
JONATHAN HAINES, PHD
Director
Jonathan Haines, PhD, is a genetic epidemiologist, Mary W. Sheldon M.D. Professor of Genomic Sciences, Chair of Department of Population and Quantitative Health Sciences, and Director of the Institute for Computational Biology. Dr. Haines has extensive experience in all aspects of genetic epidemiology with a particular focus on data analytics. He has applied his expertise to numerous neurological and ophthalmological disorders having located and identified over 20 causal and 200 associated loci. His interests are in adapting and applying statistical computational methods to biomedical big data.
Recent Publications
- Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabli, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption. Commun Med (Lond) 2025; 5 (1): 326. PubMed PMID:40745374 PubMed Central PMC12314086.
- Sherva, R, Zhu, C, Zhang, R, Mez, J, Hauger, R, Merritt, VC, Panizzon, M, Gaziano, JM, Catanzaro, V, Schellenberg, GD et al.. Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans. Alzheimers Res Ther 2025; 17 (1): 171. PubMed PMID:40708016 PubMed Central PMC12288278.
- O'Neill, N, Kurniansyah, N, Zhu, C, Olayinka, OA, Mayeux, R, Haines, JL, Pericak-Vance, MA, Wang, LS, Schellenberg, GD, Farrer, LA et al.. 2988Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores. Neurobiol Aging 2025; 155 : 44-52. PubMed PMID:40706314 .
- Bertholim-Nasciben, L, Nuytemans, K, Van Booven, D, Rajabli, F, Moura, S, Ramirez, AM, Parker, GS, Dykxhoorn, DM, Wang, L, Scott, WK et al.. Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers. Alzheimers Dement 2025; 21 (7): e70500. PubMed PMID:40704449 PubMed Central PMC12287753.
- Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol 2025; 26 (1): 210. PubMed PMID:40676597 PubMed Central PMC12273372.
- Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2025; 57 (7): 1791. PubMed PMID:40527985 PubMed Central PMC12283398.
- Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2025; 57 (7): 1788. PubMed PMID:40527984 PubMed Central PMC12283389.
- Lorincz-Comi, N, Song, W, Chen, X, Paz, IR, Hou, Y, Zhou, Y, Xu, J, Martin, W, Barnard, J, Pieper, AA et al.. Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery. Res Sq 2025; : . PubMed PMID:40502754 PubMed Central PMC12154160.
- Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults. medRxiv 2025; : . PubMed PMID:40492063 PubMed Central PMC12148254.
- Wang, P, Song, YE, Lynn, A, Miskimen, K, Gulyayev, A, Prough, MB, Dorfsman, DA, Laux, RA, Fuzzell, SL, Hochstetler, SD et al.. Alzheimer's disease plasma biomarkers in the Midwestern Amish. Alzheimers Dement 2025; 21 (6): e70328. PubMed PMID:40465679 PubMed Central PMC12136092.