Previous Positions
Crawford Graduate Student (2009-2014)
Post-Doctoral Fellow, Department of Human Genetics, University of Michigan (2014-2017)
Bioinformatics Staff Scientist, Autism & Developmental Medicine Institute (ADMI), Geisinger Health System (2017-2019)
Current Position
Assistant Professor, Geisinger Medical Center (2020-present)
Research Interests
Matt's graduate research was focused on the utilization of an EMR-linked biorepository for pharmacogenetic studies on a wide range of drugs including clopidogrel, warfarin, calcineurin-inhibitors, and statins. Matt's current research interests include the genetics of drug efficacy and adverse drug response, data-mining clinical data from electronic medical records, functional variation in pharmacogenes, and phenome-wide association studies. Matt's research skills include the design of pharmacogenomic studies in an EMR-based biobank, genetic analysis of SNP data and rare variants, and experience with large datasets.
Recent Publications
- Praveen, K, Dobbyn, L, Gurski, L, Ayer, AH, Staples, J, Mishra, S, Bai, Y, Kaufman, A, Moscati, A, Benner, C et al.. Population-scale analysis of common and rare genetic variation associated with hearing loss in adults. Commun Biol 2022; 5 (1): 540. PubMed PMID:35661827 PubMed Central PMC9166757.
- Savatt, JM, Shimelis, H, Moreno-De-Luca, A, Strande, NT, Oetjens, MT, Ledbetter, DH, Martin, CL, Myers, SM, Finucane, BM. Frequency of truncating FLCN variants and Birt-Hogg-Dubé-associated phenotypes in a health care system population. Genet Med 2022; 24 (9): 1857-1866. PubMed PMID:35639097 .
- Kousathanas, A, Pairo-Castineira, E, Rawlik, K, Stuckey, A, Odhams, CA, Walker, S, Russell, CD, Malinauskas, T, Wu, Y, Millar, J et al.. Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature 2022; 607 (7917): 97-103. PubMed PMID:35255492 PubMed Central PMC9259496.
- Jurgens, SJ, Choi, SH, Morrill, VN, Chaffin, M, Pirruccello, JP, Halford, JL, Weng, LC, Nauffal, V, Roselli, C, Hall, AW et al.. Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank. Nat Genet 2022; 54 (3): 240-250. PubMed PMID:35177841 PubMed Central PMC8930703.
- Finucane, B, Oetjens, MT, Johns, A, Myers, SM, Fisher, C, Habegger, L, Maxwell, EK, Reid, JG, Ledbetter, DH, Kirchner, HL et al.. Medical manifestations and health care utilization among adult MyCode participants with neurodevelopmental psychiatric copy number variants. Genet Med 2022; 24 (3): 703-711. PubMed PMID:34906480 PubMed Central PMC8901449.
- Deaton, AM, Parker, MM, Ward, LD, Flynn-Carroll, AO, BonDurant, L, Hinkle, G, Akbari, P, Lotta, LA, Regeneron Genetics Center, DiscovEHR Collaboration et al.. Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes. Sci Rep 2021; 11 (1): 21565. PubMed PMID:34732801 PubMed Central PMC8566487.
- Ward, LD, Tu, HC, Quenneville, CB, Tsour, S, Flynn-Carroll, AO, Parker, MM, Deaton, AM, Haslett, PAJ, Lotta, LA, Verweij, N et al.. GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms. Nat Commun 2021; 12 (1): 4571. PubMed PMID:34315874 PubMed Central PMC8316433.
- Wain, KE, Tolwinski, K, Palen, E, Heidlebaugh, AR, Holdren, K, Walsh, LK, Oetjens, MT, Ledbetter, DH, Martin, CL. Population Genomic Screening for Genetic Etiologies of Neurodevelopmental/Psychiatric Disorders Demonstrates Personal Utility and Positive Participant Responses. J Pers Med 2021; 11 (5): . PubMed PMID:34062946 PubMed Central PMC8147408.
- Wang, Y, Bae, T, Thorpe, J, Sherman, MA, Jones, AG, Cho, S, Daily, K, Dou, Y, Ganz, J, Galor, A et al.. Comprehensive identification of somatic nucleotide variants in human brain tissue. Genome Biol 2021; 22 (1): 92. PubMed PMID:33781308 PubMed Central PMC8006362.
- Kelly, MA, Leader, JB, Wain, KE, Bodian, D, Oetjens, MT, Ledbetter, DH, Martin, CL, Strande, NT. Leveraging population-based exome screening to impact clinical care: The evolution of variant assessment in the Geisinger MyCode research project. Am J Med Genet C Semin Med Genet 2021; 187 (1): 83-94. PubMed PMID:33576083 .