Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.
- Eissman, JM, Dumitrescu, L, Mahoney, ER, Smith, AN, Mukherjee, S, Lee, ML, Scollard, P, Choi, SE, Bush, WS, Engelman, CD et al.. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain 2022; : . PubMed PMID:35552371 .
- Yaghy, A, Lee, AY, Keane, PA, Keenan, TDL, Mendonca, LSM, Lee, CS, Cairns, AM, Caroll, J, Chen, H, Clark, J et al.. Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials. Exp Eye Res 2022; : 109092. PubMed PMID:35525297 .
- Ramos, J, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD, Slifer, SH, Fuzzell, MD, Fuzzell, SL, Hochstetler, SD, Miskimen, KL et al.. Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets. Alzheimers Dement 2022; : . PubMed PMID:35490390 .
- Gardner, OK, Van Booven, D, Wang, L, Gu, T, Hofmann, NK, Whitehead, PL, Nuytemans, K, Hamilton-Nelson, KL, Adams, LD, Starks, TD et al.. Genetic Architecture of RNA Editing Regulation in Alzheimer Disease across Diverse Ancestral Populations. Hum Mol Genet 2022; : . PubMed PMID:35383839 .
- Bellenguez, C, Küçükali, F, Jansen, IE, Kleineidam, L, Moreno-Grau, S, Amin, N, Naj, AC, Campos-Martin, R, Grenier-Boley, B, Andrade, V et al.. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet 2022; 54 (4): 412-436. PubMed PMID:35379992 PubMed Central PMC9005347.
- Kizil, C, Sariya, S, Kim, YA, Rajabli, F, Martin, E, Reyes-Dumeyer, D, Vardarajan, B, Maldonado, A, Haines, JL, Mayeux, R et al.. Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1. Mol Psychiatry 2022; : . PubMed PMID:35365809 .
- Vardarajan, BN, Reyes-Dumeyer, D, Piriz, AL, Lantigua, RA, Medrano, M, Rivera, D, Jiménez-Velázquez, IZ, Martin, E, Pericak-Vance, MA, Bush, W et al.. Progranulin mutations in clinical and neuropathological Alzheimer's disease. Alzheimers Dement 2022; : . PubMed PMID:35258170 .
- Jin, B, Capra, JA, Benchek, P, Wheeler, N, Naj, AC, Hamilton-Nelson, KL, Farrell, JJ, Leung, YY, Kunkle, B, Vadarajan, B et al.. An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns. Genome Res 2022; 32 (4): 778-790. PubMed PMID:35210353 PubMed Central PMC8997344.
- Shade, LM, Katsumata, Y, Hohman, TJ, Nho, K, Saykin, AJ, Mukherjee, S, Boehme, KL, Kauwe, JS, Farrer, LA, Schellenberg, GD et al.. Genome-wide association study of brain arteriolosclerosis. J Cereb Blood Flow Metab 2022; : 271678X211066299. PubMed PMID:35156446 .
- Jun, GR, You, Y, Zhu, C, Meng, G, Chung, J, Panitch, R, Hu, J, Xia, W, Alzheimer's Disease Genetics Consortium, Bennett, DA et al.. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease. Alzheimers Dement 2022; : . PubMed PMID:35142023 .