Dr. Sedor is Professor of Physiology and Biophysics and Director of the Case Center for the Study of Kidney Biology and Disease at Case Western Reserve University; Professor of Molecular Medicine at Cleveland Clinic Lerner College of Medicine; and Ray W. Gifford, M.D. Endowed Chair in Kidney Research at the Glickman Urology & Kidney Institute. Dr. Sedor is board certified in internal medicine and nephrology and is a practicing physician scientist as Staff of the Department of Nephrology and Hypertension at Cleveland Clinic. Dr. Sedor's research interests focus on progressive kidney disease mechanisms, and his research team's goals are to define clinical, cellular, and genetic bases of kidney disease to identify new therapies and diagnostic tests. Dr. Sedor is a leader and active member of several research consortia, include the Nephrotic Syndrome Study Network (NEPTUNE) and Cure Glomerulonephropathy (CureGN). Dr. Sedor is also a co-Principal Investigator of the Cleveland ascertainment site for the NIDDK-supported Kidney Precision Medicine Project (KPMP), a national collaborative effort that aims to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies. Dr. Sedor's current investigator-initiated projects focus on kidney disease attributable to APOL1 renal risk variants, the major genetic contributors to observed racial disparities in chronic kidney disease, and use of electronic health records to identify diabetic patients with renal complications.
- Crawford, DC, Sedor, JR. Biobanks Linked to Electronic Health Records Accelerate Genomic Discovery. J Am Soc Nephrol 2021; 32 (8): 1828-1829. PubMed PMID:34244324 PubMed Central PMC8455265.
- Schold, JD, Huml, AM, Poggio, ED, Sedor, JR, Husain, SA, King, KL, Mohan, S. Patients with High Priority for Kidney Transplant Who Are Not Given Expedited Placement on the Transplant Waiting List Represent Lost Opportunities. J Am Soc Nephrol 2021; : . PubMed PMID:34140398 PubMed Central PMC8425662.
- Blessing, NA, Wu, Z, Madhavan, SM, Choy, JW, Chen, M, Shin, MK, Hoek, M, Sedor, JR, O'Toole, JF, Bruggeman, LA et al.. Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys. PLoS One 2021; 16 (6): e0253197. PubMed PMID:34138902 PubMed Central PMC8211208.
- Nakhoul, GN, Mehdi, A, Taliercio, JJ, Arrigain, S, Schold, JD, Spencer, A, Greenfield, J, Diwakar, A, Snyder, G, O'Toole, J et al.. "What do you think about nephrology?" A national survey of internal medicine residents. BMC Nephrol 2021; 22 (1): 190. PubMed PMID:34020598 PubMed Central PMC8140430.
- SPRINT Research Group, Lewis, CE, Fine, LJ, Beddhu, S, Cheung, AK, Cushman, WC, Cutler, JA, Evans, GW, Johnson, KC, Kitzman, DW et al.. Final Report of a Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2021; 384 (20): 1921-1930. PubMed PMID:34010531 .
- Sedor, JR, Bruggeman, LA, O'Toole, JF. APOL1 and Preeclampsia: Intriguing Links, Uncertain Causality, Troubling Implications. Am J Kidney Dis 2021; 77 (6): 863-865. PubMed PMID:33875279 .
- Sethi, A, Miao, J, Willrich, MAV, Frinack, JL, Cattran, DC, Fervenza, FC, MENTOR study Investigators, MENTOR study investigators. Limited Significance of Antifactor H Antibodies in Patients with Membranous Nephropathy. Clin J Am Soc Nephrol 2021; 16 (6): 939-941. PubMed PMID:33858828 PubMed Central PMC8216609.
- Freedman, BI, Burke, W, Divers, J, Eberhard, L, Gadegbeku, CA, Gbadegesin, R, Hall, ME, Jones-Smith, T, Knight, R, Kopp, JB et al.. Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review. J Am Soc Nephrol 2021; : . PubMed PMID:33853887 PubMed Central PMC8425659.
- Bruggeman, LA, Sedor, JR, O'Toole, JF. Apolipoprotein L1 and mechanisms of kidney disease susceptibility. Curr Opin Nephrol Hypertens 2021; 30 (3): 317-323. PubMed PMID:33767059 PubMed Central PMC8211384.
- Nasrallah, IM, Gaussoin, SA, Pomponio, R, Dolui, S, Erus, G, Wright, CB, Launer, LJ, Detre, JA, Wolk, DA, Davatzikos, C et al.. Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial. JAMA Neurol 2021; 78 (5): 568-577. PubMed PMID:33683313 PubMed Central PMC7941253.