Jonathan Haines, Ph.D.

Jonathan Haines, Ph.D. is a genetic epidemiologist, Mary W. Sheldon M.D. Professor of Genomic Sciences, Chair of Department of Epidemiology & Biostatistics, and Director of the Institute for Computational Biology. Dr. Haines has extensive experience in all aspects of genetic epidemiology with a particular focus on data analytics.  He has applied his expertise to numerous neurological and ophthalmological disorders having located and identified over 20 causal and 200 associated loci.  His interests are in adapting and applying statistical computational methods to biomedical big data.  Learn more...

Dana Crawford, Ph.D.

Dana Crawford, Ph.D. is Associate Professor of Epidemiology and Biostatistics within the Institute for Computational Biology.  Dr. Crawford received her Ph.D. at Emory University in genetics and molecular biology in 2000 and then trained as a post-doctoral fellow as an Epidemic Intelligence Service Officer at the Centers for Disease Control and Prevention (2000-2002) and as a senior fellow at the University of Washington’s Department of Genome Sciences (2002-2006).  Prior to her most current position, Dr. Crawford spent eight years as tenure-track faculty in Department of Molecular Physiology and Biophysics and Investigator in the Center for Human Genetics Research at Vanderbilt University.  As a genetic epidemiologist at CWRU, Dr. Crawford’s broad research interests include applying genetic variation data to large-scale epidemiologic and clinical cohorts to better understand human genotype-phenotype associations with an emphasis on diverse populations.  Learn more...

Jill Barnholtz-Sloan, Ph.D.

Jill Barnholtz-Sloan, Ph.D. is the Associate Director for Clinical Informatics in the Institute for Computational Biology, the Associate Director for Bioinformatics at the Case Comprehensive Cancer Center, and Professor at Case Western Reserve University School of Medicine.  Dr. Barnholtz-Sloan is multi-disciplinary, trained in biostatistics, population genetics, and human genetics; her role in team science has been essential for multiple successful multi-disciplinary research projects.  She is responsible for managing bioinformatics analysis of high throughput “omics” data and implementing and maintaining a clinical informatics solution for research.   She is also the Director of the CWRU GI SPORE Biostatistics Core, Director of the CWRU BETRNet Bioinformatics Core, and Co-Director of the Case Comprehensive Cancer Center Biostatistics and Bioinformatics Core Facility.  Her current projects include the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA) and currently serves as a multi-site therapeutic clinical trial network for the Governors Ohio Clinical Trials Collaborative.  She also manages the Central Brain Tumor Registry for the United States (CBTRUS) and is involved in the NCI funded GLIOGENE consortium.  Dr. Barnholtz-Sloan has extensive experience with multi-site brain tumor patient recruitment, biospecimen collection and storage and clinical annotation.  Learn more...

Chun Li, Ph.D.

Chun Li, Ph.D. is an Associate Professor of Epidemiology and Biostatistics.  He has extensive experience in statistical genetics research and genetic data analysis.  He is currently working on developing methods for detecting somatic changes using next-generation sequencing data.  He is also interested in developing methods to efficiently mine electronic medical records.  Active in collaborative research, he has been working with investigators in various fields such as cancer epidemiology, clinical pharmacology, ophthalmology, cardiovascular disease, autism, type 2 diabetes, etc.  He has published in Nature Genetics, New England Journal of Medicine, Blood, American Journal of Human Genetics, Bioinformatics, etc.  Learn more...

William S. Bush, Ph.D.

William S. Bush, Ph.D. is an Assistant Professor in the Department of Epidemiology and Biostatistics and the Institute for Computational Biology at Case Western Reserve University.  Dr. Bush received his Ph.D. at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt.  Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar.  As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.  Learn more...

Ricky Chan, Ph.D.

E. Ricky Chan, Ph.D. is a Research Scientist and Director of the Computational Biology Core.  His focus for the core is to provide a gateway for labs seeking assistance in the field of bioinformatics and computational analysis.  This need has grown tremendously as additional research projects are leveraging the use of next-generation sequencing methods but lack the computational expertise to handle large datasets.  Dr. Chan received his Ph.D. from Case Western Reserve University under the mentorship of Dr. Mark Adams, mapping ENU-induced mutations in mouse models of blood disorders, uncovering a recessive mutation in the TPO receptor that leads to thrombocytopenia with over-dominance.  He continued his training as a post-doctoral fellow with Dr. David Serre at the Cleveland Clinic where his focus was on the genomic characterization of the malarial parasite Plasmodium vivax, revealing a common duplication of the Duffy binding protein in Malagasy individuals which may be involved in the uncanny observation of P. vivax infecting Duffy negative individuals in that region.  During his post-doc training Dr. Chan also developed and implemented a novel method and pipeline for the characterization of microbiome data using 16s sequencing in several disease models and studies including colon cancer, metabolic uptake, and restoration of colonization resistance of nosocomial pathogens after antimicrobial treatment.  From these highly collaborative experiences Dr. Chan has become an expert in the processing and analysis of next-generation sequencing data.  As the director of the Computational Biology core he continues to develop and test new genomic and computational tools to assist in various research studies including but not limited to infectious disease, cancer, metabolism, and the microbiome.  Please contact Dr. Chan if you have a project requiring analytical assistance with next-generation sequencing data including whole genome or exome sequencing, RNA-Seq, locus-specific sequencing, SNP and variant detection and comparative genomics.  Learn more...

Aaron Goldenberg, Ph.D., MPH

Dr. Aaron Goldenberg leads the Ethics Core for the Institute for Computational Biology and is an Associate Professor in the Department of Bioethics at Case Western Reserve University School of Medicine. He is also the Director of Research for the Department. He is also the Associate Director of the Center for Genetic Research Ethics and Law, a NIH Center of Excellence in Ethical, Legal, and Social Implications Research for the National Human Genome Research Institute. He earned his PhD in Bioethics at Case Western Reserve University. Since joining the faculty at Case Western Reserve University, Dr. Goldenberg’s work has focused on the ethical, legal, and social implications of genetics and genomics in clinical and public health settings. His research program has been grounded by a number of major project areas, including: 1) ethical implications of expanding newborn screening programs; 2) storage and use of perinatal and pediatric biological specimens for future research; 3) implications of genetics and gene-environment interactions for racial/ethnic minorities and other communities experiencing health disparities. Learn more...

Mark Beno, M.S.M.

Mark Beno, M.S.M, is the Director of Strategic Operations for the Institute for Computational Biology.  Mark received his Master’s in 2016 from the Weatherhead School of Management (Case Western Reserve University) as part of the inaugural cohort in the Master’s of Science in Management program with a focus on healthcare.  A 27-year employee of Case Western Reserve University, with a B.A. in Biochemistry (CWRU), prior to joining the ICB, Mark was the administrative and finance manager for multiple University research departments, and was involved in several multi-institutional research efforts.  He serves on multiple University standing committees, including the Retirement Plans Oversight, Fringe Benefits, and Health Advisory committees.  Mark will soon begin work, in close consultation with the steering committee and the internal advisory board, on the development of 3 and 5-year strategic plans for the Institute for Computational Biology.  The finalized plans will be released later this fall (2016).