Janina M. Jeff, PhD, MS

Dr. Janina Jeff is a post-doctoral fellow at the Icahn School of Medicine at Mount Sinai.  As a genetic epidemiologist, Dr. Jeff has an interest in identifying genetic variants that explain disease disparities observed across populations.  Dr. Jeff has applied her interests to several common human diseases and traits including quantitative cardiovascular traits, anthropometric traits, hematological traits, reproductive outcomes, chronic kidney disease, type 2 diabetes, and pharmacogenomics in highly structured admixed populations such as African Americans and Hispanics.  More recently, Dr. Jeff has developed approaches to extract data from a series of clinical data warehouses to define novel clinical phenotypes, for example extracting real-time physiologic response to short acting catacholamines administered during surgery for pharmacogenomic studies.  Dr. Jeff is a previous National Human Genome Research Institute Genome Scholar (2006) and a recipient of the Women of Excellence and Leadership award (2006) and Levi Watkins Award for Commitment to Diversity (2011).

Recent Publications

  1. Wang, B, Zhao, J, Liu, S, Feng, J, Luo, Y, He, X, Wang, Y, Ge, F, Wang, J, Ye, B et al.. ACE2 Decoy Receptor Generated by High-throughput Saturation Mutagenesis Efficiently Neutralizes SARS-CoV-2 and Its Prevalent Variants. Emerg Microbes Infect 2022; : 1-0. PubMed PMID:35587428 .
  2. Wiley, K, Findley, L, Goldrich, M, Rakhra-Burris, TK, Stevens, A, Williams, P, Bult, CJ, Chisholm, R, Deverka, P, Ginsburg, GS et al.. A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. J Am Med Inform Assoc 2022; : . PubMed PMID:35485600 .
  3. Wenric, S, Jeff, JM, Joseph, T, Yee, MC, Belbin, GM, Owusu Obeng, A, Ellis, SB, Bottinger, EP, Gottesman, O, Levin, MA et al.. Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry. Pharmacogenomics J 2021; 21 (2): 174-189. PubMed PMID:33168928 PubMed Central PMC7997806.
  4. Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS One 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
  5. Edwards, TL, Giri, A, Hellwege, JN, Hartmann, KE, Stewart, EA, Jeff, JM, Bray, MJ, Pendergrass, SA, Torstenson, ES, Keaton, JM et al.. A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids. Front Genet 2019; 10 : 511. PubMed PMID:31249589 PubMed Central PMC6582231.
  6. Wojcik, GL, Graff, M, Nishimura, KK, Tao, R, Haessler, J, Gignoux, CR, Highland, HM, Patel, YM, Sorokin, EP, Avery, CL et al.. Genetic analyses of diverse populations improves discovery for complex traits. Nature 2019; 570 (7762): 514-518. PubMed PMID:31217584 PubMed Central PMC6785182.
  7. Fernández-Rhodes, L, Malinowski, JR, Wang, Y, Tao, R, Pankratz, N, Jeff, JM, Yoneyama, S, Carty, CL, Setiawan, VW, Le Marchand, L et al.. The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis. PLoS One 2018; 13 (7): e0200486. PubMed PMID:30044860 PubMed Central PMC6059436.
  8. Hellwege, JN, Jeff, JM, Wise, LA, Gallagher, CS, Wellons, M, Hartmann, KE, Jones, SF, Torstenson, ES, Dickinson, S, Ruiz-Narváez, EA et al.. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet 2017; 136 (11-12): 1497-1498. PubMed PMID:28975356 PubMed Central PMC5909202.
  9. Belbin, GM, Odgis, J, Sorokin, EP, Yee, MC, Kohli, S, Glicksberg, BS, Gignoux, CR, Wojcik, GL, Van Vleck, T, Jeff, JM et al.. Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. Elife 2017; 6 : . PubMed PMID:28895531 PubMed Central PMC5595434.
  10. Hellwege, JN, Jeff, JM, Wise, LA, Gallagher, CS, Wellons, M, Hartmann, KE, Jones, SF, Torstenson, ES, Dickinson, S, Ruiz-Narváez, EA et al.. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet 2017; 136 (10): 1363-1373. PubMed PMID:28836065 PubMed Central PMC5628188.
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Dr. Jeff on Twitter

🧬 BODY FAT PERCENTAGE 🧬 Body fat percentage is the total amount of fat compared to our total mass which includes our muscles and bones. There are over 100 common variants in the genome that are associated with total body fat percentage. (9/9)

🧬 HORMONE FRENZY 🧬 Hormones, testosterone & estrogen play a major role when it comes to the distribution of our fat cells. We can see this mainly during puberty when our hormones are at their peak. We also see a shift in our fat distribution due to hormones as we age. (8/9)

🧬 THICKER THAN A SNICKER 🧬 Fat gets into our cells thru a process called lipolysis. Lipolysis is the metabolic process through which triacylglycerols (TAGs) break down via hydrolysis into their constituent molecules: glycerol and free fatty acids (FFAs). (7/9)

🧬 FAT DISTRIBUTION 🧬 Scientists have determined that fat distribution, not the amount of total body fat we have determines our body shape. Where fat cells develop and accumulate at various sites in the body is due to a process called adipogenesis. (6/9)

