Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Contreras, AG, Walters, S, Eissman, JM, Archer, DB, Regelson, AN, Durant, A, Clifton, M, Mukherjee, S, Lee, ML, Choi, SE et al.. Genetic modifiers of APOE-ε4-associated cognitive decline. Nat Commun 2026; : . PubMed PMID:41720779 .
  2. Lorincz-Comi, N, Song, W, Chen, X, Paz, IR, Hou, Y, Zhou, Y, Xu, J, Martin, W, Barnard, J, Pieper, AA et al.. Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery. Nat Commun 2026; : . PubMed PMID:41690969 .
  3. Dorfsman, DA, Cai, D, Hamilton-Nelson, KL, Adams, LD, Mena, PR, Rodriguez, VC, Sanchez, JJ, Valladares, GS, Lopez, M, Whitehead, PL et al.. Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181. J Alzheimers Dis 2026; : 13872877261415933. PubMed PMID:41660940 .
  4. Cruz, LA, Liu, S, Miskimen, KL, Cooke Bailey, JN, Kinzy, T, Song, YE, Laux, RA, Miron, P, Ogrocki, PK, Lerner, AJ et al.. Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort study. medRxiv 2026; : . PubMed PMID:41646721 PubMed Central PMC12870599.
  5. Chung, YC, Alhelaly, M, Nittala, MG, Velaga, SB, He, Y, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR. OCT Risk Factors for Progression to Late-Stage Age-Related Macular Degeneration in the Amish Eye Study. Ophthalmol Retina 2026; : . PubMed PMID:41577331 .
  6. Durodoye, RO, Ciesielski, TH, Benchek, P, Bartlett, J, Zhu, X, Liu, S, Naj, A, Kunkle, B, Schellenberg, GD, Mayeux, R et al.. Deviations from additivity in APOE4-mediated late-onset Alzheimer's disease risk across races and ethnicities. Hum Genet 2026; 145 (1): 16. PubMed PMID:41569459 PubMed Central PMC12827419.
  7. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, BS, Trittschuh, EH, Mez, J, Farrer, LA, Gifford, KA et al.. Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers. Alzheimers Dement 2026; 22 (1): e71024. PubMed PMID:41542929 PubMed Central PMC12809718.
  8. Khurshid, Z, Farrell, JJ, Tong, T, Zhu, C, Alzheimer's Disease Sequencing Project, Martin, ER, Bush, W, Pericak-Vance, MA, Wang, LS, Schellenberg, G et al.. Multi-ancestry exome-wide study identifies variants associated with Alzheimer's disease protection. J Alzheimers Dis 2026; 109 (3): 1274-1286. PubMed PMID:41428483 .
  9. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Local genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. medRxiv 2025; : . PubMed PMID:41404293 PubMed Central PMC12704622.
  10. Andersen, OM, de Waal, MWJ, Monti, G, Tesi, N, Jensen, AMG, de Geus, C, van Spaendonk, R, Vogel, M, Ahmad, S, Amin, N et al.. Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease. Mol Neurodegener 2025; 20 (1): 122. PubMed PMID:41327266 PubMed Central PMC12667055.
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The Haines Lab Website

Curriculum vitae

thumbnail of Haines CV 2015-07-14