WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

CC-logoCWRUlogowTag240x120

Featured Publications

Antiepileptic activity of preferential inhibitors of persistent sodium current.

Anderson LL, Thompson CH, Hawkins NA, Nath RD, Petersohn AA, Rajamani S, Bush WS, Frankel WN, Vanoye CG, Kearney JA, George AL,. Evidence from basic neurophysiology and molecular genetics has implicated persistent sodium current conducted by voltage-gated sodium (NaV ) channels as a contributor to the pathogenesis of epilepsy. Many antiepileptic drugs target NaV channels […]

eMERGEing progress in genomics-the first seven years.

Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD,. The electronic MEdical Records & GEnomics (eMERGE) network was established in 2007 by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) in part […]

Automated quantification of pancreatic β-cell mass.

Golson ML, Bush WS, Brissova M,. β-Cell mass is a parameter commonly measured in studies of islet biology and diabetes. However, the rigorous quantification of pancreatic β-cell mass using conventional histological methods is a time-consuming process. Rapidly evolving virtual slide technology with high-resolution slide scanners and newly developed image analysis tools has the potential to […]

Recent Publications

  1. Guo, Z, Duan, D, Tang, W, Zhu, J, Bush, WS, Zhang, L, Zhu, X, Jin, F, Feng, H. magpie: A power evaluation method for differential RNA methylation analysis in N6-methyladenosine sequencing. PLoS Comput Biol 2024; 20 (2): e1011875. PubMed PMID:38346081 PubMed Central PMC10890765.
  2. Leung, YY, Naj, AC, Chou, YF, Valladares, O, Schmidt, M, Hamilton-Nelson, K, Wheeler, N, Lin, H, Gangadharan, P, Qu, L et al.. Human whole-exome genotype data for Alzheimer's disease. Nat Commun 2024; 15 (1): 684. PubMed PMID:38263370 PubMed Central PMC10805795.
  3. Archer, DB, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement 2024; 20 (2): 1268-1283. PubMed PMID:37985223 PubMed Central PMC10896586.
  4. Eissman, JM, Archer, DB, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Sex-specific genetic architecture of late-life memory performance. Alzheimers Dement 2024; 20 (2): 1250-1267. PubMed PMID:37984853 .
  5. Wang, A, Shen, J, Rodriguez, AA, Saunders, EJ, Chen, F, Janivara, R, Darst, BF, Sheng, X, Xu, Y, Chou, AJ et al.. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet 2023; 55 (12): 2065-2074. PubMed PMID:37945903 PubMed Central PMC10841479.
  6. Greenfest-Allen, E, Valladares, O, Kuksa, PP, Gangadharan, P, Lee, WP, Cifello, J, Katanic, Z, Kuzma, AB, Wheeler, N, Bush, WS et al.. NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge. Alzheimers Dement 2024; 20 (2): 1123-1136. PubMed PMID:37881831 .
  7. Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project. medRxiv 2023; : . PubMed PMID:37693521 PubMed Central PMC10491367.
  8. Tejeda, M, Farrell, J, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD, Pericak-Vance, MA et al.. DNA from multiple viral species is associated with Alzheimer's disease risk. Alzheimers Dement 2024; 20 (1): 253-265. PubMed PMID:37578203 PubMed Central PMC10840621.
  9. Walters, S, Contreras, AG, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS et al.. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol 2023; 80 (9): 929-939. PubMed PMID:37459083 PubMed Central PMC10352930.
  10. Grunin, M, Palmer, E, de Jong, S, Jin, B, Rinker, D, Moth, C, Capra, JA, Haines, JL, Bush, WS, den Hollander, AI et al.. Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease. Adv Exp Med Biol 2023; 1415 : 157-163. PubMed PMID:37440029 .
Search PubMed