Symposium Speaker: Jonathan L. Haines, PhD

Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.

Recent Publications

  1. Zhu, C, Tong, T, Farrell, JJ, Martin, ER, Bush, WS, Pericak-Vance, MA, Wang, LS, Schellenberg, GD, Haines, JL, Lunetta, KL et al.. MitoH3: Mitochondrial Haplogroup and Homoplasmic/Heteroplasmic Variant Calling Pipeline for Alzheimer's Disease Sequencing Project. J Alzheimers Dis Rep 2024; 8 (1): 575-587. PubMed PMID:38746629 PubMed Central PMC11091720.
  2. Griswold, AJ, Rajabli, F, Gu, T, Arvizu, J, Golightly, CG, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Mena, PR et al.. Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer's Disease Cohorts of Diverse Genetic Ancestries. medRxiv 2024; : . PubMed PMID:38645114 PubMed Central PMC11030471.
  3. Verma, A, Nittala, MG, Corradetti, G, Nassisi, M, Velaga, SB, He, Y, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR et al.. Longitudinal Evaluation of the Distribution of Intraretinal Hyper-Reflective Foci in Eyes with Intermediate Age-Related Macular Degeneration. Curr Eye Res 2024; : 1-7. PubMed PMID:38639042 .
  4. Cukier, HN, Simon, SA, Tang, E, Golightly, CG, Laverde-Paz, MJ, Adams, LD, Starks, TD, Vance, JM, Cuccaro, ML, Haines, JL et al.. Generation of an induced pluripotent stem cell line (UMi043-A) from an African American patient with Alzheimer's disease carrying an ABCA7 deletion (p.Arg578Alafs). Stem Cell Res 2024; 76 : 103364. PubMed PMID:38422817 .
  5. Rajabli, F, Seixas, AA, Akgun, B, Adams, LD, Inciute, J, Hamilton, KL, Whithead, PG, Konidari, I, Gu, T, Arvizu, J et al.. African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer's Disease Measured by pTau181. J Alzheimers Dis 2024; 98 (1): 221-229. PubMed PMID:38393909 PubMed Central PMC11091636.
  6. Cheng, F, Wang, F, Tang, J, Zhou, Y, Fu, Z, Zhang, P, Haines, JL, Leverenz, JB, Gan, L, Hu, J et al.. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease. Cell Rep Med 2024; 5 (2): 101379. PubMed PMID:38382465 PubMed Central PMC10897520.
  7. Caban-Holt, A, Cuccaro, ML, Lloyd, SL, Starks, TD, Adams, LD, Ford, T, Haines, JL, Beecham, G, Reitz, C, Vance, JM et al.. Attitudes and Perceptions about Brain Donation Among African Americans: Implications for Recruitment into Alzheimer's Disease Research. J Alzheimers Dis 2024; 97 (4): 1621-1627. PubMed PMID:38306029 .
  8. Wang, P, Lynn, A, Miskimen, K, Song, YE, Wisniewski, T, Cohen, M, Appleby, BS, Safar, JG, Haines, JL. Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease. Alzheimers Dement 2024; 20 (3): 2034-2046. PubMed PMID:38184787 PubMed Central PMC10984493.
  9. Vance, JM, Farrer, LA, Huang, Y, Cruchaga, C, Hyman, BT, Pericak-Vance, MA, Goate, AM, Greicius, MD, Griswold, AJ, Haines, JL et al.. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Ann Neurol 2024; 95 (4): 625-634. PubMed PMID:38180638 .
  10. Main, LR, Song, YE, Lynn, A, Laux, RA, Miskimen, KL, Osterman, MD, Cuccaro, ML, Ogrocki, PK, Lerner, AJ, Vance, JM et al.. Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2. medRxiv 2023; : . PubMed PMID:38168325 PubMed Central PMC10760262.
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Curriculum vitae

thumbnail of Haines CV 2015-07-14