David C. Kaelber, MD, PhD, MPH

David Kaelber, MD, PhD, MPH, MS, FAAP, FACP, FACMI serves on the Executive Committee of the Cleveland Institute for Computational Biology. Dr. Kaelber is a practicing internist, pediatrician, Vice-President of Health Informatics, and Chief Medical Informatics Officer at the MetroHealth System.  Dr. Kaelber is also Professor in the CWRU Department of Internal Medicine with a secondary appointment in the Departments of Pediatrics and Epidemiology and Biostatistics.  MetroHealth is an integrated health system and a primary teaching site for Case Western Reserve University (CWRU).  Since the late 1990s, MetroHealth has been at the forefront in adopting electronic health records to advance high quality clinical care in the Cleveland area.  Under Dr. Kaelber's leadership, MetroHealth implemented Care Everywhere, a health information exchange program that enables MetroHealth to share patient information with other healthcare systems in the United States.  And, in 2011, Dr. Kaelber was instrumental in the development and launch of MyChart, the personal care health record complement of MetroHealth's EHR (Epic).  Dr. Kaelber's research interests are rooted in pediatric populations where he has used EHR data to identify previously under-diagnosed hypertension patients and to monitor obesity trends over time.  This work earned Dr. Kaelber recognition by the American Heart Association as one of the top ten breakthroughs in cardiovascular and stroke medicine in 2007.  More broadly, Dr. Kaelber's research interests span EHRs, clinical decision support, use of EHRs in chronic disease detection and management, personal health records, and medical informatics.

Recent Publications

  1. Liu, M, Branning, R, Lee, A, Kaelber, D, Gao, K. Racial-Ethnic Disparities in Ketamine and Esketamine Therapy for Major Depressive Disorder. Psychiatr Serv 2025; : appips20240559. PubMed PMID:40556447 .
  2. Gross, RS, Thaweethai, T, Salisbury, AL, Kleinman, LC, Mohandas, S, Rhee, KE, Snowden, JN, Tantisira, KG, Warburton, D, Wood, JC et al.. Characterizing Long COVID Symptoms During Early Childhood. JAMA Pediatr 2025; : . PubMed PMID:40554463 PubMed Central PMC12117493.
  3. Wang, W, Davis, PB, Qi, X, Gurney, M, Perry, G, Volkow, ND, Kaelber, DC, Xu, R. Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study. J Alzheimers Dis 2025; : 13872877251351329. PubMed PMID:40552638 .
  4. Calcagno, T, Issa, R, Canova, T, Issa, R, Kaelber, D, Menon, V, Tang, WHW, Griffin, B, Kwon, D, Wang, TKM et al.. Impact of SGLT2i on Cardiovascular Outcomes Following Acute Myocardial Infarction With Heart Failure With Preserved Ejection Fraction: Propensity-matched Registry Study. Angiology 2025; : 33197251345853. PubMed PMID:40534435 .
  5. Chaaban, MR, Tanzo, JT, Thatte, S, Kabalan, M, Kaelber, DC. Association of Acid-Suppressive Medication and Antimicrobial Use in Infancy with Food Allergy and Anaphylaxis. J Clin Med 2025; 14 (11): . PubMed PMID:40507633 PubMed Central PMC12155881.
  6. Gao, Z, Tabernacki, T, Dorney, I, Ding, P, Kaelber, DC, Xu, R. Association of GLP-1 receptor agonists with risk of intestinal obstruction in patients with type 2 diabetes mellitus: a retrospective cohort study. Acta Diabetol 2025; : . PubMed PMID:40471297 .
  7. Gorenflo, MP, Gao, Z, Davis, PB, Kaelber, D, Xu, R. Amphetamine use and Parkinson's disease: integration of artificial intelligence prediction, clinical corroboration, and mechanism of action analyses. PLoS One 2025; 20 (5): e0323761. PubMed PMID:40392924 PubMed Central PMC12091834.
  8. Kennemer, AA, Gao, Z, Wang, L, Davis, PB, Kaelber, DC, Xu, R. Psychiatric outcomes after mild concussion by treatment timing and age. J Psychiatr Res 2025; 187 : 233-237. PubMed PMID:40382945 .
  9. Shang, T, Kaelber, DC, Chaaban, MR. Impact of Chronic Rhinosinusitis on Granulomatosis with Polyangiitis Exacerbations. J Clin Med 2025; 14 (9): . PubMed PMID:40363994 PubMed Central PMC12073045.
  10. Das, N, Dhamija, R, Kaelber, DC, Kelly, M, Xie, P, Reddy, D. Adverse neurologic events of immune checkpoint inhibitor monotherapy vs. combination therapy for melanoma. Neurooncol Adv 2025; 7 (1): vdaf030. PubMed PMID:40351833 PubMed Central PMC12063080.
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Dr. Kaelber on Twitter

Dr. Kaelber on Twitter

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The Kaelber Lab Website

Curriculum vitae