Symposium Speaker: Carla Márquez Luna, PhD

Dr. Márquez Luna is a post-doctoral fellow at Icahn School of Medicine at Mount Sinai in the laboratory of Dr. Ron Do. Dr. Márquez Luna completed her PhD in Biostatistics at Harvard University in 2018 under the supervision of Dr. Alkes Price. Her doctoral research focused on the development of methods that leverage functional annotations and multi-ethnic data to improve polygenic risk prediction. Carla holds a Bachelors in Mathematics from National Autonomous University of Mexico (UNAM). After college, she worked as a research assistant at the National Institute of Genomic Medicine (INMEGEN) in Mexico, and did two research stays at the Broad Institute of MIT and Harvard where she worked on genome-wide association studies for metabolic traits and type 2 diabetes in Mexican populations, the latter as part of the SIGMA T2D consortium.  Dr. Márquez Luna was a 2019 panelist for RIIAA MEX, an international meeting on artificial intelligence and its applications.  She also served as a teaching fellow for the 2019 Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER) on-site training in Campeche, Mexico.

Recent Publications

  1. Márquez-Luna, C, Gazal, S, Loh, PR, Kim, SS, Furlotte, N, Auton, A, 23andMe Research Team, Price, AL. Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets. Nat Commun 2021; 12 (1): 6052. PubMed PMID:34663819 PubMed Central PMC8523709.
  2. Cheng, H, Sewda, A, Marquez-Luna, C, White, SR, Whitney, BM, Williams-Nguyen, J, Nance, RM, Lee, WJ, Kitahata, MM, Saag, MS et al.. Correction to: Genetic architecture of cardiometabolic risks in people living with HIV. BMC Med 2021; 19 (1): 114. PubMed PMID:33947393 PubMed Central PMC8097782.
  3. Forrest, IS, Chaudhary, K, Paranjpe, I, Vy, HMT, Marquez-Luna, C, Rocheleau, G, Saha, A, Chan, L, Van Vleck, T, Loos, RJF et al.. Genome-wide polygenic risk score for retinopathy of type 2 diabetes. Hum Mol Genet 2021; 30 (10): 952-960. PubMed PMID:33704450 PubMed Central PMC8165647.
  4. Kim, SS, Dey, KK, Weissbrod, O, Márquez-Luna, C, Gazal, S, Price, AL. Improving the informativeness of Mendelian disease-derived pathogenicity scores for common disease. Nat Commun 2020; 11 (1): 6258. PubMed PMID:33288751 PubMed Central PMC7721881.
  5. Weissbrod, O, Hormozdiari, F, Benner, C, Cui, R, Ulirsch, J, Gazal, S, Schoech, AP, van de Geijn, B, Reshef, Y, Márquez-Luna, C et al.. Functionally informed fine-mapping and polygenic localization of complex trait heritability. Nat Genet 2020; 52 (12): 1355-1363. PubMed PMID:33199916 PubMed Central PMC7710571.
  6. Cheng, H, Sewda, A, Marquez-Luna, C, White, SR, Whitney, BM, Williams-Nguyen, J, Nance, RM, Lee, WJ, Kitahata, MM, Saag, MS et al.. Genetic architecture of cardiometabolic risks in people living with HIV. BMC Med 2020; 18 (1): 288. PubMed PMID:33109212 PubMed Central PMC7592520.
  7. Gazal, S, Marquez-Luna, C, Finucane, HK, Price, AL. Reconciling S-LDSC and LDAK functional enrichment estimates. Nat Genet 2019; 51 (8): 1202-1204. PubMed PMID:31285579 PubMed Central PMC7006477.
  8. Márquez-Luna, C, Loh, PR, South Asian Type 2 Diabetes (SAT2D) Consortium, SIGMA Type 2 Diabetes Consortium, Price, AL. Multiethnic polygenic risk scores improve risk prediction in diverse populations. Genet Epidemiol 2017; 41 (8): 811-823. PubMed PMID:29110330 PubMed Central PMC5726434.
  9. Majithia, AR, Flannick, J, Shahinian, P, Guo, M, Bray, MA, Fontanillas, P, Gabriel, SB, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium et al.. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc Natl Acad Sci U S A 2014; 111 (36): 13127-32. PubMed PMID:25157153 PubMed Central PMC4246964.
  10. SIGMA Type 2 Diabetes Consortium, Williams, AL, Jacobs, SB, Moreno-Macías, H, Huerta-Chagoya, A, Churchhouse, C, Márquez-Luna, C, García-Ortíz, H, Gómez-Vázquez, MJ, Burtt, NP et al.. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature 2014; 506 (7486): 97-101. PubMed PMID:24390345 PubMed Central PMC4127086.
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