Symposium Speaker: Minoli Perera, PharmD, PhD

Dr. Perera is an Associate Professor in the Department of Pharmacology and Center for Pharmacogenomics at Northwestern University's Feinberg School of Medicine.  With expertise in pharmacokinetics, clinical pharmacology and human genetics, Dr. Perera focuses her research interests on pharmacogenomics in minority populations.  Examples of her work include identifying common genetic variants associated with warfarin dose and identifying genomic risk factors for venous thromboembolism, both in African Americans.  Dr. Perera anticipates that results from these and other multidisciplinary studies will allow the development of an economically sustainable program in clinical pharmacogenetics, including a consult service.  Overall, Dr. Perera's goal is to bring meaningful translation of pharmacogenetics research findings into clinical care, a goal very much consistent with precision medicine.

Recent Publications

  1. Mishra, M, Nahlawi, L, Zhong, Y, De, T, Yang, G, Alarcon, C, Perera, MA. LA-GEM: imputation of gene expression with incorporation of Local Ancestry. Pac Symp Biocomput 2024; 29 : 341-358. PubMed PMID:38160291 PubMed Central PMC10764069.
  2. Yang, G, Alarcon, C, Chanfreau, C, Lee, NH, Friedman, P, Nutescu, E, Tuck, M, O'Brien, T, Gong, L, Klein, TE et al.. Investigation of genomic and transcriptomic risk factors in clopidogrel response in African Americans. medRxiv 2023; : . PubMed PMID:38106031 PubMed Central PMC10723512.
  3. Yang, G, González, P, Moneró, M, Carrasquillo, K, Renta, JY, Hernandez-Suarez, DF, Botton, MR, Melin, K, Scott, SA, Ruaño, G et al.. Discovery of Ancestry-specific Variants Associated with Clopidogrel Response among Caribbean Hispanics. medRxiv 2023; : . PubMed PMID:37873439 PubMed Central PMC10593031.
  4. Jayasundara, SL, Algewatta, HR, Jayawardana, S, Perera, M, Peiris, LDC. Molecular Identification and Evolutionary Divergence of the Sri Lankan Sambar Deer, Rusa unicolor (Kerr 1792). Animals (Basel) 2023; 13 (18): . PubMed PMID:37760277 PubMed Central PMC10525601.
  5. Garofano, K, Rashid, K, Smith, M, Brantner, C, Suwunnakorn, S, Diemert, D, Gordon, O, Horvath, A, Khan, S, Popratiloff, A et al.. Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs. Sci Rep 2023; 13 (1): 2864. PubMed PMID:36806315 PubMed Central PMC9938282.
  6. Chen, T, O'Donnell, PH, Middlestadt, M, Ruhnke, GW, Danahey, K, van Wijk, XMR, Choksi, A, Knoebel, R, Hartman, S, Yeo, KJ et al.. Implementation of pharmacogenomics into inpatient general medicine. Pharmacogenet Genomics 2023; 33 (2): 19-23. PubMed PMID:36729768 .
  7. Linder, JE, Allworth, A, Bland, HT, Caraballo, PJ, Chisholm, RL, Clayton, EW, Crosslin, DR, Dikilitas, O, DiVietro, A, Esplin, ED et al.. Returning integrated genomic risk and clinical recommendations: The eMERGE study. Genet Med 2023; 25 (4): 100006. PubMed PMID:36621880 PubMed Central PMC10085845.
  8. Zhong, Y, De, T, Mishra, M, Avitia, J, Alarcon, C, Perera, MA. Leveraging drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans. Am J Hum Genet 2023; 110 (1): 58-70. PubMed PMID:36608685 PubMed Central PMC9892765.
  9. Yang, G, Alarcon, C, Friedman, P, Gong, L, Klein, T, O'Brien, T, Nutescu, EA, Tuck, M, Meltzer, D, Perera, MA et al.. The Role of Global and Local Ancestry on Clopidogrel Response in African Americans. Pac Symp Biocomput 2023; 28 : 221-232. PubMed PMID:36540979 PubMed Central PMC9782753.
  10. Zhang, H, Alarcon, C, Cavallari, LH, Nutescu, E, Carvill, GL, Perera, MA, Hernandez, W. Genomewide Association Study Identifies Copy Number Variants Associated With Warfarin Dose Response and Risk of Venous Thromboembolism in African Americans. Clin Pharmacol Ther 2023; 113 (3): 624-633. PubMed PMID:36507737 .
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Dr. Perera on Twitter

Dr. Perera on Twitter

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The Perera Lab Website

Curriculum vitae