Dr. Burchard is Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences Professor and Vice Chair, Departments of Bioengineering & Therapeutic Sciences and Medicine Director, Center for Genes, Environments & Health at the University of California, San Francisco. Dr. Burchard's laboratory investigates the genetic basis for differences in response to treatment for asthma. Dr. Burchard's laboratory is specifically interested in identifying "ethnic-specific" genetic and biologic risk factors for asthma, asthma severity, and drug responsiveness among US ethnic and racial minority groups as well as developing and applying statistical methods to admixed populations. Dr. Burchard is Principal Investigator of Gene-Environment Studies of Asthma in Hispanic/Latino Children (GALA) I and II among other NIH-funded studies. In March 2015, Dr. Burchard was named to the Precision Medicine Initiative (PMI) Working Group of the Advisory Committee to the National Institutes of Health (NIH) Director. More recently, Dr. Burchard was awarded the 2016 American Thoracic Society Innovations in Health Equality - Lifetime Achievement Award.
Recent Publications
- Kachuri, L, Mak, ACY, Hu, D, Eng, C, Huntsman, S, Elhawary, JR, Gupta, N, Gabriel, S, Xiao, S, Keys, KL et al.. Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture. Nat Genet 2023; : . PubMed PMID:37231098 .
- Wong, WJ, Emdin, C, Bick, AG, Zekavat, SM, Niroula, A, Pirruccello, JP, Dichtel, L, Griffin, G, Uddin, MM, Gibson, CJ et al.. Clonal haematopoiesis and risk of chronic liver disease. Nature 2023; 616 (7958): 747-754. PubMed PMID:37046084 .
- Weinstock, JS, Gopakumar, J, Burugula, BB, Uddin, MM, Jahn, N, Belk, JA, Bouzid, H, Daniel, B, Miao, Z, Ly, N et al.. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Nature 2023; 616 (7958): 755-763. PubMed PMID:37046083 .
- Perez-Garcia, J, Herrera-Luis, E, Li, A, Mak, ACY, Huntsman, S, Oh, SS, Elhawary, JR, Eng, C, Beckman, KB, Hu, D et al.. Multi-omic approach associates blood methylome with bronchodilator drug response in pediatric asthma. J Allergy Clin Immunol 2023; : . PubMed PMID:36796456 .
- Gorla, A, Sankararaman, S, Burchard, E, Flint, J, Zaitlen, N, Rahmani, E. Phenotypic subtyping via contrastive learning. bioRxiv 2023; : . PubMed PMID:36711575 PubMed Central PMC9881932.
- Li, X, Quick, C, Zhou, H, Gaynor, SM, Liu, Y, Chen, H, Selvaraj, MS, Sun, R, Dey, R, Arnett, DK et al.. Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies. Nat Genet 2023; 55 (1): 154-164. PubMed PMID:36564505 PubMed Central PMC10084891.
- Beecham, AH, Amezcua, L, Chinea, A, Manrique, CP, Gomez, L, Martinez, A, Beecham, GW, Patsopoulos, NA, Chitnis, T, Weiner, HL et al.. Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population. PLoS One 2022; 17 (12): e0279132. PubMed PMID:36548255 PubMed Central PMC9778564.
- Xiao, S, Sahasrabudhe, N, Yang, M, Hu, D, Sleiman, P, Hochstadt, S, Cabral, W, Gilliland, F, Gauderman, WJ, Martinez, F et al.. Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort Participants. J Allergy Clin Immunol Pract 2023; 11 (4): 1123-1133.e11. PubMed PMID:36403896 PubMed Central PMC10085828.
- Li, Z, Li, X, Zhou, H, Gaynor, SM, Selvaraj, MS, Arapoglou, T, Quick, C, Liu, Y, Chen, H, Sun, R et al.. A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies. Nat Methods 2022; 19 (12): 1599-1611. PubMed PMID:36303018 PubMed Central PMC10008172.
- Selvaraj, MS, Li, X, Li, Z, Pampana, A, Zhang, DY, Park, J, Aslibekyan, S, Bis, JC, Brody, JA, Cade, BE et al.. Whole genome sequence analysis of blood lipid levels in >66,000 individuals. Nat Commun 2022; 13 (1): 5995. PubMed PMID:36220816 PubMed Central PMC9553944.
