Previous Positions
Crawford Graduate Student (2009-2014)
Post-Doctoral Fellow, Department of Human Genetics, University of Michigan (2014-2017)
Bioinformatics Staff Scientist, Autism & Developmental Medicine Institute (ADMI), Geisinger Health System (2017-2019)
Current Position
Assistant Professor, Geisinger Medical Center (2020-present)
Research Interests
Matt's graduate research was focused on the utilization of an EMR-linked biorepository for pharmacogenetic studies on a wide range of drugs including clopidogrel, warfarin, calcineurin-inhibitors, and statins. Matt's current research interests include the genetics of drug efficacy and adverse drug response, data-mining clinical data from electronic medical records, functional variation in pharmacogenes, and phenome-wide association studies. Matt's research skills include the design of pharmacogenomic studies in an EMR-based biobank, genetic analysis of SNP data and rare variants, and experience with large datasets.
Recent Publications
- Deaton, AM, Parker, MM, Ward, LD, Flynn-Carroll, AO, BonDurant, L, Hinkle, G, Akbari, P, Lotta, LA, Regeneron Genetics Center, DiscovEHR Collaboration et al.. Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes. Sci Rep 2021; 11 (1): 21565. PubMed PMID:34732801 PubMed Central PMC8566487.
- Ward, LD, Tu, HC, Quenneville, CB, Tsour, S, Flynn-Carroll, AO, Parker, MM, Deaton, AM, Haslett, PAJ, Lotta, LA, Verweij, N et al.. GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms. Nat Commun 2021; 12 (1): 4571. PubMed PMID:34315874 PubMed Central PMC8316433.
- Wain, KE, Tolwinski, K, Palen, E, Heidlebaugh, AR, Holdren, K, Walsh, LK, Oetjens, MT, Ledbetter, DH, Martin, CL. Population Genomic Screening for Genetic Etiologies of Neurodevelopmental/Psychiatric Disorders Demonstrates Personal Utility and Positive Participant Responses. J Pers Med 2021; 11 (5): . PubMed PMID:34062946 PubMed Central PMC8147408.
- Wang, Y, Bae, T, Thorpe, J, Sherman, MA, Jones, AG, Cho, S, Daily, K, Dou, Y, Ganz, J, Galor, A et al.. Comprehensive identification of somatic nucleotide variants in human brain tissue. Genome Biol 2021; 22 (1): 92. PubMed PMID:33781308 PubMed Central PMC8006362.
- Kelly, MA, Leader, JB, Wain, KE, Bodian, D, Oetjens, MT, Ledbetter, DH, Martin, CL, Strande, NT. Leveraging population-based exome screening to impact clinical care: The evolution of variant assessment in the Geisinger MyCode research project. Am J Med Genet C Semin Med Genet 2021; 187 (1): 83-94. PubMed PMID:33576083 .
- Moreno-De-Luca, A, Millan, F, Pesacreta, DR, Elloumi, HZ, Oetjens, MT, Teigen, C, Wain, KE, Scuffins, J, Myers, SM, Torene, RI et al.. Molecular Diagnostic Yield of Exome Sequencing in Patients With Cerebral Palsy. JAMA 2021; 325 (5): 467-475. PubMed PMID:33528536 PubMed Central PMC7856544.
- Campbell-Salome, G, Jones, LK, Masnick, MF, Walton, NA, Ahmed, CD, Buchanan, AH, Brangan, A, Esplin, ED, Kann, DG, Ladd, IG et al.. Developing and Optimizing Innovative Tools to Address Familial Hypercholesterolemia Underdiagnosis: Identification Methods, Patient Activation, and Cascade Testing for Familial Hypercholesterolemia. Circ Genom Precis Med 2021; 14 (1): e003120. PubMed PMID:33480803 PubMed Central PMC7892261.
- Oetjens, MT, Luo, JZ, Chang, A, Leader, JB, Hartzel, DN, Moore, BS, Strande, NT, Kirchner, HL, Ledbetter, DH, Justice, AE et al.. Electronic health record analysis identifies kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients. PLoS One 2020; 15 (11): e0242182. PubMed PMID:33180868 PubMed Central PMC7660530.
- Martin, CL, Wain, KE, Oetjens, MT, Tolwinski, K, Palen, E, Hare-Harris, A, Habegger, L, Maxwell, EK, Reid, JG, Walsh, LK et al.. Identification of Neuropsychiatric Copy Number Variants in a Health Care System Population. JAMA Psychiatry 2020; 77 (12): 1276-1285. PubMed PMID:32697297 PubMed Central PMC7376464.
- Oetjens, MT, Kelly, MA, Sturm, AC, Martin, CL, Ledbetter, DH. Quantifying the polygenic contribution to variable expressivity in eleven rare genetic disorders. Nat Commun 2019; 10 (1): 4897. PubMed PMID:31653860 PubMed Central PMC6814771.