DANA C. CRAWFORD, PHD

Associate Director for Population and Diversity Research

Dana Craw­ford, PhD, is Asso­ciate Pro­fes­sor in the Departments of Population and Quantitative Health Sciences (primary) and Genetics and Genome Sciences (secondary) and Assistant Director for Population and Diversity Research in the Cleveland Insti­tute for Com­pu­ta­tional Biol­ogy. Dr. Craw­ford received her Ph.D. at Emory Uni­ver­sity in genet­ics and mol­e­c­u­lar biol­ogy in 2000 and then trained as a post-doctoral fel­low as an Epi­demic Intel­li­gence Ser­vice Offi­cer at the Cen­ters for Dis­ease Con­trol and Pre­ven­tion (2000–2002) and as a senior fel­low at the Uni­ver­sity of Washington’s Depart­ment of Genome Sci­ences (2002–2006). Prior to her most cur­rent posi­tion, Dr. Craw­ford spent eight years as tenure-track fac­ulty in Depart­ment of Mol­e­c­u­lar Phys­i­ol­ogy and Bio­physics and Inves­ti­ga­tor in the Cen­ter for Human Genet­ics Research at Van­der­bilt Uni­ver­sity. As a genetic epi­demi­ol­o­gist at CWRU, Dr. Crawford’s broad research inter­ests include apply­ing genetic vari­a­tion data to large-scale epi­demi­o­logic and clin­i­cal cohorts to bet­ter under­stand human genotype-phenotype asso­ci­a­tions with an empha­sis on diverse populations.

Affiliations

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Featured Publications

Characterization of the Metabochip in diverse populations from the International HapMap Project in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project.

Crawford DC, Goodloe R, Brown-Gentry K, Wilson S, Roberson J, Gillani NB, Ritchie MD, Dilks HH, Bush WS,. Genome-wide association studies (GWAS) have identified hundreds of genomic regions associated with common human disease and quantitative traits. A major research avenue for mature genotype-phenotype associations is the identification of the true risk or functional variant for […]

Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study.

Bush WS, Boston J, Pendergrass SA, Dumitrescu L, Goodloe R, Brown-Gentry K, Wilson S, McClellan B, Torstenson E, Basford MA, Spencer KL, Ritchie MD, Crawford DC,. Genetic association studies have rapidly become a major tool for identifying the genetic basis of common human diseases. The advent of cost-effective genotyping coupled with large collections of samples […]

Recent Publications

  1. Darst, BF, Wan, P, Sheng, X, Bensen, JT, Ingles, SA, Rybicki, BA, Nemesure, B, John, EM, Fowke, JH, Stevens, VL et al.. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur. Urol. 2020; : . PubMed PMID:32409115 .
  2. Koroshetz, WJ, Behrman, S, Brame, CJ, Branchaw, JL, Brown, EN, Clark, EA, Dockterman, D, Elm, JJ, Gay, PL, Green, KM et al.. Framework for advancing rigorous research. Elife 2020; 9 : . PubMed PMID:32127131 PubMed Central PMC7056268.
  3. Pendergrass, SA, Buyske, S, Jeff, JM, Frase, A, Dudek, S, Bradford, Y, Ambite, JL, Avery, CL, Buzkova, P, Deelman, E et al.. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. PLoS ONE 2019; 14 (12): e0226771. PubMed PMID:31891604 PubMed Central PMC6938343.
  4. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
  5. Bush, WS, Cooke Bailey, JN, Beno, MF, Crawford, DC. Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. Public Health Genomics 2019; 22 (1-2): 16-24. PubMed PMID:31454805 PubMed Central PMC6752968.
  6. Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC et al.. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
  7. Crawford, DC, Cooke Bailey, JN, Briggs, FBS. Mind the gap: resources required to receive, process and interpret research-returned whole genome data. Hum. Genet. 2019; 138 (7): 691-701. PubMed PMID:31161416 PubMed Central PMC6767905.
  8. Hollister, BM, Farber-Eger, E, Aldrich, MC, Crawford, DC. A Social Determinant of Health May Modify Genetic Associations for Blood Pressure: Evidence From a SNP by Education Interaction in an African American Population. Front Genet 2019; 10 : 428. PubMed PMID:31134134 PubMed Central PMC6523518.
  9. Pendergrass, SA, Crawford, DC. Using Electronic Health Records To Generate Phenotypes For Research. Curr Protoc Hum Genet 2019; 100 (1): e80. PubMed PMID:30516347 PubMed Central PMC6318047.
  10. Restrepo, NA, Laper, SM, Farber-Eger, E, Crawford, DC. Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records. BMC Med Genomics 2018; 11 (Suppl 3): 70. PubMed PMID:30255811 PubMed Central PMC6157155.
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Curriculum vitae