Symposium Speaker: Marylyn D. Ritchie, PhD, MS

Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University.  Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic.  Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases.  Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease.  Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research.  Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years.  Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014).  Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.

Recent Publications

  1. Lau-Min, KS, McKenna, D, Asher, SB, Bardakjian, T, Wollack, C, Bleznuck, J, Biros, D, Anantharajah, A, Clark, DF, Condit, C et al.. Impact of integrating genomic data into the electronic health record on genetics care delivery. Genet Med 2022; : . PubMed PMID:36107166 .
  2. Ramdas, S, Judd, J, Graham, SE, Kanoni, S, Wang, Y, Surakka, I, Wenz, B, Clarke, SL, Chesi, A, Wells, A et al.. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet 2022; 109 (8): 1366-1387. PubMed PMID:35931049 PubMed Central PMC9388392.
  3. COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19. Nature 2022; 608 (7921): E1-E10. PubMed PMID:35922517 PubMed Central PMC9352569.
  4. Tcheandjieu, C, Zhu, X, Hilliard, AT, Clarke, SL, Napolioni, V, Ma, S, Lee, KM, Fang, H, Chen, F, Lu, Y et al.. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med 2022; 28 (8): 1679-1692. PubMed PMID:35915156 PubMed Central PMC9419655.
  5. Chen, BY, Bone, WP, Lorenz, K, Levin, M, Ritchie, MD, Voight, BF. ColocQuiaL: A QTL-GWAS colocalization pipeline. Bioinformatics 2022; : . PubMed PMID:35894642 PubMed Central PMC9477517.
  6. Banday, AR, Stanifer, ML, Florez-Vargas, O, Onabajo, OO, Papenberg, BW, Zahoor, MA, Mirabello, L, Ring, TJ, Lee, CH, Albert, PS et al.. Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nat Genet 2022; 54 (8): 1103-1116. PubMed PMID:35835913 PubMed Central PMC9355882.
  7. Liu, H, Doke, T, Guo, D, Sheng, X, Ma, Z, Park, J, Vy, HMT, Nadkarni, GN, Abedini, A, Miao, Z et al.. Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease. Nat Genet 2022; 54 (7): 950-962. PubMed PMID:35710981 .
  8. Zhang, X, Lucas, AM, Veturi, Y, Drivas, TG, Bone, WP, Verma, A, Chung, WK, Crosslin, D, Denny, JC, Hebbring, S et al.. Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders. Nat Commun 2022; 13 (1): 3428. PubMed PMID:35701404 PubMed Central PMC9198016.
  9. Zhang, C, Verma, A, Feng, Y, Melo, MCR, McQuillan, M, Hansen, M, Lucas, A, Park, J, Ranciaro, A, Thompson, S et al.. Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection. Proc Natl Acad Sci U S A 2022; 119 (21): e2123000119. PubMed PMID:35580180 PubMed Central PMC9173769.
  10. Cindi, Z, Kawuma, AN, Maartens, G, Bradford, Y, Venter, F, Sokhela, S, Chandiwana, N, Wasmann, RE, Denti, P, Wiesner, L et al.. Pharmacogenetics of dolutegravir plasma exposure among Southern Africans living with HIV. J Infect Dis 2022; : . PubMed PMID:35512135 .
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Dr. Ritchie on Twitter

Dr. Ritchie on Twitter

Same here. Zoom went boom! 💥…

@merrylindseyphd I have on my to do list: "schedule meeting". Oops. No clue with who or about what.

@NouraAbulHusn @23andMe @annewoj23 Wow! I just heard the news today. congratulations @NouraAbulHusn . Sounds really exciting. I cannot wait to run into you and @AmyCurrySturm to hear about what y'all are up to out there. Best wishes to you in your new role.

I could not be more proud of you, @TDrivas. Congratulations!!!! It brings me so much joy to work with you. I can’t wait to see all the exciting discoveries you make in the coming years.…

Aloha Friday 🌴 and congratulations to the two newest PhD candidates in the Ritchie Lab. @scientistvan and @karlkeat passed their candidacy exams this week in @UPennGCB. #proudmentor #nextgeneration

test Twitter Media - Aloha Friday 🌴 and congratulations to the two newest PhD candidates in the Ritchie Lab. @scientistvan and @karlkeat passed their candidacy exams this week in @UPennGCB. #proudmentor #nextgeneration

@cazencott Sorry to hear this. I hope you feel better soon.

@drGregBowman Congrats!!! I hope the rest of the move goes as smoothly. You are going to love working @Penn.

Congratulations to @sudhaveturi whose paper made it into the @AMIAinformatics #IS22 TBI Year in Review #YIR22. Thank you to @nicktatonetti for recognizing this exciting and important paper. Also special thanks to all the co-authors. Here is the paper:…

It was so fun to get back into the podcast studio this weekend. Sometimes, it is difficult to find a quiet hour to record. But when I get into the studio, it always makes me happy. I hope this episode is helpful to those of you looking for mentors. #worklifeharmony #mentor…

Are you a grad student trying to decide what lab you should join? Are you trying to decide what PhD program is right for you? Or are you a person who is looking for mentors in any stage of life? If you answered yes to any of these, then this episode is for you! #mentorship…

I am really excited to share my strategies on work-life harmony at this webinar. This important topic is the focus of my podcast @theCALMpodcast. Thank you for the opportunity @GeneticsSociety…

@AllofUsCEO @GwasDiversity Congratulations! What an amazing milestone. I’m excited to start working with the data.

The Ritchie Lab Website

Curriculum vitae