Symposium Speaker: Giuseppe Tosto, MD

Dr. Giuseppe Tosto is a neurologist and Assistant Professor in Neurology at Columbia University, New York. He completed his residency training in Neurology at University “La Sapienza” in Rome (Italy) where he also completed the Neuroscience PhD program. He then joined Columbia University in 2011, first as a post-doc and then as an Assistant Professor of Neurology. His lab conducts genetic epidemiology research focusing on Alzheimer’s Disease and Related Dementia in admixed populations. He is the PI of multiple projects currently recruiting participants in U.S, Mexico, Peru, and Bolivia.


Recent Publications

  1. Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv 2023; : . PubMed PMID:37461624 PubMed Central PMC10350126.
  2. Walters, S, Contreras, AG, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS et al.. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol 2023; 80 (9): 929-939. PubMed PMID:37459083 PubMed Central PMC10352930.
  3. Siddiqui, T, Cosacak, MI, Popova, S, Bhattarai, P, Yilmaz, E, Lee, AJ, Min, Y, Wang, X, Allen, M, İş, Ö et al.. Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease. NPJ Regen Med 2023; 8 (1): 33. PubMed PMID:37429840 PubMed Central PMC10333226.
  4. Yang, Z, Huaman, BC, Reyes-Dumeyer, D, Montesinos, R, Soto-Añari, M, Custodio, N, Tosto, G. A benchmark study on current GWAS models in admixed populations. bioRxiv 2023; : . PubMed PMID:37163101 PubMed Central PMC10168347.
  5. Qiao, M, Lee, AJ, Reyes-Dumeyer, D, Tosto, G, Faber, K, Goate, A, Renton, A, Chao, M, Boeve, B, Cruchaga, C et al.. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. Ann Clin Transl Neurol 2023; 10 (5): 744-756. PubMed PMID:36946865 PubMed Central PMC10187719.
  6. Liu, M, Khasiyev, F, Sariya, S, Spagnolo-Allende, A, Sanchez, DL, Andrews, H, Yang, Q, Beiser, A, Qiao, Y, Thomas, EA et al.. Chromosome 10q24.32 Variants Associate with Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study. medRxiv 2023; : . PubMed PMID:36778463 PubMed Central PMC9915818.
  7. Rajabli, F, Tosto, G, Hamilton-Nelson, KL, Kunkle, BW, Vardarajan, BN, Naj, A, Whitehead, PG, Gardner, OK, Bush, WS, Sariya, S et al.. Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans. Alzheimers Dement 2023; 19 (6): 2538-2548. PubMed PMID:36539198 PubMed Central PMC10272044.
  8. Felsky, D, Santa-Maria, I, Cosacak, MI, French, L, Schneider, JA, Bennett, DA, De Jager, PL, Kizil, C, Tosto, G. The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms. Neurobiol Dis 2023; 176 : 105938. PubMed PMID:36462719 PubMed Central PMC10039465.
  9. Cosacak, MI, Bhattarai, P, De Jager, PL, Menon, V, Tosto, G, Kizil, C. Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer's Disease. Cells 2022; 11 (11): . PubMed PMID:35681503 PubMed Central PMC9180693.
  10. Lee, AJ, Raghavan, NS, Bhattarai, P, Siddiqui, T, Sariya, S, Reyes-Dumeyer, D, Flowers, XE, Cardoso, SAL, De Jager, PL, Bennett, DA et al.. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease. Acta Neuropathol 2022; 144 (1): 59-79. PubMed PMID:35608697 PubMed Central PMC9217776.
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The Tosto Lab Website

Curriculum vitae