Dr. Marylyn Ritchie is Professor in the Department of Biochemistry and Molecular Biology and Director, Center for Systems Genomics at the Pennsylvania State University. Dr. Ritchie is also Director of the new Biomedical and Translational Informatics at Geisinger Clinic. Dr. Ritchie’s research interests as a statistical geneticist include the development and application of novel statistical and computational methods to identify genetic variants associated with human diseases. Dr. Ritchie’s lab places a special emphasis on the development of methods to detect gene-gene interactions, gene-environment interactions, and network/pathway effects associated with disease. Dr. Ritchie has extensive experience in Big Data science and the use of electronic health records in genomic research. Dr. Ritchie has been the electronic MEdical Records & GEnomics (eMERGE) Coordinating Center genomics lead for the past eight years. Dr. Ritchie’s other accomplishments include being named Genome Technology’s “Rising Young Investigator” (2006), a Sloan Research Fellow (2010), and a Kavli Frontiers in Sciences fellow by the National Academy of Science (2011-2014). Dr. Ritchie was most recently named Thomas Reuters Most Highly Cited Researchers in 2014.
Recent Publications
- Moore, A, Ritchie, MD. Cross-phenotype associations between Alzheimer's Disease and its comorbidities may provide clues to progression. medRxiv 2023; : . PubMed PMID:37986758 PubMed Central PMC10659497.
- Ferar, K, Hall, TO, Crawford, DC, Rowley, R, Satterfield, BA, Li, R, Gragert, L, Karlson, EW, de Andrade, M, Kullo, IJ et al.. Author Correction: Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection. Sci Rep 2023; 13 (1): 19972. PubMed PMID:37968452 PubMed Central PMC10652012.
- Ferar, K, Hall, TO, Crawford, DC, Rowley, R, Satterfield, BA, Li, R, Gragert, L, Karlson, EW, de Andrade, M, Kullo, IJ et al.. Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection. Sci Rep 2023; 13 (1): 18532. PubMed PMID:37898691 PubMed Central PMC10613277.
- Yang, G, González, P, Moneró, M, Carrasquillo, K, Renta, JY, Hernandez-Suarez, DF, Botton, MR, Melin, K, Scott, SA, Ruaño, G et al.. Discovery of Ancestry-specific Variants Associated with Clopidogrel Response among Caribbean Hispanics. medRxiv 2023; : . PubMed PMID:37873439 PubMed Central PMC10593031.
- Roychowdhury, T, Klarin, D, Levin, MG, Spin, JM, Rhee, YH, Deng, A, Headley, CA, Tsao, NL, Gellatly, C, Zuber, V et al.. Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nat Genet 2023; 55 (11): 1831-1842. PubMed PMID:37845353 PubMed Central PMC10632148.
- Li, B, Sangkuhl, K, Whaley, R, Woon, M, Keat, K, Whirl-Carrillo, M, Ritchie, MD, Klein, TE. Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank. Am J Hum Genet 2023; 110 (10): 1628-1647. PubMed PMID:37757824 PubMed Central PMC10577080.
- Painter, MM, Johnston, TS, Lundgreen, KA, Santos, JJS, Qin, JS, Goel, RR, Apostolidis, SA, Mathew, D, Fulmer, B, Williams, JC et al.. Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection. Nat Immunol 2023; 24 (10): 1711-1724. PubMed PMID:37735592 .
- Pividori, M, Lu, S, Li, B, Su, C, Johnson, ME, Wei, WQ, Feng, Q, Namjou, B, Kiryluk, K, Kullo, IJ et al.. Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms. Nat Commun 2023; 14 (1): 5562. PubMed PMID:37689782 PubMed Central PMC10492839.
- Safonov, A, Nomakuchi, TT, Chao, E, Horton, C, Dolinsky, JS, Yussuf, A, Richardson, M, Speare, V, Li, S, Bogus, ZC et al.. A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations. medRxiv 2023; : . PubMed PMID:37609227 PubMed Central PMC10441497.
- Compher, CW, Quinn, R, Haslam, R, Bader, E, Weaver, J, Dudek, S, Ritchie, MD, Lewis, JD, Wu, GD. Penn Healthy Diet survey: pilot validation and scoring. Br J Nutr 2023; : 1-7. PubMed PMID:37519237 .
