Ignacio Mata, PhD, is Assistant Professor at Cleveland Clinic Lerner College of Medicine. He hold a Bachelor of Science and PhD in Human/Medical Genetics from la Universidad de Oviedo in Asturias, Spain, and he received his PhD in Neurogenetics from Mayo Clinic. Dr. Mata's lab is working towards identifying and understanding the genes that play a role in those diseases that affect the brain (neurological disorders). These include the very well-known Parkinson’s disease (PD), but also other less common disorders such as a form of PD that presents with severe cognitive problems/dementia (PDD) and another type of dementia called Dementia with Lewy Bodies (DLB).
Recent Publications
- Blauwendraat, C, Noyce, AJ, Mata, IF, Screven, LA, Solle, J, Dumanis, SB, Riley, EA, Periñan, MT, Okubadejo, N, Klein, C et al.. Tackling a disease on a global scale, the Global Parkinson's Genetics Program, GP2: A new generation of opportunities. Am J Hum Genet 2025; : . PubMed PMID:40834859 .
- Step, K, Leal, TP, Kamel, WA, Waldo, E, Bardien, S, Mata, IF. X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome. Front Genet 2025; 16 : 1650259. PubMed PMID:40809846 PubMed Central PMC12343220.
- Leal, TP, Waldo, E, Duarte-Zambrano, F, Inca-Martinez, M, Ramchandra, J, Chaparro-Solano, HM, Anello, AE, Borda, V, Gouveia, MH, Teixeira-Dos-Santos, D et al.. Genotype-phenotype association study conducted on LARGE-PD reveals novel loci associated with Parkinson's Disease. medRxiv 2025; : . PubMed PMID:40791673 PubMed Central PMC12338945.
- Step, K, Leal, TP, Waldo, E, Madula, L, Swart, Y, Hernández, CF, Kim, JJ, Bandres-Ciga, S, Global Parkinson’s Genetics Program (GP2), Mata, IF et al.. Genome-wide association analyses reveal susceptibility variants linked to Parkinson's disease in the South African population using inferred global and local ancestry. medRxiv 2025; : . PubMed PMID:40766124 PubMed Central PMC12324638.
- Saffie-Awad, P, Grant, SM, Makarious, MB, Elsayed, I, Sanyaolu, AO, Crea, PW, Schumacher Schuh, AF, Levine, KS, Vitale, D, Koretsky, MJ et al.. Insights into ancestral diversity in Parkinson's disease risk: a comparative assessment of polygenic risk scores. NPJ Parkinsons Dis 2025; 11 (1): 201. PubMed PMID:40610451 PubMed Central PMC12229533.
- Gouveia, MH, Meeks, KAC, Borda, V, Leal, TP, Kehdy, FSG, Mogire, R, Doumatey, AP, Tarazona-Santos, E, Kittles, RA, Mata, IF et al.. Subcontinental genetic variation in the All of Us Research Program: Implications for biomedical research. Am J Hum Genet 2025; 112 (6): 1286-1301. PubMed PMID:40480197 PubMed Central PMC12256905.
- Step, K, Hernández, CF, Eltaraifee, E, Hernández-Medrano, AJ, Kung, PJ, Ostrožovičová, M, Zirra, A, Pérez-Palma, E, Mencacci, NE, Keller Sarmiento, IJ et al.. Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson's disease etiology across diverse ancestral populations. medRxiv 2025; : . PubMed PMID:40475162 PubMed Central PMC12140525.
- Tumas, V, Brito, MMCM, Borges, V, Ferraz, HB, Zabetian, CP, Mata, IF, Santos-Lobato, BL. Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics. Arq Neuropsiquiatr 2025; 83 (4): 1-5. PubMed PMID:40393687 PubMed Central PMC12092165.
- Piccinin, CC, Anis, S, Yu, JRT, Salles, PA, Chaparro-Solano, HM, Kundrick, A, Ivary, S, Liao, JY, Nagel, SJ, Mata, IF et al.. Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next. Mov Disord 2025; 40 (7): 1233-1247. PubMed PMID:40266017 PubMed Central PMC12273625.
- Schlickmann, TH, Tessari, MS, Borelli, WV, Marconi, GA, Pereira, GM, Zimmer, E, Noyce, A, Mata, IF, de Mello Rieder, CR, Teixeira-Dos-Santos, D et al.. Prevalence, distribution and future projections of Parkinson disease in Brazil: insights from the ELSI-Brazil cohort study. Lancet Reg Health Am 2025; 44 : 101046. PubMed PMID:40230590 PubMed Central PMC11995787.
