JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Wang, P, Song, YE, Lynn, A, Miskimen, K, Gulyayev, A, Prough, MB, Dorfsman, DA, Laux, RA, Fuzzell, SL, Hochstetler, SD et al.. Heritability of Alzheimer's disease-related plasma biomarkers in the Amish population. Alzheimers Dement (Amst) 2026; 18 (2): e70388. PubMed PMID:42339066 PubMed Central PMC13283917.
  2. Wang, TC, Archer, DB, Ali, M, Wu, Y, Mormino, E, Buckley, RF, Lee, AJ, Saykin, AJ, De Jager, PL, Schneider, JA et al.. Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery. Brain 2026; : . PubMed PMID:42334898 .
  3. Liu, C, Zhu, Z, Lin, H, Bush, WS, Jenq, RR, Cominelli, F, Pillai, JA, Haines, JL, Zhu, X, Xu, R et al.. The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities. Front Mol Biosci 2026; 13 : 1735332. PubMed PMID:42325435 PubMed Central PMC13275447.
  4. Rose, CM, Bush, WS, Beno, MF, Williams, SM, Haines, JL, Crawford, DC. Leadership, Informatics Expertise, and Resources: Determinants of Institutional Data Sharing in the National Clinical Cohort Collaborative (N3C). AMIA Jt Summits Transl Sci Proc 2026; 2026 : 381-389. PubMed PMID:42317826 PubMed Central PMC13274281.
  5. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease. Am J Hum Genet 2026; 113 (6): 1279-1296. PubMed PMID:42066773 PubMed Central PMC13247992.
  6. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. Alzheimers Dement 2026; 22 (4): e71433. PubMed PMID:42043782 PubMed Central PMC13116102.
  7. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-specific genetic drivers of memory, executive functioning and language in older adults. Brain 2026; : . PubMed PMID:41989867 .
  8. Nam, Y, DeRosa, BA, Ramirez, AM, Ayele, BA, Whitehead-Gay, P, Adams, LD, Golightly, CG, Starks, TD, Laverde-Paz, MJ, Cukier, HN et al.. Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7-associated Alzheimer's disease risk. Alzheimers Dement 2026; 22 (4): e71312. PubMed PMID:41912785 PubMed Central PMC13140508.
  9. Dorfsman, D, Prough, MB, Gulyayev, A, Caywood, LJ, Clouse, JE, Herington, SD, Slifer, SH, Adams, LD, Laux, RA, Song, YE et al.. WDR12 and HIVEP3 are contributors to cognitive preservation in Amish SuperAgers. Alzheimers Dement 2026; 22 (3): e71293. PubMed PMID:41894147 PubMed Central PMC13093529.
  10. Liu, S, Bush, WS, Kunkle, BW, Byrd, GS, Reitz, C, Tosto, G, Rajabli, F, Caban-Holt, AM, Cuccaro, M, Starks, T et al.. Dissecting Alzheimer's disease heritability across populations. Alzheimers Dement 2026; 22 (3): e71236. PubMed PMID:41880092 PubMed Central PMC13093350.
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