WILLIAM S. BUSH, PH.D.

Associate Director for Bioinformatics Research

William S. Bush, Ph.D. is an Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his Ph.D. at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

ICD-9 tobacco use codes are effective identifiers of smoking status.

Wiley LK, Shah A, Xu H, Bush WS,. To evaluate the validity of, characterize the usage of, and propose potential research applications for International Classification of Diseases, Ninth Revision (ICD-9) tobacco codes in clinical populations.Using data on cancer cases and cancer-free controls from Vanderbilt’s biorepository, BioVU, we evaluated the utility of ICD-9 tobacco use codes […]

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.

Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, , Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL,. Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system, and numerous studies have shown that MS has a strong genetic component. […]

Recent Publications

  1. Li, Y, Xiao, X, Bossé, Y, Gorlova, O, Gorlov, I, Han, Y, Byun, J, Leighl, N, Johansen, JS, Barnett, M et al.. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development. Oncotarget 2019; 10 (19): 1760-1774. PubMed PMID:30956756 PubMed Central PMC6442994.
  2. Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A et al.. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat. Genet. 2019; 51 (3): 414-430. PubMed PMID:30820047 PubMed Central PMC6463297.
  3. Beecham, GW, Vardarajan, B, Blue, E, Bush, W, Jaworski, J, Barral, S, DeStefano, A, Hamilton-Nelson, K, Kunkle, B, Martin, ER et al.. Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease. Neurol Genet 2018; 4 (6): e286. PubMed PMID:30569016 PubMed Central PMC6278241.
  4. Arabnejad, M, Dawkins, BA, Bush, WS, White, BC, Harkness, AR, McKinney, BA. Transition-transversion encoding and genetic relationship metric in ReliefF feature selection improves pathway enrichment in GWAS. BioData Min 2018; 11 : 23. PubMed PMID:30410580 PubMed Central PMC6215626.
  5. Kallianpur, AR, Gittleman, H, Letendre, S, Ellis, R, Barnholtz-Sloan, JS, Bush, WS, Heaton, R, Samuels, DC, Franklin, DR Jr, Rosario-Cookson, D et al.. Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection. Mol. Neurobiol. 2018; : . PubMed PMID:30209774 .
  6. Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE et al.. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol. Psychiatry 2018; : . PubMed PMID:30108311 PubMed Central PMC6375806.
  7. Ji, X, Bossé, Y, Landi, MT, Gui, J, Xiao, X, Qian, D, Joubert, P, Lamontagne, M, Li, Y, Gorlov, I et al.. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nat Commun 2018; 9 (1): 3221. PubMed PMID:30104567 PubMed Central PMC6089967.
  8. Igo, RP Jr, Hall, NB, Malone, LL, Hall, JB, Truitt, B, Qiu, F, Tao, L, Mupere, E, Schnell, A, Hawn, TR et al.. Fine-mapping analysis of a chromosome 2 region linked to resistance to Mycobacterium tuberculosis infection in Uganda reveals potential regulatory variants. Genes Immun. 2018; : . PubMed PMID:30100616 PubMed Central PMC6374218.
  9. Smieszek, S, Jia, P, Samuels, DC, Zhao, Z, Barnholtz-Sloan, J, Kaur, H, Letendre, S, Ellis, R, Franklin, DR, Hulgan, T et al.. Nuclear-Mitochondrial interactions influence susceptibility to HIV-associated neurocognitive impairment. Mitochondrion 2018; : . PubMed PMID:30026132 PubMed Central PMC6336535.
  10. Deming, Y, Dumitrescu, L, Barnes, LL, Thambisetty, M, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL et al.. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018; 136 (6): 857-872. PubMed PMID:29967939 PubMed Central PMC6280657.
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