Dr. Sedor is Professor of Physiology and Biophysics and Director of the Case Center for the Study of Kidney Biology and Disease at Case Western Reserve University; Professor of Molecular Medicine at Cleveland Clinic Lerner College of Medicine; and Ray W. Gifford, M.D. Endowed Chair in Kidney Research at the Glickman Urology & Kidney Institute. Dr. Sedor is board certified in internal medicine and nephrology and is a practicing physician scientist as Staff of the Department of Nephrology and Hypertension at Cleveland Clinic. Dr. Sedor's research interests focus on progressive kidney disease mechanisms, and his research team's goals are to define clinical, cellular, and genetic bases of kidney disease to identify new therapies and diagnostic tests. Dr. Sedor is a leader and active member of several research consortia, include the Nephrotic Syndrome Study Network (NEPTUNE) and Cure Glomerulonephropathy (CureGN). Dr. Sedor is also a co-Principal Investigator of the Cleveland ascertainment site for the NIDDK-supported Kidney Precision Medicine Project (KPMP), a national collaborative effort that aims to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies. Dr. Sedor's current investigator-initiated projects focus on kidney disease attributable to APOL1 renal risk variants, the major genetic contributors to observed racial disparities in chronic kidney disease, and use of electronic health records to identify diabetic patients with renal complications.
- KDIGO Conference Participants. Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 2022; 101 (6): 1126-1141. PubMed PMID:35460632 .
- Butler, CR, Appelbaum, PS, Ascani, H, Aulisio, M, Campbell, CE, de Boer, IH, Dighe, AL, Hall, DE, Himmelfarb, J, Knight, R et al.. A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project. Am J Kidney Dis 2021; : . PubMed PMID:34871700 .
- Kurella Tamura, M, Gaussoin, S, Pajewski, NM, Zaharchuk, G, Freedman, BI, Rapp, SR, Auchus, AP, Haley, WE, Oparil, S, Kendrick, J et al.. Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure. Am J Kidney Dis 2022; 79 (5): 677-687.e1. PubMed PMID:34543687 PubMed Central PMC8926938.
- Crawford, DC, Sedor, JR. Biobanks Linked to Electronic Health Records Accelerate Genomic Discovery. J Am Soc Nephrol 2021; 32 (8): 1828-1829. PubMed PMID:34244324 PubMed Central PMC8455265.
- Schold, JD, Huml, AM, Poggio, ED, Sedor, JR, Husain, SA, King, KL, Mohan, S. Patients with High Priority for Kidney Transplant Who Are Not Given Expedited Placement on the Transplant Waiting List Represent Lost Opportunities. J Am Soc Nephrol 2021; : . PubMed PMID:34140398 PubMed Central PMC8425662.
- Blessing, NA, Wu, Z, Madhavan, SM, Choy, JW, Chen, M, Shin, MK, Hoek, M, Sedor, JR, O'Toole, JF, Bruggeman, LA et al.. Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys. PLoS One 2021; 16 (6): e0253197. PubMed PMID:34138902 PubMed Central PMC8211208.
- Nakhoul, GN, Mehdi, A, Taliercio, JJ, Arrigain, S, Schold, JD, Spencer, A, Greenfield, J, Diwakar, A, Snyder, G, O'Toole, J et al.. "What do you think about nephrology?" A national survey of internal medicine residents. BMC Nephrol 2021; 22 (1): 190. PubMed PMID:34020598 PubMed Central PMC8140430.
- SPRINT Research Group, Lewis, CE, Fine, LJ, Beddhu, S, Cheung, AK, Cushman, WC, Cutler, JA, Evans, GW, Johnson, KC, Kitzman, DW et al.. Final Report of a Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2021; 384 (20): 1921-1930. PubMed PMID:34010531 .
- Sedor, JR, Bruggeman, LA, O'Toole, JF. APOL1 and Preeclampsia: Intriguing Links, Uncertain Causality, Troubling Implications. Am J Kidney Dis 2021; 77 (6): 863-865. PubMed PMID:33875279 .
- Sethi, A, Miao, J, Willrich, MAV, Frinack, JL, Cattran, DC, Fervenza, FC, MENTOR study Investigators, MENTOR study investigators. Limited Significance of Antifactor H Antibodies in Patients with Membranous Nephropathy. Clin J Am Soc Nephrol 2021; 16 (6): 939-941. PubMed PMID:33858828 PubMed Central PMC8216609.