WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry.

Dumitrescu L, Restrepo NA, Goodloe R, Boston J, Farber-Eger E, Pendergrass SA, Bush WS, Crawford DC,. Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed populations, such as African Americans, provides a unique opportunity to identify […]

Gene expression in cell lines from propionic acidemia patients, carrier parents, and controls.

Chapman KA, Bush WS, Zhang Z,. Propionic acidemia (PA) is an inborn of metabolism which usually presents with metabolic acidosis and accumulation of 3-hydroxypropionate among other toxins. Examining the gene expression in lymphoblastoid cell lines (LCLs) from PA patients, their carrier parents and age/sex-matched controls at normal glucose and low glucose growth conditions demonstrated differences […]

Sex-Specific Parental Effects on Offspring Lipid Levels.

Predazzi IM, Sobota RS, Sanna S, Bush WS, Bartlett J, Lilley JS, Linton MF, Schlessinger D, Cucca F, Fazio S, Williams SM,. Plasma lipid levels are highly heritable traits, but known genetic loci can only explain a small portion of their heritability.In this study, we analyzed the role of parental levels of total cholesterol (TC), […]

Recent Publications

  1. Guo, Z, Duan, D, Tang, W, Zhu, J, Bush, WS, Zhang, L, Zhu, X, Jin, F, Feng, H. magpie: A power evaluation method for differential RNA methylation analysis in N6-methyladenosine sequencing. PLoS Comput Biol 2024; 20 (2): e1011875. PubMed PMID:38346081 PubMed Central PMC10890765.
  2. Leung, YY, Naj, AC, Chou, YF, Valladares, O, Schmidt, M, Hamilton-Nelson, K, Wheeler, N, Lin, H, Gangadharan, P, Qu, L et al.. Human whole-exome genotype data for Alzheimer's disease. Nat Commun 2024; 15 (1): 684. PubMed PMID:38263370 PubMed Central PMC10805795.
  3. Archer, DB, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement 2024; 20 (2): 1268-1283. PubMed PMID:37985223 PubMed Central PMC10896586.
  4. Eissman, JM, Archer, DB, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS, Kunkle, BW et al.. Sex-specific genetic architecture of late-life memory performance. Alzheimers Dement 2024; 20 (2): 1250-1267. PubMed PMID:37984853 .
  5. Wang, A, Shen, J, Rodriguez, AA, Saunders, EJ, Chen, F, Janivara, R, Darst, BF, Sheng, X, Xu, Y, Chou, AJ et al.. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet 2023; 55 (12): 2065-2074. PubMed PMID:37945903 PubMed Central PMC10841479.
  6. Greenfest-Allen, E, Valladares, O, Kuksa, PP, Gangadharan, P, Lee, WP, Cifello, J, Katanic, Z, Kuzma, AB, Wheeler, N, Bush, WS et al.. NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge. Alzheimers Dement 2024; 20 (2): 1123-1136. PubMed PMID:37881831 .
  7. Lee, WP, Choi, SH, Shea, MG, Cheng, PL, Dombroski, BA, Pitsillides, AN, Heard-Costa, NL, Wang, H, Bulekova, K, Kuzma, AB et al.. Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project. medRxiv 2023; : . PubMed PMID:37693521 PubMed Central PMC10491367.
  8. Tejeda, M, Farrell, J, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD, Pericak-Vance, MA et al.. DNA from multiple viral species is associated with Alzheimer's disease risk. Alzheimers Dement 2024; 20 (1): 253-265. PubMed PMID:37578203 PubMed Central PMC10840621.
  9. Walters, S, Contreras, AG, Eissman, JM, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Trittschuh, EH, Mez, JB, Bush, WS et al.. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol 2023; 80 (9): 929-939. PubMed PMID:37459083 PubMed Central PMC10352930.
  10. Grunin, M, Palmer, E, de Jong, S, Jin, B, Rinker, D, Moth, C, Capra, JA, Haines, JL, Bush, WS, den Hollander, AI et al.. Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease. Adv Exp Med Biol 2023; 1415 : 157-163. PubMed PMID:37440029 .
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