Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Khurshid, Z, Farrell, JJ, Tong, T, Zhu, C, Alzheimer's Disease Sequencing Project, Martin, ER, Bush, W, Pericak-Vance, MA, Wang, LS, Schellenberg, G et al.. Multi-ancestry exome-wide study identifies variants associated with Alzheimer's disease protection. J Alzheimers Dis 2025; : 13872877251405497. PubMed PMID:41428483 .
  2. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. medRxiv 2025; : . PubMed PMID:41404293 PubMed Central PMC12704622.
  3. Andersen, OM, de Waal, MWJ, Monti, G, Tesi, N, Jensen, AMG, de Geus, C, van Spaendonk, R, Vogel, M, Ahmad, S, Amin, N et al.. Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease. Mol Neurodegener 2025; 20 (1): 122. PubMed PMID:41327266 PubMed Central PMC12667055.
  4. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer's Disease. bioRxiv 2025; : . PubMed PMID:41279621 PubMed Central PMC12637479.
  5. Dacey, R, Hou, L, Gurnani, A, Han, X, Paller-Moore, MR, Chung, J, Durape, S, Rosenthaler, M, Uretsky, M, Abdolmohammadi, B et al.. Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking. Alzheimers Dement 2025; 21 (11): e70922. PubMed PMID:41268768 PubMed Central PMC12635870.
  6. Mustafa, Y, Main, LR, Mews, M, Janve, VA, Hohman, TJ, Haines, JL, Song, YE, Griswold, AJ, Pericak-Vance, MA, Scott, WK et al.. Monocyte inflammation and resilience to Alzheimer's disease: novel genetic risk genes identified by transcriptome-wide association study. Transl Psychiatry 2025; 15 (1): 481. PubMed PMID:41253753 PubMed Central PMC12627486.
  7. Liu, Y, Song, YE, Lynn, A, Wang, W, Miskimen, K, Fuzzell, SL, Hochstetler, SD, Laux, RA, Caywood, LJ, Clouse, JE et al.. No association of Alzheimer disease with the joint effect of HFE and TF in the mid-western Amish. J Med Genet 2025; : . PubMed PMID:41207713 PubMed Central PMC12722393.
  8. Gorski, M, Grunin, M, Herold, JM, Fröhlich, B, Behr, M, Wheeler, N, Bush, WS, Song, YE, Zhu, X, Blanton, SH et al.. Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls. Invest Ophthalmol Vis Sci 2025; 66 (13): 51. PubMed PMID:41159651 PubMed Central PMC12577769.
  9. Liu, Y, Song, YE, Lynn, A, Wang, W, Miskimen, K, Fuzzell, SL, Hochstetler, SD, Laux, RA, Caywood, LJ, Clouse, JE et al.. Telomere length, aging, and cognitive function in the Midwestern Amish. HGG Adv 2025; 7 (1): 100533. PubMed PMID:41108082 PubMed Central PMC12639303.
  10. Cukier, HN, DeRosa, BA, Coombs, LE, Tang, E, Leyva, DR, Lazzaro, AR, Gu, E, Dykxhoorn, DM, Haines, JL, Pericak-Vance, MA et al.. Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome. Stem Cell Res 2025; 89 : 103851. PubMed PMID:41086611 .
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Curriculum vitae

thumbnail of Haines CV 2015-07-14