WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Bioinformatics challenges in genome-wide association studies (GWAS).

De R, Bush WS, Moore JH,. Genome-wide association studies (GWAS) are a powerful tool for investigators to examine the human genome to detect genetic risk factors, reveal the genetic architecture of diseases and open up new opportunities for treatment and prevention. However, despite its successes, GWAS have not been able to identify genetic loci that […]

Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes.

Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA,. G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received […]

Recent Publications

  1. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
  2. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, UKGPCS Collaborators, Lophatananon, A, Tangen, CM et al.. African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Int J Cancer 2020; : . PubMed PMID:32930425 .
  3. Tang, ZZ, Sliwoski, GR, Chen, G, Jin, B, Bush, WS, Li, B, Capra, JA. PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection. Genome Biol 2020; 21 (1): 217. PubMed PMID:32847609 PubMed Central PMC7448521.
  4. Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al.. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain 2020; 143 (8): 2561-2575. PubMed PMID:32844198 PubMed Central PMC7447518.
  5. Griswold, AJ, Sivasankaran, SK, Van Booven, D, Gardner, OK, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Scott, AM, Hofmann, NK et al.. Immune and Inflammatory Pathways Implicated by Whole Blood Transcriptomic Analysis in a Diverse Ancestry Alzheimer's Disease Cohort. J Alzheimers Dis 2020; 76 (3): 1047-1060. PubMed PMID:32597797 .
  6. Darst, BF, Wan, P, Sheng, X, Bensen, JT, Ingles, SA, Rybicki, BA, Nemesure, B, John, EM, Fowke, JH, Stevens, VL et al.. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur Urol 2020; 78 (3): 316-320. PubMed PMID:32409115 .
  7. Ji, X, Mukherjee, S, Landi, MT, Bosse, Y, Joubert, P, Zhu, D, Gorlov, I, Xiao, X, Han, Y, Gorlova, O et al.. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun 2020; 11 (1): 2220. PubMed PMID:32393777 PubMed Central PMC7214407.
  8. Bush, WS, Wheeler, N, Beaulieu-Jones, B, Darabos, C. Packaging Biocomputing Software to Maximize Distribution and Reuse. Pac Symp Biocomput 2020; 25 : 739-742. PubMed PMID:31797644 .
  9. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
  10. Wheeler, NR, Benchek, P, Kunkle, BW, Hamilton-Nelson, KL, Warfe, M, Fondran, JR, Haines, JL, Bush, WS. Hadoop and PySpark for reproducibility and scalability of genomic sequencing studies. Pac Symp Biocomput 2020; 25 : 523-534. PubMed PMID:31797624 PubMed Central PMC6956992.
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