Dr. Perera is an Associate Professor in the Department of Pharmacology and Center for Pharmacogenomics at Northwestern University's Feinberg School of Medicine. With expertise in pharmacokinetics, clinical pharmacology and human genetics, Dr. Perera focuses her research interests on pharmacogenomics in minority populations. Examples of her work include identifying common genetic variants associated with warfarin dose and identifying genomic risk factors for venous thromboembolism, both in African Americans. Dr. Perera anticipates that results from these and other multidisciplinary studies will allow the development of an economically sustainable program in clinical pharmacogenetics, including a consult service. Overall, Dr. Perera's goal is to bring meaningful translation of pharmacogenetics research findings into clinical care, a goal very much consistent with precision medicine.
Recent Publications
- Garofano, K, Rashid, K, Smith, M, Brantner, C, Suwunnakorn, S, Diemert, D, Gordon, O, Horvath, A, Khan, S, Popratiloff, A et al.. Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs. Sci Rep 2023; 13 (1): 2864. PubMed PMID:36806315 PubMed Central PMC9938282.
- Chen, T, O'Donnell, PH, Middlestadt, M, Ruhnke, GW, Danahey, K, van Wijk, XMR, Choksi, A, Knoebel, R, Hartman, S, Yeo, KJ et al.. Implementation of pharmacogenomics into inpatient general medicine. Pharmacogenet Genomics 2023; 33 (2): 19-23. PubMed PMID:36729768 .
- Linder, JE, Allworth, A, Bland, ST, Caraballo, PJ, Chisholm, RL, Clayton, EW, Crosslin, DR, Dikilitas, O, DiVietro, A, Esplin, ED et al.. Returning integrated genomic risk and clinical recommendations: The eMERGE study. Genet Med 2023; 25 (4): 100006. PubMed PMID:36621880 PubMed Central PMC10085845.
- Zhong, Y, De, T, Mishra, M, Avitia, J, Alarcon, C, Perera, MA. Leveraging drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans. Am J Hum Genet 2023; 110 (1): 58-70. PubMed PMID:36608685 PubMed Central PMC9892765.
- Yang, G, Alarcon, C, Friedman, P, Gong, L, Klein, T, O'Brien, T, Nutescu, EA, Tuck, M, Meltzer, D, Perera, MA et al.. The Role of Global and Local Ancestry on Clopidogrel Response in African Americans. Pac Symp Biocomput 2023; 28 : 221-232. PubMed PMID:36540979 PubMed Central PMC9782753.
- Zhang, H, Alarcon, C, Cavallari, LH, Nutescu, E, Carvill, GL, Perera, MA, Hernandez, W. Genomewide Association Study Identifies Copy Number Variants Associated With Warfarin Dose Response and Risk of Venous Thromboembolism in African Americans. Clin Pharmacol Ther 2023; 113 (3): 624-633. PubMed PMID:36507737 .
- Yang, G, Mishra, M, Perera, MA. Multi-Omics Studies in Historically Excluded Populations: The Road to Equity. Clin Pharmacol Ther 2023; 113 (3): 541-556. PubMed PMID:36495075 .
- Steiner, HE, Carrion, KC, Giles, JB, Lima, AR, Yee, K, Sun, X, Cavallari, LH, Perera, MA, Duconge, J, Karnes, JH et al.. Local Ancestry-Informed Candidate Pathway Analysis of Warfarin Stable Dose in Latino Populations. Clin Pharmacol Ther 2023; 113 (3): 680-691. PubMed PMID:36321873 PubMed Central PMC9957812.
- Lindley, KJ, Limdi, NA, Cavallari, LH, Perera, MA, Lenzini, P, Johnson, JA, Wu, AHB, Ridker, PM, King, CR, Eby, CS et al.. Warfarin Dosing in Patients With CYP2C9*5 Variant Alleles. Clin Pharmacol Ther 2022; 111 (4): 950-955. PubMed PMID:35108398 .
- Saulsberry, L, Danahey, K, Middlestadt, M, O'Leary, KJ, Nutescu, EA, Chen, T, Lee, JC, Ruhnke, GW, George, D, House, L et al.. Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients. J Pers Med 2021; 11 (12): . PubMed PMID:34945816 PubMed Central PMC8709436.
