Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University. Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic. Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases. Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease. Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research. Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years. Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014). Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.
Recent Publications
- Zaidi, AA, Verma, A, Morse, C, Penn Medicine BioBank, Ritchie, MD, Mathieson, I. The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort. HGG Adv 2023; 4 (3): 100202. PubMed PMID:37255673 PubMed Central PMC10225932.
- Graham, SE, Clarke, SL, Wu, KH, Kanoni, S, Zajac, GJM, Ramdas, S, Surakka, I, Ntalla, I, Vedantam, S, Winkler, TW et al.. Author Correction: The power of genetic diversity in genome-wide association studies of lipids. Nature 2023; : . PubMed PMID:37237109 .
- Raizen, DM, Mullington, J, Anaclet, C, Clarke, G, Critchley, H, Dantzer, R, Davis, R, Drew, KL, Fessel, J, Fuller, PM et al.. Beyond the Symptom: The Biology of Fatigue. Sleep 2023; : . PubMed PMID:37224457 .
- Singhal, P, Verma, SS, Ritchie, MD. Gene Interactions in Human Disease Studies-Evidence Is Mounting. Annu Rev Biomed Data Sci 2023; : . PubMed PMID:37196359 .
- Reza, N, Levin, MG, Vidula, MK, Bravo, PE, Damrauer, SM, Ritchie, MD, Regeneron Genetics Center, Chahal, CAA, Owens, AT. Prevalence of Pathogenic Variants in Dilated Cardiomyopathy-Associated Genes in Patients Evaluated for Cardiac Sarcoidosis. Circ Genom Precis Med 2023; : e003850. PubMed PMID:37194596 .
- Dwyer, DB, Chand, GB, Pigoni, A, Khuntia, A, Wen, J, Antoniades, M, Hwang, G, Erus, G, Doshi, J, Srinivasan, D et al.. Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium. Mol Psychiatry 2023; : . PubMed PMID:37147389 .
- Mateza, S, Bradford, Y, Maartens, G, Sokhela, S, Chandiwana, NC, Venter, WDF, Post, FA, Ritchie, MD, Haas, DW, Sinxadi, P et al.. Pharmacogenetics of tenofovir renal toxicity in HIV-positive Southern Africans. Pharmacogenet Genomics 2023; 33 (5): 91-100. PubMed PMID:37099271 PubMed Central PMC10234323.
- Cindi, Z, Kawuma, AN, Maartens, G, Bradford, Y, Sokhela, S, Chandiwana, N, Venter, WDF, Wasmann, RE, Denti, P, Wiesner, L et al.. Pharmacogenetics of tenofovir clearance among Southern Africans living with HIV. Pharmacogenet Genomics 2023; 33 (4): 79-87. PubMed PMID:37098852 PubMed Central PMC10154044.
- Suzuki, K, Hatzikotoulas, K, Southam, L, Taylor, HJ, Yin, X, Lorenz, KM, Mandla, R, Huerta-Chagoya, A, Rayner, NW, Bocher, O et al.. Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications. medRxiv 2023; : . PubMed PMID:37034649 PubMed Central PMC10081410.
- Singhal, P, Veturi, Y, Dudek, SM, Lucas, A, Frase, A, van Steen, K, Schrodi, SJ, Fasel, D, Weng, C, Pendergrass, R et al.. Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets. Am J Hum Genet 2023; 110 (4): 575-591. PubMed PMID:37028392 PubMed Central PMC10119154.
