Past Crew Member: Janina M. Jeff, PhD, MS

Previous Positions

Crawford Graduate Student (2007-2012)

Crawford Post-Doctoral Fellow (2012-2013)

Post-Doctoral Fellow at the Icahn School of Medicine at Mount Sinai (2013-2015)

Current Position

Global Bioinformatics Specialist, Illumina (2015-present)

In Those Genes podcast, founder (2019-present) and ASHG Advocacy Awardee (2020)

Research Interests

As a genetic epidemiologist, Janina has an interest in identifying genetic variants that explain disease disparities observed across populations.  Janina has applied her interests to several common human diseases and traits including quantitative cardiovascular traits, anthropometric traits, hematological traits, reproductive outcomes, chronic kidney disease, type 2 diabetes, and pharmacogenomics in highly structured admixed populations such as African Americans and Hispanics.  Janina has developed approaches to extract data from a series of clinical data warehouses to define novel clinical phenotypes, for example extracting real-time physiologic response to short acting catacholamines administered during surgery for pharmacogenomic studies.

Recent Publications

  1. Wiley, K, Findley, L, Goldrich, M, Rakhra-Burris, TK, Stevens, A, Williams, P, Bult, CJ, Chisholm, R, Deverka, P, Ginsburg, GS et al.. A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. J Am Med Inform Assoc 2022; 29 (8): 1342-1349. PubMed PMID:35485600 PubMed Central PMC9277642.
  2. Wenric, S, Jeff, JM, Joseph, T, Yee, MC, Belbin, GM, Owusu Obeng, A, Ellis, SB, Bottinger, EP, Gottesman, O, Levin, MA et al.. Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry. Pharmacogenomics J 2021; 21 (2): 174-189. PubMed PMID:33168928 PubMed Central PMC7997806.
  3. Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS One 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
  4. Edwards, TL, Giri, A, Hellwege, JN, Hartmann, KE, Stewart, EA, Jeff, JM, Bray, MJ, Pendergrass, SA, Torstenson, ES, Keaton, JM et al.. A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids. Front Genet 2019; 10 : 511. PubMed PMID:31249589 PubMed Central PMC6582231.
  5. Wojcik, GL, Graff, M, Nishimura, KK, Tao, R, Haessler, J, Gignoux, CR, Highland, HM, Patel, YM, Sorokin, EP, Avery, CL et al.. Genetic analyses of diverse populations improves discovery for complex traits. Nature 2019; 570 (7762): 514-518. PubMed PMID:31217584 PubMed Central PMC6785182.
  6. Fernández-Rhodes, L, Malinowski, JR, Wang, Y, Tao, R, Pankratz, N, Jeff, JM, Yoneyama, S, Carty, CL, Setiawan, VW, Le Marchand, L et al.. The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis. PLoS One 2018; 13 (7): e0200486. PubMed PMID:30044860 PubMed Central PMC6059436.
  7. Hellwege, JN, Jeff, JM, Wise, LA, Gallagher, CS, Wellons, M, Hartmann, KE, Jones, SF, Torstenson, ES, Dickinson, S, Ruiz-Narváez, EA et al.. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet 2017; 136 (11-12): 1497-1498. PubMed PMID:28975356 PubMed Central PMC5909202.
  8. Belbin, GM, Odgis, J, Sorokin, EP, Yee, MC, Kohli, S, Glicksberg, BS, Gignoux, CR, Wojcik, GL, Van Vleck, T, Jeff, JM et al.. Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. Elife 2017; 6 : . PubMed PMID:28895531 PubMed Central PMC5595434.
  9. Hellwege, JN, Jeff, JM, Wise, LA, Gallagher, CS, Wellons, M, Hartmann, KE, Jones, SF, Torstenson, ES, Dickinson, S, Ruiz-Narváez, EA et al.. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet 2017; 136 (10): 1363-1373. PubMed PMID:28836065 PubMed Central PMC5628188.
  10. Levin, MA, Joseph, TT, Jeff, JM, Nadukuru, R, Ellis, SB, Bottinger, EP, Kenny, EE. iGAS: A framework for using electronic intraoperative medical records for genomic discovery. J Biomed Inform 2017; 67 : 80-89. PubMed PMID:28193464 .
Search PubMed

