Symposium Speaker: Marylyn D. Ritchie, PhD, MS

Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University.  Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic.  Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases.  Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease.  Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research.  Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years.  Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014).  Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.

Recent Publications

  1. Hou, B, Wen, Z, Bao, J, Zhang, R, Tong, B, Yang, S, Wen, J, Cui, Y, Moore, JH, Saykin, AJ et al.. Interpretable deep clustering survival machines for Alzheimer's disease subtype discovery. Med Image Anal 2024; 97 : 103231. PubMed PMID:38941858 .
  2. Vu, PT, Chahine, C, Chatterjee, N, MacLean, MT, Swago, S, Bhattaru, A, Thompson, EW, Ikhlas, A, Oteng, E, Davidson, L et al.. CT imaging-derived phenotypes for abdominal muscle and their association with age and sex in a medical biobank. Sci Rep 2024; 14 (1): 14807. PubMed PMID:38926479 PubMed Central PMC11208425.
  3. Yang, X, Sullivan, PF, Li, B, Fan, Z, Ding, D, Shu, J, Guo, Y, Paschou, P, Bao, J, Shen, L et al.. Multi-organ imaging-derived polygenic indexes for brain and body health. medRxiv 2024; : . PubMed PMID:38883759 PubMed Central PMC11177904.
  4. Bao, J, Lee, BN, Wen, J, Kim, M, Mu, S, Yang, S, Davatzikos, C, Long, Q, Ritchie, MD, Shen, L et al.. Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes. Annu Rev Biomed Data Sci 2024; : . PubMed PMID:38848574 .
  5. Moore, A, Ritchie, MD. Cross-phenotype associations between Alzheimer's Disease and its comorbidities may provide clues to progression. AMIA Jt Summits Transl Sci Proc 2024; 2024 : 623-631. PubMed PMID:38827078 PubMed Central PMC11141840.
  6. Hou, B, Mondragón, A, Tarzanagh, DA, Zhou, Z, Saykin, AJ, Moore, JH, Ritchie, MD, Long, Q, Shen, L. PFERM: A Fair Empirical Risk Minimization Approach with Prior Knowledge. AMIA Jt Summits Transl Sci Proc 2024; 2024 : 211-220. PubMed PMID:38827072 PubMed Central PMC11141835.
  7. Kumar, R, Venkatesh, R, Ritchie, MD. SABER: Statistical Identification of Loci of Interest in GWAS Summary Statistics using a Bayesian Gaussian Mixture Model. AMIA Jt Summits Transl Sci Proc 2024; 2024 : 575-583. PubMed PMID:38827044 PubMed Central PMC11141805.
  8. Hui, D, Dudek, S, Kiryluk, K, Walunas, TL, Kullo, IJ, Wei, WQ, Tiwari, HK, Peterson, JF, Chung, WK, Davis, B et al.. Risk factors affecting polygenic score performance across diverse cohorts. medRxiv 2024; : . PubMed PMID:38645167 PubMed Central PMC11030495.
  9. Romano, JD, Truong, V, Kumar, R, Venkatesan, M, Graham, BE, Hao, Y, Matsumoto, N, Li, X, Wang, Z, Ritchie, MD et al.. The Alzheimer's Knowledge Base: A Knowledge Graph for Alzheimer Disease Research. J Med Internet Res 2024; 26 : e46777. PubMed PMID:38635981 PubMed Central PMC11066745.
  10. Yun, JS, Jung, SH, Lee, SN, Jung, SM, Penn Medicine Biobank, Won, HH, Kim, D, Choi, JA. Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks. J Transl Med 2024; 22 (1): 355. PubMed PMID:38622600 PubMed Central PMC11020996.
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Dr. Ritchie on Twitter

Dr. Ritchie on Twitter

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The Ritchie Lab Website

Curriculum vitae