Symposium Speaker: Jacob L. McCauley, PhD

Dr. McCauley is Associate Professor of Pathology and Dr. John T. Macdonald Foundation Department of Human Genetics at the University of Miami.  Dr. McCauley is also Associate Director at the Center for Genome Technology, John P. Hussman Institute for Human Genomics and Director of the Biorepository Core Facility in the Center for Genome Technology at the John P Hussman Institute for Human Genomics.  Dr. McCauley is formally trained in human genetics, and his primary interest is to improve the understanding of human disease through disease gene discovery, genomics, and in-depth examination of environmental factors that influence disease outcome. His research focuses on the use of molecular techniques, bioinformatics, and statistical methods to identify genetic variation and to characterize its role in disease susceptibility and outcomes within a variety of human diseases. He has significant experience overseeing biological sample collection, tracking, quality control, genotyping, sequencing and analysis involved in large-scale human genetics projects. Dr. McCauley is a member of several multidisciplinary collaborations with colleagues both nationally and internationally. He has been involved in studying a variety of complex human diseases including autism, Alzheimer disease, stroke, multiple sclerosis, and inflammatory bowel disease.

Recent Publications

  1. Kittner, SJ, Sekar, P, Comeau, ME, Anderson, CD, Parikh, GY, Tavarez, T, Flaherty, ML, Testai, FD, Frankel, MR, James, ML et al.. Ethnic and Racial Variation in Intracerebral Hemorrhage Risk Factors and Risk Factor Burden. JAMA Netw Open 2021; 4 (8): e2121921. PubMed PMID:34424302 PubMed Central PMC8383133.
  2. Chandler, PD, Clark, CR, Zhou, G, Noel, NL, Achilike, C, Mendez, L, Ramirez, AH, Loperena-Cortes, R, Mayo, K, Cohn, E et al.. Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research. Sci Rep 2021; 11 (1): 12849. PubMed PMID:34158555 PubMed Central PMC8219813.
  3. Chiong-Rivero, H, Robers, M, Martinez, A, Manrique, CP, Diaz, A, Polito, K, Vajdi, B, Chan, C, Burnett, M, Delgado, SR et al.. Effectiveness of film as a health communication tool to improve perceptions and attitudes in multiple sclerosis. Mult Scler J Exp Transl Clin ; 7 (1): 2055217321995947. PubMed PMID:33717502 PubMed Central PMC7923991.
  4. Somineni, HK, Nagpal, S, Venkateswaran, S, Cutler, DJ, Okou, DT, Haritunians, T, Simpson, CL, Begum, F, Datta, LW, Quiros, AJ et al.. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. Am J Hum Genet 2021; 108 (3): 431-445. PubMed PMID:33600772 PubMed Central PMC8008495.
  5. Nimer, SD, Chapman, J, Reidy, L, Alencar, A, Wu, Y, Williams, S, Pagan, L, Gjolaj, L, MacIntyre, J, Triana, M et al.. A How-to Guide to Building a Robust SARS-CoV-2 Testing Program at a University-Based Health System. Acad Pathol ; 7 : 2374289520958200. PubMed PMID:33088910 PubMed Central PMC7545514.
  6. Nakatsuka, N, Patterson, N, Patsopoulos, NA, Altemose, N, Tandon, A, Beecham, AH, McCauley, JL, Isobe, N, Hauser, S, De Jager, PL et al.. Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans. Sci Rep 2020; 10 (1): 16902. PubMed PMID:33037294 PubMed Central PMC7547691.
  7. Biffi, A, Urday, S, Kubiszewski, P, Gilkerson, L, Sekar, P, Rodriguez-Torres, A, Bettin, M, Charidimou, A, Pasi, M, Kourkoulis, C et al.. Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. Stroke 2020; 51 (7): 2153-2160. PubMed PMID:32517581 PubMed Central PMC7311289.
  8. Fazia, T, Nova, A, Gentilini, D, Beecham, A, Piras, M, Saddi, V, Ticca, A, Bitti, P, McCauley, JL, Berzuini, C et al.. Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach. Front Bioeng Biotechnol 2020; 8 : 397. PubMed PMID:32432099 PubMed Central PMC7216783.
  9. Benatar, M, Zhang, L, Wang, L, Granit, V, Statland, J, Barohn, R, Swenson, A, Ravits, J, Jackson, C, Burns, TM et al.. Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS. Neurology 2020; 95 (1): e59-e69. PubMed PMID:32385188 PubMed Central PMC7371380.
  10. Cuccaro, ML, Manrique, CP, Quintero, MA, Martinez, R, McCauley, JL. Understanding Participation in Genetic Research Among Patients With Multiple Sclerosis: The Influences of Ethnicity, Gender, Education, and Age. Front Genet 2020; 11 : 120. PubMed PMID:32231680 PubMed Central PMC7082924.
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The McCauley Lab Website

Curriculum vitae