Dr. Burchard is Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences Professor and Vice Chair, Departments of Bioengineering & Therapeutic Sciences and Medicine Director, Center for Genes, Environments & Health at the University of California, San Francisco. Dr. Burchard's laboratory investigates the genetic basis for differences in response to treatment for asthma. Dr. Burchard's laboratory is specifically interested in identifying "ethnic-specific" genetic and biologic risk factors for asthma, asthma severity, and drug responsiveness among US ethnic and racial minority groups as well as developing and applying statistical methods to admixed populations. Dr. Burchard is Principal Investigator of Gene-Environment Studies of Asthma in Hispanic/Latino Children (GALA) I and II among other NIH-funded studies. In March 2015, Dr. Burchard was named to the Precision Medicine Initiative (PMI) Working Group of the Advisory Committee to the National Institutes of Health (NIH) Director. More recently, Dr. Burchard was awarded the 2016 American Thoracic Society Innovations in Health Equality - Lifetime Achievement Award.
Recent Publications
- Walker, MT, Bloodworth, JC, Kountz, TS, McCarty, SL, Green, JE, Ferrie, RP, Campbell, JA, Averill, SH, Beckman, KB, Grammer, LC et al.. 5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function. Front Allergy 2024; 5 : 1385168. PubMed PMID:38845678 PubMed Central PMC11153829.
- Keener, R, Chhetri, SB, Connelly, CJ, Taub, MA, Conomos, MP, Weinstock, J, Ni, B, Strober, B, Aslibekyan, S, Auer, PL et al.. Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes. Nat Commun 2024; 15 (1): 4417. PubMed PMID:38789417 PubMed Central PMC11126610.
- Diao, JA, He, Y, Khazanchi, R, Nguemeni Tiako, MJ, Witonsky, JI, Pierson, E, Rajpurkar, P, Elhawary, JR, Melas-Kyriazi, L, Yen, A et al.. Implications of Race Adjustment in Lung-Function Equations. N Engl J Med 2024; 390 (22): 2083-2097. PubMed PMID:38767252 .
- Everman, JL, Sajuthi, SP, Liegeois, MA, Jackson, ND, Collet, EH, Peters, MC, Chioccioli, M, Moore, CM, Patel, BB, Dyjack, N et al.. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nat Commun 2024; 15 (1): 3900. PubMed PMID:38724552 PubMed Central PMC11082194.
- Witonsky, JI, Elhawary, JR, Eng, C, Oh, SS, Salazar, S, Contreras, MG, Medina, V, Secor, EA, Zhang, P, Everman, JL et al.. The Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes (PRIMERO): Design and Baseline Characteristics for a Birth Cohort Study of Early-life Viral Respiratory Illnesses and Airway Dysfunction in Puerto Rican Children. medRxiv 2024; : . PubMed PMID:38699325 PubMed Central PMC11065009.
- Madden, EB, Hindorff, LA, Bonham, VL, Akintobi, TH, Burchard, EG, Baker, KE, Begay, RL, Carpten, JD, Cox, NJ, Di Francesco, V et al.. Advancing genomics to improve health equity. Nat Genet 2024; 56 (5): 752-757. PubMed PMID:38684898 PubMed Central PMC11096049.
- de Smith, AJ, Wahlster, L, Jeon, S, Kachuri, L, Black, S, Langie, J, Cato, LD, Nakatsuka, N, Chan, TF, Xia, G et al.. A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. Cell Genom 2024; 4 (4): 100526. PubMed PMID:38537633 PubMed Central PMC11019360.
- Witonsky, J, Burchard, EG. Race/Ethnicity and Clinical Prediction Algorithms for Childhood Asthma. NEJM Evid 2023; 2 (10): EVIDe2300187. PubMed PMID:38320186 .
- Herrera-Luis, E, Rosa-Baez, C, Huntsman, S, Eng, C, Beckman, KB, LeNoir, MA, Rodriguez-Santana, JR, Villar, J, Laprise, C, Borrell, LN et al.. Novel insights into the whole-blood DNA methylome of asthma in ethnically diverse children and youth. Eur Respir J 2023; 62 (6): . PubMed PMID:37802634 PubMed Central PMC10841414.
- Budu-Aggrey, A, Kilanowski, A, Sobczyk, MK, 23andMe Research Team, Shringarpure, SS, Mitchell, R, Reis, K, Reigo, A, Estonian Biobank Research Team, Mägi, R et al.. European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation. Nat Commun 2023; 14 (1): 6172. PubMed PMID:37794016 PubMed Central PMC10550990.
