Symposium Speaker: Marylyn D. Ritchie, PhD, MS

Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University.  Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic.  Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases.  Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease.  Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research.  Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years.  Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014).  Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.

Recent Publications

  1. Bergmeijer, TO, Yasmina, A, Vos, GJA, Janssen, PWA, Hackeng, CM, Kelder, JC, Verma, SS, Ritchie, MD, Gong, L, Klein, TE et al.. Effect of CYP3A4*22 and PPAR-α Genetic Variants on Platelet Reactivity in Patients Treated with Clopidogrel and Lipid-Lowering Drugs Undergoing Elective Percutaneous Coronary Intervention. Genes (Basel) 2020; 11 (9): . PubMed PMID:32932966 .
  2. Kember, RL, Merikangas, AK, Verma, SS, Verma, A, Judy, R, Regeneron Genetics Center, Damrauer, SM, Ritchie, MD, Rader, DJ, Bućan, M et al.. Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals. Biol. Psychiatry 2020; : . PubMed PMID:32919613 .
  3. Leonard, MA, Cindi, Z, Bradford, Y, Bourgi, K, Koethe, J, Turner, M, Norwood, J, Woodward, B, Erdem, H, Basham, R et al.. Efavirenz Pharmacogenetics and Weight Gain following Switch to Integrase Inhibitor-containing Regimens. Clin. Infect. Dis. 2020; : . PubMed PMID:32829410 .
  4. Verma, SS, Bergmeijer, TO, Gong, L, Reny, JL, Lewis, JP, Mitchell, BD, Alexopoulos, D, Aradi, D, Altman, RB, Bliden, K et al.. Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium. Clin. Pharmacol. Ther. 2020; : . PubMed PMID:32472697 .
  5. Moore, JH, Barnett, I, Boland, MR, Chen, Y, Demiris, G, Gonzalez-Hernandez, G, Herman, DS, Himes, BE, Hubbard, RA, Kim, D et al.. Ideas for how informaticians can get involved with COVID-19 research. BioData Min 2020; 13 : 3. PubMed PMID:32419848 PubMed Central PMC7216865.
  6. Murray, MF, Kenny, EE, Ritchie, MD, Rader, DJ, Bale, AE, Giovanni, MA, Abul-Husn, NS. COVID-19 outcomes and the human genome. Genet. Med. 2020; 22 (7): 1175-1177. PubMed PMID:32393819 .
  7. Li, R, Chen, Y, Ritchie, MD, Moore, JH. Electronic health records and polygenic risk scores for predicting disease risk. Nat. Rev. Genet. 2020; 21 (8): 493-502. PubMed PMID:32235907 .
  8. Lucas, AM, Palmiero, NE, McGuigan, J, Passero, K, Zhou, J, Orie, D, Ritchie, MD, Hall, MA. CLARITE Facilitates the Quality Control and Analysis Process for EWAS of Metabolic-Related Traits. Front Genet 2019; 10 : 1240. PubMed PMID:31921293 PubMed Central PMC6930237.
  9. Joo, YY, Actkins, K, Pacheco, JA, Basile, AO, Carroll, R, Crosslin, DR, Day, F, Denny, JC, Velez Edwards, DR, Hakonarson, H et al.. A Polygenic and Phenotypic Risk Prediction for Polycystic Ovary Syndrome Evaluated by Phenome-Wide Association Studies. J. Clin. Endocrinol. Metab. 2020; 105 (6): . PubMed PMID:31917831 PubMed Central PMC7453038.
  10. Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS ONE 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
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Dr. Ritchie on Twitter

Dr. Ritchie on Twitter

Congratulations @5inghalp. Your hard work paid off. Time to do some cool science! twitter.com/5inghalp/statu…

Seems like the right outfit for a day with 8 zoom calls. #workfromhome #remotework

test Twitter Media - Seems like the right outfit for a day with 8 zoom calls. #workfromhome #remotework https://t.co/hYI7UrQFJy

@NohaSharafeldin Awe, thank you for the feedback. Thank YOU for inviting me. I really enjoyed putting this talk together and delivering it to your community. I look forward to a visit in real life pos-COVID.

Preparing to give my talk in the Cancer Outcomes Seminar for @UAB_ICOS. Today, I’m talking about ‘Medical Biobanks for Precision Medicine Research’. Thanks for the invite @NohaSharafeldin

test Twitter Media - Preparing to give my talk in the Cancer Outcomes Seminar for @UAB_ICOS.  Today, I’m talking about ‘Medical Biobanks for Precision Medicine Research’. Thanks for the invite @NohaSharafeldin https://t.co/cuPfRSRpqC

“The Back to School Shitshow” is the topic of this week’s @theCALMpodcast. We survived!! Everyone is speaking to each other in my house. We can do this, parents, teachers and administrators. Congrats to all for making it though the first week. It will get easier from here.

Great work @TDrivas! I have learned so much about #cilia through this project. I am also excited about your approach of looking at Mendelian disease genes through the lens of common, complex traits. #bioinformatics twitter.com/TDrivas/status…

@Eric_Fauman Thanks for the feedback and the points about the paper. The beauty of pre-prints is that we can get feedback before we submit to a journal. I appreciate you taking the time to give us comments and suggestions. @victoria_bll - take a look at this thread before we submit.

@miltondp @theCALMpodcast Those look delicious!! Cooking new things is one of my goals for the fall! I should try making those.

@SpringtonLakeMS Students can’t wait! You all are doing a fabulous job. Thank you!

YES!! 100% this 🙌🏻 My goal and expectation right now for my lab is for everyone to take care of their mental and physical health. If science happens to get done, it’s the cherry 🍒 on top of the icing on the cake. twitter.com/rafalab/status…

@mariamenounos @amyjccuddy OMG!! I can’t wait!! @amyjccuddy is game changing. Everyone in science and academia should read Presence and then do all the things in it. The culture of life in science needs to change and this book is a great start!

What are you doing to get better?Amy Cuddy, author of Presence and Harvard professor answers: working less. I loved this answer! This episode of Better Together is incredible, especially for scientists. Thank you @mariamenounos #phdchat #phdlife #AcademicChatter #AcademicTwitter

test Twitter Media - What are you doing to get better?Amy Cuddy, author of Presence and Harvard professor answers: working less. I loved this answer! This episode of Better Together is incredible, especially for scientists. Thank you @mariamenounos #phdchat #phdlife #AcademicChatter #AcademicTwitter https://t.co/s1SJNgxB3S

I’ve taken a few weeks off from recording @theCALMpodcast. It’s been busy at work; then some vacation time. I will be back to recording next week. While on a break, I found a new podcast that I love. “Better Together” with @mariamenounos. I highly recommend 👍🏻👍🏻 #selfcare

Well said!! This goes for life as a scientist after you get your PhD too! twitter.com/thoughtsofaphd…

The Ritchie Lab Website

Curriculum vitae