Previous Positions
Crawford Graduate Student (2009-2014)
Post-Doctoral Fellow, Department of Human Genetics, University of Michigan (2014-2017)
Bioinformatics Staff Scientist, Autism & Developmental Medicine Institute (ADMI), Geisinger Health System (2017-2019)
Current Position
Assistant Professor, Geisinger Medical Center (2020-present)
Research Interests
Matt's graduate research was focused on the utilization of an EMR-linked biorepository for pharmacogenetic studies on a wide range of drugs including clopidogrel, warfarin, calcineurin-inhibitors, and statins. Matt's current research interests include the genetics of drug efficacy and adverse drug response, data-mining clinical data from electronic medical records, functional variation in pharmacogenes, and phenome-wide association studies. Matt's research skills include the design of pharmacogenomic studies in an EMR-based biobank, genetic analysis of SNP data and rare variants, and experience with large datasets.
Recent Publications
- Weng, LC, Khurshid, S, Hall, AW, Nauffal, V, Morrill, VN, Sun, YV, Rämö, JT, Beer, D, Lee, S, Nadkarni, G et al.. Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias. Circ Genom Precis Med 2024; 17 (3): e004320. PubMed PMID:38804128 PubMed Central PMC11187659.
- Torene, RI, Guillen Sacoto, MJ, Millan, F, Zhang, Z, McGee, S, Oetjens, M, Heise, E, Chong, K, Sidlow, R, O'Grady, L et al.. Systematic analysis of variants escaping nonsense-mediated decay uncovers candidate Mendelian diseases. Am J Hum Genet 2024; 111 (1): 70-81. PubMed PMID:38091987 PubMed Central PMC10806863.
- Berry, ASF, Jones, LK, Sijbrands, EJ, Gidding, SS, Oetjens, MT. Subtyping Severe Hypercholesterolemia by Genetic Determinant to Stratify Risk of Coronary Artery Disease. Arterioscler Thromb Vasc Biol 2023; 43 (10): 2058-2067. PubMed PMID:37589137 PubMed Central PMC10538409.
- Gidding, SS, Kirchner, HL, Brangan, A, Howard, W, Kelly, MA, Myers, KD, Morgan, KM, Oetjens, MT, Shuey, TC, Staszak, D et al.. Yield of Familial Hypercholesterolemia Genetic and Phenotypic Diagnoses After Electronic Health Record and Genomic Data Screening. J Am Heart Assoc 2023; 12 (13): e030073. PubMed PMID:37382153 PubMed Central PMC10356068.
- Rajagopal, VM, Watanabe, K, Mbatchou, J, Ayer, A, Quon, P, Sharma, D, Kessler, MD, Praveen, K, Gelfman, S, Parikshak, N et al.. Rare coding variants in CHRNB2 reduce the likelihood of smoking. Nat Genet 2023; 55 (7): 1138-1148. PubMed PMID:37308787 PubMed Central PMC10335934.
- Berry, ASF, Finucane, BM, Myers, SM, Abril, A, Kirchner, HL, Ledbetter, DH, Martin, CL, Oetjens, MT. Association of Supernumerary Sex Chromosome Aneuploidies With Venous Thromboembolism. JAMA 2023; 329 (3): 235-243. PubMed PMID:36648468 PubMed Central PMC9857362.
- Savatt, JM, Oetjens, MT, Myers, SM, Finucane, BM. Response to van Riel et al. Genet Med 2023; 25 (1): 161-163. PubMed PMID:36609148 .
- Shimelis, H, Oetjens, MT, Walsh, LK, Wain, KE, Znidarsic, M, Myers, SM, Finucane, BM, Ledbetter, DH, Martin, CL. Prevalence and Penetrance of Rare Pathogenic Variants in Neurodevelopmental Psychiatric Genes in a Health Care System Population. Am J Psychiatry 2023; 180 (1): 65-72. PubMed PMID:36475376 PubMed Central PMC10017070.
- Praveen, K, Patel, GC, Gurski, L, Ayer, AH, Persaud, T, Still, MD, Miloscio, L, Van Zyl, T, Di Gioia, SA, Brumpton, B et al.. ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma. Commun Biol 2022; 5 (1): 1051. PubMed PMID:36192519 PubMed Central PMC9529959.
- Praveen, K, Dobbyn, L, Gurski, L, Ayer, AH, Staples, J, Mishra, S, Bai, Y, Kaufman, A, Moscati, A, Benner, C et al.. Population-scale analysis of common and rare genetic variation associated with hearing loss in adults. Commun Biol 2022; 5 (1): 540. PubMed PMID:35661827 PubMed Central PMC9166757.