Dr. Jonathan Haines is Mary W. Sheldon, MD, Professor of Genome Sciences; Chair of the Department of Epidemiology and Biostatistics; and Director of the Institute for Computational Biology at Case Western Reserve University School of Medicine. Dr. Haines is a genetic epidemiologist with a focus on adapting and applying statistical computational approaches to identify genetic variants and their modifiers that impact common human diseases with a focus on ocular and neurological diseases including age-related macular degeneration, primary open angle glaucoma, multiple sclerosis, autism, Parkinson’s disease, Alzheimer’s disease, to name a few. Dr. Haines is also active in Big Data science and electronic health records research and was the previous principal investigator of the National Human Genome Research Institute (NHGRI)-funded electronic MEdical Records & GEnomics (eMERGE) Coordinating Center. More recently, Dr. Haines founded the CWRU Institute for Computational Biology (ICB) as part of a multi-institutional funded effort involving Case Western Reserve University (CWRU), University of Hospital, Cleveland Clinic Foundation, and MetroHealth. Physically located at CWRU, the ICB aims to bring together electronic health records data in a de-identified environment to be accessed by investigators for research purposes. The ICB also aims to provide educational opportunities and resources such as databasing capabilities and the development of statistical methods for big data analysis. Dr. Haines has several accolades in recognition of his discoveries including the Zenith Award for Excellence in Alzheimer’s Disease Research (1993) and the Vanderbilt University School of Medicine Sidney P. Colowick Award for Research in Diverse Areas (2005). Dr. Haines was named a fellow in the American Association for the Advancement of Science in 2010.
- Archer, DB, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement 2023; : . PubMed PMID:37985223 .
- Eissman, JM, Archer, DB, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Sex-specific genetic architecture of late-life memory performance. Alzheimers Dement 2023; : . PubMed PMID:37984853 .
- Nuytemans, K, Rajabli, F, Jean-Francois, M, Kurup, JT, Adams, LD, Starks, TD, Whitehead, PL, Kunkle, BW, Caban-Holt, A, Haines, JL et al.. Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer's Disease in individuals of African Ancestry. Neurobiol Aging 2024; 133 : 125-133. PubMed PMID:37952397 .
- Osterman, MD, Song, YE, Lynn, A, Miskimen, K, Adams, LD, Laux, RA, Caywood, LJ, Prough, MB, Clouse, JE, Herington, SD et al.. Founder population-specific weights yield improvements in performance of polygenic risk scores for Alzheimer's disease in the Midwestern Amish. HGG Adv 2023; 4 (4): 100241. PubMed PMID:37742071 PubMed Central PMC10565871.
- Liu, WW, Kinzy, TG, Cooke Bailey, JN, Xu, Z, Hysi, P, Wiggs, JL, NEIGHBORHOOD Consortium. Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma. Sci Rep 2023; 13 (1): 15871. PubMed PMID:37741866 PubMed Central PMC10517927.
- Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project. medRxiv 2023; : . PubMed PMID:37693521 PubMed Central PMC10491367.
- Celis, K, Zaman, A, Adams, LD, Gardner, O, Farid, R, Starks, TD, Lacroix, FC, Hamilton-Nelson, K, Mena, P, Tejada, S et al.. Neuropsychiatric features in a multi-ethnic population with Alzheimer disease and mild cognitive impairment. Int J Geriatr Psychiatry 2023; 38 (9): e5992. PubMed PMID:37655494 PubMed Central PMC10518518.
- Tejeda, M, Farrell, J, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD, Pericak-Vance, MA et al.. DNA from multiple viral species is associated with Alzheimer's disease risk. Alzheimers Dement 2023; : . PubMed PMID:37578203 .
- Verma, A, Corradetti, G, He, Y, Nittala, MG, Nassisi, M, Velaga, SB, Haines, JL, Pericak-Vance, MA, Stambolian, D, Sadda, SR et al.. Relationship between the distribution of intra-retinal hyper-reflective foci and the progression of intermediate age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2023; 261 (12): 3437-3447. PubMed PMID:37566303 PubMed Central PMC10667133.
- Prough, MB, Zaman, A, Caywood, LJ, Clouse, JE, Herington, SD, Slifer, SH, Dorfsman, DA, Adams, LA, Laux, RA, Song, YE et al.. Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias. Alzheimer Dis Assoc Disord ; 37 (3): 195-199. PubMed PMID:37561946 PubMed Central PMC10529392.