Ignacio Mata, PhD, is Assistant Professor at Cleveland Clinic Lerner College of Medicine. He hold a Bachelor of Science and PhD in Human/Medical Genetics from la Universidad de Oviedo in Asturias, Spain, and he received his PhD in Neurogenetics from Mayo Clinic. Dr. Mata's lab is working towards identifying and understanding the genes that play a role in those diseases that affect the brain (neurological disorders). These include the very well-known Parkinson’s disease (PD), but also other less common disorders such as a form of PD that presents with severe cognitive problems/dementia (PDD) and another type of dementia called Dementia with Lewy Bodies (DLB).
Recent Publications
- Step, K, Madula, L, Kuznetsov, N, Maasdorp, E, Carr, J, van Coller, R, Möller, M, Mata, IF, Bardien, S, Global Parkinson's Genetics Program (GP2) et al.. Comprehensive genetic screening of the South African Parkinson's disease study collection using the NeuroBooster array. Clin Park Relat Disord 2026; 15 : 100508. PubMed PMID:42890374 PubMed Central PMC13672830.
- Chaparro-Solano, HM, Saadatpour, L, Yu, JRT, Sonneborn, C, Peixoto-Leal, T, Piccinin, CC, Anis, S, Kaur, H, Assaedi, E, Mata, IF et al.. Disentangling amantadine response variability in levodopa related dyskinesias: Role of clinical and genetic factors. Parkinsonism Relat Disord 2026; 153 : 109000. PubMed PMID:42832827 .
- Waldo, E, Chaparro-Solano, HM, Isayan, M, Leal, TP, Duarte-Zambrano, F, Inca-Martinez, M, Ramchandra, J, Rivera Paz, M, Makarious, MB, Hernandez, C et al.. Genomic Landscape of Early-Onset and Familial Latin American Parkinson's Patients. medRxiv 2026; : . PubMed PMID:42818089 PubMed Central PMC13622300.
- Jones, L, Cerquera-Cleves, C, Schuh, AFS, Makarious, M, Iwaki, H, Nalls, M, Noyce, AJ, Blauwendraat, C, Singleton, AB, Mata, IF et al.. Population Attributable Risk in Alzheimer and Parkinson Diseases. Neurol Genet 2026; 12 (4): e200415. PubMed PMID:42639394 PubMed Central PMC13501451.
- Lange, LM, Fang, ZH, Makarious, MB, Kuznetsov, N, Atterling Brolin, K, Ballard, S, Bardien, S, Doquenia, ML, Heutink, P, Houlden, H et al.. Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications. Lancet Neurol 2026; 25 (8): 741-754. PubMed PMID:42456684 PubMed Central PMC13446284.
- Reyes-Pérez, P, Hor, JW, Toh, TS, Sanyaolu, AO, Pantazis, CB, Leal, TP, Yeboah, S, Bandres-Ciga, S, Morris, HR, Makarious, MB et al.. Exploring MAPT-containing H1 and H2 haplotypes in Parkinson's disease across diverse populations. NPJ Parkinsons Dis 2026; 12 (1): . PubMed PMID:42342696 PubMed Central PMC13452820.
- Wu, LY, du Toit, T, Georgiades, T, Stafford, EJ, Levine, K, Fang, ZH, Jasaityte, S, Martinez, AG, Cullinane, P, De Pablo-Fernandez, E et al.. Pathology and Genetics in a Global Cohort of Parkinsonian Disorders. JAMA Neurol 2026; 83 (8): 798-807. PubMed PMID:42258190 PubMed Central PMC13247843.
- Correa, LVS, do Nascimento, AM, Santos-Lobato, BL, Chaparro-Solano, HM, Mata, IF, Tumas, V. Placebo Effect in Levodopa-Induced Dyskinesia: A Systematic Review and Meta-Analysis. Mov Disord Clin Pract 2026; : . PubMed PMID:42185744 PubMed Central PMC13339215.
- Flores-Ocampo, V, Zirra, A, Tay, YW, van Midden, V, Mata, IF, Noyce, AJ, Periñan, MT, Global Parkinson's Genetics Program (GP2). The Global Parkinson's Genetics Program (GP2): Advancing genetic discovery and capacity building worldwide. J Parkinsons Dis 2026; 16 (4): 617-628. PubMed PMID:42159407 PubMed Central PMC13435180.
- Atterling Brolin, K, Lange, LM, Navarro-Jones, E, Jasaityte, S, Ye Beh, Y, Fang, ZH, Iwaki, H, Jones, L, Klein, C, Kleinz, T et al.. Bridging Genetics and Precision Medicine in Parkinson's Disease through GP2. medRxiv 2026; : . PubMed PMID:42051573 PubMed Central PMC13119358.
