Dr. Giuseppe Tosto is a neurologist and Assistant Professor in Neurology at Columbia University, New York. He completed his residency training in Neurology at University “La Sapienza” in Rome (Italy) where he also completed the Neuroscience PhD program. He then joined Columbia University in 2011, first as a post-doc and then as an Assistant Professor of Neurology. His lab conducts genetic epidemiology research focusing on Alzheimer’s Disease and Related Dementia in admixed populations. He is the PI of multiple projects currently recruiting participants in U.S, Mexico, Peru, and Bolivia.
Recent Publications
- Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol 2025; 26 (1): 210. PubMed PMID:40676597 PubMed Central PMC12273372.
- Liu, M, Khasiyev, F, Spagnolo-Allende, A, Sanchez, DL, Andrews, H, Yang, Q, Beiser, A, Qiao, Y, Romero, JR, Rundek, T et al.. Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis. medRxiv 2025; : . PubMed PMID:40385396 PubMed Central PMC12083599.
- Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. medRxiv 2025; : . PubMed PMID:40343016 PubMed Central PMC12060970.
- Barral, S, Yang, Z, Phillips, N, Barber, RC, Brickman, AM, Honig, LS, Cieza, B, Reyes-Dumeyer, D, Mayeux, R, Rajabli, F et al.. APOE and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos. Alzheimers Dement 2025; 21 (4): e70138. PubMed PMID:40219824 PubMed Central PMC11992591.
- Sariya, S, Tosto, G. GARCOM: A user-friendly R package for genetic mutation counts. F1000Res 2021; 10 : 524. PubMed PMID:40083425 PubMed Central PMC11904396.
- Pandey, N, Yang, Z, Cieza, B, Reyes-Dumeyer, D, Kang, MS, Montesinos, R, Soto-Añari, M, Custodio, N, Honig, LS, Tosto, G et al.. Plasma phospho-tau217 as a predictive biomarker for Alzheimer's disease in a large south American cohort. Alzheimers Res Ther 2025; 17 (1): 1. PubMed PMID:39743558 PubMed Central PMC11694372.
- Samper-Ternent, R, Zazueta-Borboa, JD, Michaels-Obregon, A, Reyes-Dumeyer, D, Barral, S, Tosto, G, Wong, R. Mexican Health and Aging Study Biomarker and Genetic Data Profile. J Gerontol A Biol Sci Med Sci 2024; 80 (1): . PubMed PMID:39692026 PubMed Central PMC11653003.
- Tayran, H, Yilmaz, E, Bhattarai, P, Min, Y, Wang, X, Ma, Y, Wang, N, Jeong, I, Nelson, N, Kassara, N et al.. ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer's disease through BDNF/NGFR signaling. Cell Genom 2024; 4 (9): 100642. PubMed PMID:39216475 PubMed Central PMC11480862.
- Ma, Y, Reyes-Dumeyer, D, Piriz, A, Recio, P, Mejia, DR, Medrano, M, Lantigua, RA, Vonsattel, JPG, Tosto, G, Teich, AF et al.. Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups. Acta Neuropathol 2024; 148 (1): 27. PubMed PMID:39177846 PubMed Central PMC11343944.
- Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabali, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country Level Incidence of Alzheimer Disease and Related Dementias is Associated with Increased Omega6 PUFA Consumption. medRxiv 2024; : . PubMed PMID:39148832 PubMed Central PMC11326357.
