Past Crew Member: Matthew T. Oetjens, PhD, MS

Previous Positions

Crawford Graduate Student (2009-2014)

Post-Doctoral Fellow, Department of Human Genetics, University of Michigan (2014-2017)

Bioinformatics Staff Scientist, Autism & Developmental Medicine Institute (ADMI), Geisinger Health System (2017-2019)

Current Position

Assistant Professor, Geisinger Medical Center (2020-present)

Research Interests

Matt's graduate research was focused on the utilization of an EMR-linked biorepository for pharmacogenetic studies on a wide range of drugs including clopidogrel, warfarin, calcineurin-inhibitors, and statins.  Matt's current research interests include the genetics of drug efficacy and adverse drug response, data-mining clinical data from electronic medical records, functional variation in pharmacogenes, and phenome-wide association studies.  Matt's research skills include the design of pharmacogenomic studies in an EMR-based biobank, genetic analysis of SNP data and rare variants, and experience with large datasets.

Recent Publications

  1. Weng, LC, Khurshid, S, Hall, AW, Nauffal, V, Morrill, VN, Sun, YV, Rämö, JT, Beer, D, Lee, S, Nadkarni, G et al.. Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias. Circ Genom Precis Med 2024; : e004320. PubMed PMID:38804128 .
  2. Torene, RI, Guillen Sacoto, MJ, Millan, F, Zhang, Z, McGee, S, Oetjens, M, Heise, E, Chong, K, Sidlow, R, O'Grady, L et al.. Systematic analysis of variants escaping nonsense-mediated decay uncovers candidate Mendelian diseases. Am J Hum Genet 2024; 111 (1): 70-81. PubMed PMID:38091987 PubMed Central PMC10806863.
  3. Berry, ASF, Jones, LK, Sijbrands, EJ, Gidding, SS, Oetjens, MT. Subtyping Severe Hypercholesterolemia by Genetic Determinant to Stratify Risk of Coronary Artery Disease. Arterioscler Thromb Vasc Biol 2023; 43 (10): 2058-2067. PubMed PMID:37589137 PubMed Central PMC10538409.
  4. Gidding, SS, Kirchner, HL, Brangan, A, Howard, W, Kelly, MA, Myers, KD, Morgan, KM, Oetjens, MT, Shuey, TC, Staszak, D et al.. Yield of Familial Hypercholesterolemia Genetic and Phenotypic Diagnoses After Electronic Health Record and Genomic Data Screening. J Am Heart Assoc 2023; 12 (13): e030073. PubMed PMID:37382153 PubMed Central PMC10356068.
  5. Rajagopal, VM, Watanabe, K, Mbatchou, J, Ayer, A, Quon, P, Sharma, D, Kessler, MD, Praveen, K, Gelfman, S, Parikshak, N et al.. Rare coding variants in CHRNB2 reduce the likelihood of smoking. Nat Genet 2023; 55 (7): 1138-1148. PubMed PMID:37308787 PubMed Central PMC10335934.
  6. Berry, ASF, Finucane, BM, Myers, SM, Abril, A, Kirchner, HL, Ledbetter, DH, Martin, CL, Oetjens, MT. Association of Supernumerary Sex Chromosome Aneuploidies With Venous Thromboembolism. JAMA 2023; 329 (3): 235-243. PubMed PMID:36648468 PubMed Central PMC9857362.
  7. Savatt, JM, Oetjens, MT, Myers, SM, Finucane, BM. Response to van Riel et al. Genet Med 2023; 25 (1): 161-163. PubMed PMID:36609148 .
  8. Shimelis, H, Oetjens, MT, Walsh, LK, Wain, KE, Znidarsic, M, Myers, SM, Finucane, BM, Ledbetter, DH, Martin, CL. Prevalence and Penetrance of Rare Pathogenic Variants in Neurodevelopmental Psychiatric Genes in a Health Care System Population. Am J Psychiatry 2023; 180 (1): 65-72. PubMed PMID:36475376 PubMed Central PMC10017070.
  9. Praveen, K, Patel, GC, Gurski, L, Ayer, AH, Persaud, T, Still, MD, Miloscio, L, Van Zyl, T, Di Gioia, SA, Brumpton, B et al.. ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma. Commun Biol 2022; 5 (1): 1051. PubMed PMID:36192519 PubMed Central PMC9529959.
  10. Praveen, K, Dobbyn, L, Gurski, L, Ayer, AH, Staples, J, Mishra, S, Bai, Y, Kaufman, A, Moscati, A, Benner, C et al.. Population-scale analysis of common and rare genetic variation associated with hearing loss in adults. Commun Biol 2022; 5 (1): 540. PubMed PMID:35661827 PubMed Central PMC9166757.
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