Symposium Speaker: Timothy A. Thornton, PhD

Dr. Thornton is Associate Professor of Biostatistics at the University of Washington (UW) and an Affiliate Investigator at the Fred Hutchinson Cancer Research Center.  Dr. Thornton's research involves the development and application of statistical methods for the analysis of large-scale genomic data for the identification of genetic variants that influence complex diseases and quantitative traits. Currently, Dr. Thornton's collaborative research is largely focused on using statistical methods to identify novel genetic variants for complex traits in ancestrally diverse populations, including underrepresented minority populations in the U.S., including African Americans, Latinos, and American Indian and Alaska Native (AI/AN) populations.   Dr. Thornton currently serves as a lead statistician and co-investigator for Hispanic Community Health Study (HCHS)/Study of Latinos (SOL), and this cohort was recently included in the multi-cohort Population Architecture using Genomics and Epidemiology (PAGE) II study.

Recent Publications

  1. Taub, MA, Conomos, MP, Keener, R, Iyer, KR, Weinstock, JS, Yanek, LR, Lane, J, Miller-Fleming, TW, Brody, JA, Raffield, LM et al.. Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed. Cell Genom 2022; 2 (1): . PubMed PMID:35530816 PubMed Central PMC9075703.
  2. Hu, X, Qiao, D, Kim, W, Moll, M, Balte, PP, Lange, LA, Bartz, TM, Kumar, R, Li, X, Yu, B et al.. Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program. Am J Hum Genet 2022; 109 (5): 857-870. PubMed PMID:35385699 PubMed Central PMC9118106.
  3. Wainschtein, P, Jain, D, Zheng, Z, TOPMed Anthropometry Working Group, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Cupples, LA, Shadyab, AH, McKnight, B, Shoemaker, BM, Mitchell, BD et al.. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nat Genet 2022; 54 (3): 263-273. PubMed PMID:35256806 PubMed Central PMC9119698.
  4. Schubert, R, Geoffroy, E, Gregga, I, Mulford, AJ, Aguet, F, Ardlie, K, Gerszten, R, Clish, C, Van Den Berg, D, Taylor, KD et al.. Protein prediction for trait mapping in diverse populations. PLoS One 2022; 17 (2): e0264341. PubMed PMID:35202437 PubMed Central PMC8870552.
  5. Sillah, A, Peters, U, Watson, NF, Tykodi, SS, Hall, ET, Silverman, A, Malen, RC, Thompson, JA, Lee, SM, Bhatia, S et al.. Associating sleep problems with advanced cancer diagnosis, and immune checkpoint treatment outcomes: a pilot study. Support Care Cancer 2022; 30 (5): 3829-3838. PubMed PMID:35034197 PubMed Central PMC8761099.
  6. Katz, DH, Tahir, UA, Bick, AG, Pampana, A, Ngo, D, Benson, MD, Yu, Z, Robbins, JM, Chen, ZZ, Cruz, DE et al.. Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease. Circulation 2022; 145 (5): 357-370. PubMed PMID:34814699 .
  7. Sillah, A, Watson, NF, Peters, U, Biggs, ML, Nieto, FJ, Li, CI, Gozal, D, Thornton, T, Barrie, S, Phipps, AI et al.. Sleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS). Cancer Epidemiol 2022; 76 : 102057. PubMed PMID:34798387 PubMed Central PMC8792277.
  8. Luo, Y, Kanai, M, Choi, W, Li, X, Sakaue, S, Yamamoto, K, Ogawa, K, Gutierrez-Arcelus, M, Gregersen, PK, Stuart, PE et al.. Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. Nat Genet 2021; 53 (12): 1722. PubMed PMID:34728834 PubMed Central PMC8978071.
  9. Olson, NC, Raffield, LM, Moxley, AH, Miller-Fleming, TW, Auer, PL, Franceschini, N, Ngo, D, Thornton, TA, Lange, EM, Li, Y et al.. Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circ Genom Precis Med 2021; 14 (6): e003421. PubMed PMID:34706549 PubMed Central PMC8692389.
  10. Horimoto, ARVR, Xue, D, Cai, J, Lash, JP, Daviglus, ML, Franceschini, N, Thornton, TA. Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identifies European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States. J Am Soc Nephrol 2022; 33 (1): 77-87. PubMed PMID:34670813 PubMed Central PMC8763178.
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The Thornton Lab Website

Curriculum vitae