Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed populations, such as African Americans, provides a unique opportunity to identify genomic regions and variants associated with the clinical variability observed for diseases and traits across populations.To […]
There’s a chill in the air. Leaves have turned from bright green to brilliant red, yellow, and orange. The wind is picking up. You know what that means. Yes, it’s time for the annual American Society of Human Genetics (ASHG) meeting! ASHG is the professional organization for human genetics and has had an annual meeting […]
Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10% of individuals over age 80. AMD has a large genetic component, with heritability estimated to be between 45% and 70%. Numerous variants have been identified and implicate various molecular mechanisms and […]
Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the elderly in developed countries and typically affects more than 10% of individuals over age 80. AMD has a large genetic component, with heritability estimated to be between 45% and 70%. Numerous variants have been identified and implicate various molecular mechanisms and […]
The Pacific Symposium on Biocomputing is a unique mid-sized conference focused on computational methods with applications to the biomedical sciences. Hosted in Hawaii (Figures 1 and 2), PSB has been around since 1996, and many attendees have been to every single meeting. I had not heard of PSB until I met Dr. Marylyn Ritchie and […]
Propionic acidemia (PA) is an inborn of metabolism which usually presents with metabolic acidosis and accumulation of 3-hydroxypropionate among other toxins. Examining the gene expression in lymphoblastoid cell lines (LCLs) from PA patients, their carrier parents and age/sex-matched controls at normal glucose and low glucose growth conditions demonstrated differences among and between these groups. Using […]
Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.In this study, we analyzed the role of parental levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TGs) in explaining the values of the corresponding traits in adult offspring. […]
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis. Mutations in […]
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Summer is almost over—where has the time gone? What have we done? Well, the Crawford lab was abuzz with activity starting with the PhD commencement ceremony in May (Figure 1). Congrats to Nicole Restrepo, our newly minted PhD in human genetics! In June, both Nicole Restrepo and Haines lab post-doctoral fellow Jessica Cooke Bailey gave […]
Check back regularly for announcements and news from the Crawford lab, past and present!