🧬 TYPES OF FAT PART 3 🧬 There is some evidence that African populations have less visceral & more subcutaneous fat compared to European populations. It has also been reported that Asian descendants have more visceral fat compared to their European & Africans counterparts. (5/9)

🧬 TYPES OF FAT PART 2 🧬 Visceral & subcutaneous fat are considered white adipose tissue. Genetics accounts for 22 to 76% of fat distribution. The amount varies when we look at visceral and subcutaneous fat with visceral fat being is more heritable than subcutaneous fat. (4/9)

🧬 TYPES OF FAT PART 1 🧬 Humans have 3 types of fat: Brown fat, visceral fat, & subcutaneous fat. All of these play a major role in how our bodies function properly. (3/9)

🧬 FAT TO THE RESCUE 🧬 Fat is stored in cells called adipocytes - a cell specialized for the storage of fat. Our bodies like adipose tissue. If there was to be an absence of food, they are already well equipped with energy stored just in case we need it. (2/9)

Part 2 of your fave Henrietta Facts from episode 6! Take a look & share with friends & fam! 🚀 What's one new fact you learned during our final show of the season? Sound off in the comments!📢 (1/9)

test Twitter Media - Part 2 of your fave Henrietta Facts from episode 6! Take a look & share with friends & fam!
🚀
What's one new fact you learned during our final show of
the season? Sound off in the comments!📢 (1/9) https://t.co/mrU6i9SYtB

We STILL growing the ITG fam! Everyone, meet Warner Meadows! He’s our brand new composer for the show! 🚀 Warner has been working on the last few episode of season 2 and we can’t wait to see what else he has in store for season 3! Let’s give him a warm welcome! 🧬📣

test Twitter Media - We STILL growing the ITG fam! Everyone, meet Warner Meadows! 
He’s our brand new composer for the show! 
🚀
Warner has been working on the last few episode of season 2 and we can’t wait to see what else he has in store for season 3! Let’s give him a warm welcome! 🧬📣 https://t.co/kUhQevmXaO
test Twitter Media - We STILL growing the ITG fam! Everyone, meet Warner Meadows! 
He’s our brand new composer for the show! 
🚀
Warner has been working on the last few episode of season 2 and we can’t wait to see what else he has in store for season 3! Let’s give him a warm welcome! 🧬📣 https://t.co/kUhQevmXaO

🧬 WHAT WAST? 🧬 Waist to hip ratio (WHR) is the size of your waist as compared to the size of your hips. The estimated total amount of it is attributed to 30-70% genetics. Due to lack of research it is unclear as to whether WHR varies between populations.

🧬 HOWS THE WEATHER UP THERE? 🧬 Height can influence body shape. Those that are taller might have lower waist to height ratios (lean), & those that are shorter have higher waist to height ratios (stout) To date, we estimate that genetics can explain up to 18.5% of body shapes

🧬 THE STUDY OF ANTHROPOMETRY 🧬 Some of the most common traits used to describe body shape are: height, waist to hip ratio, fat distribution, and BMl.

🧬 THE STUDY OF ANTHROPOMETRY 🧬 Somatotype is the scientific term used to describe body shape. Scientists describe body shape as the measurements & proportions of our bodies. Anthropometry is the scientific study of body shape.

We’ve got our Henrietta Facts from our final episode of the season, “Baby Got Black” hot and ready for y’all! ❤️‍🔥🔥🧬 We hope you enjoy this first batch…more is coming your way! Don’t forget: You can listen to the full episode by clicking the link in the bio!❤️🙏🏾🧬 (1/7)

test Twitter Media - We’ve got our Henrietta Facts from our final episode of the season, “Baby Got Black” hot and ready for y’all! ❤️‍🔥🔥🧬 

We hope you enjoy this first batch…more is coming your way!

Don’t forget: You can listen to the full episode by clicking the link in the bio!❤️🙏🏾🧬 (1/7) https://t.co/mAH6YICuaK

Hey everybody! 👋🏾 As the show gears up for summer break, we would love to hear feedback from YOU - our audience! You can access our Season 2 Listener Survey by clicking the link below! (It’s completely anonymous too) 👍🏾❤️‍🔥 (1/2)

test Twitter Media - Hey everybody! 👋🏾 
As the show gears up for summer break, we would love to hear feedback from YOU - our audience! 
You can access our Season 2 Listener Survey by clicking the link below! (It’s completely anonymous too) 👍🏾❤️‍🔥 (1/2) https://t.co/LU6t7tSF7j

Podcast alert! “In Those Genes” is amazing if you’re into genetics, history, race and culture. Even if you aren’t it’s amazing and should be required listening. @inthosegenespod Retweeted by Dr. Jay Electronica

Medical gaslighting: Telling the patient that their problems will be solved with weight loss. REAL symptoms get brushed off. We know very little about optimal weight and health. Fatphobia is rooted in anti blackness: @inthosegenespod “Baby Got Black” @running2_med @lupusincolor Retweeted by Dr. Jay Electronica

The Jeff Lab Website

Curriculum Vitae