Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Dacey, R, Hou, L, Gurnani, A, Han, X, Paller-Moore, MR, Chung, J, Durape, S, Rosenthaler, M, Uretsky, M, Abdolmohammadi, B et al.. Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking. Alzheimers Dement 2025; 21 (11): e70922. PubMed PMID:41268768 PubMed Central PMC12635870.
  2. Mustafa, Y, Main, LR, Mews, M, Janve, VA, Hohman, TJ, Haines, JL, Song, YE, Griswold, AJ, Pericak-Vance, MA, Scott, WK et al.. Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study. Transl Psychiatry 2025; 15 (1): 481. PubMed PMID:41253753 PubMed Central PMC12627486.
  3. Liu, Y, Song, YE, Lynn, A, Wang, W, Miskimen, K, Fuzzell, SL, Hochstetler, SD, Laux, RA, Caywood, LJ, Clouse, JE et al.. No association of Alzheimer disease with the joint effect of HFE and TF in the mid-western Amish. J Med Genet 2025; : . PubMed PMID:41207713 .
  4. Gorski, M, Grunin, M, Herold, JM, Fröhlich, B, Behr, M, Wheeler, N, Bush, WS, Song, YE, Zhu, X, Blanton, SH et al.. Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls. Invest Ophthalmol Vis Sci 2025; 66 (13): 51. PubMed PMID:41159651 PubMed Central PMC12577769.
  5. Liu, Y, Song, YE, Lynn, A, Wang, W, Miskimen, K, Fuzzell, SL, Hochstetler, SD, Laux, RA, Caywood, LJ, Clouse, JE et al.. Telomere length, aging, and cognitive function in the Midwestern Amish. HGG Adv 2025; 7 (1): 100533. PubMed PMID:41108082 .
  6. Cukier, HN, DeRosa, BA, Coombs, LE, Tang, E, Leyva, DR, Lazzaro, AR, Gu, E, Dykxhoorn, DM, Haines, JL, Pericak-Vance, MA et al.. Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome. Stem Cell Res 2025; 89 : 103851. PubMed PMID:41086611 .
  7. Kurniansyah, N, Tasaki, S, Rehman, H, Zhu, C, Farrell, J, Sherva, R, Hauger, R, Merritt, VC, Panizzon, M, Zhang, R et al.. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv 2025; : . PubMed PMID:41040715 PubMed Central PMC12486013.
  8. Verma, A, Nittala, MG, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR. Spatial distribution of Intra-retinal Hyper-reflective foci and impact on progression in eyes with intermediate Age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2025; : . PubMed PMID:40996501 .
  9. Kang, M, Ang, TFA, Devine, SA, Sherva, R, Mukherjee, S, Trittschuh, EH, Scollard, P, Lee, M, Choi, SE, Klinedinst, B et al.. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. Alzheimers Dement 2025; 21 (9): e70681. PubMed PMID:40951946 PubMed Central PMC12434708.
  10. Liu, S, Bush, WS, Akinyemi, RO, Byrd, GS, Caban-Holt, AM, Rajabli, F, Reitz, C, Kunkle, BW, Tosto, G, Vance, JM et al.. Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. PLoS Genet 2025; 21 (9): e1011701. PubMed PMID:40906820 PubMed Central PMC12419754.
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The Haines Lab Website

Curriculum vitae

thumbnail of Haines CV 2015-07-14