JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

CWRUlogowTag240x120

Recent Publications

  1. Newman, C, Tejeda, M, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD et al.. Alzheimer's Imaging Consortium. Alzheimers Dement 2025; 21 Suppl 8 (Suppl 8): e110049. PubMed PMID:41433538 PubMed Central PMC12725695.
  2. Khurshid, Z, Farrell, JJ, Tong, T, Zhu, C, Alzheimer's Disease Sequencing Project, Martin, ER, Bush, W, Pericak-Vance, MA, Wang, LS, Schellenberg, G et al.. Multi-ancestry exome-wide study identifies variants associated with Alzheimer's disease protection. J Alzheimers Dis 2025; : 13872877251405497. PubMed PMID:41428483 .
  3. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. medRxiv 2025; : . PubMed PMID:41404293 PubMed Central PMC12704622.
  4. Andersen, OM, de Waal, MWJ, Monti, G, Tesi, N, Jensen, AMG, de Geus, C, van Spaendonk, R, Vogel, M, Ahmad, S, Amin, N et al.. Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease. Mol Neurodegener 2025; 20 (1): 122. PubMed PMID:41327266 PubMed Central PMC12667055.
  5. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease. bioRxiv 2025; : . PubMed PMID:41279621 PubMed Central PMC12637479.
  6. Dacey, R, Hou, L, Gurnani, A, Han, X, Paller-Moore, MR, Chung, J, Durape, S, Rosenthaler, M, Uretsky, M, Abdolmohammadi, B et al.. Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking. Alzheimers Dement 2025; 21 (11): e70922. PubMed PMID:41268768 PubMed Central PMC12635870.
  7. Mustafa, Y, Main, LR, Mews, M, Janve, VA, Hohman, TJ, Haines, JL, Song, YE, Griswold, AJ, Pericak-Vance, MA, Scott, WK et al.. Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study. Transl Psychiatry 2025; 15 (1): 481. PubMed PMID:41253753 PubMed Central PMC12627486.
  8. Liu, Y, Song, YE, Lynn, A, Wang, W, Miskimen, K, Fuzzell, SL, Hochstetler, SD, Laux, RA, Caywood, LJ, Clouse, JE et al.. No association of Alzheimer disease with the joint effect of HFE and TF in the mid-western Amish. J Med Genet 2025; : . PubMed PMID:41207713 PubMed Central PMC12722393.
  9. Gorski, M, Grunin, M, Herold, JM, Fröhlich, B, Behr, M, Wheeler, N, Bush, WS, Song, YE, Zhu, X, Blanton, SH et al.. Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls. Invest Ophthalmol Vis Sci 2025; 66 (13): 51. PubMed PMID:41159651 PubMed Central PMC12577769.
  10. Liu, Y, Song, YE, Lynn, A, Wang, W, Miskimen, K, Fuzzell, SL, Hochstetler, SD, Laux, RA, Caywood, LJ, Clouse, JE et al.. Telomere length, aging, and cognitive function in the Midwestern Amish. HGG Adv 2025; 7 (1): 100533. PubMed PMID:41108082 PubMed Central PMC12639303.
Search PubMed