Symposium Speaker: William C.L. Stewart, PhD, MS

Dr. William Stewart is Assistant Professor of Pediatrics at the Ohio State University. Dr. Stewart is also Principal Investigator at The Research Institute of Nationwide Children’s Hospital and a faculty member of the Battelle Center for Mathematical Medicine. Dr. Stewart’s broad research interests include the development of statistical models for quick and efficient analyses of complex datasets, deterministic math models, gene networks, and problems in computational molecular biology.

Recent Publications

  1. Giuliani, G, Chavan, D, Gaddam, R, Stewart, WC, Li, Z, Jayaprakash, C, Das, J. Immune and non-immune cell fencing of tumor cells is a widespread and functionally relevant spatial pattern in solid cancers. Comput Struct Biotechnol J 2025; 27 : 5537-5548. PubMed PMID:41446806 PubMed Central PMC12722985.
  2. Nayak, I, Biondo, R, Stewart, WC, Fulton, RJ, Möker, N, Zhang, C, Khakoo, SI, Das, J. Modeling the response to interleukin-21 to inform natural killer cell immunotherapy. Immunol Cell Biol 2025; 103 (8): 820. PubMed PMID:40814796 PubMed Central PMC12587366.
  3. Stewart, WCL, Jayaprakash, C, Das, J. An Entropy-Based Approach to Model Selection with Application to Single-Cell Time-Stamped Snapshot Data. Entropy (Basel) 2025; 27 (3): . PubMed PMID:40149198 PubMed Central PMC11941135.
  4. Nayak, I, Biondo, R, Stewart, WC, Fulton, RJ, Möker, N, Zhang, C, Khakoo, SI, Das, J. Modeling the response to interleukin-21 to inform natural killer cell immunotherapy. Immunol Cell Biol 2025; 103 (2): 192-212. PubMed PMID:39865344 PubMed Central PMC11792776.
  5. Stewart, WC, Jayaprakash, C, Das, J. An Entropy-Based Approach to Model Selection with Application to Single-Cell Time-Stamped Snapshot Data. bioRxiv 2025; : . PubMed PMID:39803546 PubMed Central PMC11722210.
  6. Ahmad, S, Xing, K, Rajakaruna, H, Stewart, WC, Beckwith, KA, Nayak, I, Kararoudi, MN, Lee, DA, Das, J. A framework integrating multiscale in-silico modeling and experimental data predicts CD33CAR-NK cytotoxicity across target cell types. bioRxiv 2025; : . PubMed PMID:39803543 PubMed Central PMC11722217.
  7. Wu, J, Stewart, WCL, Jayaprakash, C, Das, J. BioNetGMMFit: estimating parameters of a BioNetGen model from time-stamped snapshots of single cells. NPJ Syst Biol Appl 2023; 9 (1): 46. PubMed PMID:37736766 PubMed Central PMC10516955.
  8. Chen, S, Abou-Khalil, BW, Afawi, Z, Ali, QZ, Amadori, E, Anderson, A, Anderson, J, Andrade, DM, Annesi, G, Arslan, M et al.. Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes. medRxiv 2024; : . PubMed PMID:36865150 PubMed Central PMC9980234.
  9. Subaran, RL, Stewart, WCL. FREQMAX provides an alternative approach for determining high-resolution allele frequency thresholds in carrier screening. Hum Mutat 2020; 41 (12): 2078-2086. PubMed PMID:33032373 .
  10. Pathak, S, Stewart, WCL, Burd, CE, Hester, ME, Greenberg, DA. Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice. PLoS One 2020; 15 (6): e0234910. PubMed PMID:32559200 PubMed Central PMC7304595.
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Dr. Stewart on Twitter

The Stewart Lab Website

Curriculum vitae