JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Wang, P, Song, YE, Lynn, A, Miskimen, K, Gulyayev, A, Prough, MB, Dorfsman, DA, Laux, RA, Fuzzell, SL, Hochstetler, SD et al.. Alzheimer's disease plasma biomarkers in the Midwestern Amish. Alzheimers Dement 2025; 21 (6): e70328. PubMed PMID:40465679 PubMed Central PMC12136092.
  2. Wang, P, Song, YE, Lynn, A, Miskimen, K, Gulyayev, A, Prough, MB, Dorfsman, DA, Laux, RA, Fuzzell, SL, Hochstetler, SD et al.. Heritability of Alzheimer-related plasma biomarkers in the Amish population. medRxiv 2025; : . PubMed PMID:40463532 PubMed Central PMC12132146.
  3. Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL et al.. Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset. Alzheimers Dement 2025; 21 (5): e70237. PubMed PMID:40407102 PubMed Central PMC12100500.
  4. Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. medRxiv 2025; : . PubMed PMID:40343016 PubMed Central PMC12060970.
  5. Griswold, AJ, Rajabli, F, Gu, T, Arvizu, J, Golightly, CG, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Mena, PR et al.. Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries. Alzheimers Dement 2025; 21 (3): e14367. PubMed PMID:40133765 PubMed Central PMC11936763.
  6. Phillips, JM, Dumitrescu, LC, Archer, DB, Regelson, AN, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Kukull, WA et al.. Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease. Brain 2025; : . PubMed PMID:40111762 .
  7. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, BS, Trittschuh, EH, Mez, J, Farrer, LA, Gifford, KA et al.. Evaluating the association of APOE genotype and cognitive resilience in SuperAgers. medRxiv 2025; : . PubMed PMID:39830268 PubMed Central PMC11741496.
  8. Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Examination of MGMT as a risk gene for dementia in the Amish. Alzheimers Dement 2025; 21 (1): e14356. PubMed PMID:39711484 PubMed Central PMC11782184.
  9. Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL et al.. Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset. medRxiv 2024; : . PubMed PMID:39677464 PubMed Central PMC11643159.
  10. Gorman, BR, Voloudakis, G, Igo, RP Jr, Kinzy, T, Halladay, CW, Bigdeli, TB, Zeng, B, Venkatesh, S, Cooke Bailey, JN, Crawford, DC et al.. Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. Nat Genet 2024; 56 (12): 2659-2671. PubMed PMID:39623103 .
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