Janina on Twitter

Such an honor meeting you! twitter.com/nnkinsi/status…

It’s wrap The Lightbox at #IGF illuminating voices about the way to better human health. @NNkinsi @inthosegenespod Retweeted by Dr. Jay Electronica

“Equity is about relinquishing power” - @NNkinsi at the @illumina genomics forum #IGF

Disease knows no boundaries and neither should #genomic healthcare. #genomicsforall means access for everyone, everywhere. No exceptions. Thank you to @AndrewFarnum @KeoluFox @Nnkinsi @ay_zhou Byron Scott for having a real dialogue. Now we need to move from talk to action. #IGF Retweeted by Dr. Jay Electronica

@CrunchyNeuroSci Such a great paper! Congrats and thanks so much for your help and guidance for our episode, it’s definitely one of my faves!

For a fascinating and nuanced dive into musical rhythm, the brain, culture, and genetic ancestry, check out this extraordinarily well-produced episode of the podcast IN THOSE GENES by @inthosegenespod Dr. Janina Jeff ("Geneti-SIS") player.audiostaq.com/inthosegenes/r… #musicscience #genomics Retweeted by Dr. Jay Electronica

There is something for every listener (scientist, general public, and musician) in this hour-long episode. Many thanks to host @inthosegenespod Dr. Jeff for the shout-out to the preprint of our beat synchronization GWAS study, as well! Final paper here nature.com/articles/s4156… Retweeted by Dr. Jay Electronica

When thinking about the hurdles and challenges in diversifying the entire genomics ecosystem it’s really easy to get discouraged and I often think such changes won’t happen in my lifetime but this reminded me to appreciate that we are doing better despite the long journey ahead!

test Twitter Media - When thinking about the hurdles and challenges in diversifying the entire genomics ecosystem it’s really easy to get discouraged and I often think such changes won’t happen in my lifetime but this reminded me to appreciate that we are doing better despite the long journey ahead! https://t.co/mtX13dyyiL
test Twitter Media - When thinking about the hurdles and challenges in diversifying the entire genomics ecosystem it’s really easy to get discouraged and I often think such changes won’t happen in my lifetime but this reminded me to appreciate that we are doing better despite the long journey ahead! https://t.co/mtX13dyyiL

Still in awe that I was able to hear @BarackObama speak! It’s truly astonishing what my career in science has opened my world too! So many key moments that I’ll share over time but the one that stands out today is “sometimes better is the best we can do”. #IGF2022 @illumina

test Twitter Media - Still in awe that I was able to hear @BarackObama speak! It’s truly astonishing what my career in science has opened my world too! So many key moments that I’ll share over time but the one that stands out today is “sometimes better is the best we can do”. #IGF2022 @illumina https://t.co/8yHzSkmjLR

What an announcement, “we are in the genome era!”. Check out this thread for the full details! #IGF twitter.com/illumina/statu…

Literally blushing! twitter.com/MichaelGallad/…

“Leadership is unlocking others people’s power” - President Barack Obama at @illumina ‘s genomic forum #IGF

🧬☀️ | The #SanDiego sunshine is upon us as we invite change-makers to #IGF. @illumina #genomics #PrecisionMedicine Retweeted by Dr. Jay Electronica

Former President Obama has taken the stage at #IGF! It’s happening right now! President Obama is such an important voice in the conversation about equity and accessibility in healthcare to improve quality of life for all. Illumina is thrilled and honored to host him. Retweeted by Dr. Jay Electronica

🖤🤎💛 | ICYMI: Only 2% of African/African decent are included in genomic studies of disease risks. #Genomics shouldn’t only be accessible for the rich or the lucky. We can give everyone access to their personal genome. #RepresentationMatters #STEMeducation #IGF Retweeted by Dr. Jay Electronica

The Jeff Lab Website

Curriculum Vitae