WILLIAM S. BUSH, PH.D.

Associate Director for Bioinformatics Research

William S. Bush, Ph.D. is an Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his Ph.D. at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Bioinformatics challenges in genome-wide association studies (GWAS).

De R, Bush WS, Moore JH,. Genome-wide association studies (GWAS) are a powerful tool for investigators to examine the human genome to detect genetic risk factors, reveal the genetic architecture of diseases and open up new opportunities for treatment and prevention. However, despite its successes, GWAS have not been able to identify genetic loci that […]

Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes.

Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA,. G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received […]

Recent Publications

  1. Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Bush, WS, Gifford, KA, Chibnik, LB, Mukherjee, S, De Jager, PL et al.. Sex differences in the genetic predictors of Alzheimer's pathology. Brain 2019; 142 (9): 2581-2589. PubMed PMID:31497858 PubMed Central PMC6736148.
  2. Bush, WS, Cooke Bailey, JN, Beno, MF, Crawford, DC. Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines. Public Health Genomics 2019; 22 (1-2): 16-24. PubMed PMID:31454805 PubMed Central PMC6752968.
  3. Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A et al.. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat. Genet. 2019; 51 (9): 1423-1424. PubMed PMID:31417202 .
  4. Gardner, OK, Wang, L, Van Booven, D, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Starks, TD, Hofmann, NK, Vance, JM, Cuccaro, ML et al.. RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways. Hum. Mol. Genet. 2019; 28 (18): 3053-3061. PubMed PMID:31162550 PubMed Central PMC6737295.
  5. Li, Y, Xiao, X, Bossé, Y, Gorlova, O, Gorlov, I, Han, Y, Byun, J, Leighl, N, Johansen, JS, Barnett, M et al.. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development. Oncotarget 2019; 10 (19): 1760-1774. PubMed PMID:30956756 PubMed Central PMC6442994.
  6. Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A et al.. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat. Genet. 2019; 51 (3): 414-430. PubMed PMID:30820047 PubMed Central PMC6463297.
  7. Beecham, GW, Vardarajan, B, Blue, E, Bush, W, Jaworski, J, Barral, S, DeStefano, A, Hamilton-Nelson, K, Kunkle, B, Martin, ER et al.. Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease. Neurol Genet 2018; 4 (6): e286. PubMed PMID:30569016 PubMed Central PMC6278241.
  8. Arabnejad, M, Dawkins, BA, Bush, WS, White, BC, Harkness, AR, McKinney, BA. Transition-transversion encoding and genetic relationship metric in ReliefF feature selection improves pathway enrichment in GWAS. BioData Min 2018; 11 : 23. PubMed PMID:30410580 PubMed Central PMC6215626.
  9. Kallianpur, AR, Gittleman, H, Letendre, S, Ellis, R, Barnholtz-Sloan, JS, Bush, WS, Heaton, R, Samuels, DC, Franklin, DR Jr, Rosario-Cookson, D et al.. Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection. Mol. Neurobiol. 2019; 56 (5): 3808-3818. PubMed PMID:30209774 .
  10. Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al.. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol. Psychiatry 2018; : . PubMed PMID:30108311 PubMed Central PMC6375806.
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