Janina M. Jeff, PhD, MS

Dr. Janina Jeff is a post-doctoral fellow at the Icahn School of Medicine at Mount Sinai.  As a genetic epidemiologist, Dr. Jeff has an interest in identifying genetic variants that explain disease disparities observed across populations.  Dr. Jeff has applied her interests to several common human diseases and traits including quantitative cardiovascular traits, anthropometric traits, hematological traits, reproductive outcomes, chronic kidney disease, type 2 diabetes, and pharmacogenomics in highly structured admixed populations such as African Americans and Hispanics.  More recently, Dr. Jeff has developed approaches to extract data from a series of clinical data warehouses to define novel clinical phenotypes, for example extracting real-time physiologic response to short acting catacholamines administered during surgery for pharmacogenomic studies.  Dr. Jeff is a previous National Human Genome Research Institute Genome Scholar (2006) and a recipient of the Women of Excellence and Leadership award (2006) and Levi Watkins Award for Commitment to Diversity (2011).

Recent Publications

  1. Wiley, K, Findley, L, Goldrich, M, Rakhra-Burris, TK, Stevens, A, Williams, P, Bult, CJ, Chisholm, R, Deverka, P, Ginsburg, GS et al.. A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. J Am Med Inform Assoc 2022; 29 (8): 1342-1349. PubMed PMID:35485600 PubMed Central PMC9277642.
  2. Wenric, S, Jeff, JM, Joseph, T, Yee, MC, Belbin, GM, Owusu Obeng, A, Ellis, SB, Bottinger, EP, Gottesman, O, Levin, MA et al.. Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry. Pharmacogenomics J 2021; 21 (2): 174-189. PubMed PMID:33168928 PubMed Central PMC7997806.
  3. Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS One 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
  4. Edwards, TL, Giri, A, Hellwege, JN, Hartmann, KE, Stewart, EA, Jeff, JM, Bray, MJ, Pendergrass, SA, Torstenson, ES, Keaton, JM et al.. A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids. Front Genet 2019; 10 : 511. PubMed PMID:31249589 PubMed Central PMC6582231.
  5. Wojcik, GL, Graff, M, Nishimura, KK, Tao, R, Haessler, J, Gignoux, CR, Highland, HM, Patel, YM, Sorokin, EP, Avery, CL et al.. Genetic analyses of diverse populations improves discovery for complex traits. Nature 2019; 570 (7762): 514-518. PubMed PMID:31217584 PubMed Central PMC6785182.
  6. Fernández-Rhodes, L, Malinowski, JR, Wang, Y, Tao, R, Pankratz, N, Jeff, JM, Yoneyama, S, Carty, CL, Setiawan, VW, Le Marchand, L et al.. The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis. PLoS One 2018; 13 (7): e0200486. PubMed PMID:30044860 PubMed Central PMC6059436.
  7. Hellwege, JN, Jeff, JM, Wise, LA, Gallagher, CS, Wellons, M, Hartmann, KE, Jones, SF, Torstenson, ES, Dickinson, S, Ruiz-Narváez, EA et al.. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet 2017; 136 (11-12): 1497-1498. PubMed PMID:28975356 PubMed Central PMC5909202.
  8. Belbin, GM, Odgis, J, Sorokin, EP, Yee, MC, Kohli, S, Glicksberg, BS, Gignoux, CR, Wojcik, GL, Van Vleck, T, Jeff, JM et al.. Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. Elife 2017; 6 : . PubMed PMID:28895531 PubMed Central PMC5595434.
  9. Hellwege, JN, Jeff, JM, Wise, LA, Gallagher, CS, Wellons, M, Hartmann, KE, Jones, SF, Torstenson, ES, Dickinson, S, Ruiz-Narváez, EA et al.. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet 2017; 136 (10): 1363-1373. PubMed PMID:28836065 PubMed Central PMC5628188.
  10. Levin, MA, Joseph, TT, Jeff, JM, Nadukuru, R, Ellis, SB, Bottinger, EP, Kenny, EE. iGAS: A framework for using electronic intraoperative medical records for genomic discovery. J Biomed Inform 2017; 67 : 80-89. PubMed PMID:28193464 .
Search PubMed

Dr. Jeff on Twitter

Will you help me support incredible #WomenInSTEM like @rosedontwalk, @DrJasmineDrake @SeannaLeathPhD @SyritaSteib and @inthosegenespod? They are changing the world one project at a time! Donate here: 500womenscientists.org/donate Retweeted by Dr. Jay Electronica

New ep. of #alittlejujupodcast features Dr. Janina Jeff host of @inthosegenespod ! We are speaking to a geneticist about ancestral veneration +science, how trauma may be imprinted in our dna, & what we make of ancestry tests in finding out who we *are*. open.spotify.com/episode/22P6Ba… Retweeted by Dr. Jay Electronica

Ovarian aging predicts aging rates in other tissues. Women reaching menopause before 40 are 2x as likely to die early than those reaching it between 50-54. Reversing ovarian aging may help reverse overall aging. In mice we’ve done it. Let’s give women the option ⬇️ Retweeted by Dr. Jay Electronica

Yesterday was my last day of working at Google. Perhaps this comes as surprise to you twitter folks, as I haven't widely announced that I left academia to try something new. Here's what I learned in 9 months as a Data Analyst who (temporarily) left Astronomy for Big Tech. 1/n Retweeted by Dr. Jay Electronica

Congrats!!! twitter.com/kinkofahq/stat…

Happy Bey Day @cdiggi1 ! We can’t compete with @Beyonce ‘s bday gift but we love you just as much ! 🐝🧬🐝🧬

test Twitter Media - Happy Bey Day @cdiggi1 ! We can’t compete with @Beyonce ‘s bday gift but we love you just as much ! 🐝🧬🐝🧬 https://t.co/bkYz9PBE4h

This song geauxs hard though! open.spotify.com/track/5de5oSUF… twitter.com/clavtastic/sta…

Congratulations to @CGM_MGH faculty member @HeidiRehm on winning the highly prestigious Curt Stern award from @GeneticsSociety. Heidi is a unique leader in our field and has championed the advancement of genomic medicine for researchers, healthcare providers, and patients alike! Retweeted by Dr. Jay Electronica

Episode 4 features @kaylee_byers @ShawnHercules & Dr Janina Jeff discussing genes, race &ancestry. Then Dr Eske Willerslev drops in to chat ancient ancestors, old DNA &ethics. Find #NiceGenes here: link.chtbl.com/JWzOSzPM @inthosegenespod @SFU_FHS @pmcancercentre @UCPH_Research Retweeted by Dr. Jay Electronica

Episode 1 of “Why Am I Like This?” is out now! Watch to learn about why we smell 👃🏼🥸🐽 Let me know what you think and what traits do you want to learn about next? twitter.com/PBSDS/status/1… Retweeted by Dr. Jay Electronica

Today is Gregor Mendel’s birthday! Mendel was an Austrian monk who, in the 19th century, worked out the basic laws of inheritance through experiments with pea plants. go.usa.gov/xSKUM Retweeted by Dr. Jay Electronica

Congrats to my post doc advisor and mentor @EimearEKenny for receiving the 2022 Early Career Award from @GeneticsSociety , long overdue and well deserved! twitter.com/EimearEKenny/s…

The Jeff Lab Website

Curriculum Vitae