Symposium Speaker: John Sedor, MD

Dr. Sedor is Professor of Physiology and Biophysics and Director of the Case Center for the Study of Kidney Biology and Disease at Case Western Reserve University; Professor of Molecular Medicine at Cleveland Clinic Lerner College of Medicine; and Ray W. Gifford, M.D. Endowed Chair in Kidney Research at the Glickman Urology & Kidney Institute.  Dr. Sedor is board certified in internal medicine and nephrology and is a practicing physician scientist as Staff of the Department of Nephrology and Hypertension at Cleveland Clinic.  Dr. Sedor's research interests focus on progressive kidney disease mechanisms, and his research team's goals are to define clinical, cellular, and genetic bases of kidney disease to identify new therapies and diagnostic tests.  Dr. Sedor is a leader and active member of several research consortia, include the Nephrotic Syndrome Study Network (NEPTUNE) and Cure Glomerulonephropathy (CureGN).  Dr. Sedor is also a co-Principal Investigator of the Cleveland ascertainment site for the NIDDK-supported Kidney Precision Medicine Project (KPMP), a national collaborative effort that aims to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies.  Dr. Sedor's current investigator-initiated projects focus on kidney disease attributable to APOL1 renal risk variants, the major genetic contributors to observed racial disparities in chronic kidney disease, and use of electronic health records to identify diabetic patients with renal complications.

Recent Publications

  1. Lake, BB, Menon, R, Winfree, S, Hu, Q, Melo Ferreira, R, Kalhor, K, Barwinska, D, Otto, EA, Ferkowicz, M, Diep, D et al.. An atlas of healthy and injured cell states and niches in the human kidney. Nature 2023; 619 (7970): 585-594. PubMed PMID:37468583 PubMed Central PMC10356613.
  2. Sedor, JR. APOL1 Kidney Disease: Discovery to Targeted Therapy in 10 Years. Clin J Am Soc Nephrol 2023; : . PubMed PMID:37459117 .
  3. Sedor, JR. Kidney Genetics: Continuing Discoveries and a Roadmap to the Clinic. J Am Soc Nephrol 2023; 34 (4): 519-520. PubMed PMID:36758119 PubMed Central PMC10103286.
  4. Cholin, LK, Schold, JD, Arrigain, S, Poggio, ED, Sedor, JR, O'Toole, JF, Augustine, JJ, Wee, AC, Huml, AM. Characteristics of Potential and Actual Living Kidney Donors: A Single-center Experience. Transplantation 2023; 107 (4): 941-951. PubMed PMID:36476994 .
  5. Mariani, LH, Eddy, S, AlAkwaa, FM, McCown, PJ, Harder, JL, Nair, V, Eichinger, F, Martini, S, Ademola, AD, Boima, V et al.. Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis. Kidney Int 2023; 103 (3): 565-579. PubMed PMID:36442540 PubMed Central PMC10347421.
  6. Hong, C, Eichinger, F, Atta, MG, Estrella, MM, Fine, DM, Ross, MJ, Wyatt, C, Hwang, TH, Kretzler, M, Sedor, JR et al.. Viral associations with kidney disease diagnosis and altered kidney metatranscriptome by kidney function. Kidney Int 2023; 103 (1): 218-222. PubMed PMID:36356649 PubMed Central PMC9822862.
  7. Liu, J, Nair, V, Zhao, YY, Chang, DY, Limonte, C, Bansal, N, Fermin, D, Eichinger, F, Tanner, EC, Bellovich, KA et al.. Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease. Diabetes 2022; 71 (12): 2664-2676. PubMed PMID:36331122 PubMed Central PMC9750948.
  8. Liu, S, Bush, WS, Miskimen, K, Gonzalez-Vicente, A, Bailey, JNC, Konidari, I, McCauley, JL, Sedor, JR, O'Toole, JF, Crawford, DC et al.. T-cell receptor diversity in minimal change disease in the NEPTUNE study. Pediatr Nephrol 2023; 38 (4): 1115-1126. PubMed PMID:35943576 PubMed Central PMC10037226.
  9. Madhavan, SM, Konieczkowski, M, Bruggeman, LA, DeWalt, M, Nguyen, JK, O'Toole, JF, Sedor, JR. Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier. Am J Physiol Renal Physiol 2022; 323 (3): F272-F287. PubMed PMID:35862649 PubMed Central PMC9394782.
  10. KDIGO Conference Participants. Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 2022; 101 (6): 1126-1141. PubMed PMID:35460632 PubMed Central PMC9922534.
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The Sedor Website

Curriculum vitae