Samira Asgari, PhD, is Assistant Professor in the Department of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai. Dr. Asgari completed her undergraduate and MS. studies at the University of Tehran, Iran and her PhD at EPFL, Switzerland (Jacques Fellay lab). Her postdoctoral training was at Brigham and Women's Hospital in Boston (Soumya Raychaudhuri lab). At Mount Sinai, her research group focuses on understanding the human genetic basis of infection and immunity. Some of the questions her group asks include: What are the human genetic variants underlying susceptibility and resistance to specific pathogens? What are the molecular mechanisms connecting these variants to cellular functions and immune responses? and How do differences in population history and demography play into susceptibility and resistance to specific pathogens? Dr. Asgari and her research group use a combination of statistical, functional, and population genomics methods to answer these questions.
Recent Publications
- Luo, Y, Huang, CC, Howard, NC, Wang, X, Liu, Q, Li, X, Zhu, J, Amariuta, T, Asgari, S, Ishigaki, K et al.. Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis. Nat Commun 2024; 15 (1): 10393. PubMed PMID:39613754 PubMed Central PMC11607449.
- Cullina, S, Shemirani, R, Asgari, S, Kenny, EE. Systematic comparison of phenome-wide admixture mapping and genome-wide association in a diverse biobank. medRxiv 2024; : . PubMed PMID:39606401 PubMed Central PMC11601690.
- Adebekun, J, Nadig, A, Saarah, P, Asgari, S, Kachuri, L, Alagpulinsa, DA. Genetic relations between type 1 diabetes, coronary artery disease and leukocyte counts. Diabetologia 2024; 67 (11): 2518-2529. PubMed PMID:39141130 .
- Nieto-Caballero, VE, Reijneveld, JF, Ruvalcaba, A, Innocenzi, G, Abeydeera, N, Asgari, S, Lopez, K, Iwany, SK, Luo, Y, Nathan, A et al.. History of tuberculosis disease is associated with genetic regulatory variation in Peruvians. PLoS Genet 2024; 20 (6): e1011313. PubMed PMID:38870230 PubMed Central PMC11208071.
- Asgari, S, Pousaz, LA. Prehistoric events might explain European multiple sclerosis risk. Nature 2024; 625 (7994): 247-249. PubMed PMID:38200304 .
- Tegtmeyer, M, Arora, J, Asgari, S, Cimini, BA, Nadig, A, Peirent, E, Liyanage, D, Way, GP, Weisbart, E, Nathan, A et al.. High-dimensional phenotyping to define the genetic basis of cellular morphology. Nat Commun 2024; 15 (1): 347. PubMed PMID:38184653 PubMed Central PMC10771466.
- Cullina, S, Wojcik, GL, Shemirani, R, Klarin, D, Gorman, BR, Sorokin, EP, Gignoux, CR, Belbin, GM, Pyarajan, S, Asgari, S et al.. Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35. Front Genet 2023; 14 : 1181167. PubMed PMID:37600667 PubMed Central PMC10432698.
- Suliman, S, Nieto-Caballero, VE, Asgari, S, Lopez, K, Iwany, SK, Luo, Y, Nathan, A, Fernandez-Salinas, D, Chiñas, M, Huang, CC et al.. History of tuberculosis disease is associated with genetic regulatory variation in Peruvians. medRxiv 2023; : . PubMed PMID:37425785 PubMed Central PMC10327177.
- Cullina, S, Wojcik, GL, Shemirani, R, Klarin, D, Gorman, BR, Sorokin, EP, Gignoux, CR, Belbin, GM, Pyarajan, S, Asgari, S et al.. Admixture Mapping of Peripheral Artery Disease in a Dominican Population Reveals a Novel Risk Locus on 2q35. medRxiv 2023; : . PubMed PMID:37034679 PubMed Central PMC10081406.
- Novembre, J, Stein, C, Asgari, S, Gonzaga-Jauregui, C, Landstrom, A, Lemke, A, Li, J, Mighton, C, Taylor, M, Tishkoff, S et al.. Addressing the challenges of polygenic scores in human genetic research. Am J Hum Genet 2022; 109 (12): 2095-2100. PubMed PMID:36459976 PubMed Central PMC9808501.
- Asgari, S, Luo, Y, Huang, CC, Zhang, Z, Calderon, R, Jimenez, J, Yataco, R, Contreras, C, Galea, JT, Lecca, L et al.. Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk. Cell Genom 2022; 2 (7): . PubMed PMID:35873671 PubMed Central PMC9306274.
- Nathan, A, Asgari, S, Ishigaki, K, Valencia, C, Amariuta, T, Luo, Y, Beynor, JI, Baglaenko, Y, Suliman, S, Price, AL et al.. Single-cell eQTL models reveal dynamic T cell state dependence of disease loci. Nature 2022; 606 (7912): 120-128. PubMed PMID:35545678 PubMed Central PMC9842455.
- Reshef, YA, Rumker, L, Kang, JB, Nathan, A, Korsunsky, I, Asgari, S, Murray, MB, Moody, DB, Raychaudhuri, S. Co-varying neighborhood analysis identifies cell populations associated with phenotypes of interest from single-cell transcriptomics. Nat Biotechnol 2022; 40 (3): 355-363. PubMed PMID:34675423 PubMed Central PMC8930733.
