WILLIAM S. BUSH, PHD, MS

Associate Director for Bioinformatics Research

William S. Bush, PhD, MS, is Associate Professor in the Department of Population and Quantitative Health Sciences and the Cleveland Institute for Computational Biology at Case Western Reserve University. Dr. Bush received his PhD at Vanderbilt University in Human Genetics in 2008 and then continued as a post-doctoral fellow in the Neurogenomics Training Program at Vanderbilt. Dr. Bush was recently named a Mt. Sinai Health Care Foundation Scholar. As a human geneticist and bioinformatician, Dr. Bush’s research interests include understanding the functional impact of genetic variation, developing statistical and bioinformatics approaches for integrating functional genomics knowledge into genetic analysis, and the use of electronic medical records for translational research.

Affiliations

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Featured Publications

Bioinformatics challenges in genome-wide association studies (GWAS).

De R, Bush WS, Moore JH,. Genome-wide association studies (GWAS) are a powerful tool for investigators to examine the human genome to detect genetic risk factors, reveal the genetic architecture of diseases and open up new opportunities for treatment and prevention. However, despite its successes, GWAS have not been able to identify genetic loci that […]

Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes.

Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA,. G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received […]

Recent Publications

  1. Ray, NR, Kumar, A, Kunkle, BW, Rajabli, F, Bush, WS, Wang, L, Xu, W, Jin, F, Yilmaz, E, Kizil, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107411. PubMed PMID:41447296 PubMed Central PMC12739895.
  2. Benchek, P, Reitz, C, Dietrich, ST, Ray, NR, Hamilton-Nelson, KL, Beecham, GW, Vance, JM, Byrd, GS, Kurup, JT, Tosto, G et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107285. PubMed PMID:41447272 PubMed Central PMC12739911.
  3. Gulhan, A, Tejeda, M, Newman, C, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Bush, WS, Martin, ER, Wang, LS et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107340. PubMed PMID:41447170 PubMed Central PMC12739684.
  4. Mews, M, Mustafa, Y, Wheeler, NR, Gu, T, Gomez, L, Adams, LD, Starks, TD, Cornejo-Olivas, M, Illanes-Manrique, M, Silva, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106835. PubMed PMID:41447076 PubMed Central PMC12739627.
  5. Martin, ER, Griswold, AJ, Rajabli, F, Gu, T, Golightly, CG, Whitehead, PG, Hamilton-Nelson, KL, Adams, LD, Sanchez, JJ, Rodriguez, VC et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e107001. PubMed PMID:41447028 PubMed Central PMC12739569.
  6. Tejeda, M, Farrell, JJ, Zhu, C, Wetzler, L, Lunetta, KL, Mez, J, Bush, WS, Martin, ER, Wang, LS, Schellenberg, GD et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106840. PubMed PMID:41446937 PubMed Central PMC12739538.
  7. Wheeler, NR, Hamilton-Nelson, KL, Naj, AC, Reitz, C, Williams, SM, Tosto, G, Byrd, GS, Akinyemi, JO, Adams, LD, Coker, M et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106790. PubMed PMID:41445535 PubMed Central PMC12739542.
  8. Yang, Y, Bai, H, Benchek, P, Dumitrescu, L, Hohman, TJ, Hamilton-Nelson, KL, Griswold, AJ, Martin, ER, Schellenberg, GD, Mayeux, R et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106626. PubMed PMID:41445431 PubMed Central PMC12739442.
  9. Mena, PR, Zaman, AF, Cuccaro, ML, McInerney, KF, Adams, LD, Chavez, J, Reitz, C, Tosto, G, Bush, WS, Haines, JL et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106589. PubMed PMID:41445168 PubMed Central PMC12739226.
  10. Durant, A, Mukherjee, S, Lee, ML, Choi, SE, Scollard, P, Klinedinst, B, Trittschuh, EH, Mez, J, Farrer, LA, Cruchaga, C et al.. Basic Science and Pathogenesis. Alzheimers Dement 2025; 21 Suppl 1 (Suppl 1): e106764. PubMed PMID:41444932 PubMed Central PMC12738471.
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