Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Li, D, Farrell, JJ, Mez, J, Martin, ER, Bush, WS, Ruiz, A, Boada, M, de Rojas, I, Mayeux, R, Haines, JL et al.. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. Alzheimers Dement 2023; : . PubMed PMID:37260021 .
  2. Byfield, G, Starks, TD, Luther, R, Edwards, CL, Lloyd, SL, Caban-Holt, A, Adams, LD, Vance, JM, Cuccaro, M, Haines, JL et al.. Leveraging African American family connectors for Alzheimer's disease genomic studies. Alzheimers Dement 2023; : . PubMed PMID:37212603 .
  3. Oncel, D, Corradetti, G, He, Y, Ashrafkhorasani, M, Nittala, MG, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Assessment of intraretinal hyperreflective foci using multimodal imaging in eyes with age-related macular degeneration. Acta Ophthalmol 2023; : . PubMed PMID:37199278 .
  4. Oncel, D, Corradetti, G, Wakatsuki, Y, Nittala, MG, Velaga, SB, Stambolian, D, Pericak-Vance, MA, Haines, JL, Sadda, SR. Drusen morphometrics on optical coherence tomography in eyes with age-related macular degeneration and normal aging. Graefes Arch Clin Exp Ophthalmol 2023; : . PubMed PMID:37133500 .
  5. Bai, H, Naj, AC, Benchek, P, Dumitrescu, L, Hohman, T, Hamilton-Nelson, K, Kallianpur, AR, Griswold, AJ, Vardarajan, B, Martin, ER et al.. A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease. Alzheimers Dement 2023; : . PubMed PMID:37051669 .
  6. Qiao, M, Lee, AJ, Reyes-Dumeyer, D, Tosto, G, Faber, K, Goate, A, Renton, A, Chao, M, Boeve, B, Cruchaga, C et al.. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. Ann Clin Transl Neurol 2023; 10 (5): 744-756. PubMed PMID:36946865 PubMed Central PMC10187719.
  7. Zaman, A, Caywood, L, Prough, M, Clouse, J, Harrington, S, Adams, L, Fuzzell, D, Fuzzell, S, Laux, R, Hochstetler, SD et al.. Psychometric approaches to defining cognitive phenotypes in the Old Order Amish. Int J Geriatr Psychiatry 2023; 38 (4): e5903. PubMed PMID:36929524 .
  8. Aboobakar, IF, Kinzy, TG, Zhao, Y, Fan, B, Pasquale, LR, Qassim, A, Kolovos, A, Schmidt, JM, Craig, JE, Cooke Bailey, JN et al.. Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes. Ophthalmology 2023; : . PubMed PMID:36813040 .
  9. de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Jansen, IE, Pedersen, NL, Stringa, N, Zettergren, A, Hernández, I et al.. Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun 2023; 14 (1): 716. PubMed PMID:36759603 PubMed Central PMC9911386.
  10. Rajabli, F, Tosto, G, Hamilton-Nelson, KL, Kunkle, BW, Vardarajan, BN, Naj, A, Whitehead, PG, Gardner, OK, Bush, WS, Sariya, S et al.. Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans. Alzheimers Dement 2022; : . PubMed PMID:36539198 .
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The Haines Lab Website

Curriculum vitae

thumbnail of Haines CV 2015-07-14