WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Anderson LL, Thompson CH, Hawkins NA, Nath RD, Petersohn AA, Rajamani S, Bush WS, Frankel WN, Vanoye CG, Kearney JA, George AL,. Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by voltage-gated sodium (NaV ) channels as a contributor to the pathogenesis of epilepsy. Many antiepileptic drugs target NaV channels […]

eMERGEing progress in genomics-the first seven years.

Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD,. The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007 by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in part […]

Automated quantification of pancreatic β-cell mass.

Golson ML, Bush WS, Brissova M,. β-Cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using conventional histological methods is a time-consuming process. Rapidly evolving virtual slide technology with high-resolution slide scanners and newly developed image analysis tools has the potential to […]

Recent Publications

  1. Cooke Bailey, JN, Bush, WS, Crawford, DC. Editorial: The Importance of Diversity in Precision Medicine Research. Front Genet 2020; 11 : 875. PubMed PMID:33005167 PubMed Central PMC7479241.
  2. Karunamuni, RA, Huynh-Le, MP, Fan, CC, Thompson, W, Eeles, RA, Kote-Jarai, Z, Muir, K, UKGPCS Collaborators, Lophatananon, A, Tangen, CM et al.. African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer. Int J Cancer 2020; : . PubMed PMID:32930425 .
  3. Tang, ZZ, Sliwoski, GR, Chen, G, Jin, B, Bush, WS, Li, B, Capra, JA. PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection. Genome Biol 2020; 21 (1): 217. PubMed PMID:32847609 PubMed Central PMC7448521.
  4. Dumitrescu, L, Mahoney, ER, Mukherjee, S, Lee, ML, Bush, WS, Engelman, CD, Lu, Q, Fardo, DW, Trittschuh, EH, Mez, J et al.. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain 2020; 143 (8): 2561-2575. PubMed PMID:32844198 PubMed Central PMC7447518.
  5. Griswold, AJ, Sivasankaran, SK, Van Booven, D, Gardner, OK, Rajabli, F, Whitehead, PL, Hamilton-Nelson, KL, Adams, LD, Scott, AM, Hofmann, NK et al.. Immune and Inflammatory Pathways Implicated by Whole Blood Transcriptomic Analysis in a Diverse Ancestry Alzheimer's Disease Cohort. J Alzheimers Dis 2020; 76 (3): 1047-1060. PubMed PMID:32597797 .
  6. Darst, BF, Wan, P, Sheng, X, Bensen, JT, Ingles, SA, Rybicki, BA, Nemesure, B, John, EM, Fowke, JH, Stevens, VL et al.. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur Urol 2020; 78 (3): 316-320. PubMed PMID:32409115 .
  7. Ji, X, Mukherjee, S, Landi, MT, Bosse, Y, Joubert, P, Zhu, D, Gorlov, I, Xiao, X, Han, Y, Gorlova, O et al.. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun 2020; 11 (1): 2220. PubMed PMID:32393777 PubMed Central PMC7214407.
  8. Bush, WS, Wheeler, N, Beaulieu-Jones, B, Darabos, C. Packaging Biocomputing Software to Maximize Distribution and Reuse. Pac Symp Biocomput 2020; 25 : 739-742. PubMed PMID:31797644 .
  9. Crawford, DC, Lin, J, Cooke Bailey, JN, Kinzy, T, Sedor, JR, O'Toole, JF, Bush, WS. Frequency of ClinVar Pathogenic Variants in Chronic Kidney Disease Patients Surveyed for Return of Research Results at a Cleveland Public Hospital. Pac Symp Biocomput 2020; 25 : 575-586. PubMed PMID:31797629 PubMed Central PMC6931908.
  10. Wheeler, NR, Benchek, P, Kunkle, BW, Hamilton-Nelson, KL, Warfe, M, Fondran, JR, Haines, JL, Bush, WS. Hadoop and PySpark for reproducibility and scalability of genomic sequencing studies. Pac Symp Biocomput 2020; 25 : 523-534. PubMed PMID:31797624 PubMed Central PMC6956992.
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