Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Sherva, R, Zhu, C, Zhang, R, Mez, J, Hauger, R, Merritt, VC, Panizzon, M, Gaziano, JM, Catanzaro, V, Schellenberg, GD et al.. Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans. Alzheimers Res Ther 2025; 17 (1): 171. PubMed PMID:40708016 PubMed Central PMC12288278.
  2. O'Neill, N, Kurniansyah, N, Zhu, C, Olayinka, OA, Mayeux, R, Haines, JL, Pericak-Vance, MA, Wang, LS, Schellenberg, GD, Farrer, LA et al.. 2988Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores. Neurobiol Aging 2025; 155 : 44-52. PubMed PMID:40706314 .
  3. Bertholim-Nasciben, L, Nuytemans, K, Van Booven, D, Rajabli, F, Moura, S, Ramirez, AM, Parker, GS, Dykxhoorn, DM, Wang, L, Scott, WK et al.. Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers. Alzheimers Dement 2025; 21 (7): e70500. PubMed PMID:40704449 PubMed Central PMC12287753.
  4. Rajabli, F, Benchek, P, Tosto, G, Kushch, N, Sha, J, Bazemore, K, Zhu, C, Lee, WP, Haut, J, Hamilton-Nelson, KL et al.. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol 2025; 26 (1): 210. PubMed PMID:40676597 PubMed Central PMC12273372.
  5. Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2025; 57 (7): 1791. PubMed PMID:40527985 PubMed Central PMC12283398.
  6. Shade, LMP, Katsumata, Y, Abner, EL, Aung, KZ, Claas, SA, Qiao, Q, Heberle, BA, Brandon, JA, Page, ML, Hohman, TJ et al.. Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia. Nat Genet 2025; 57 (7): 1788. PubMed PMID:40527984 PubMed Central PMC12283389.
  7. Lorincz-Comi, N, Song, W, Chen, X, Paz, IR, Hou, Y, Zhou, Y, Xu, J, Martin, W, Barnard, J, Pieper, AA et al.. Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery. Res Sq 2025; : . PubMed PMID:40502754 PubMed Central PMC12154160.
  8. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults. medRxiv 2025; : . PubMed PMID:40492063 PubMed Central PMC12148254.
  9. Wang, P, Song, YE, Lynn, A, Miskimen, K, Gulyayev, A, Prough, MB, Dorfsman, DA, Laux, RA, Fuzzell, SL, Hochstetler, SD et al.. Alzheimer's disease plasma biomarkers in the Midwestern Amish. Alzheimers Dement 2025; 21 (6): e70328. PubMed PMID:40465679 PubMed Central PMC12136092.
  10. Wang, P, Song, YE, Lynn, A, Miskimen, K, Gulyayev, A, Prough, MB, Dorfsman, DA, Laux, RA, Fuzzell, SL, Hochstetler, SD et al.. Heritability of Alzheimer-related plasma biomarkers in the Amish population. medRxiv 2025; : . PubMed PMID:40463532 PubMed Central PMC12132146.
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Curriculum vitae

thumbnail of Haines CV 2015-07-14