Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University. Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic. Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases. Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease. Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research. Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years. Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014). Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.
- Lau-Min, KS, McKenna, D, Asher, SB, Bardakjian, T, Wollack, C, Bleznuck, J, Biros, D, Anantharajah, A, Clark, DF, Condit, C et al.. Impact of integrating genomic data into the electronic health record on genetics care delivery. Genet Med 2022; : . PubMed PMID:36107166 .
- Ramdas, S, Judd, J, Graham, SE, Kanoni, S, Wang, Y, Surakka, I, Wenz, B, Clarke, SL, Chesi, A, Wells, A et al.. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet 2022; 109 (8): 1366-1387. PubMed PMID:35931049 PubMed Central PMC9388392.
- COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19. Nature 2022; 608 (7921): E1-E10. PubMed PMID:35922517 PubMed Central PMC9352569.
- Tcheandjieu, C, Zhu, X, Hilliard, AT, Clarke, SL, Napolioni, V, Ma, S, Lee, KM, Fang, H, Chen, F, Lu, Y et al.. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med 2022; 28 (8): 1679-1692. PubMed PMID:35915156 PubMed Central PMC9419655.
- Chen, BY, Bone, WP, Lorenz, K, Levin, M, Ritchie, MD, Voight, BF. ColocQuiaL: A QTL-GWAS colocalization pipeline. Bioinformatics 2022; : . PubMed PMID:35894642 PubMed Central PMC9477517.
- Banday, AR, Stanifer, ML, Florez-Vargas, O, Onabajo, OO, Papenberg, BW, Zahoor, MA, Mirabello, L, Ring, TJ, Lee, CH, Albert, PS et al.. Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nat Genet 2022; 54 (8): 1103-1116. PubMed PMID:35835913 PubMed Central PMC9355882.
- Liu, H, Doke, T, Guo, D, Sheng, X, Ma, Z, Park, J, Vy, HMT, Nadkarni, GN, Abedini, A, Miao, Z et al.. Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease. Nat Genet 2022; 54 (7): 950-962. PubMed PMID:35710981 .
- Zhang, X, Lucas, AM, Veturi, Y, Drivas, TG, Bone, WP, Verma, A, Chung, WK, Crosslin, D, Denny, JC, Hebbring, S et al.. Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders. Nat Commun 2022; 13 (1): 3428. PubMed PMID:35701404 PubMed Central PMC9198016.
- Zhang, C, Verma, A, Feng, Y, Melo, MCR, McQuillan, M, Hansen, M, Lucas, A, Park, J, Ranciaro, A, Thompson, S et al.. Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection. Proc Natl Acad Sci U S A 2022; 119 (21): e2123000119. PubMed PMID:35580180 PubMed Central PMC9173769.
- Cindi, Z, Kawuma, AN, Maartens, G, Bradford, Y, Venter, F, Sokhela, S, Chandiwana, N, Wasmann, RE, Denti, P, Wiesner, L et al.. Pharmacogenetics of dolutegravir plasma exposure among Southern Africans living with HIV. J Infect Dis 2022; : . PubMed PMID:35512135 .