Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Kiser, H, Budu-Aggrey, A, Bailey, JNC, Villaplana-Velasco, A, Bernabeu, MO, Jiang, X, Owen, CG, Haines, JL, Pasquale, LR, MacGregor, S et al.. Can we identify people with Alzheimer's disease from examination of the eye? A bidirectional Mendelian randomization (MR) study. J Prev Alzheimers Dis 2026; 13 (8): 100635. PubMed PMID:42430965 .
  2. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Mustafa, Y, Wang, LS, Leung, YY, Schellenberg, GD et al.. Evaluating sequence-to-function deep learning models for ancestry-stratified regulatory variant effect prediction using multi-ancestry blood eQTLs. bioRxiv 2026; : . PubMed PMID:42395544 PubMed Central PMC13320881.
  3. Wang, P, Song, YE, Lynn, A, Miskimen, K, Gulyayev, A, Prough, MB, Dorfsman, DA, Laux, RA, Fuzzell, SL, Hochstetler, SD et al.. Heritability of Alzheimer's disease-related plasma biomarkers in the Amish population. Alzheimers Dement (Amst) 2026; 18 (2): e70388. PubMed PMID:42339066 PubMed Central PMC13283917.
  4. Wang, TC, Archer, DB, Ali, M, Wu, Y, Mormino, E, Buckley, RF, Lee, AJ, Saykin, AJ, De Jager, PL, Schneider, JA et al.. Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery. Brain 2026; : . PubMed PMID:42334898 .
  5. Liu, C, Zhu, Z, Lin, H, Bush, WS, Jenq, RR, Cominelli, F, Pillai, JA, Haines, JL, Zhu, X, Xu, R et al.. The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities. Front Mol Biosci 2026; 13 : 1735332. PubMed PMID:42325435 PubMed Central PMC13275447.
  6. Rose, CM, Bush, WS, Beno, MF, Williams, SM, Haines, JL, Crawford, DC. Leadership, Informatics Expertise, and Resources: Determinants of Institutional Data Sharing in the National Clinical Cohort Collaborative (N3C). AMIA Jt Summits Transl Sci Proc 2026; 2026 : 381-389. PubMed PMID:42317826 PubMed Central PMC13274281.
  7. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease. Am J Hum Genet 2026; 113 (6): 1279-1296. PubMed PMID:42066773 PubMed Central PMC13247992.
  8. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. Alzheimers Dement 2026; 22 (4): e71433. PubMed PMID:42043782 PubMed Central PMC13116102.
  9. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-specific genetic drivers of memory, executive functioning and language in older adults. Brain 2026; : . PubMed PMID:41989867 .
  10. Nam, Y, DeRosa, BA, Ramirez, AM, Ayele, BA, Whitehead-Gay, P, Adams, LD, Golightly, CG, Starks, TD, Laverde-Paz, MJ, Cukier, HN et al.. Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7-associated Alzheimer's disease risk. Alzheimers Dement 2026; 22 (4): e71312. PubMed PMID:41912785 PubMed Central PMC13140508.
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The Haines Lab Website

Curriculum vitae

thumbnail of Haines CV 2015-07-14