Dr. Giuseppe Tosto is a neurologist and Assistant Professor in Neurology at Columbia University, New York. He completed his residency training in Neurology at University “La Sapienza” in Rome (Italy) where he also completed the Neuroscience PhD program. He then joined Columbia University in 2011, first as a post-doc and then as an Assistant Professor of Neurology. His lab conducts genetic epidemiology research focusing on Alzheimer’s Disease and Related Dementia in admixed populations. He is the PI of multiple projects currently recruiting participants in U.S, Mexico, Peru, and Bolivia.
Recent Publications
- Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease. Am J Hum Genet 2026; : . PubMed PMID:42066773 .
- Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. Alzheimers Dement 2026; 22 (4): e71433. PubMed PMID:42043782 PubMed Central PMC13116102.
- Liu, S, Bush, WS, Kunkle, BW, Byrd, GS, Reitz, C, Tosto, G, Rajabli, F, Caban-Holt, AM, Cuccaro, M, Starks, T et al.. Dissecting Alzheimer's disease heritability across populations. Alzheimers Dement 2026; 22 (3): e71236. PubMed PMID:41880092 PubMed Central PMC13093350.
- Contreras, AG, Walters, S, Eissman, JM, Archer, DB, Regelson, AN, Durant, A, Clifton, M, Mukherjee, S, Lee, ML, Choi, SE et al.. Genetic modifiers of APOE-ε4-associated cognitive decline. Nat Commun 2026; 17 (1): . PubMed PMID:41720779 PubMed Central PMC13036010.
- Dorfsman, DA, Cai, D, Hamilton-Nelson, KL, Adams, LD, Mena, PR, Rodriguez, VC, Sanchez, JJ, Valladares, GS, Lopez, M, Whitehead, PL et al.. Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181. J Alzheimers Dis 2026; 110 (2): 685-695. PubMed PMID:41660940 PubMed Central PMC12982544.
- Durodoye, RO, Ciesielski, TH, Benchek, P, Bartlett, J, Zhu, X, Liu, S, Naj, A, Kunkle, B, Schellenberg, GD, Mayeux, R et al.. Deviations from additivity in APOE4-mediated late-onset Alzheimer's disease risk across races and ethnicities. Hum Genet 2026; 145 (1): 16. PubMed PMID:41569459 PubMed Central PMC12827419.
- Zegarra-Valdivia, J, Mamani Quispe, RD, Chinoapaza Turpo, J, Paredes-Manrique, C, Malaga, M, Mamani-Benito, O, Montesinos, R, Custodio, N, Tosto, G. Prevalence of Neurocognitive Disorders in the Elderly Quechua Population Using the Q-RUDAS. Brain Sci 2025; 15 (12): . PubMed PMID:41440103 PubMed Central PMC12730204.
- Custodio, N, Soto-Añari, M, Montesinos, R, Malaga, M, Custodio, B, Chambergo-Michilot, D, Bustamante-Paytan, D, Yauri, Z, Agüero, K, Verastegui, G et al.. The modified Rowland Universal Dementia Assessment Scale for dementia screening in the Peruvian population. Dement Neuropsychol 2026; 20 : e2025377. PubMed PMID:41427105 PubMed Central PMC12714329.
- Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. medRxiv 2025; : . PubMed PMID:41404293 PubMed Central PMC12704622.
- Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease. bioRxiv 2025; : . PubMed PMID:41279621 PubMed Central PMC12637479.
