WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Genetic and clinical risk prediction model for postoperative atrial fibrillation.

Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D,. Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at […]

Knowledge-constrained K-medoids Clustering of Regulatory Rare Alleles for Burden Tests.

Sivley RM, Fish AE, Bush WS,. Rarely occurring genetic variants are hypothesized to influence human diseases, but statistically associating these rare variants to disease is challenging due to a lack of statistical power in most feasibly sized datasets. Several statistical tests have been developed to either collapse multiple rare variants from a genomic region into […]

SecureMA: protecting participant privacy in genetic association meta-analysis.

Xie W, Kantarcioglu M, Bush WS, Crawford D, Denny JC, Heatherly R, Malin BA,. Sharing genomic data is crucial to support scientific investigation such as genome-wide association studies. However, recent investigations suggest the privacy of the individual participants in these studies can be compromised, leading to serious concerns and consequences, such as overly restricted access […]

Recent Publications

  1. Wang, TC, Archer, DB, Ali, M, Wu, Y, Mormino, E, Buckley, RF, Lee, AJ, Saykin, AJ, De Jager, PL, Schneider, JA et al.. Combining post-mortem and neuroimaging measures of brain amyloidosis to accelerate genomic discovery. Brain 2026; : . PubMed PMID:42334898 .
  2. Liu, C, Zhu, Z, Lin, H, Bush, WS, Jenq, RR, Cominelli, F, Pillai, JA, Haines, JL, Zhu, X, Xu, R et al.. The gut-brain axis in Alzheimer's disease: early detection, microbial metabolites, mechanisms, and therapeutic opportunities. Front Mol Biosci 2026; 13 : 1735332. PubMed PMID:42325435 PubMed Central PMC13275447.
  3. Rose, CM, Bush, WS, Beno, MF, Williams, SM, Haines, JL, Crawford, DC. Leadership, Informatics Expertise, and Resources: Determinants of Institutional Data Sharing in the National Clinical Cohort Collaborative (N3C). AMIA Jt Summits Transl Sci Proc 2026; 2026 : 381-389. PubMed PMID:42317826 PubMed Central PMC13274281.
  4. Sun, X, Mews, M, Wheeler, NR, Benchek, P, Gu, T, Gomez, L, Ray, N, Reitz, C, Naj, AC, Below, JE et al.. Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease. Am J Hum Genet 2026; 113 (6): 1279-1296. PubMed PMID:42066773 PubMed Central PMC13247992.
  5. Ray, NR, Kurup, J, Kumar, A, Rajabli, F, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C, Bertholim-Nasciben, L et al.. Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. Alzheimers Dement 2026; 22 (4): e71433. PubMed PMID:42043782 PubMed Central PMC13116102.
  6. Eissman, JM, Regelson, AN, Walters, S, Archer, DB, Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH et al.. Sex-specific genetic drivers of memory, executive functioning and language in older adults. Brain 2026; : . PubMed PMID:41989867 .
  7. Liu, S, Bush, WS, Kunkle, BW, Byrd, GS, Reitz, C, Tosto, G, Rajabli, F, Caban-Holt, AM, Cuccaro, M, Starks, T et al.. Dissecting Alzheimer's disease heritability across populations. Alzheimers Dement 2026; 22 (3): e71236. PubMed PMID:41880092 PubMed Central PMC13093350.
  8. Bledsoe, X, Wang, TC, Wu, Y, Archer, D, Chen, HH, Naj, AC, Bush, WS, Hohman, TJ, Dumitrescu, L, Below, JE et al.. Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease. Alzheimers Dement 2026; 22 (2): e71217. PubMed PMID:41732108 PubMed Central PMC12930104.
  9. Contreras, AG, Walters, S, Eissman, JM, Archer, DB, Regelson, AN, Durant, A, Clifton, M, Mukherjee, S, Lee, ML, Choi, SE et al.. Genetic modifiers of APOE-ε4-associated cognitive decline. Nat Commun 2026; 17 (1): . PubMed PMID:41720779 PubMed Central PMC13036010.
  10. Dorfsman, DA, Cai, D, Hamilton-Nelson, KL, Adams, LD, Mena, PR, Rodriguez, VC, Sanchez, JJ, Valladares, GS, Lopez, M, Whitehead, PL et al.. Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181. J Alzheimers Dis 2026; 110 (2): 685-695. PubMed PMID:41660940 PubMed Central PMC12982544.
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