Symposium Speaker: Marylyn D. Ritchie, PhD, MS

Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University.  Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic.  Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases.  Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease.  Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research.  Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years.  Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014).  Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.

Recent Publications

  1. Zhang, C, Verma, A, Feng, Y, Melo, MCR, McQuillan, M, Hansen, M, Lucas, A, Park, J, Ranciaro, A, Thompson, S et al.. Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection. Proc Natl Acad Sci U S A 2022; 119 (21): e2123000119. PubMed PMID:35580180 .
  2. Cindi, Z, Kawuma, AN, Maartens, G, Bradford, Y, Venter, F, Sokhela, S, Chandiwana, N, Wasmann, RE, Denti, P, Wiesner, L et al.. Pharmacogenetics of dolutegravir plasma exposure among Southern Africans living with HIV. J Infect Dis 2022; : . PubMed PMID:35512135 .
  3. Wiley, K, Findley, L, Goldrich, M, Rakhra-Burris, TK, Stevens, A, Williams, P, Bult, CJ, Chisholm, R, Deverka, P, Ginsburg, GS et al.. A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. J Am Med Inform Assoc 2022; : . PubMed PMID:35485600 .
  4. Verma, A, Tsao, NL, Thomann, LO, Ho, YL, Iyengar, SK, Luoh, SW, Carr, R, Crawford, DC, Efird, JT, Huffman, JE et al.. A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. PLoS Genet 2022; 18 (4): e1010113. PubMed PMID:35482673 PubMed Central PMC9049369.
  5. Chand, GB, Singhal, P, Dwyer, DB, Wen, J, Erus, G, Doshi, J, Srinivasan, D, Mamourian, E, Varol, E, Sotiras, A et al.. Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population. Am J Psychiatry 2022; : appiajp21070686. PubMed PMID:35410495 .
  6. Wen, J, Fu, CHY, Tosun, D, Veturi, Y, Yang, Z, Abdulkadir, A, Mamourian, E, Srinivasan, D, Skampardoni, I, Singh, A et al.. Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression. JAMA Psychiatry 2022; 79 (5): 464-474. PubMed PMID:35262657 PubMed Central PMC8908227.
  7. Kousathanas, A, Pairo-Castineira, E, Rawlik, K, Stuckey, A, Odhams, CA, Walker, S, Russell, CD, Malinauskas, T, Wu, Y, Millar, J et al.. Whole genome sequencing reveals host factors underlying critical Covid-19. Nature 2022; : . PubMed PMID:35255492 .
  8. Horowitz, JE, Kosmicki, JA, Damask, A, Sharma, D, Roberts, GHL, Justice, AE, Banerjee, N, Coignet, MV, Yadav, A, Leader, JB et al.. Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease. Nat Genet 2022; 54 (4): 382-392. PubMed PMID:35241825 PubMed Central PMC9005345.
  9. Bellomo, TR, Bone, WP, Chen, BY, Gawronski, KAB, Zhang, D, Park, J, Levin, M, Tsao, N, Klarin, D, Lynch, J et al.. Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci. Front Genet 2021; 12 : 787545. PubMed PMID:35186008 PubMed Central PMC8847690.
  10. Haas, DW, Abdelwahab, MT, van Beek, SW, Baker, P, Maartens, G, Bradford, Y, Ritchie, MD, Wasserman, S, Meintjes, G, Beeri, K et al.. Pharmacogenetics of Between-Individual Variability in Plasma Clearance of Bedaquiline and Clofazimine in South Africa. J Infect Dis 2022; : . PubMed PMID:35091749 .
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Dr. Ritchie on Twitter

Dr. Ritchie on Twitter

@cazencott Sorry to hear this. I hope you feel better soon.

@drGregBowman Congrats!!! I hope the rest of the move goes as smoothly. You are going to love working @Penn.

Congratulations to @sudhaveturi whose paper made it into the @AMIAinformatics #IS22 TBI Year in Review #YIR22. Thank you to @nicktatonetti for recognizing this exciting and important paper. Also special thanks to all the co-authors. Here is the paper:…

It was so fun to get back into the podcast studio this weekend. Sometimes, it is difficult to find a quiet hour to record. But when I get into the studio, it always makes me happy. I hope this episode is helpful to those of you looking for mentors. #worklifeharmony #mentor…

Are you a grad student trying to decide what lab you should join? Are you trying to decide what PhD program is right for you? Or are you a person who is looking for mentors in any stage of life? If you answered yes to any of these, then this episode is for you! #mentorship…

I am really excited to share my strategies on work-life harmony at this webinar. This important topic is the focus of my podcast @theCALMpodcast. Thank you for the opportunity @GeneticsSociety…

@AllofUsCEO @GwasDiversity Congratulations! What an amazing milestone. I’m excited to start working with the data.

@joanneberghout I just used one in a paper last year to show pleiotropy. I think it made the point.

This was an amazing conversation. Thanks to your all. Cheers to #bespokecareers…

Great work by @AnastasiaMLucas to create this package to make Hudson plots.…

@scientistvan Thanks for sharing. Great reminder for the mentors.

We love having @karlkeat in the Ritchie Lab. I am excited to learn about his fancy cocktail and coffee making skills. Looks like it’s time to set up a bar in the lab (Coffee til’ Cocktails). Happy Friday!…

I am honored and grateful to have the opportunity to serve the Penn Medicine community as the new Director of IBI.…

These credits are available for early career researchers - this means students and postdocs. Hey @UPennGCB students and @PennBPP postdocs, this is a great opportunity to get credits to use UK Biobank on the new Research Analysis Platform.…

The Ritchie Lab Website

Curriculum vitae