Jessica Cooke Bailey, PhD, MA, is Assistant Professor in the Department of Population and Quantitative Health Sciences and a member of the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Cooke Bailey received her PhD in Molecular Medicine and Translational Science at Wake Forest University. As a CSTC KL2 Scholar, Dr. Cooke Bailey earned her MA in Bioethics at Case Western Reserve University. Prior to joining the faculty at Case, Dr. Cooke Bailey was a post-doctoral fellow at Vanderbilt University in the Center for Human Genetics Research. Her research has focused on applying sophisticated statistical methods to understand the genetic basis of glaucoma and age-related macular degeneration in European Americans, including the Amish. Dr. Cooke Bailey is now expanding her work to harness the power of electronic health record (EHR) data coupled with genomics and other “omics” data to understand why African Americans are at increased risk for glaucoma compared with other populations. Understanding glaucoma risk factors will begin to address health disparities with the goal of informing treatment options.
Recent Publications
- Gorman, BR, Voloudakis, G, Igo, RP Jr, Kinzy, T, Halladay, CW, Bigdeli, TB, Zeng, B, Venkatesh, S, Cooke Bailey, JN, Crawford, DC et al.. Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries. Nat Genet 2024; 56 (12): 2659-2671. PubMed PMID:39623103 .
- Diaz-Torres, S, He, W, Yu, R, IGGC International Glaucoma Genetics Consortium, Khawaja, AP, Hammond, CJ, Hysi, PG, Pasquale, LR, Wu, Y, Kubo, M et al.. Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma. Nat Commun 2024; 15 (1): 9959. PubMed PMID:39551815 PubMed Central PMC11570636.
- Chang-Wolf, JM, Kinzy, TG, Driessen, SJ, Cruz, LA, Iyengar, SK, Peachey, NS, Aung, T, Khor, CC, Williams, SE, Ramsay, M et al.. Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent. JAMA Ophthalmol 2025; 143 (1): 7-14. PubMed PMID:39541127 PubMed Central PMC11565374.
- Liu, WW, Kinzy, TG, Cooke Bailey, JN, Xu, Z, Hysi, P, Wiggs, JL, NEIGHBORHOOD Consortium. Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma. Sci Rep 2023; 13 (1): 15871. PubMed PMID:37741866 PubMed Central PMC10517927.
- Han, X, Gharahkhani, P, Hamel, AR, Ong, JS, Rentería, ME, Mehta, P, Dong, X, Pasutto, F, Hammond, C, Young, TL et al.. Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci. Nat Genet 2023; 55 (7): 1116-1125. PubMed PMID:37386247 PubMed Central PMC10335935.
- Cruz, LA, Cooke Bailey, JN, Crawford, DC. Importance of Diversity in Precision Medicine: Generalizability of Genetic Associations Across Ancestry Groups Toward Better Identification of Disease Susceptibility Variants. Annu Rev Biomed Data Sci 2023; 6 : 339-356. PubMed PMID:37196357 PubMed Central PMC10720270.
- Nealon, CL, Halladay, CW, Gorman, BR, Simpson, P, Roncone, DP, Canania, RL, Anthony, SA, Sawicki Rogers, LR, Leber, JN, Dougherty, JM et al.. Association Between Fuchs Endothelial Corneal Dystrophy, Diabetes Mellitus, and Multimorbidity. Cornea 2023; 42 (9): 1140-1149. PubMed PMID:37170406 PubMed Central PMC10523841.
- Aboobakar, IF, Kinzy, TG, Zhao, Y, Fan, B, Pasquale, LR, Qassim, A, Kolovos, A, Schmidt, JM, Craig, JE, Cooke Bailey, JN et al.. Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes. Ophthalmology 2023; 130 (7): 756-763. PubMed PMID:36813040 PubMed Central PMC10330404.
- Cooke Bailey, JN, Funk, KL, Cruz, LA, Waksmunski, AR, Kinzy, TG, Wiggs, JL, Hauser, MA. Diversity in Polygenic Risk of Primary Open-Angle Glaucoma. Genes (Basel) 2022; 14 (1): . PubMed PMID:36672852 PubMed Central PMC9859496.
- Waksmunski, AR, Kinzy, TG, Cruz, LA, Nealon, CL, Halladay, CW, Anthony, SA, Greenberg, PB, Sullivan, JM, Wu, WC, Iyengar, SK et al.. Diversity is key for cross-ancestry transferability of glaucoma genetic risk scores in Hispanic Veterans in the Million Veteran Program. Pac Symp Biocomput 2023; 28 : 413-424. PubMed PMID:36540996 PubMed Central PMC9997528.