMC12407738.
- Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. PLoS Genet 2025; 21 (9): e1011701. PubMed PMID:40906820 PubMed Central PMC12419754.
- Liu, M, Khasiyev, F, Spagnolo-Allende, A, Sanchez, DL, Andrews, H, Yang, Q, Beiser, AS, Qiao, Y, Romero, JR, Rundek, T et al.. Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci Associated with Asymptomatic Intracranial Large Artery Stenosis. Int J Stroke 2025; : 17474930251374471. PubMed PMID:40851121 .
- Cheng, PL, Wang, H, Dombroski, BA, Farrell, JJ, Horng, I, Chung, T, Tosto, G, Kunkle, BW, Bush, WS, Vardarajan, B et al.. A specialized reference panel with structural variants integration for improving genotype imputation in Alzheimer disease and related dementias. HGG Adv 2025; 6 (4): 100487. PubMed PMID:40751311 PubMed Central PMC12362095.
- Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabli, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption. Commun Med (Lond) 2025; 5 (1): 326. PubMed PMID:40745374 PubMed Central PMC12314086.
- Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol 2025; 26 (1): 210. PubMed PMID:40676597 PubMed Central PMC12273372.
- Liu, M, Khasiyev, F, Spagnolo-Allende, A, Sanchez, DL, Andrews, H, Yang, Q, Beiser, A, Qiao, Y, Romero, JR, Rundek, T et al.. Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis. medRxiv 2025; : . PubMed PMID:40385396 PubMed Central PMC12083599.
- Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. medRxiv 2025; : . PubMed PMID:40343016 PubMed Central PMC12060970.
- Barral, S, Yang, Z, Phillips, N, Barber, RC, Brickman, AM, Honig, LS, Cieza, B, Reyes-Dumeyer, D, Mayeux, R, Rajabli, F et al.. APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos. Alzheimers Dement 2025; 21 (4): e70138. PubMed PMID:40219824 PubMed Central PMC11992591.
- Sariya, S, Tosto, G. GARCOM: A user-friendly R package for genetic mutation counts. F1000Res 2021; 10 : 524. PubMed PMID:40083425 PubMed Central PMC11904396.
