Ignacio Mata, PhD, is Assistant Professor at Cleveland Clinic Lerner College of Medicine. He hold a Bachelor of Science and PhD in Human/Medical Genetics from la Universidad de Oviedo in Asturias, Spain, and he received his PhD in Neurogenetics from Mayo Clinic. Dr. Mata's lab is working towards identifying and understanding the genes that play a role in those diseases that affect the brain (neurological disorders). These include the very well-known Parkinson’s disease (PD), but also other less common disorders such as a form of PD that presents with severe cognitive problems/dementia (PDD) and another type of dementia called Dementia with Lewy Bodies (DLB).
Recent Publications
- Saffie-Awad, P, Grant, SM, Makarious, MB, Elsayed, I, Sanyaolu, AO, Crea, PW, Schumacher Schuh, AF, Levine, KS, Vitale, D, Koretsky, MJ et al.. Insights into ancestral diversity in Parkinson's disease risk: a comparative assessment of polygenic risk scores. NPJ Parkinsons Dis 2025; 11 (1): 201. PubMed PMID:40610451 PubMed Central PMC12229533.
- Gouveia, MH, Meeks, KAC, Borda, V, Leal, TP, Kehdy, FSG, Mogire, R, Doumatey, AP, Tarazona-Santos, E, Kittles, RA, Mata, IF et al.. Subcontinental genetic variation in the All of Us Research Program: Implications for biomedical research. Am J Hum Genet 2025; 112 (6): 1286-1301. PubMed PMID:40480197 PubMed Central PMC12256905.
- Step, K, Hernández, CF, Eltaraifee, E, Hernández-Medrano, AJ, Kung, PJ, Ostrožovičová, M, Zirra, A, Pérez-Palma, E, Mencacci, NE, Keller Sarmiento, IJ et al.. Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson's disease etiology across diverse ancestral populations. medRxiv 2025; : . PubMed PMID:40475162 PubMed Central PMC12140525.
- Tumas, V, Brito, MMCM, Borges, V, Ferraz, HB, Zabetian, CP, Mata, IF, Santos-Lobato, BL. Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics. Arq Neuropsiquiatr 2025; 83 (4): 1-5. PubMed PMID:40393687 PubMed Central PMC12092165.
- Piccinin, CC, Anis, S, Yu, JRT, Salles, PA, Chaparro-Solano, HM, Kundrick, A, Ivary, S, Liao, JY, Nagel, SJ, Mata, IF et al.. Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next. Mov Disord 2025; 40 (7): 1233-1247. PubMed PMID:40266017 PubMed Central PMC12273625.
- Schlickmann, TH, Tessari, MS, Borelli, WV, Marconi, GA, Pereira, GM, Zimmer, E, Noyce, A, Mata, IF, de Mello Rieder, CR, Teixeira-Dos-Santos, D et al.. Prevalence, distribution and future projections of Parkinson disease in Brazil: insights from the ELSI-Brazil cohort study. Lancet Reg Health Am 2025; 44 : 101046. PubMed PMID:40230590 PubMed Central PMC11995787.
- Chaparro-Solano, HM, Mata, IF. Authors' reply to "Comment on Chaparro-Solano et al.: 'Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review'". Parkinsonism Relat Disord 2025; 134 : 107804. PubMed PMID:40157818 .
- Lange, LM, Levine, K, Fox, SH, Marras, C, Ahmed, N, Kuznetsov, N, Vitale, D, Iwaki, H, Lohmann, K, Marsili, L et al.. The LRRK2 p.L1795F variant causes Parkinson's disease in the European population. NPJ Parkinsons Dis 2025; 11 (1): 58. PubMed PMID:40133296 PubMed Central PMC11937388.
- Tumas, V, Aureliano, MJ, Rieder, CRM, Schuh, AFS, Ferraz, HB, Borges, V, Soares, MC, Boone, DL, Silva, CCD, Costa, MC et al.. Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review. Arq Neuropsiquiatr 2025; 83 (3): 1-10. PubMed PMID:40107260 PubMed Central PMC11922612.
- Ramchandra, J, Inca-Martinez, M, Leal, TP, Chaparro-Solano, HM, Salim, A, Gatto, EM, Rojas, NG, Da Prat, G, Micheli, F, Santos-Lobato, BL et al.. Sex differences in the diagnosis latency of Parkinson's disease in Latin America. Parkinsonism Relat Disord 2025; 134 : 107344. PubMed PMID:40058072 .
