Symposium Speaker: Timothy A. Thornton, PhD

Dr. Thornton is Associate Professor of Biostatistics at the University of Washington (UW) and an Affiliate Investigator at the Fred Hutchinson Cancer Research Center.  Dr. Thornton's research involves the development and application of statistical methods for the analysis of large-scale genomic data for the identification of genetic variants that influence complex diseases and quantitative traits. Currently, Dr. Thornton's collaborative research is largely focused on using statistical methods to identify novel genetic variants for complex traits in ancestrally diverse populations, including underrepresented minority populations in the U.S., including African Americans, Latinos, and American Indian and Alaska Native (AI/AN) populations.   Dr. Thornton currently serves as a lead statistician and co-investigator for Hispanic Community Health Study (HCHS)/Study of Latinos (SOL), and this cohort was recently included in the multi-cohort Population Architecture using Genomics and Epidemiology (PAGE) II study.

Recent Publications

  1. Sillah, A, Watson, NF, Peters, U, Biggs, ML, Nieto, FJ, Li, CI, Gozal, D, Thornton, T, Barrie, S, Phipps, AI et al.. Sleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS). Cancer Epidemiol 2021; 76 : 102057. PubMed PMID:34798387 .
  2. Luo, Y, Kanai, M, Choi, W, Li, X, Sakaue, S, Yamamoto, K, Ogawa, K, Gutierrez-Arcelus, M, Gregersen, PK, Stuart, PE et al.. Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. Nat Genet 2021; : . PubMed PMID:34728834 .
  3. Olson, NC, Raffield, LM, Moxley, AH, Miller-Fleming, TW, Auer, PL, Franceschini, N, Ngo, D, Thornton, TA, Lange, EM, Li, Y et al.. Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Blacks. Circ Genom Precis Med 2021; : CIRCGEN121003421. PubMed PMID:34706549 .
  4. Horimoto, A, Xue, D, Cai, J, Lash, J, Daviglus, M, Franceschini, N, Thornton, T. Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identify European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States. J Am Soc Nephrol 2021; : . PubMed PMID:34670813 .
  5. Yue, K, Ma, J, Thornton, T, Shojaie, A. REHE: Fast variance components estimation for linear mixed models. Genet Epidemiol 2021; 45 (8): 891-905. PubMed PMID:34658056 PubMed Central PMC8604792.
  6. Luo, Y, Kanai, M, Choi, W, Li, X, Sakaue, S, Yamamoto, K, Ogawa, K, Gutierrez-Arcelus, M, Gregersen, PK, Stuart, PE et al.. A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. Nat Genet 2021; 53 (10): 1504-1516. PubMed PMID:34611364 .
  7. Mikhaylova, AV, McHugh, CP, Polfus, LM, Raffield, LM, Boorgula, MP, Blackwell, TW, Brody, JA, Broome, J, Chami, N, Chen, MH et al.. Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program. Am J Hum Genet 2021; 108 (10): 1836-1851. PubMed PMID:34582791 PubMed Central PMC8546043.
  8. Little, A, Hu, Y, Sun, Q, Jain, D, Broome, J, Chen, MH, Thibord, F, McHugh, C, Surendran, P, Blackwell, TW et al.. Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative. Hum Mol Genet 2021; : . PubMed PMID:34553764 .
  9. Schaefer, KR, Avey, JP, Todd, MR, Beans, JA, Dillard, DA, Shireman, LM, Thornton, TA, Tyndale, RF, Thummel, KE, Robinson, RF et al.. Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke. Clin Transl Sci 2021; 14 (6): 2474-2486. PubMed PMID:34520119 PubMed Central PMC8604252.
  10. Cade, BE, Lee, J, Sofer, T, Wang, H, Zhang, M, Chen, H, Gharib, SA, Gottlieb, DJ, Guo, X, Lane, JM et al.. Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med 2021; 13 (1): 136. PubMed PMID:34446064 PubMed Central PMC8394596.
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The Thornton Lab Website

Curriculum vitae