Symposium Speaker: Misa Graff, PhD, MS

Dr. Misa Graff is Research Assistant Professor of Epidemiology at the University of North Carolina Gillings School of Global Public Health.  Dr. Graff's research interests focus on the genetics of obesity and cardiovascular disease risk traits, with an overarching goal of integrating understanding of both genetic and environmental risk factors for disease, particularly among minority populations.  Dr. Graff's current projects include the genetic epidemiology of weight gain across adolescence into young adulthood; gene-environment interactions across multiple large cohorts; the genetic architecture of adiposity in African Americans and Hispanics; and examination of genetic effects influencing cardiovascular disease risk traits and diseases burdening minority populations.

Recent Publications

  1. Howson, JMM, Zhao, W, Barnes, DR, Ho, WK, Young, R, Paul, DS, Waite, LL, Freitag, DF, Fauman, EB, Salfati, EL et al.. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat. Genet. 2017; 49 (7): 1113-1119. PubMed PMID:28530674 PubMed Central PMC5555387.
  2. Fernández-Rhodes, L, Gong, J, Haessler, J, Franceschini, N, Graff, M, Nishimura, KK, Wang, Y, Highland, HM, Yoneyama, S, Bush, WS et al.. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Hum. Genet. 2017; 136 (6): 771-800. PubMed PMID:28391526 PubMed Central PMC5485655.
  3. Fernández-Rhodes, L, Hodonsky, CJ, Graff, M, Love, SM, Howard, AG, Seyerle, AA, Avery, CL, Chittoor, G, Franceschini, N, Voruganti, VS et al.. Comparison of 2 models for gene-environment interactions: an example of simulated gene-medication interactions on systolic blood pressure in family-based data. BMC Proc 2016; 10 (Suppl 7): 371-377. PubMed PMID:27980664 PubMed Central PMC5133512.
  4. Justice, AE, Howard, AG, Chittoor, G, Fernandez-Rhodes, L, Graff, M, Voruganti, VS, Diao, G, Love, SM, Franceschini, N, O'Connell, JR et al.. Genome-wide association of trajectories of systolic blood pressure change. BMC Proc 2016; 10 (Suppl 7): 321-327. PubMed PMID:27980656 PubMed Central PMC5133524.
  5. Graff, M, Richardson, AS, Young, KL, Mazul, AL, Highland, H, North, KE, Mohlke, KL, Lange, LA, Lange, EM, Harris, KM et al.. The interaction between physical activity and obesity gene variants in association with BMI: Does the obesogenic environment matter? Health Place 2016; 42 : 159-165. PubMed PMID:27771443 PubMed Central PMC5116401.
  6. Young, KL, Graff, M, North, KE, Richardson, AS, Mohlke, KL, Lange, LA, Lange, EM, Harris, KM, Gordon-Larsen, P. Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health. BMC Genet. 2015; 16 : 131. PubMed PMID:26537541 PubMed Central PMC4634717.
  7. Lin, DY, Tao, R, Kalsbeek, WD, Zeng, D, Gonzalez, F 2nd, Fernández-Rhodes, L, Graff, M, Koch, GG, North, KE, Heiss, G et al.. Genetic association analysis under complex survey sampling: the Hispanic Community Health Study/Study of Latinos. Am. J. Hum. Genet. 2014; 95 (6): 675-88. PubMed PMID:25480034 PubMed Central PMC4259979.
  8. Graff, M, Ngwa, JS, Workalemahu, T, Homuth, G, Schipf, S, Teumer, A, Völzke, H, Wallaschofski, H, Abecasis, GR, Edward, L et al.. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum. Mol. Genet. 2013; 22 (17): 3597-607. PubMed PMID:23669352 PubMed Central PMC3736869.
  9. Graff, M, North, KE, Franceschini, N, Reiner, AP, Feitosa, M, Carr, JJ, Gordon-Larsen, P, Wojczynski, MK, Borecki, IB. PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: the NHLBI family heart study. Int J Obes (Lond) 2013; 37 (3): 432-8. PubMed PMID:22546774 PubMed Central PMC3410967.
  10. North, KE, Graff, M, Franceschini, N, Reiner, AP, Feitosa, MF, Carr, JJ, Gordon-Larsen, P, Wojczynski, MK, Borecki, IB. Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study. Eur J Gastroenterol Hepatol 2012; 24 (1): 9-16. PubMed PMID:21900826 PubMed Central PMC3233637.
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Graff Lab Website

Curriculum vitae