Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.
- den Hollander, AI, Mullins, RF, Orozco, LD, Voigt, AP, Chen, HH, Strunz, T, Grassmann, F, Haines, JL, Kuiper, JJW, Tumminia, SJ et al.. Systems genomics in age-related macular degeneration. Exp Eye Res 2022; : 109248. PubMed PMID:36108770 .
- Waksmunski, AR, Miskimen, K, Song, YE, Grunin, M, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M et al.. Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish. Invest Ophthalmol Vis Sci 2022; 63 (9): 8. PubMed PMID:35930268 PubMed Central PMC9363678.
- Osterman, MD, Song, YE, Nittala, M, Sadda, SR, Scott, WK, Stambolian, D, Pericak-Vance, MA, Haines, JL. Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 2022; 63 (8): 17. PubMed PMID:35857289 PubMed Central PMC9315071.
- Rajabli, F, Beecham, GW, Hendrie, HC, Baiyewu, O, Ogunniyi, A, Gao, S, Kushch, NA, Lipkin-Vasquez, M, Hamilton-Nelson, KL, Young, JI et al.. A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry. PLoS Genet 2022; 18 (7): e1009977. PubMed PMID:35788729 PubMed Central PMC9286282.
- Chung, J, Das, A, Sun, X, Sobreira, DR, Leung, YY, Igartua, C, Mozaffari, S, Chou, YF, Thiagalingam, S, Mez, J et al.. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement 2022; : . PubMed PMID:35770850 .
- Oncel, D, Manafi, N, Nittala, MG, Velaga, SB, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Effect of OCT B-Scan Density on Sensitivity for Detection of Intraretinal Hyperreflective Foci in Eyes with Age-Related Macular Degeneration. Curr Eye Res 2022; 47 (9): 1294-1299. PubMed PMID:35603911 .
- Osterman, MD, Song, YE, Adams, LD, Laux, RA, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD, Slifer, SH, Lynn, A et al.. The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish. HGG Adv 2022; 3 (3): 100114. PubMed PMID:35599847 PubMed Central PMC9114685.
- Eissman, JM, Dumitrescu, L, Mahoney, ER, Smith, AN, Mukherjee, S, Lee, ML, Scollard, P, Choi, SE, Bush, WS, Engelman, CD et al.. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain 2022; 145 (7): 2541-2554. PubMed PMID:35552371 PubMed Central PMC9337804.
- Yaghy, A, Lee, AY, Keane, PA, Keenan, TDL, Mendonca, LSM, Lee, CS, Cairns, AM, Carroll, J, Chen, H, Clark, J et al.. Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials. Exp Eye Res 2022; 220 : 109092. PubMed PMID:35525297 PubMed Central PMC9405680.
- Ramos, J, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD, Slifer, SH, Fuzzell, MD, Fuzzell, SL, Hochstetler, SD, Miskimen, KL et al.. Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets. Alzheimers Dement 2022; : . PubMed PMID:35490390 .