Sarah A. Pendergrass, PhD, MS

Dr. Sarah Pendergrass is Assistant (Investigator I) Professor in the Biomedical and Translational Informatics Program at Geisinger Health System.  Dr. Pendergrass is a genetic bioinformatician who focuses on high-throughput data analysis and data-mining approaches to studying complex human diseases and traits.  Dr. Pendergrass has extensive experience in using both epidemiologic and clinic-based resources to perform phenome-wide association studies (PheWAS) to identify cross-phenotype associations and pleiotropy.  Dr. Pendergrass also develops software tools to visualize complex data.  In recognition for her innovative work, Dr. Pendergrass was named one of Genome Technology’s PIs of Tomorrow (2013).

Recent Publications

  1. Haggerty, CM, James, CA, Calkins, H, Tichnell, C, Leader, JB, Hartzel, DN, Nevius, CD, Pendergrass, SA, Person, TN, Schwartz, M et al.. Electronic health record phenotype in subjects with genetic variants associated with arrhythmogenic right ventricular cardiomyopathy: a study of 30,716 subjects with exome sequencing. Genet. Med. 2017; : . PubMed PMID:28471438 .
  2. Verma, A, Bradford, Y, Verma, SS, Pendergrass, SA, Daar, ES, Venuto, C, Morse, GD, Ritchie, MD, Haas, DW. Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Pharmacogenet. Genomics 2017; 27 (3): 101-111. PubMed PMID:28099408 PubMed Central PMC5285297.
  3. Dewey, FE, Murray, MF, Overton, JD, Habegger, L, Leader, JB, Fetterolf, SN, O'Dushlaine, C, Van Hout, CV, Staples, J, Gonzaga-Jauregui, C et al.. Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study. Science 2016; 354 (6319): . PubMed PMID:28008009 .
  4. Verma, SS, Lucas, AM, Lavage, DR, Leader, JB, Metpally, R, Krishnamurthy, S, Dewey, F, Borecki, I, Lopez, A, Overton, J et al.. IDENTIFYING GENETIC ASSOCIATIONS WITH VARIABILITY IN METABOLIC HEALTH AND BLOOD COUNT LABORATORY VALUES: DIVING INTO THE QUANTITATIVE TRAITS BY LEVERAGING LONGITUDINAL DATA FROM AN EHR. Pac Symp Biocomput 2016; 22 : 533-544. PubMed PMID:27897004 .
  5. Bauer, CR, Lavage, D, Snyder, J, Leader, J, Mahoney, JM, Pendergrass, SA. OPENING THE DOOR TO THE LARGE SCALE USE OF CLINICAL LAB MEASURES FOR ASSOCIATION TESTING: EXPLORING DIFFERENT METHODS FOR DEFINING PHENOTYPES. Pac Symp Biocomput 2016; 22 : 356-367. PubMed PMID:27896989 .
  6. Basile, AO, Verma, A, Byrska-Bishop, M, Pendergrass, SA, Darabos, C, Lester Kirchner, H. PATTERNS IN BIOMEDICAL DATA-HOW DO WE FIND THEM? Pac Symp Biocomput 2016; 22 : 177-183. PubMed PMID:27896973 .
  7. Verma, A, Verma, SS, Pendergrass, SA, Crawford, DC, Crosslin, DR, Kuivaniemi, H, Bush, WS, Bradford, Y, Kullo, I, Bielinski, SJ et al.. eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants. BMC Med Genomics 2016; 9 Suppl 1 : 32. PubMed PMID:27535653 PubMed Central PMC4989894.
  8. Verma, A, Basile, AO, Bradford, Y, Kuivaniemi, H, Tromp, G, Carey, D, Gerhard, GS, Crowe, JE Jr, Ritchie, MD, Pendergrass, SA et al.. Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. PLoS ONE 2016; 11 (8): e0160573. PubMed PMID:27508393 PubMed Central PMC4980020.
  9. Oetjens, MT, Bush, WS, Denny, JC, Birdwell, K, Kodaman, N, Verma, A, Dilks, HH, Pendergrass, SA, Ritchie, MD, Crawford, DC et al.. Evidence for extensive pleiotropy among pharmacogenes. Pharmacogenomics 2016; 17 (8): 853-66. PubMed PMID:27249515 PubMed Central PMC5352965.
  10. Butkiewicz, M, Cooke Bailey, JN, Frase, A, Dudek, S, Yaspan, BL, Ritchie, MD, Pendergrass, SA, Haines, JL. Pathway analysis by randomization incorporating structure-PARIS: an update. Bioinformatics 2016; 32 (15): 2361-3. PubMed PMID:27153576 PubMed Central PMC4965631.
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Dr. Pendergrass on Twitter

#NoConfederate twitter.com/ReignOfApril/s…

Characterizing and managing missing data in the #EHR A collaboration with Geisinger and Penn @beaulieujones biorxiv.org/content/early/…

I had such a great trip to Dartmouth and opportunity to speak as a Grad Alum, really thankful for the opportunity! twitter.com/DartGRAD/statu…

I'm in a March today where people can exercise their freedom to protest, but many can't say where they work due to risking job loss

test Twitter Media - I'm in a March today where people can exercise their freedom to protest, but many can't say where they work due to risking job loss https://t.co/JqrBBgjeWj

Yes. twitter.com/roguenasa/stat…

The Pendergrass Lab Website

Curriculum Vitae