Symposium Speaker: Timothy A. Thornton, PhD

Dr. Thornton is Associate Professor of Biostatistics at the University of Washington (UW) and an Affiliate Investigator at the Fred Hutchinson Cancer Research Center.  Dr. Thornton's research involves the development and application of statistical methods for the analysis of large-scale genomic data for the identification of genetic variants that influence complex diseases and quantitative traits. Currently, Dr. Thornton's collaborative research is largely focused on using statistical methods to identify novel genetic variants for complex traits in ancestrally diverse populations, including underrepresented minority populations in the U.S., including African Americans, Latinos, and American Indian and Alaska Native (AI/AN) populations.   Dr. Thornton currently serves as a lead statistician and co-investigator for Hispanic Community Health Study (HCHS)/Study of Latinos (SOL), and this cohort was recently included in the multi-cohort Population Architecture using Genomics and Epidemiology (PAGE) II study.

Recent Publications

  1. Li, X, Quick, C, Zhou, H, Gaynor, SM, Liu, Y, Chen, H, Selvaraj, MS, Sun, R, Dey, R, Arnett, DK et al.. Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies. Nat Genet 2023; 55 (1): 154-164. PubMed PMID:36564505 .
  2. Li, Z, Li, X, Zhou, H, Gaynor, SM, Selvaraj, MS, Arapoglou, T, Quick, C, Liu, Y, Chen, H, Sun, R et al.. A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies. Nat Methods 2022; 19 (12): 1599-1611. PubMed PMID:36303018 .
  3. Selvaraj, MS, Li, X, Li, Z, Pampana, A, Zhang, DY, Park, J, Aslibekyan, S, Bis, JC, Brody, JA, Cade, BE et al.. Whole genome sequence analysis of blood lipid levels in >66,000 individuals. Nat Commun 2022; 13 (1): 5995. PubMed PMID:36220816 PubMed Central PMC9553944.
  4. Tahir, UA, Katz, DH, Avila-Pachecho, J, Bick, AG, Pampana, A, Robbins, JM, Yu, Z, Chen, ZZ, Benson, MD, Cruz, DE et al.. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nat Commun 2022; 13 (1): 4923. PubMed PMID:35995766 PubMed Central PMC9395431.
  5. Loesch, DP, Horimoto, ARVR, Sarihan, EI, Inca-Martinez, M, Mason, E, Cornejo-Olivas, M, Torres, L, Mazzetti, P, Cosentino, C, Sarapura-Castro, E et al.. Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort. Parkinsonism Relat Disord 2022; 102 : 7-15. PubMed PMID:35917738 .
  6. Taub, MA, Conomos, MP, Keener, R, Iyer, KR, Weinstock, JS, Yanek, LR, Lane, J, Miller-Fleming, TW, Brody, JA, Raffield, LM et al.. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed. Cell Genom 2022; 2 (1): . PubMed PMID:35530816 PubMed Central PMC9075703.
  7. Hu, X, Qiao, D, Kim, W, Moll, M, Balte, PP, Lange, LA, Bartz, TM, Kumar, R, Li, X, Yu, B et al.. Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program. Am J Hum Genet 2022; 109 (5): 857-870. PubMed PMID:35385699 PubMed Central PMC9118106.
  8. Wainschtein, P, Jain, D, Zheng, Z, TOPMed Anthropometry Working Group, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Cupples, LA, Shadyab, AH, McKnight, B, Shoemaker, BM, Mitchell, BD et al.. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nat Genet 2022; 54 (3): 263-273. PubMed PMID:35256806 PubMed Central PMC9119698.
  9. Schubert, R, Geoffroy, E, Gregga, I, Mulford, AJ, Aguet, F, Ardlie, K, Gerszten, R, Clish, C, Van Den Berg, D, Taylor, KD et al.. Protein prediction for trait mapping in diverse populations. PLoS One 2022; 17 (2): e0264341. PubMed PMID:35202437 PubMed Central PMC8870552.
  10. Sillah, A, Peters, U, Watson, NF, Tykodi, SS, Hall, ET, Silverman, A, Malen, RC, Thompson, JA, Lee, SM, Bhatia, S et al.. Associating sleep problems with advanced cancer diagnosis, and immune checkpoint treatment outcomes: a pilot study. Support Care Cancer 2022; 30 (5): 3829-3838. PubMed PMID:35034197 PubMed Central PMC8761099.
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Curriculum vitae