Past Crew Member: Sabrina L. Mitchell

Previous Position

Crawford Post-Doctoral Fellow, co-mentored with Dr. Deborah Murdock (2010-2015)

Vanderbilt University Medical Center post-doctoral fellow (2015-2016)

Staff Scientist, Division of Genetic Medicine, Vanderbilt University Medical Center (2017)

Current Position

Staff Scientist, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center (2018-present)

 Research Interests

Sabrina’s research interests include understanding the impact of mitochondrial genetic variation on complex traits and disease, developing methods for high-throughput classification of mitochondrial haplogroups, understanding the mechanisms mitochondria employ to communicate with the nucleus to regulate gene expression, and bridging statistical and molecular genetics to determine functional variants that influence disease risk.

Recent Publications

  1. Breeyear, JH, Hellwege, JN, Schroeder, PH, House, JS, Poisner, HM, Mitchell, SL, Charest, B, Khakharia, A, Basnet, TB, Halladay, CW et al.. Adaptive selection at G6PD and disparities in diabetes complications. Nat Med 2024; : . PubMed PMID:38918629 .
  2. Obremskey, WT, Tornetta, P 3rd, Luly, J, Morshed, S, O'Toole, RV, Hsu, JR, Mitchell, SL, Mackenzie, EJ, Frey, KP, Castillo, RC et al.. Outcomes of Patients With Large Versus Small Bone Defects in Open Tibia Fractures Treated With an Intramedullary Nail: A Descriptive Analysis of a Multicenter Retrospective Study. J Orthop Trauma 2022; 36 (8): 388-393. PubMed PMID:34962235 .
  3. Peters, KS, Rivera, E, Warden, C, Harlow, PA, Mitchell, SL, Calcutt, MW, Samuels, DC, Brantley, MA Jr. Plasma Arginine and Citrulline are Elevated in Diabetic Retinopathy. Am J Ophthalmol 2022; 235 : 154-162. PubMed PMID:34587493 .
  4. McLaughlin, KH, Mitchell, SL, Archer, KR, Master, H, Morshed, S, Gary, JL, Jones, CB, MacKenzie, EJ, Reider, L, METRC et al.. Effect of Severe Distal Tibia, Ankle, and Mid- to Hindfoot Trauma on Meeting Physical Activity Guidelines 18 Months After Injury. Arch Phys Med Rehabil 2022; 103 (3): 409-417.e2. PubMed PMID:34425087 PubMed Central PMC9178527.
  5. Mitchell, SL, Leon, DAC, Chaugai, S, Kawai, VK, Levinson, RT, Wei, WQ, Stein, CM. Pharmacogenetics of hypoglycemia associated with sulfonylurea therapy in usual clinical care. Pharmacogenomics J 2020; 20 (6): 831-839. PubMed PMID:32504053 PubMed Central PMC8174577.
  6. Sumarriva, K, Uppal, K, Ma, C, Herren, DJ, Wang, Y, Chocron, IM, Warden, C, Mitchell, SL, Burgess, LG, Goodale, MP et al.. Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy. Invest Ophthalmol Vis Sci 2019; 60 (8): 3119-3126. PubMed PMID:31323682 PubMed Central PMC6645705.
  7. Mitchell, SL, Uppal, K, Williamson, SM, Liu, K, Burgess, LG, Tran, V, Umfress, AC, Jarrell, KL, Cooke Bailey, JN, Agarwal, A et al.. The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 2018; 59 (12): 4978-4985. PubMed PMID:30326066 PubMed Central PMC6188466.
  8. Smieszek, S, Mitchell, SL, Farber-Eger, EH, Veatch, OJ, Wheeler, NR, Goodloe, RJ, Wells, QS, Murdock, DG, Crawford, DC. Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification. PeerJ 2018; 6 : e5149. PubMed PMID:29967758 PubMed Central PMC6022720.
  9. Mitchell, SL, Neininger, AC, Bruce, CN, Chocron, IM, Bregman, JA, Estopinal, CB, Muhammad, A, Umfress, AC, Jarrell, KL, Warden, C et al.. Mitochondrial Haplogroups Modify the Effect of Diabetes Duration and HbA1c on Proliferative Diabetic Retinopathy Risk in Patients With Type 2 Diabetes. Invest Ophthalmol Vis Sci 2017; 58 (14): 6481-6488. PubMed PMID:29288266 PubMed Central PMC5749245.
  10. Clay, HB, Parl, AK, Mitchell, SL, Singh, L, Bell, LN, Murdock, DG. Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling. PLoS One 2016; 11 (3): e0151171. PubMed PMID:26963735 PubMed Central PMC4786287.
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