Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Epi­demi­ol­ogy & Bio­sta­tis­tics, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.



Recent Publications

  1. Huang, KL, Marcora, E, Pimenova, AA, Di Narzo, AF, Kapoor, M, Jin, SC, Harari, O, Bertelsen, S, Fairfax, BP, Czajkowski, J et al.. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nat. Neurosci. 2017; : . PubMed PMID:28628103 .
  2. Aung, T, Ozaki, M, Lee, MC, Schlötzer-Schrehardt, U, Thorleifsson, G, Mizoguchi, T, Igo, RP Jr, Haripriya, A, Williams, SE, Astakhov, YS et al.. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat. Genet. 2017; : . PubMed PMID:28553957 .
  3. Kunkle, BW, Carney, RM, Kohli, MA, Naj, AC, Hamilton-Nelson, KL, Whitehead, PL, Wang, L, Lang, R, Cuccaro, ML, Vance, JM et al.. Targeted sequencing of ABCA7 identifies splicing, stop-gain and intronic risk variants for Alzheimer disease. Neurosci. Lett. 2017; 649 : 124-129. PubMed PMID:28400126 .
  4. Butkiewicz, M, Haines, JL, Bush, WS. Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants. Bioinformatics 2017; 33 (10): 1561-1562. PubMed PMID:28122779 PubMed Central PMC5423451.
  5. Miskimen, KL, Chan, ER, Haines, JL. Assay for Transposase-Accessible Chromatin Using Sequencing (ATAC-seq) Data Analysis. Curr Protoc Hum Genet 2017; 92 : 20.4.1-20.4.13. PubMed PMID:28075484 .
  6. Springelkamp, H, Iglesias, AI, Mishra, A, Höhn, R, Wojciechowski, R, Khawaja, AP, Nag, A, Wang, YX, Wang, JJ, Cuellar-Partida, G et al.. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum. Mol. Genet. 2017; 26 (2): 438-453. PubMed PMID:28073927 .
  7. Sardell, RJ, Persad, PJ, Pan, SS, Whitehead, P, Adams, LD, Laux, RA, Fortun, JA, Brantley, MA Jr, Kovach, JL, Schwartz, SG et al.. Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus. Invest. Ophthalmol. Vis. Sci. 2016; 57 (14): 6107-6115. PubMed PMID:27832277 PubMed Central PMC5104418.
  8. Pasquale, LR, Aschard, H, Kang, JH, Bailey, JN, Lindström, S, Chasman, DI, Christen, WG, Allingham, RR, Ashley-Koch, A, Lee, RK et al.. Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample. Menopause 2017; 24 (2): 150-156. PubMed PMID:27760082 PubMed Central PMC5266624.
  9. Sardell, RJ, Nittala, MG, Adams, LD, Laux, RA, Cooke Bailey, JN, Fuzzell, D, Fuzzell, S, Reinhart-Mercer, L, Caywood, LJ, Horst, V et al.. Heritability of Choroidal Thickness in the Amish. Ophthalmology 2016; 123 (12): 2537-2544. PubMed PMID:27771146 .
  10. Mez, J, Chung, J, Jun, G, Kriegel, J, Bourlas, AP, Sherva, R, Logue, MW, Barnes, LL, Bennett, DA, Buxbaum, JD et al.. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement 2017; 13 (2): 119-129. PubMed PMID:27770636 PubMed Central PMC5318231.
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