Propionic acidemia (PA) is an inborn of metabolism which usually presents with metabolic acidosis and accumulation of 3-hydroxypropionate among other toxins. Examining the gene expression in lymphoblastoid cell lines (LCLs) from PA patients, their carrier parents and age/sex-matched controls at normal glucose and low glucose growth conditions demonstrated differences among and between these groups. Using […]
Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.In this study, we analyzed the role of parental levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) in explaining the values of the corresponding traits in adult offspring. […]
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis. Mutations in […]
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Summer is almost over—where has the time gone? What have we done? Well, the Crawford lab was abuzz with activity starting with the PhD commencement ceremony in May (Figure 1). Congrats to Nicole Restrepo, our newly minted PhD in human genetics! In June, both Nicole Restrepo and Haines lab post-doctoral fellow Jessica Cooke Bailey gave […]
Check back regularly for announcements and news from the Crawford lab, past and present!
Dr. Dana Crawford presented a poster on environmental variables and GxE studies at the 2015 Pacific Symposium on Biocomputing meeting (left). The poster has been published as a peer-review article in the conference proceedings (PMID:25592578).
Human islet research is providing new insights into human islet biology and diabetes, using islets isolated at multiple US centers from donors with varying characteristics. This creates challenges for understanding, interpreting, and integrating research findings from the many laboratories that use these islets. In what is, to our knowledge, the first standardized assessment of human […]
Dr. Jonathan Haines presented a poster on the Genetic Architecture of Alzheimer’s Disease at the Alzheimer’s Disease/Parkison’s Disease Meeting. A PDF of this poster is available at the left.
Dr. Hadrian Djohari, High Performance Computing Manager at Case Western Reserve University organized the first annual CWRU Cyberinfrastructure Day, held on March 27, 2015. Dr. Will Bush spoke on the use of large scale computing for biomedical research. Slides from this presentation are at the left.
Jake Hall of the Bush Lab presented “Mixed-model Analysis of Common Variation Reveals Pathways Explaining Variance in AMD Risk” at the International Genetic Epidemiology Society 2014 annual meeting in Vienna, Austria. Slides from this presentation are available to the left.