WILLIAM S. BUSH, PHD, MS
Associate Director for Bioinformatics Research
William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.
Featured Publications
ICD-9 tobacco use codes are effective identifiers of smoking status.
Wiley LK, Shah A, Xu H, Bush WS,. To evaluate the validity of, characterize the usage of, and propose potential research applications for International Classification of Diseases, Ninth Revision (ICD-9) tobacco codes in clinical populations.Using data on cancer cases and cancer-free controls from Vanderbilt’s biorepository, BioVU, we evaluated the utility of ICD-9 tobacco use codes […]
A small number of candidate gene SNPs reveal continental ancestry in African Americans.
Kodaman N, Aldrich MC, Smith JR, Signorello LB, Bradley K, Breyer J, Cohen SS, Long J, Cai Q, Giles J, Bush WS, Blot WJ, Matthews CE, Williams SM,. Using genetic data from an obesity candidate gene study of self-reported African Americans and European Americans, we investigated the number of Ancestry Informative Markers (AIMs) and candidate […]
A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data.
Buchanan CC, Torstenson ES, Bush WS, Ritchie MD,. Since publication of the human genome in 2003, geneticists have been interested in risk variant associations to resolve the etiology of traits and complex diseases. The International HapMap Consortium undertook an effort to catalog all common variation across the genome (variants with a minor allele frequency (MAF) […]
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.
Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, , Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL,. Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system, and numerous studies have shown that MS has a strong genetic component. […]
A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility.
Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD, ,. Gene-gene interactions are proposed as an important component of the genetic architecture of complex diseases, and are just beginning to be evaluated in the context of […]
Recent Publications
- Zhang, X, Gomez, L, Below, JE, Naj, AC, Martin, ER, Kunkle, BW, Bush, WS. An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer's Disease. J Alzheimers Dis 2024; 98 (3): 1053-1067. PubMed PMID:38489177 .
- Guo, Z, Duan, D, Tang, W, Zhu, J, Bush, WS, Zhang, L, Zhu, X, Jin, F, Feng, H. magpie: A power evaluation method for differential RNA methylation analysis in N6-methyladenosine sequencing. PLoS Comput Biol 2024; 20 (2): e1011875. PubMed PMID:38346081 PubMed Central PMC10890765.
- Leung, YY, Naj, AC, Chou, YF, Valladares, O, Schmidt, M, Hamilton-Nelson, K, Wheeler, N, Lin, H, Gangadharan, P, Qu, L et al.. Human whole-exome genotype data for Alzheimer's disease. Nat Commun 2024; 15 (1): 684. PubMed PMID:38263370 PubMed Central PMC10805795.
- Archer, DB, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement 2024; 20 (2): 1268-1283. PubMed PMID:37985223 PubMed Central PMC10896586.
- Eissman, JM, Archer, DB, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Sex-specific genetic architecture of late-life memory performance. Alzheimers Dement 2024; 20 (2): 1250-1267. PubMed PMID:37984853 PubMed Central PMC10917043.
- Wang, A, Shen, J, Rodriguez, AA, Saunders, EJ, Chen, F, Janivara, R, Darst, BF, Sheng, X, Xu, Y, Chou, AJ et al.. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet 2023; 55 (12): 2065-2074. PubMed PMID:37945903 PubMed Central PMC10841479.
- Greenfest-Allen, E, Valladares, O, Kuksa, PP, Gangadharan, P, Lee, WP, Cifello, J, Katanic, Z, Kuzma, AB, Wheeler, N, Bush, WS et al.. NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge. Alzheimers Dement 2024; 20 (2): 1123-1136. PubMed PMID:37881831 PubMed Central PMC10916966.
- Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project. medRxiv 2023; : . PubMed PMID:37693521 PubMed Central PMC10491367.
- Tejeda, M, Farrell, J, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD, Pericak-Vance, MA et al.. DNA from multiple viral species is associated with Alzheimer's disease risk. Alzheimers Dement 2024; 20 (1): 253-265. PubMed PMID:37578203 PubMed Central PMC10840621.
- Walters, S, Contreras, AG, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS et al.. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol 2023; 80 (9): 929-939. PubMed PMID:37459083 PubMed Central PMC10352930.