Stephanie L. Silva-Del Toro University of Iowa Iowa City, IA Mechanisms of H. Pylori-Induced Neutrophil Nuclear Hypersegmentation Stephanie L. Silva-Del Toro*, University of Iowa and Lee-Ann Allen, University of Iowa Inflammation Program Helicobacter pylori is a human pathogen that resides in the gastric mucosa, eliciting a neutrophil (PMN) dominant inflammatory response that can progress […]
Melissa Roberts University of California, Berkeley Berkeley, CA A Genetic Strategy to Identify Lipid Droplet Protein Degradation Pathways Melissa Roberts*1; Dara Leto2; Julian Stevenson1; Kartoosh Heydari1; Lawrence Bacudio1; Ron Kopito2; Michael Bassik2 and James Olzmann1, (1)University of California, Berkeley, (2)Stanford University Nearly all cells store lipids in endoplasmic reticulum (ER)-derived organelles called lipid droplets […]
Before becoming a member of the American Society of Human Genetics (ASHG) and attending the annual meeting, I was not all that familiar with San Diego. Sure, we had visited a time or two as kids, but geez, that was a long time ago. Now we go so often, San Diego seems like a second […]
For those of us trained in human genetics, we know that pretty much any trait or disease has a heritable component. Yet, no matter how big, we also know heritability (additive genetics) is only part of story. The environment, alone and in combination or interaction with genetics, and gene-gene interactions also affect phenotypes. It’s complex, […]
The little paper that could. What that might be? You know, that little project based on a small sample size that generated big opportunities. Ever had one of those? Well, we recently did. The “we” in this post was our MetroHealth/Institute for Computational Biology Pilot study, affectionately known as MIPs. Collaborators Drs. John Sedor and […]
What can I say–this end-of-the-year update is extremely late. I mean, it’s February and 2019 is well underway. I blame it on the polar vortex. Actually, this was supposed to be a 2018 summer update, so it is not fair to blame the CLE winter for my tardiness. Ah, summer (Figure 1). Where did you […]
As you may or may not know, I organize the annual Cleveland Institute for Computational Biology (CICB) annual symposium, otherwise and affectionately known as the North Coast Conference on Precision Medicine (Figure 1). I organized the first one-day symposium in 2015, and I was pretty proud of it as we were the only ones in […]
Unless you have been living under a rock, you know that NIH has launched the largest effort to date to establish a cohort in the United States. Chatter about the need for a nationally representative cohort bubbled up more than ten years ago in a commentary by Dr. Francis Collins (PMID:15164074), then head of the […]
SACNAS, San Antonio, TX, 2018 The Importance of Diversity in Precision Medicine Research Narrative: National efforts are underway to ascertain one million participants for precision medicine research and an intense interest in ensuring this cohort is diverse across multiple dimensions. We provide here an overview of the importance of diversity in precision medicine research highlighting […]