WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

CC-logoCWRUlogowTag240x120

Featured Publications

Genetic and clinical risk prediction model for postoperative atrial fibrillation.

Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D,. Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that atrial fibrillation susceptibility single nucleotide polymorphisms (SNPs) at […]

Knowledge-constrained K-medoids Clustering of Regulatory Rare Alleles for Burden Tests.

Sivley RM, Fish AE, Bush WS,. Rarely occurring genetic variants are hypothesized to influence human diseases, but statistically associating these rare variants to disease is challenging due to a lack of statistical power in most feasibly sized datasets. Several statistical tests have been developed to either collapse multiple rare variants from a genomic region into […]

SecureMA: protecting participant privacy in genetic association meta-analysis.

Xie W, Kantarcioglu M, Bush WS, Crawford D, Denny JC, Heatherly R, Malin BA,. Sharing genomic data is crucial to support scientific investigation such as genome-wide association studies. However, recent investigations suggest the privacy of the individual participants in these studies can be compromised, leading to serious concerns and consequences, such as overly restricted access […]

Recent Publications

  1. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
  2. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, UKGPCS Collaborators, Lophatananon, A, Tangen, CM et al.. African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Int J Cancer 2020; : . PubMed PMID:32930425 .
  3. Tang, ZZ, Sliwoski, GR, Chen, G, Jin, B, Bush, WS, Li, B, Capra, JA. PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection. Genome Biol 2020; 21 (1): 217. PubMed PMID:32847609 PubMed Central PMC7448521.
  4. Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al.. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain 2020; 143 (8): 2561-2575. PubMed PMID:32844198 PubMed Central PMC7447518.
  5. Griswold, AJ, Sivasankaran, SK, Van Booven, D, Gardner, OK, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Scott, AM, Hofmann, NK et al.. Immune and Inflammatory Pathways Implicated by Whole Blood Transcriptomic Analysis in a Diverse Ancestry Alzheimer's Disease Cohort. J Alzheimers Dis 2020; 76 (3): 1047-1060. PubMed PMID:32597797 .
  6. Darst, BF, Wan, P, Sheng, X, Bensen, JT, Ingles, SA, Rybicki, BA, Nemesure, B, John, EM, Fowke, JH, Stevens, VL et al.. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur Urol 2020; 78 (3): 316-320. PubMed PMID:32409115 .
  7. Ji, X, Mukherjee, S, Landi, MT, Bosse, Y, Joubert, P, Zhu, D, Gorlov, I, Xiao, X, Han, Y, Gorlova, O et al.. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun 2020; 11 (1): 2220. PubMed PMID:32393777 PubMed Central PMC7214407.
  8. Bush, WS, Wheeler, N, Beaulieu-Jones, B, Darabos, C. Packaging Biocomputing Software to Maximize Distribution and Reuse. Pac Symp Biocomput 2020; 25 : 739-742. PubMed PMID:31797644 .
  9. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
  10. Wheeler, NR, Benchek, P, Kunkle, BW, Hamilton-Nelson, KL, Warfe, M, Fondran, JR, Haines, JL, Bush, WS. Hadoop and PySpark for reproducibility and scalability of genomic sequencing studies. Pac Symp Biocomput 2020; 25 : 523-534. PubMed PMID:31797624 PubMed Central PMC6956992.
Search PubMed