Jonathan Haines, Ph.D., is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Epi­demi­ol­ogy & Bio­sta­tis­tics, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.



Recent Publications

  1. Kunkle, BW, Carney, RM, Kohli, MA, Naj, AC, Hamilton-Nelson, KL, Whitehead, PL, Wang, L, Lang, R, Cuccaro, ML, Vance, JM et al.. Targeted sequencing of ABCA7 identifies splicing, stop-gain and intronic risk variants for Alzheimer disease. Neurosci. Lett. 2017; 649 : 124-129. PubMed PMID:28400126 .
  2. Butkiewicz, M, Haines, JL, Bush, WS. Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants. Bioinformatics 2017; : . PubMed PMID:28122779 .
  3. Miskimen, KL, Chan, ER, Haines, JL. Assay for Transposase-Accessible Chromatin Using Sequencing (ATAC-seq) Data Analysis. Curr Protoc Hum Genet 2017; 92 : 20.4.1-20.4.13. PubMed PMID:28075484 .
  4. Springelkamp, H, Iglesias, AI, Mishra, A, Höhn, R, Wojciechowski, R, Khawaja, AP, Nag, A, Wang, YX, Wang, JJ, Cuellar-Partida, G et al.. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum. Mol. Genet. 2017; 26 (2): 438-453. PubMed PMID:28073927 .
  5. Sardell, RJ, Persad, PJ, Pan, SS, Whitehead, P, Adams, LD, Laux, RA, Fortun, JA, Brantley, MA Jr, Kovach, JL, Schwartz, SG et al.. Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus. Invest. Ophthalmol. Vis. Sci. 2016; 57 (14): 6107-6115. PubMed PMID:27832277 PubMed Central PMC5104418.
  6. Pasquale, LR, Aschard, H, Kang, JH, Bailey, JN, Lindström, S, Chasman, DI, Christen, WG, Allingham, RR, Ashley-Koch, A, Lee, RK et al.. Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample. Menopause 2017; 24 (2): 150-156. PubMed PMID:27760082 PubMed Central PMC5266624.
  7. Sardell, RJ, Nittala, MG, Adams, LD, Laux, RA, Cooke Bailey, JN, Fuzzell, D, Fuzzell, S, Reinhart-Mercer, L, Caywood, LJ, Horst, V et al.. Heritability of Choroidal Thickness in the Amish. Ophthalmology 2016; 123 (12): 2537-2544. PubMed PMID:27771146 .
  8. Mez, J, Chung, J, Jun, G, Kriegel, J, Bourlas, AP, Sherva, R, Logue, MW, Barnes, LL, Bennett, DA, Buxbaum, JD et al.. Two novel loci, COBL and SLC10A2, for Alzheimer’s disease in African Americans. Alzheimers Dement 2017; 13 (2): 119-129. PubMed PMID:27770636 PubMed Central PMC5318231.
  9. Khawaja, AP, Cooke Bailey, JN, Kang, JH, Allingham, RR, Hauser, MA, Brilliant, M, Budenz, DL, Christen, WG, Fingert, J, Gaasterland, D et al.. Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses. Invest. Ophthalmol. Vis. Sci. 2016; 57 (11): 5046-5052. PubMed PMID:27661856 PubMed Central PMC5040191.
  10. Sardell, RJ, Bailey, JN, Courtenay, MD, Whitehead, P, Laux, RA, Adams, LD, Fortun, JA, Brantley, MA Jr, Kovach, JL, Schwartz, SG et al.. Whole exome sequencing of extreme age-related macular degeneration phenotypes. Mol. Vis. 2016; 22 : 1062-76. PubMed PMID:27625572 PubMed Central PMC5007100.

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