WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Genetic and clinical risk prediction model for postoperative atrial fibrillation.

Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D,. Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at […]

Knowledge-constrained K-medoids Clustering of Regulatory Rare Alleles for Burden Tests.

Sivley RM, Fish AE, Bush WS,. Rarely occurring genetic variants are hypothesized to influence human diseases, but statistically associating these rare variants to disease is challenging due to a lack of statistical power in most feasibly sized datasets. Several statistical tests have been developed to either collapse multiple rare variants from a genomic region into […]

SecureMA: protecting participant privacy in genetic association meta-analysis.

Xie W, Kantarcioglu M, Bush WS, Crawford D, Denny JC, Heatherly R, Malin BA,. Sharing genomic data is crucial to support scientific investigation such as genome-wide association studies. However, recent investigations suggest the privacy of the individual participants in these studies can be compromised, leading to serious concerns and consequences, such as overly restricted access […]

Recent Publications

  1. Kaur, H, Bush, WS, Letendre, SL, Ellis, RJ, Heaton, RK, Patton, SM, Connor, JR, Samuels, DC, Franklin, DR, Hulgan, T et al.. Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV. Mol Neurobiol 2021; 58 (10): 4842-4855. PubMed PMID:34195939 .
  2. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Lui, A, Martinez, ME, Rose, BS, Mahal, B, Eeles, RA, Kote-Jarai, Z et al.. Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24. Prostate Cancer Prostatic Dis 2021; : . PubMed PMID:34127801 .
  3. Patel, N, Bush, WS. Modeling transcriptional regulation using gene regulatory networks based on multi-omics data sources. BMC Bioinformatics 2021; 22 (1): 200. PubMed PMID:33874910 PubMed Central PMC8056605.
  4. Pillai, JA, Bebek, G, Khrestian, M, Bena, J, Bergmann, CC, Bush, WS, Leverenz, JB, Bekris, LM. TNFRSF1B Gene Variants and Related Soluble TNFR2 Levels Impact Resilience in Alzheimer's Disease. Front Aging Neurosci 2021; 13 : 638922. PubMed PMID:33716716 PubMed Central PMC7947258.
  5. Huynh-Le, MP, Fan, CC, Karunamuni, R, Thompson, WK, Martinez, ME, Eeles, RA, Kote-Jarai, Z, Muir, K, Schleutker, J, Pashayan, N et al.. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. Nat Commun 2021; 12 (1): 1236. PubMed PMID:33623038 PubMed Central PMC7902617.
  6. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (3): 413. PubMed PMID:33473200 .
  7. Stein, CM, Benchek, P, Bartlett, J, Igo, RP, Sobota, RS, Chervenak, K, Mayanja-Kizza, H, von Reyn, CF, Lahey, T, Bush, WS et al.. Methylome-wide Analysis Reveals Epigenetic Marks Associated With Resistance to Tuberculosis in Human Immunodeficiency Virus-Infected Individuals From East Africa. J Infect Dis 2021; 224 (4): 695-704. PubMed PMID:33400784 PubMed Central PMC8366433.
  8. Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T et al.. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet 2021; 53 (1): 65-75. PubMed PMID:33398198 PubMed Central PMC8148035.
  9. Liu, LY, Bush, WS, Koyutürk, M, Karakurt, G. Interplay between traumatic brain injury and intimate partner violence: data driven analysis utilizing electronic health records. BMC Womens Health 2020; 20 (1): 269. PubMed PMID:33287806 PubMed Central PMC7720451.
  10. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
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