In a typical calendar year, my conference season tends to be concentrated to the fall semester, culminating with the Pacific Symposium on Biocomputing in the first week of January just before or as the spring semester begins. Travel outside this schedule is generally limited to special meetings such as NIH study section, consortium meetings, etc. […]
It’s the end of another semester, and in this case, another academic year. This past semester, I taught EPBI 444 Communicating in Population Health Science Research and co-organized EPBI 502 Seminar in Genetic Epidemiology and Bioinformatics. I don’t mind teaching all by myself, but it’s certainly more fun with friends! This past semester, I was […]
Population stratification or confounding by genetic ancestry is a potential cause of false associations in genetic association studies. Estimation of and adjustment for genetic ancestry has become common practice thanks in part to the availability of ancestry informative markers on genome-wide association study (GWAS) arrays. While array data is now widespread, these data are not […]
Population stratification or confounding by genetic ancestry is a potential cause of false associations in genetic association studies. Estimation of and adjustment for genetic ancestry has become common practice thanks in part to the availability of ancestry informative markers on genome-wide association study (GWAS) arrays. While array data is now widespread, these data are not […]
Population stratification or confounding by genetic ancestry is a potential cause of false associations in genetic association studies. Estimation of and adjustment for genetic ancestry has become common practice thanks in part to the availability of ancestry informative markers on genome-wide association study (GWAS) arrays. While array data is now widespread, these data are not […]
Population stratification or confounding by genetic ancestry is a potential cause of false associations in genetic association studies. Estimation of and adjustment for genetic ancestry has become common practice thanks in part to the availability of ancestry informative markers on genome-wide association study (GWAS) arrays. While array data is now widespread, these data are not […]
Population stratification or confounding by genetic ancestry is a potential cause of false associations in genetic association studies. Estimation of and adjustment for genetic ancestry has become common practice thanks in part to the availability of ancestry informative markers on genome-wide association study (GWAS) arrays. While array data is now widespread, these data are not […]
Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) are not elevated. This is a timely issue because recent studies have questioned whether HDL-C […]
It’s official—spring is here and everything’s blooming in Cleveland (Figures 1 and 2). The sun is out, which puts a spring in our step. You know what else puts a spring in my step? Good news from the Crawford lab! First thing’s first: kudos to current Crawford crew member Brittany Hollister for surviving her latest […]
We are at the time of the year when I like to reflect back on the Pacific Symposium on Biocomputing (PSB). It’s February, which means the snow is still blowing here at CWRU, and the temperatures are not inspiring the use of swimwear (Figure 1). The most recent PSB meeting was January 4-8, 2016, on […]
Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the influence of this admixture on human traits is largely unknown. We analyzed the contribution of common Neandertal variants to over 1000 electronic health record (EHR)-derived phenotypes in 28,000 adults of European ancestry. We discovered and replicated associations of […]
Late-onset Alzheimer disease (AD) has a complex genetic etiology, involving locus heterogeneity, polygenic inheritance, and gene-gene interactions; however, the investigation of interactions in recent genome-wide association studies has been limited. We used a biological knowledge-driven approach to evaluate gene-gene interactions for consistency across 13 data sets from the Alzheimer Disease Genetics Consortium. Fifteen single nucleotide […]