
Dr. Burcu Darst received her PhD in Epidemiology from the University of Wisconsin and recently completed post-doctoral training at the University of Southern California under the mentorship of Drs. Christopher Haiman and David Conti. Dr. Darst's research is focused on identifying and understanding genetic and multi-omic risk factors of prostate cancer in diverse populations. She has extensive expertise in genetic epidemiology as well as genetic association and metabolomic investigations. Her research focuses on understanding genetic risk of prostate cancer in multi-ancestry populations, particularly using rare variants captured with whole exome sequencing, genome-wide association studies, polygenic risk scores and metabolomics to distinguish aggressive from non-aggressive disease and to understand the stark health disparities that contribute to prostate cancer risk. She has also done research on genetic testing in precision medicine, developmental neurogenetics, and the genetics of complex aging traits and worked to integrate genomic and metabolomic data to understand the underlying mechanisms contributing to complex aging traits and Alzheimer’s disease. Currently, she is leading an effort to improve understanding of the genomic and metabolic mechanisms contributing to prostate cancer risk in men from diverse populations as well as improving the utility of polygenic risk scores and rare genetic variants for the prediction of prostate cancer across patient populations. Dr. Darst has received multiple awards for her work including the Prostate Cancer Foundation Young Investigator Award and the AACR NextGen Star award.
Recent Publications
- Kim, D, Highland, HM, Smit, RAJ, Hysong, MR, Buchanan, VL, Young, KL, Zhao, C, Spracklen, CN, Kilpeläinen, TO, Guo, B et al.. Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease. Genome Med 2025; 17 (1): 113. PubMed PMID:41053791 PubMed Central PMC12502452.
- Guo, B, Cai, Y, Kim, D, Smit, RAJ, Wang, Z, Iyer, KR, Hilliard, AT, Haessler, J, Tao, R, Broadaway, KA et al.. Polygenic risk score for type 2 diabetes shows context-dependent effects across populations. Nat Commun 2025; 16 (1): 8632. PubMed PMID:41034193 PubMed Central PMC12488948.
- Lu, Y, Xu, H, Sun, Y, Ihejirika, SA, Chiang, CW, Darst, BF, Song, S, Shen, Y, Ye, K. Gene-Diet Interaction Analysis in UK Biobank Identified Genetic Loci That Modify the Association Between Fish Oil Supplementation and the Incidence of Dementia. Curr Dev Nutr 2025; 9 (9): 107524. PubMed PMID:40949174 PubMed Central PMC12423404.
- Lee, JR, Morehead, D, Young, B, Tolbert, V, Masembe, J, Britt, G, Neuenschwander, L, Schuppe, K, Pelman, R, Johnson, D et al.. Patient and Physician Perceptions of Prostate-Specific Antigen Testing Among Black Individuals. JAMA Netw Open 2025; 8 (9): e2530946. PubMed PMID:40920378 PubMed Central PMC12418120.
- Wang, L, Xu, H, Simons, RL, Beach, SRH, Lei, MK, Ong, ML, Philibert, RA, Mielke, MM, Sun, Y, Lu, Y et al.. Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry. Neurology 2025; 105 (5): e213976. PubMed PMID:40779734 PubMed Central PMC12341075.
- Khan, AT, Adebamowo, C, Fullerton, SM, Hirbo, J, Konigsberg, IR, Kraft, P, Martin, I, Nelson, SC, Ramsay, M, Wojcik, GL et al.. A data model for population descriptors in genomic research. Am J Hum Genet 2025; 112 (7): 1504-1514. PubMed PMID:40513563 PubMed Central PMC12256887.
- Scadden, AW, Kakar, A, Litkowski, EM, Meyer, MC, Armstrong, ND, Buyske, S, Cai, Y, Cheng, I, Darst, BF, Fornage, M et al.. Type 2 Diabetes Polygenic Risk Score Interactions with Lifestyle Risk Factors in Black Americans. Lifestyle Genom 2025; 18 (1): 90-97. PubMed PMID:40451158 PubMed Central PMC12235720.
- Hu, Y, Haessler, J, Lundin, JI, Darst, BF, Whitsel, EA, Grove, M, Guan, W, Xia, R, Szeto, M, Raffield, LM et al.. Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants. Clin Epigenetics 2025; 17 (1): 54. PubMed PMID:40176173 PubMed Central PMC11967142.
- Fuller, H, Agasaro, OP, Darst, BF. Pre-diagnostic circulating metabolomics and prostate cancer risk: A systematic review and meta-analysis. medRxiv 2025; : . PubMed PMID:40061317 PubMed Central PMC11888532.
- Guo, B, Cai, Y, Kim, D, Smit, RAJ, Wang, Z, Iyer, KR, Hilliard, AT, Haessler, J, Tao, R, Broadaway, KA et al.. Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations. medRxiv 2025; : . PubMed PMID:40034751 PubMed Central PMC11875254.