Dr. Giuseppe Tosto is a neurologist and Assistant Professor in Neurology at Columbia University, New York. He completed his residency training in Neurology at University “La Sapienza” in Rome (Italy) where he also completed the Neuroscience PhD program. He then joined Columbia University in 2011, first as a post-doc and then as an Assistant Professor of Neurology. His lab conducts genetic epidemiology research focusing on Alzheimer’s Disease and Related Dementia in admixed populations. He is the PI of multiple projects currently recruiting participants in U.S, Mexico, Peru, and Bolivia.
Recent Publications
- Durodoye, RO, Ciesielski, TH, Benchek, P, Bartlett, J, Zhu, X, Liu, S, Naj, A, Kunkle, B, Schellenberg, GD, Mayeux, R et al.. Deviations from additivity in APOE4-mediated late-onset Alzheimer's disease risk across races and ethnicities. Hum Genet 2026; 145 (1): 16. PubMed PMID:41569459 PubMed Central PMC12827419.
- Zegarra-Valdivia, J, Mamani Quispe, RD, Chinoapaza Turpo, J, Paredes-Manrique, C, Malaga, M, Mamani-Benito, O, Montesinos, R, Custodio, N, Tosto, G. Prevalence of Neurocognitive Disorders in the Elderly Quechua Population Using the Q-RUDAS. Brain Sci 2025; 15 (12): . PubMed PMID:41440103 PubMed Central PMC12730204.
- Custodio, N, Soto-Añari, M, Montesinos, R, Malaga, M, Custodio, B, Chambergo-Michilot, D, Bustamante-Paytan, D, Yauri, Z, Agüero, K, Verastegui, G et al.. The modified Rowland Universal Dementia Assessment Scale for dementia screening in the Peruvian population. Dement Neuropsychol 2026; 20 : e2025377. PubMed PMID:41427105 PubMed Central PMC12714329.
- Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. medRxiv 2025; : . PubMed PMID:41404293 PubMed Central PMC12704622.
- Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease. bioRxiv 2025; : . PubMed PMID:41279621 PubMed Central PMC12637479.
- Cieza, B, Pandey, N, Ruhela, V, Ali, S, Tosto, G. SAGA (Simplified Association Genome-wide Analyses): a user-friendly Pipeline to Democratize Genome-Wide Association Studies. bioRxiv 2025; : . PubMed PMID:40909723 PubMed Central PMC12407738.
- Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. PLoS Genet 2025; 21 (9): e1011701. PubMed PMID:40906820 PubMed Central PMC12419754.
- Liu, M, Khasiyev, F, Spagnolo-Allende, A, Sanchez, DL, Andrews, H, Yang, Q, Beiser, A, Qiao, Y, Romero, JR, Rundek, T et al.. Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis. Int J Stroke 2025; : 17474930251374471. PubMed PMID:40851121 .
- Cheng, PL, Wang, H, Dombroski, BA, Farrell, JJ, Horng, I, Chung, T, Tosto, G, Kunkle, BW, Bush, WS, Vardarajan, B et al.. A specialized reference panel with structural variants integration for improving genotype imputation in Alzheimer disease and related dementias. HGG Adv 2025; 6 (4): 100487. PubMed PMID:40751311 PubMed Central PMC12362095.
- Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabli, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption. Commun Med (Lond) 2025; 5 (1): 326. PubMed PMID:40745374 PubMed Central PMC12314086.
