Dr. Giuseppe Tosto is a neurologist and Assistant Professor in Neurology at Columbia University, New York. He completed his residency training in Neurology at University “La Sapienza” in Rome (Italy) where he also completed the Neuroscience PhD program. He then joined Columbia University in 2011, first as a post-doc and then as an Assistant Professor of Neurology. His lab conducts genetic epidemiology research focusing on Alzheimer’s Disease and Related Dementia in admixed populations. He is the PI of multiple projects currently recruiting participants in U.S, Mexico, Peru, and Bolivia.
Recent Publications
- Carter, RC, Yang, Z, Akkaya-Hocagil, T, Jacobson, SW, Jacobson, JL, Dodge, NC, Hoyme, HE, Zeisel, SH, Meintjes, EM, Kizil, C et al.. Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in the South African Cape Coloured population. medRxiv 2024; : . PubMed PMID:38633769 PubMed Central PMC11023663.
- Ma, Y, Reyes-Dumeyer, D, Piriz, A, Recio, P, Mejia, DR, Medrano, M, Lantigua, RA, Vonsattel, JPG, Tosto, G, Teich, AF et al.. Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups. medRxiv 2024; : . PubMed PMID:38405911 PubMed Central PMC10889011.
- Xicota, L, Cosentino, S, Vardarajan, B, Mayeux, R, Perls, TT, Andersen, SL, Zmuda, JM, Thyagarajan, B, Yashin, A, Wojczynski, MK et al.. Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement 2024; 20 (4): 2670-2679. PubMed PMID:38380866 PubMed Central PMC11032545.
- Leung, YY, Naj, AC, Chou, YF, Valladares, O, Schmidt, M, Hamilton-Nelson, K, Wheeler, N, Lin, H, Gangadharan, P, Qu, L et al.. Human whole-exome genotype data for Alzheimer's disease. Nat Commun 2024; 15 (1): 684. PubMed PMID:38263370 PubMed Central PMC10805795.
- Tayran, H, Yilmaz, E, Bhattarai, P, Min, Y, Wang, X, Ma, Y, Nelson, N, Kassara, N, Cosacak, MI, Dogru, RM et al.. ABCA7-dependent Neuropeptide-Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer's disease. bioRxiv 2024; : . PubMed PMID:38260408 PubMed Central PMC10802315.
- Liu, M, Khasiyev, F, Sariya, S, Spagnolo-Allende, A, Sanchez, DL, Andrews, H, Yang, Q, Beiser, A, Qiao, Y, Thomas, EA et al.. Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study. J Am Heart Assoc 2023; 12 (23): e030935. PubMed PMID:38038215 PubMed Central PMC10727334.
- Yang, Z, Cieza, B, Reyes-Dumeyer, D, Montesinos, R, Soto-Añari, M, Custodio, N, Tosto, G. A benchmark study on current GWAS models in admixed populations. Brief Bioinform 2023; 25 (1): . PubMed PMID:38037235 PubMed Central PMC10689347.
- Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv 2023; : . PubMed PMID:37461624 PubMed Central PMC10350126.
- Walters, S, Contreras, AG, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS et al.. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol 2023; 80 (9): 929-939. PubMed PMID:37459083 PubMed Central PMC10352930.
- Siddiqui, T, Cosacak, MI, Popova, S, Bhattarai, P, Yilmaz, E, Lee, AJ, Min, Y, Wang, X, Allen, M, İş, Ö et al.. Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease. NPJ Regen Med 2023; 8 (1): 33. PubMed PMID:37429840 PubMed Central PMC10333226.
