Symposium Speaker: Minoli Perera, PharmD, PhD

Dr. Perera is an Associate Professor in the Department of Pharmacology and Center for Pharmacogenomics at Northwestern University's Feinberg School of Medicine.  With expertise in pharmacokinetics, clinical pharmacology and human genetics, Dr. Perera focuses her research interests on pharmacogenomics in minority populations.  Examples of her work include identifying common genetic variants associated with warfarin dose and identifying genomic risk factors for venous thromboembolism, both in African Americans.  Dr. Perera anticipates that results from these and other multidisciplinary studies will allow the development of an economically sustainable program in clinical pharmacogenetics, including a consult service.  Overall, Dr. Perera's goal is to bring meaningful translation of pharmacogenetics research findings into clinical care, a goal very much consistent with precision medicine.

Recent Publications

  1. Lindley, KJ, Limdi, NA, Cavallari, LH, Perera, MA, Lenzini, P, Johnson, JA, Wu, AHB, Ridker, PM, King, CR, Eby, CS et al.. Warfarin Dosing in Patients With CYP2C9*5 Variant Alleles. Clin Pharmacol Ther 2022; 111 (4): 950-955. PubMed PMID:35108398 .
  2. Saulsberry, L, Danahey, K, Middlestadt, M, O'Leary, KJ, Nutescu, EA, Chen, T, Lee, JC, Ruhnke, GW, George, D, House, L et al.. Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients. J Pers Med 2021; 11 (12): . PubMed PMID:34945816 PubMed Central PMC8709436.
  3. Perera, DDBD, Perera, KML, Peiris, DC. A Novel In Silico Benchmarked Pipeline Capable of Complete Protein Analysis: A Possible Tool for Potential Drug Discovery. Biology (Basel) 2021; 10 (11): . PubMed PMID:34827106 PubMed Central PMC8615085.
  4. De, T, Zhang, H, Alarcon, C, Lec, B, Avitia, J, Smithberger, E, Chen, C, Horvath, M, Kwan, S, Young, M et al.. Genetic association of primary nonresponse to anti-TNFα therapy in patients with inflammatory bowel disease. Pharmacogenet Genomics 2022; 32 (1): 1-9. PubMed PMID:34380996 PubMed Central PMC8578201.
  5. Garofano, K, Park, CS, Alarcon, C, Avitia, J, Barbour, A, Diemert, D, Fraser, CM, Friedman, PN, Horvath, A, Rashid, K et al.. Differences in the Platelet mRNA Landscape Portend Racial Disparities in Platelet Function and Suggest Novel Therapeutic Targets. Clin Pharmacol Ther 2021; 110 (3): 702-713. PubMed PMID:34255863 .
  6. COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature 2021; 600 (7889): 472-477. PubMed PMID:34237774 PubMed Central PMC8674144.
  7. Singh, A, Zhong, Y, Nahlawi, L, Park, CS, De, T, Alarcon, C, Perera, MA. Incorporation of DNA methylation into eQTL mapping in African Americans. Pac Symp Biocomput 2021; 26 : 244-255. PubMed PMID:33691021 PubMed Central PMC7958994.
  8. Zhong, Y, De, T, Alarcon, C, Park, CS, Lec, B, Perera, MA. Discovery of novel hepatocyte eQTLs in African Americans. PLoS Genet 2020; 16 (4): e1008662. PubMed PMID:32310939 PubMed Central PMC7192504.
  9. Agrawal, S, Heiss, MS, Fenter, RB, Abramova, TV, Perera, MA, Pacheco, JA, Smith, ME, Rasmussen-Torvik, LJ, George, AL Jr. Impact of CYP2C9-Interacting Drugs on Warfarin Pharmacogenomics. Clin Transl Sci 2020; 13 (5): 941-949. PubMed PMID:32270628 PubMed Central PMC7485961.
  10. Nooruddin, M, Scherr, C, Friedman, P, Subrahmanyam, R, Banagan, J, Moreno, D, Sathyanarayanan, M, Nutescu, E, Jeyaram, T, Harris, M et al.. Why African Americans say "No": A Study of Pharmacogenomic Research Participation. Ethn Dis 2020; 30 (Suppl 1): 159-166. PubMed PMID:32269457 PubMed Central PMC7138442.
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Dr. Perera on Twitter

Dr. Perera on Twitter

This release includes new pathways for ribavirin PK & Prednisone and Prednisolone PK created as part of a collaboration between PharmGKB & @reactome! More at our blog pharmgkb.blogspot.com/2022/09/pharmg… #pharmacogenomics #pharmacology twitter.com/reactome/statu… Retweeted by Dr. Minoli Perera

👇👇👇YES! we need to lobby for our place. @TheACMG. PharmDs are health care providers and the best source for #PGx delivery twitter.com/JasmineLuzum/s…

New preprint alert: we develop isoTWAS, a powerful, multivariate framework to integrate transcript-isoforms with GWAS to significantly boost power to detect genetic associations with underlying transcriptomic mechanisms, with @bpasaniuc @mikejg84. medrxiv.org/content/10.110… Retweeted by Dr. Minoli Perera

There are very few times that comeuppance is so swift. Small victory but I’ll take it. twitter.com/iamalmostlegen…

Someone got video of me this morning… twitter.com/HeckinGoodDogs…

He did so well! What a good Boi!! Bravo, BRAVO!!! Retweeted by Dr. Minoli Perera

📢@NatureGenet is looking to hire an Associate/Senior Editor. This is a rare and exciting opportunity to help publish the best research in genetics and genomics. 🧬 Please share the word! careers.springernature.com/job/New-York-A… Retweeted by Dr. Minoli Perera

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals medrxiv.org/content/10.110… Retweeted by Dr. Minoli Perera

PIs searching for postdocs in 2022 Retweeted by Dr. Minoli Perera

Congrats to a neighbor on getting that one past Jesse White’s people. Retweeted by Dr. Minoli Perera

test Twitter Media - RT @chicagobars: Congrats to a neighbor on getting that one past Jesse White’s people. https://t.co/HxoyJoHjEX

There is no perfect T-shirt for me….wait… Retweeted by Dr. Minoli Perera

test Twitter Media - RT @DisastrousComms: There is no perfect T-shirt for me….wait… https://t.co/u8NLZgf5h5

Trying to get reviewers to get your new grant proposal. twitter.com/buitengebieden…

Perera Lab killin’ it at Bocce last night. Who knew Cristina was such a competitor!

test Twitter Media - Perera Lab killin’ it at Bocce last night. Who knew Cristina was such a competitor! https://t.co/I3pYZ8Xfap
test Twitter Media - Perera Lab killin’ it at Bocce last night. Who knew Cristina was such a competitor! https://t.co/I3pYZ8Xfap
test Twitter Media - Perera Lab killin’ it at Bocce last night. Who knew Cristina was such a competitor! https://t.co/I3pYZ8Xfap
test Twitter Media - Perera Lab killin’ it at Bocce last night. Who knew Cristina was such a competitor! https://t.co/I3pYZ8Xfap

@pgrnhub twitter.com/NUCATSInstitut…

The Perera Lab Website

Curriculum vitae