JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Liu, Y, Song, YE, Lynn, A, Wang, W, Miskimen, K, Fuzzell, SL, Hochstetler, SD, Laux, RA, Caywood, LJ, Clouse, JE et al.. Telomere Length, Aging, and Cognitive Function in the Midwestern Amish. HGG Adv 2025; : 100533. PubMed PMID:41108082 .
  2. Cukier, HN, DeRosa, BA, Coombs, LE, Tang, E, Leyva, DR, Lazzaro, AR, Gu, E, Dykxhoorn, DM, Haines, JL, Pericak-Vance, MA et al.. Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome. Stem Cell Res 2025; 89 : 103851. PubMed PMID:41086611 .
  3. Kurniansyah, N, Tasaki, S, Rehman, H, Zhu, C, Farrell, J, Sherva, R, Hauger, R, Merritt, VC, Panizzon, M, Zhang, R et al.. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv 2025; : . PubMed PMID:41040715 PubMed Central PMC12486013.
  4. Verma, A, Nittala, MG, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR. Spatial distribution of Intra-retinal Hyper-reflective foci and impact on progression in eyes with intermediate Age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2025; : . PubMed PMID:40996501 .
  5. Kang, M, Ang, TFA, Devine, SA, Sherva, R, Mukherjee, S, Trittschuh, EH, Scollard, P, Lee, M, Choi, SE, Klinedinst, B et al.. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. Alzheimers Dement 2025; 21 (9): e70681. PubMed PMID:40951946 PubMed Central PMC12434708.
  6. Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. PLoS Genet 2025; 21 (9): e1011701. PubMed PMID:40906820 PubMed Central PMC12419754.
  7. Osterman, MD, Song, YE, Lynn, A, Miskimen, K, Wheeler, NR, Bartlett, J, Farrer, LA, Schellenberg, GD, Martin, ER, Pericak-Vance, MA et al.. Examining the Performance of Polygenic Risk Scores for Alzheimer Disease Within and Across Populations Using k-Fold Cross-Validation. Neurol Genet 2024; 10 (6): e200198. PubMed PMID:40881139 PubMed Central PMC11727989.
  8. Dorfsman, DA, Prough, MB, Gulyayev, AV, Caywood, LJ, Clouse, JE, Herington, SD, Slifer, SH, Adams, LD, Laux, RA, Song, YE et al.. Linkage and association of preserved cognitive function in the midwestern Amish at a higher genetic risk of Alzheimer's disease. Alzheimers Dement 2025; 21 (8): e70627. PubMed PMID:40855969 PubMed Central PMC12378373.
  9. Akgun, B, Gulyayev, AV, Coker, M, Hamilton-Nelson, KL, Olalusi, O, Adams, LD, Akinwande, K, Whitehead, PG, Diala, S, Ogunronbi, M et al.. ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African-ancestry populations. Alzheimers Dement 2025; 21 (8): e70583. PubMed PMID:40832784 PubMed Central PMC12365657.
  10. Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabli, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption. Commun Med (Lond) 2025; 5 (1): 326. PubMed PMID:40745374 PubMed Central PMC12314086.
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