JONATHAN HAINES, PHD

Director

Jonathan Haines, PhD, is a genetic epi­demi­ol­o­gist, Mary W. Shel­don M.D. Pro­fes­sor of Genomic Sci­ences, Chair of Depart­ment of Population and Quantitative Health Sciences, and Direc­tor of the Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Haines has exten­sive expe­ri­ence in all aspects of genetic epi­demi­ol­ogy with a par­tic­u­lar focus on data ana­lyt­ics. He has applied his exper­tise to numer­ous neu­ro­log­i­cal and oph­thal­mo­log­i­cal dis­or­ders hav­ing located and iden­ti­fied over 20 causal and 200 asso­ci­ated loci. His inter­ests are in adapt­ing and apply­ing sta­tis­ti­cal com­pu­ta­tional meth­ods to bio­med­ical big data.

Affiliations

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Recent Publications

  1. Akgun, B, Gulyayev, AV, Coker, M, Hamilton-Nelson, KL, Olalusi, O, Adams, LD, Akinwande, K, Whitehead, PG, Diala, S, Ogunronbi, M et al.. ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African-ancestry populations. Alzheimers Dement 2025; 21 (8): e70583. PubMed PMID:40832784 PubMed Central PMC12365657.
  2. Ciesielski, TH, Tosto, G, Durodoye, RO, Rajabli, F, Akinyemi, RO, Byrd, GS, Bush, WS, Kunkle, BW, Reitz, C, Vance, JM et al.. Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption. Commun Med (Lond) 2025; 5 (1): 326. PubMed PMID:40745374 PubMed Central PMC12314086.
  3. Sherva, R, Zhu, C, Zhang, R, Mez, J, Hauger, R, Merritt, VC, Panizzon, M, Gaziano, JM, Catanzaro, V, Schellenberg, GD et al.. Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans. Alzheimers Res Ther 2025; 17 (1): 171. PubMed PMID:40708016 PubMed Central PMC12288278.
  4. O'Neill, N, Kurniansyah, N, Zhu, C, Olayinka, OA, Mayeux, R, Haines, JL, Pericak-Vance, MA, Wang, LS, Schellenberg, GD, Farrer, LA et al.. 2988Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores. Neurobiol Aging 2025; 155 : 44-52. PubMed PMID:40706314 .
  5. Bertholim-Nasciben, L, Nuytemans, K, Van Booven, D, Rajabli, F, Moura, S, Ramirez, AM, Parker, GS, Dykxhoorn, DM, Wang, L, Scott, WK et al.. Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers. Alzheimers Dement 2025; 21 (7): e70500. PubMed PMID:40704449 PubMed Central PMC12287753.
  6. Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol 2025; 26 (1): 210. PubMed PMID:40676597 PubMed Central PMC12273372.
  7. Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2025; 57 (7): 1791. PubMed PMID:40527985 PubMed Central PMC12283398.
  8. Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2025; 57 (7): 1788. PubMed PMID:40527984 PubMed Central PMC12283389.
  9. Lorincz-Comi, N, Song, W, Chen, X, Paz, IR, Hou, Y, Zhou, Y, Xu, J, Martin, W, Barnard, J, Pieper, AA et al.. Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery. Res Sq 2025; : . PubMed PMID:40502754 PubMed Central PMC12154160.
  10. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults. medRxiv 2025; : . PubMed PMID:40492063 PubMed Central PMC12148254.
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